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公开(公告)号：WO2003020688A1
公开(公告)日：2003-03-13
申请号：PCT/US2002/024506
申请日：2002-08-01
Applicant: ABBOTT LABORATORIES
Inventor： LIU, Gang , SZCZEPANKIEWICZ, Bruce, G. , PEI, Zhonghua , XIN, Zhili , JANOWICK, David, A.
IPC: C07C237/22
CPC classification number: C07C209/68 , C07C233/56 , C07C235/74 , C07C237/22 , C07C237/24 , C07C237/42 , C07C271/20 , C07C271/22 , C07C275/24 , C07C311/06 , C07C311/47 , C07C317/40 , C07C323/59 , C07C2601/04 , C07C2601/14 , C07C2601/18 , C07C2602/10 , C07D209/08 , C07D211/20 , C07D241/18 , C07D265/06 , C07D295/135 , C07D295/155 , C07D295/185 , C07D319/18
Abstract: Compounds of formula (I) or therapeutically acceptable salts thereof, are selective protein tyrosine kinase-B (PTP1B) inhibitors. Preparation of the compounds, compositions containing the compounds, and treatment of disorders using the compounds are disclosed.
Abstract translation: 式（I）化合物或其治疗上可接受的盐是选择性蛋白酪氨酸激酶-B（PTP1B）抑制剂。 公开了化合物的制备，含有该化合物的组合物和使用该化合物治疗病症。
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2.发明申请NOVEL BENZO-1,3-DIOXOLYL- AND BENZOFURANYL SUBSTITUTED PYRROLIDINE DERIVATIVES AS ENDOTHELIN ANTAGONISTS 审中-公开新戊酰-1,3-二氧基 - 和苯并呋喃取代的吡咯烷酮衍生物作为内皮素拮抗剂
公开(公告)号：WO1997030045A1
公开(公告)日：1997-08-21
申请号：PCT/US1997001936
申请日：1997-02-12
Applicant: ABBOTT LABORATORIES
Inventor： ABBOTT LABORATORIES , WINN, Martin , BOYD, Steven, A. , HUTCHINS, Charles, W. , JAE, Hwan-Soo , TASKER, Andrew, S. , VON GELDERN, Thomas, W. , KESTER, Jeffrey, A. , SORENSEN, Bryan, K. , SZCZEPANKIEWICZ, Bruce, G. , HENRY, Kenneth, J., Jr. , LIU, Gang , WITTENBERGER, Steven, J. , KING, Steven, A.
IPC: C07D405/04
CPC classification number: C07D401/04 , C07D207/16 , C07D405/04 , C07D405/12 , C07D405/14 , Y02P20/55
Abstract: A compound of formula (I), or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.
Abstract translation: 公开了式（I）化合物或其药学上可接受的盐，以及其制备方法和中间体，以及拮抗内皮素的方法。
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公开(公告)号：WO2008134690A1
公开(公告)日：2008-11-06
申请号：PCT/US2008/061948
申请日：2008-04-30
Applicant: ABBOTT LABORATORIES , LIU, Gang , XIN, Zhili , KYM, Philip R. , SOUERS, Andrew J
Inventor： LIU, Gang , XIN, Zhili , KYM, Philip R. , SOUERS, Andrew J
IPC: C07D487/04 , A61K31/519 , A61P3/04 , A61P3/10
CPC classification number: C07D487/04
Abstract: The present invention relates to compounds of formula (I): wherein R 1 , R 2 , and R 3 , are defined herein. Pharmaceutical compositions and methods for treating DGAT-1 related diseases or conditions are also disclosed.
Abstract translation: 本发明涉及式（I）化合物：其中R 1，R 2和R 3是本文定义的。 还公开了治疗DGAT-1相关疾病或病症的药物组合物和方法。
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公开(公告)号：WO2003072537A3
公开(公告)日：2003-09-04
申请号：PCT/US2003/003663
申请日：2003-02-06
Applicant: ABBOTT LABORATORIES
Inventor： SZCZEPANKIEWICZ, Bruce, G. , LIU, Gang , JANOWICK, David, A. , PEI, Zhonghua , XIN, Zhili , LI, Xiaofeng , OOST, Thorsten, K.
IPC: C07C237/22
Abstract: Compounds of formula (I), or therapeutically acceptable salts thereof, are selective protein tyrosine kinase-B (PTP1B) inhibitors. Preparation of the compounds, compositions containing the compounds, and treatment of disorders using the compounds are disclosed.
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公开(公告)号：WO2003072537A2
公开(公告)日：2003-09-04
申请号：PCT/US2003/003663
申请日：2003-02-06
Applicant: ABBOTT LABORATORIES
Inventor： SZCZEPANKIEWICZ, Bruce, G. , LIU, Gang , JANOWICK, David, A. , PEI, Zhonghua , XIN, Zhili , LI, Xiaofeng , OOST, Thorsten, K.
IPC: C07C237/22
CPC classification number: C07C209/68 , C07C233/42 , C07C233/56 , C07C235/74 , C07C237/22 , C07C237/24 , C07C237/42 , C07C271/20 , C07C271/22 , C07C275/24 , C07C311/06 , C07C311/47 , C07C317/40 , C07C323/59 , C07C2601/04 , C07C2601/14 , C07C2601/18 , C07C2602/10 , C07D209/08 , C07D209/44 , C07D211/20 , C07D241/18 , C07D265/06 , C07D295/135 , C07D295/155 , C07D295/185 , C07D319/18
Abstract: Compounds of formula (I), or therapeutically acceptable salts thereof, are selective protein tyrosine kinase-B (PTP1B) inhibitors. Preparation of the compounds, compositions containing the compounds, and treatment of disorders using the compounds are disclosed.
Abstract translation: 式（I）化合物或其治疗可接受的盐是选择性蛋白酪氨酸激酶-B（PTP1B）抑制剂。 该化合物的制备，含有该化合物的组合物以及使用该化合物治疗疾病被公开。
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Patent Agency Ranking
公开(公告)号：WO2006083673A2
公开(公告)日：2006-08-10
申请号：PCT/US2006/002789
申请日：2006-01-24
Applicant: ABBOTT LABORATORIES , LIU, Gang , SHAM, Hing, L. , SZCZEPANKIEWICZ, Bruce, G. , XIN, Zhili , ZHAO, Hongyu , SERBY, Michael, D. , LIU, Bo , LIU, Mei
Inventor： LIU, Gang , SHAM, Hing, L. , SZCZEPANKIEWICZ, Bruce, G. , XIN, Zhili , ZHAO, Hongyu , SERBY, Michael, D. , LIU, Bo , LIU, Mei
IPC: C07D213/85 , C07D405/12 , C07D409/12 , C07D401/12 , C07D409/04 , C07D405/04 , C07D213/73 , C07D401/14 , A61K31/44 , A61P3/00 , A61P19/00 , A61P25/00
CPC classification number: C07D417/12 , C07D213/73 , C07D213/81 , C07D213/84 , C07D213/85 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/06 , C07D413/10 , C07D417/06 , C07D417/10
Abstract: The present invention relates to compounds that are inhibitors of c-jun N-terminal kinase 1, 2, or 3 (JNK1, JNK2, or JNK3), compositions containing the compounds and the use of the compounds in the prevention or treatment of disorders regulated by the activation of JNK1, JNK2 and JNK3.
Abstract translation: 本发明涉及作为c-jun N-末端激酶1,2或3（JNK1，JNK2或JNK3）的抑制剂的化合物，含有这些化合物的组合物和该化合物在预防或治疗调节疾病中的用途 通过激活JNK1，JNK2和JNK3。
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7.发明申请DIAMINOPYRIMIDINE DERIVATIVES AS SELECTIVE GROWTH HORMONE SECRECTGOGUE RECEPTOR (GHS-R) ANTAGONISTS 审中-公开作为选择性生长激素分泌受体（GHS-R）拮抗剂的二氨基嘧啶衍生物
公开(公告)号：WO2005030734A1
公开(公告)日：2005-04-07
申请号：PCT/US2004/031115
申请日：2004-09-23
Applicant: ABBOTT LABORATORIES , XIN, Zhili , LIU, Bo , LIU, Gang , LIU, Mei , SERBY, Michael, D. , ZHAO, Hongyu
Inventor： XIN, Zhili , LIU, Bo , LIU, Gang , LIU, Mei , SERBY, Michael, D. , ZHAO, Hongyu
IPC: C07D239/48
CPC classification number: C07D239/48 , C07D401/12 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/12
Abstract: The present invention is related to compounds of formula (I), (I), or a therapeutically suitable salt or prodrug thereof, the preparation of the compounds, compositions containing the compounds and the use of the compounds in the prevention or treatment of disorders regulated by the action of ghrelin receptor, including Prader-Willi syndrome, eating disorder, weight gain, weight-loss maintainance following diet and exercise, obesity and disorders associated with obesity such as non-insulin dependent diabetes mellitus.
Abstract translation: 本发明涉及式（I），（I）的化合物或其治疗上合适的盐或前药，化合物的制备，含有化合物的组合物以及该化合物在预防或治疗调节疾病中的用途 通过生长激素释放肽受体的作用，包括Prader-Willi综合征，进食障碍，体重增加，饮食和运动后的体重减轻维持，肥胖症和与肥胖相关的疾病如非胰岛素依赖性糖尿病。
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公开(公告)号：EP2142552B1
公开(公告)日：2012-08-01
申请号：EP08747140.5
申请日：2008-04-30
Applicant: Abbott Laboratories
Inventor： LIU, Gang , XIN, Zhili , KYM, Philip R. , SOUERS, Andrew J
IPC: C07D487/04 , A61K31/519 , A61P3/04 , A61P3/10
CPC classification number: C07D487/04
Abstract: The present invention relates to compounds of formula (I): wherein R1, R2, and R3, are defined herein. Pharmaceutical compositions and methods for treating DGAT-1 related diseases or conditions are also disclosed.
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9.发明公开AMINO(OXO)ACETIC ACID PROTEIN TYROSINE PHOSPHATASE INHIBITORS 审中-公开氨基酸（OXO）ESSIGSURE ALS蛋白质 - 酪氨酸磷酸化酶
公开(公告)号：EP1313696A2
公开(公告)日：2003-05-28
申请号：EP01964500.1
申请日：2001-08-29
Applicant: ABBOTT LABORATORIES
Inventor： LIU, Gang , SZCZEPANKIEWICZ, Bruce, G. , PEI, Zhonghua , Xin, Zhili , OOST, Thorsten, K. , JANOWICK, David, A.
IPC: C07C233/56 , C07C237/42 , C07D239/04 , C07D209/30 , C07D319/10 , A61K31/404 , A61K31/357 , A61K31/535 , A61P3/10
CPC classification number: C07D295/185 , C07C209/68 , C07C233/56 , C07C235/74 , C07C237/22 , C07C237/24 , C07C237/42 , C07C271/20 , C07C271/22 , C07C275/24 , C07C311/06 , C07C311/47 , C07C317/40 , C07C323/59 , C07C2601/04 , C07C2601/14 , C07C2601/18 , C07C2602/10 , C07D209/08 , C07D211/20 , C07D241/18 , C07D265/06 , C07D295/135 , C07D295/155 , C07D319/18
Abstract: Compound of formula (I) or therapeutically acceptable salts thereof, are protein tyrosine kinase PTP1B inhibitors. Preparation of the compounds, compositions containing the compounds, and treatment of diseases using the compounds are disclosed.
Abstract translation: 式（I）化合物或其治疗上可接受的盐是蛋白酪氨酸激酶PTP1B抑制剂。 公开了化合物的制备，含有该化合物的组合物和使用该化合物治疗疾病。
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10.发明授权NOVEL BENZO-1,3-DIOXOLYL- AND BENZOFURANYL SUBSTITUTED PYRROLIDINE DERIVATIVES AS ENDOTHELIN ANTAGONISTS 失效新苯并-1,3-二唑和取代的苯并呋喃PYRROLIDINEDERIVATE ALS内皮素拮抗剂
公开(公告)号：EP0885215B1
公开(公告)日：2006-04-19
申请号：EP97905816.1
申请日：1997-02-12
Applicant: ABBOTT LABORATORIES
Inventor： WINN, Martin , BOYD, Steven, A. , HUTCHINS, Charles, W. , JAE, Hwan-Soo , TASKER, Andrew, S. , VON GELDERN, Thomas, W. , KESTER, Jeffrey, A. , SORENSEN, Bryan, K. , SZCZEPANKIEWICZ, Bruce, G. , HENRY, Kenneth, J., Jr. , LIU, Gang , WITTENBERGER, Steven, J. , KING, Steven, A.
IPC: C07D405/04 , C07D207/16 , A61K31/40 , C07D405/14 , C07F9/59 , C07F9/572 , C07D401/04
CPC classification number: C07D401/04 , C07D207/16 , C07D405/04 , C07D405/12 , C07D405/14 , Y02P20/55
Abstract: A compound of formula (I), or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.
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