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    METHODS AND MEANS FOR DETERMINING THE FEMALE FERTILE PERIOD
    2.
    发明申请
    METHODS AND MEANS FOR DETERMINING THE FEMALE FERTILE PERIOD 审中-公开
    方法和手段确定女性适应期

    公开(公告)号：WO1995016920A1

    公开(公告)日：1995-06-22

    申请号：PCT/US1994014455

    申请日：1994-12-16

    Applicant: ABBOTT LABORATORIES

    Inventor： ABBOTT LABORATORIES ,  MARCH, Steven, C. ,  JENG, Tzyy-Wen

    IPC: G01N33/74

    CPC classification number: G01N33/743 ,  G06F19/00 ,  G16H40/63

    Abstract: Provided is a highly reliable method to predict the beginning and/or ending of the fertile period for a female for each menstrual cycle. The methods and means provided advantageously address the day-to-day, cycle-to-cycle, and women-to-women variability in fertility hormone levels by analyzing the measurements of serial hormone concentrations in the midst of daily hormonal variations to determine when an actual and significant increase in the concentration of the monitored hormone has begun. Thus the present disclosure is directed to a method that combines existing hormone assay methods with calculation procedures to optimize the predictive values of daily hormonal changes. In this way a reliable and useful prediction of the fertile period is achieved with the concomitant assurance that the beginning and/or end of the fertile period has been reached so that such declarations are sufficient to provide both fertility enhancement and contraceptive utility.

    Abstract translation: 提供了一种高度可靠的方法来预测每个月经周期中女性的肥沃期的开始和/或结束。 提供的方法和手段有利地通过分析日常激素变异中的连续激素浓度的测量来确定生育激素水平的日常，周期与周期以及妇女与女性的变异性，以确定何时 监测的激素的浓度的实际和显着增加已经开始。 因此，本公开涉及将现有激素测定方法与计算程序组合以优化每日激素变化的预测值的方法。 以这种方式，可以有效地预测肥沃期，同时确保已经达到肥沃期的开始和/或结束，以便这种声明足以提供生育能力和避孕效用。

    REAGENTLESS ANALYSIS OF BIOLOGICAL SAMPLES
    4.
    发明公开
    REAGENTLESS ANALYSIS OF BIOLOGICAL SAMPLES 审中-公开
    生物样本的试剂批次分析

    公开(公告)号：EP1110075A2

    公开(公告)日：2001-06-27

    申请号：EP99942503.6

    申请日：1999-08-27

    Applicant: ABBOTT LABORATORIES

    Inventor： JENG, Tzyy-Wen ,  MC DOWELL, Larry, L. ,  PEZZANITI, Joseph, L. ,  OOSTA, Gary, M. ,  SHAIN, Eric, B.

    IPC: G01N21/27 ,  G01N21/41 ,  G01N21/05 ,  B01L3/14

    CPC classification number: G01N21/4133 ,  G01N21/05 ,  G01N21/274 ,  Y10T436/144444 ,  Y10T436/146666 ,  Y10T436/147777 ,  Y10T436/171538 ,  Y10T436/200833

    Abstract: Apparatus and method for determining at least one parameter, e.g., concentration, of at least one analyte, e.g., urea, of a biological sample, e.g., urine. A biological sample particularly suitable for the apparatus and method of this invention is urine. In general, spectroscopic measurements can be used to quantify the concentrations of one or more analytes in a biological sample. In order to obtain concentration values of certain analytes, such as hemoglobin and bilirubin, visible light absorption spectroscopy can be used. In order to obtain concentration values of other analytes, such as urea, creatinine, glucose, ketones, and protein, infrared light absorption spectroscopy can be used. The apparatus and method of this invention utilize one or more mathematical techniques to improve the accuracy of measurement of parameters of analytes in a biological sample. The invention also provides an apparatus and method for measuring the refractive index of a sample of biological fluid while making spectroscopic measurements substantially simultaneously.

    OPTICAL SENSOR HAVING A SELECTABLE SAMPLING DISTANCE FOR DETERMINATION OF ANALYTES
    7.
    发明公开
    OPTICAL SENSOR HAVING A SELECTABLE SAMPLING DISTANCE FOR DETERMINATION OF ANALYTES 审中-公开
    随着对距离选择性样品光学传感器用于测定分析

    公开(公告)号：EP1210582A1

    公开(公告)日：2002-06-05

    申请号：EP00953748.1

    申请日：2000-07-28

    Applicant: ABBOTT LABORATORIES

    Inventor： KHALIL, Omar, S. ,  WU, Xiaomao ,  YEH, Shu-jen ,  HANNA, Charles, F. ,  KANTOR, Stanislaw ,  JENG, Tzyy-Wen

    IPC: G01N21/49 ,  G01N21/31 ,  A61B5/00

    CPC classification number: A61B5/1455 ,  A61B5/14532 ,  A61B2562/0233 ,  A61B2562/0242 ,  A61B2562/043 ,  G01N21/49

    Abstract: A method and apparatus for the measurement of trans-cutaneous diffuse reflectance at a single sampling distance for determining the concentration of an analyte in a biological sample, such as, for example, human tissue. The determination of the concentration of the analyte has been found to depend on the sampling distance and reaches an optimal result at a defined sampling distance for a given analyte and a given sample. The method involves measuring the light re-emitted from the sample at a distance from a light introduction site and correlating the intensity of the re-emitted light to the concentration of an analyte. For a given sample, the distance between the light collection site and a light introduction site (i.e., the sampling distance) corresponds to the depth from the surface into the sample at which scattering and absorption events significantly affect the intensity of re-emitted light (i.e., the sampling depth). Prior knowledge about the sample determines the optimal sampling depth for performing a measurement for a specific analyte and the corresponding sampling distance needed to reach that optimal sampling depth. Optimization of the sampling distance, as well as the correlation relationship, can be established in a calibration procedure.

    METHOD AND APPARATUS FOR NON-INVASIVELY MEASURING GLUCOSE
    8.
    发明公开
    METHOD AND APPARATUS FOR NON-INVASIVELY MEASURING GLUCOSE 审中-公开
    方法和装置非侵入式葡萄糖测量

    公开(公告)号：EP1139862A1

    公开(公告)日：2001-10-10

    申请号：EP99966375.0

    申请日：1999-12-16

    Applicant: ABBOTT LABORATORIES

    Inventor： JENG, Tzyy-Wen ,  YEH, Shu-Jen ,  LINDBERG, John, M. ,  PEZZANITI, Joseph, Larry ,  KHALIL, Omar, S. ,  OOSTA, Gary, M. ,  HANNA, Charles, F. ,  STALDER, Arnold, F. ,  SZUTS, Ete Z.

    IPC: A61B5/00

    CPC classification number: A61B5/1455 ,  A61B5/14532

    Abstract: A method and apparatus for measuring the concentration of an analyte of interest, e.g. glucose, in blood non-invasively. The method and apparatus of this invention can also be adapted to allow a portion of a body part to be engorged with blood to bring about greater accuracy in optical measurements. In the method of this invention, at least two similar, but not identical, measurements are made concurrently. For example, two similar, but not identical, wavelengths of electromagnetic radiation can be used. The two wavelengths should not be overlapping to allow maximum non-identity. By making measurements concurrently, each measurement channel in the system experiences variations as they occur substantially simultaneously in all channels. By selecting one of the channels as a reference channel and by normalizing the optical measurements of the other channels to this reference channel, the variations common to all channels are eliminated. Removing these common variations from the optical measurements by normalization, such as by calculating ratios of the measurement of each of the measuring channels to that of the reference channel, will allow the actual changes of the signal for a specific analyte of interest to be measured.

    NONINVASIVE OPTICAL DETERMINATION OF HEMOGLOBIN AND HEMATOCRIT
    9.
    发明公开
    NONINVASIVE OPTICAL DETERMINATION OF HEMOGLOBIN AND HEMATOCRIT 审中-公开
    非侵入式光学测定血红蛋白和红细胞压积

    公开(公告)号：EP1282380A2

    公开(公告)日：2003-02-12

    申请号：EP01933059.6

    申请日：2001-05-07

    Applicant: Abbott Laboratories

    Inventor： KHALIL, Omar, S. ,  WU, Xiaomao ,  YEH, Shu-Jen ,  HANNA, Charles, F. ,  KANTOR, Stanislaw ,  JENG, Tzyy-Wen

    IPC: A61B5/00

    CPC classification number: G01N21/4795 ,  A61B5/0059 ,  A61B5/14535 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/1491 ,  A61B5/6824 ,  A61B2562/0233 ,  A61B2562/0242 ,  A61B2562/043

    Abstract: A method for the determination of hemoglobin and hematocrit by means of an apparatus that is capable of controlling the temperature of a defined subcutaneous volume of human skin. The method involves a calculation of hemoglobin concentration and hematocrit value that takes into consideration the values of optical parameters of the sample at various pre-set temperatures. It employs steady state optical measurements of samples, such as, for example, human tissue, by means of a reflectance tissue photometer and localized control of the temperature of the sample. An optical signal from a defined subcutaneous volume of human skin is measured as the temperature of this volume is controlled. This allows determination of hemoglobin concentration and hematocrit value non-invasively in a population of subjects having different skin colors by means of steady state reflectance measurements. The determination of hemoglobin concentration and hematocrit value is useful for monitoring patients, testing at the point of care, and screening for anemia. This method has the advantage for the determination of analytes in weak cardiac pulse situations, such as, for example, in elderly patients.

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