SELF-VENTING IMMUNODIAGNOSTIC DEVICES AND METHODS OF PERFORMING ASSAYS
    3.
    发明申请
    SELF-VENTING IMMUNODIAGNOSTIC DEVICES AND METHODS OF PERFORMING ASSAYS 审中-公开
    自我发射免疫组化设备及其测定方法

    公开(公告)号:WO1995017966A1

    公开(公告)日:1995-07-06

    申请号:PCT/US1994014936

    申请日:1994-12-28

    Abstract: Methods and devices are provided involving an inlet port, at least one chamber, a channel providing access for fluids to flow through via capillary action or differential pressure, reagents, detection means and self-venting materials. The devices allow for the appropriate mixing, reacting, incubating needed to give a detectable signal which can be read. The self-venting materials allow for the 1) displacement of gases inside a track to the outside of the device and 2) oxygen movement into the track from the outside.

    Abstract translation: 提供的方法和装置包括入口端口,至少一个腔室,通道,用于通过毛细作用或差压流体流过流体,试剂,检测装置和自排气材料。 这些装置允许适当的混合,反应,孵育所需的,以产生可读信号。 自放气材料允许1)将轨道内的气体置换到设备外部,以及2)氧气从外部进入轨道。

    METHOD AND APPARATUS FOR NON-INVASIVELY MEASURING GLUCOSE
    6.
    发明公开
    METHOD AND APPARATUS FOR NON-INVASIVELY MEASURING GLUCOSE 审中-公开
    方法和装置非侵入式葡萄糖测量

    公开(公告)号:EP1139862A1

    公开(公告)日:2001-10-10

    申请号:EP99966375.0

    申请日:1999-12-16

    CPC classification number: A61B5/1455 A61B5/14532

    Abstract: A method and apparatus for measuring the concentration of an analyte of interest, e.g. glucose, in blood non-invasively. The method and apparatus of this invention can also be adapted to allow a portion of a body part to be engorged with blood to bring about greater accuracy in optical measurements. In the method of this invention, at least two similar, but not identical, measurements are made concurrently. For example, two similar, but not identical, wavelengths of electromagnetic radiation can be used. The two wavelengths should not be overlapping to allow maximum non-identity. By making measurements concurrently, each measurement channel in the system experiences variations as they occur substantially simultaneously in all channels. By selecting one of the channels as a reference channel and by normalizing the optical measurements of the other channels to this reference channel, the variations common to all channels are eliminated. Removing these common variations from the optical measurements by normalization, such as by calculating ratios of the measurement of each of the measuring channels to that of the reference channel, will allow the actual changes of the signal for a specific analyte of interest to be measured.

    REAGENTLESS ANALYSIS OF BIOLOGICAL SAMPLES
    7.
    发明公开
    REAGENTLESS ANALYSIS OF BIOLOGICAL SAMPLES 审中-公开
    生物样本的试剂批次分析

    公开(公告)号:EP1110075A2

    公开(公告)日:2001-06-27

    申请号:EP99942503.6

    申请日:1999-08-27

    Abstract: Apparatus and method for determining at least one parameter, e.g., concentration, of at least one analyte, e.g., urea, of a biological sample, e.g., urine. A biological sample particularly suitable for the apparatus and method of this invention is urine. In general, spectroscopic measurements can be used to quantify the concentrations of one or more analytes in a biological sample. In order to obtain concentration values of certain analytes, such as hemoglobin and bilirubin, visible light absorption spectroscopy can be used. In order to obtain concentration values of other analytes, such as urea, creatinine, glucose, ketones, and protein, infrared light absorption spectroscopy can be used. The apparatus and method of this invention utilize one or more mathematical techniques to improve the accuracy of measurement of parameters of analytes in a biological sample. The invention also provides an apparatus and method for measuring the refractive index of a sample of biological fluid while making spectroscopic measurements substantially simultaneously.

    MULTIPLEX SENSOR AND METHOD OF USE
    9.
    发明公开
    MULTIPLEX SENSOR AND METHOD OF USE 审中-公开
    多传感器及使用方法

    公开(公告)号:EP1037554A1

    公开(公告)日:2000-09-27

    申请号:EP98959566.5

    申请日:1998-11-20

    Abstract: A multiplex sensor and a method of use that provides enhanced selectivity and sensitivity. In this method, one or more parameters of the sample are measured by means of multiple spectroscopic techniques, and the interferences from physiological and spectral variables are reduced or eliminated. One embodiment of the present invention comprises a multiplex sensor and a method of use that provides enhanced selectivity and sensitivity. One or more parameters of the sample are measured by means of at least two different spectroscopic techniques, wherein the at least two different spectroscopic techniques are selected from the group consisting of: (a) infrared absorbance, (b) scattering, (c) emission, (d) polarization, and (e) photoacoutics.

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