公开(公告)号：WO2008079683A2

公开(公告)日：2008-07-03

申请号：PCT/US2007/087163

申请日：2007-12-12

Applicant: ABBOTT LABORATORIES ,  GOMTSYAN, Arthur R. ,  SCHMIDT, Robert G. ,  DAANEN, Jerome F. ,  BAYBURT, Erol K. ,  LEE, Chih-Hung ,  LATSHAW, Steven P.

Inventor： GOMTSYAN, Arthur R. ,  SCHMIDT, Robert G. ,  DAANEN, Jerome F. ,  BAYBURT, Erol K. ,  LEE, Chih-Hung ,  LATSHAW, Steven P.

IPC: C07C275/32 ,  C07D311/58 ,  C07D215/42 ,  A61K31/17 ,  A61K31/353 ,  A61K31/47 ,  A61P25/04

CPC classification number: C07C275/32 ,  C07D215/12 ,  C07D215/42 ,  C07D215/54 ,  C07D311/58 ,  C07D311/74

Abstract: The present application is directed to compounds that are TRPV1 antagonictc and have formula(I): wherein variables Ar 1 , L 1 , R 1 , R 2 , R 3 , R 4 , R 5 , Y 1 , Y 2 , and Y 3 , are as defined in the description, which are useful for treating disorders caused by or exacerbated by vanilloid receptor activity.

Abstract translation: 本申请涉及TRPV1拮抗剂并具有式（I）的化合物：其中变量Ar 1，L 1，R 1， R 2，R 3，R 4，R 5，Y 1， Y 2和Y 3是如描述中所定义的，其可用于治疗由香草素受体活性引起或加剧的病症。

公开(公告)号：WO2010045402A1

公开(公告)日：2010-04-22

申请号：PCT/US2009/060734

申请日：2009-10-15

Applicant: ABBOTT LABORATORIES ,  GOMTSYAN, Arthur R. ,  VOIGHT, Eric A. ,  BAYBURT, Erol K. ,  CHEN, Jun ,  DAANEN, Jerome F. ,  DIDOMENICO, Stanley, Jr. ,  KORT, Michael E. ,  KYM, Philip R. ,  MCDONALD, Heath A. ,  PERNER, Richard J. ,  SCHMIDT, Robert G.

Inventor： GOMTSYAN, Arthur R. ,  VOIGHT, Eric A. ,  BAYBURT, Erol K. ,  CHEN, Jun ,  DAANEN, Jerome F. ,  DIDOMENICO, Stanley, Jr. ,  KORT, Michael E. ,  KYM, Philip R. ,  MCDONALD, Heath A. ,  PERNER, Richard J. ,  SCHMIDT, Robert G.

IPC: C07D311/74 ,  C07D405/12 ,  A61K31/33 ,  A61P19/02

CPC classification number: C07D405/12 ,  C07D311/74

Abstract: Disclosed herein are compounds of formula (I), or pharmaceutically acceptable salts, solvates, prodrugs, salts of prodrugs, or combinations thereof, wherein R1, R2, R3, R4, and m are defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.

Abstract translation: 本文公开了式（I）化合物或其药学上可接受的盐，溶剂合物，前药，前药盐或其组合，其中R1，R2，R3，R4和m在说明书中定义。 还公开了包含这些化合物的组合物和使用这些化合物和组合物治疗病症和病症的方法。

公开(公告)号：WO2010045401A1

公开(公告)日：2010-04-22

申请号：PCT/US2009/060732

申请日：2009-10-15

Applicant: ABBOTT LABORATORIES ,  GOMTSYAN, Arthur R. ,  VOIGHT, Eric A. ,  BAYBURT, Erol K. ,  CHEN, Jun ,  DAANEN, Jerome F. ,  DIDOMENICO, JR., Stanley ,  KORT, Michael E. ,  KYM, Philip R. ,  MCDONALD, Heath A. ,  PERNER, Richard J. ,  SCHMIDT, Robert G.

Inventor： GOMTSYAN, Arthur R. ,  VOIGHT, Eric A. ,  BAYBURT, Erol K. ,  CHEN, Jun ,  DAANEN, Jerome F. ,  DIDOMENICO, JR., Stanley ,  KORT, Michael E. ,  KYM, Philip R. ,  MCDONALD, Heath A. ,  PERNER, Richard J. ,  SCHMIDT, Robert G.

IPC: C07D311/74 ,  C07D405/12 ,  A61K31/33 ,  A61P19/02

CPC classification number: C07D311/74 ,  C07D405/12

Abstract: Disclosed herein are compounds of Formula (I), or pharmaceutically acceptable salts, solvates, prodrugs, salts of prodrugs, or combinations thereof, wherein R 1 , R 2 , R 3 , R 4 , and m are defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.

Abstract translation: 本文公开了式（I）的化合物或其药学上可接受的盐，溶剂合物，前药，前药的盐或其组合，其中R1，R2，R3，R4和m在说明书中定义。 还公开了包含这些化合物的组合物和使用这些化合物和组合物治疗病症和病症的方法。

公开(公告)号：WO2009055629A2

公开(公告)日：2009-04-30

申请号：PCT/US2008/081042

申请日：2008-10-24

Applicant: ABBOTT LABORATORIES ,  GOMTSYAN, Arthur R. ,  SCHMIDT, Robert G. ,  BAYBURT, Erol K. ,  DAANEN, Jerome, F. ,  KORT, Michael E.

Inventor： GOMTSYAN, Arthur R. ,  SCHMIDT, Robert G. ,  BAYBURT, Erol K. ,  DAANEN, Jerome, F. ,  KORT, Michael E.

CPC classification number: C07D213/62 ,  C07D213/06 ,  C07D277/22

Abstract: The present invention relates to compounds of formula (I), wherein X, R 1 , R 2 , R 3 , R 4 , R 5 , m, and n are defined in the specification are TRPV1 antagonists. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.

Abstract translation: 本发明涉及式（I）化合物，其中X，R 1，R 2，R 3，R 4，R 5，m和n在本说明书中定义为TRPV1拮抗剂。 还公开了包含这些化合物的组合物和使用这些化合物和组合物治疗病症和病症的方法。

公开(公告)号：WO2007121299A2

公开(公告)日：2007-10-25

申请号：PCT/US2007/066515

申请日：2007-04-12

Applicant: ABBOTT LABORATORIES ,  BROWN, Brian S. ,  KOENIG, John R. ,  GOMTSYAN, Arthur R. ,  LEE, Chih-Hung

Inventor： BROWN, Brian S. ,  KOENIG, John R. ,  GOMTSYAN, Arthur R. ,  LEE, Chih-Hung

IPC: A61K31/519 ,  A61K31/4747 ,  C07D498/10

CPC classification number: C07D491/107 ,  C07D405/12 ,  C07D493/10

Abstract: The present invention is directed to compounds of formula (I), wherein variables X 1 , X 2 , Y, R 1a , R1 b , R 2a , R 2b , A 1 , A 2 , A 3 , and A 4 are as defined in the description, and methods of use to treat pain, neuropathic pain, allodynia, pain associated with inflammation or an inflammatory disease, inflammatory hyperalgesia, bladder overactivity, and urinary incontinence.

Abstract translation: 本发明涉及式（I）化合物，其中X 1，X 2，Y，R 1a，R 1， R b，R 2b，R 2b，A 1，A 2，A SUB， > 3 和A 4 <4>如描述中所定义，以及用于治疗疼痛，神经性疼痛，异常性疼痛，与炎症或炎性疾病相关的疼痛，炎性痛觉过敏，膀胱 过度活动和尿失禁。

公开(公告)号：EP2352726A1

公开(公告)日：2011-08-10

申请号：EP09740591.4

申请日：2009-10-15

Applicant: Abbott Laboratories

Inventor： GOMTSYAN, Arthur R. ,  VOIGHT, Eric A. ,  BAYBURT, Erol K. ,  CHEN, Jun ,  DAANEN, Jerome F. ,  DIDOMENICO, JR., Stanley ,  KORT, Michael E. ,  KYM, Philip R. ,  MCDONALD, Heath A. ,  PERNER, Richard J. ,  SCHMIDT, Robert G.

IPC: C07D311/74 ,  C07D405/12 ,  A61K31/33 ,  A61P19/02

CPC classification number: C07D311/74 ,  C07D405/12

Abstract: Disclosed herein are compounds of Formula (I), or pharmaceutically acceptable salts, solvates, prodrugs, salts of prodrugs, or combinations thereof, wherein R
1 , R
2 , R
3 , R
4 , and m are defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.

公开(公告)号：EP2352727A1

公开(公告)日：2011-08-10

申请号：EP09740592.2

申请日：2009-10-15

Applicant: Abbott Laboratories

Inventor： GOMTSYAN, Arthur R. ,  VOIGHT, Eric A. ,  BAYBURT, Erol K. ,  CHEN, Jun ,  DAANEN, Jerome F. ,  DIDOMENICO, Stanley, Jr. ,  KORT, Michael E. ,  KYM, Philip R. ,  MCDONALD, Heath A. ,  PERNER, Richard J. ,  SCHMIDT, Robert G.

IPC: C07D311/74 ,  C07D405/12 ,  A61K31/33 ,  A61P19/02

CPC classification number: C07D405/12 ,  C07D311/74

Abstract: Disclosed herein are compounds of formula (I), or pharmaceutically acceptable salts, solvates, prodrugs, salts of prodrugs, or combinations thereof, wherein R1, R2, R3, R4, and m are defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.

Abstract translation: 本文公开了式（I）的化合物或其药学上可接受的盐，溶剂化物，前药，前药的盐或其组合，其中R 1，R 2，R 3，R 4和m在说明书中定义。 还公开了包含此类化合物的组合物以及使用此类化合物和组合物治疗疾病和病症的方法。

公开(公告)号：EP2134678A2

公开(公告)日：2009-12-23

申请号：EP07855088.6

申请日：2007-12-12

Applicant: ABBOTT LABORATORIES

Inventor： GOMTSYAN, Arthur R. ,  SCHMIDT, Robert G. ,  DAANEN, Jerome F. ,  BAYBURT, Erol K. ,  LEE, Chih-Hung ,  LATSHAW, Steven P.

IPC: C07C275/32 ,  C07D311/58 ,  C07D215/42 ,  A61K31/17 ,  A61K31/353 ,  A61K31/47 ,  A61P25/04

CPC classification number: C07C275/32 ,  C07D215/12 ,  C07D215/42 ,  C07D215/54 ,  C07D311/58 ,  C07D311/74

Abstract: The present application is directed to compounds that are TRPV1 antagonists and have formula: (I); wherein variables Ar1, L1, R1, R2, R3, R4, R5, Y1, Y2, and Y3, are as defined in the description, which are useful for treating disorders caused by or exacerbated by vanilloid receptor activity.

公开(公告)号：EP2215061A2

公开(公告)日：2010-08-11

申请号：EP08842703.4

申请日：2008-10-24

Applicant: Abbott Laboratories

Inventor： GOMTSYAN, Arthur R. ,  SCHMIDT, Robert G. ,  BAYBURT, Erol K. ,  DAANEN, Jerome, F. ,  KORT, Michael E.

IPC: C07D213/06 ,  C07D213/62 ,  C07D277/22 ,  A61K31/44 ,  A61K31/426 ,  A61P29/00

CPC classification number: C07D213/62 ,  C07D213/06 ,  C07D277/22

Abstract: The present invention relates to compounds of formula (I), wherein X, R1, R2, R3, R4, R5, m, and n are defined in the specification are TRPV1 antagonists. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.

公开(公告)号：EP2012778A2

公开(公告)日：2009-01-14

申请号：EP07760554.1

申请日：2007-04-12

Applicant: Abbott Laboratories

Inventor： BROWN, Brian S. ,  KOENIG, John R. ,  GOMTSYAN, Arthur R. ,  LEE, Chih-Hung

IPC: A61K31/416 ,  A61K31/352 ,  C07D231/56 ,  C07D493/00

CPC classification number: C07D491/107 ,  C07D405/12 ,  C07D493/10

Abstract: The present invention is directed to compounds of formula (I), wherein variables X1, X2, Y, R1a, R1b, R2a, R2b, A1, A2, A3, and A4 are as defined in the description, and methods of use to treat pain, neuropathic pain, allodynia, pain associated with inflammation or an inflammatory disease, inflammatory hyperalgesia, bladder overactivity, and urinary incontinence.