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公开(公告)号：WO2009067578A2
公开(公告)日：2009-05-28
申请号：PCT/US2008/084142
申请日：2008-11-20
Applicant: ABBOTT LABORATORIES , VON GELDERN, Thomas W. , BURKALOW, Jufang H. , BARNES, David M. , HAIGHT, Anghony R. , HENGEVELD, John E. , LI, Xiaofeng , MCLAUGHLIN, Maureen A. , NOONAN, William T. , PEI, Zhonghua , WU-WONG, Jinshyun Ruth
Inventor： VON GELDERN, Thomas W. , BURKALOW, Jufang H. , BARNES, David M. , HAIGHT, Anghony R. , HENGEVELD, John E. , LI, Xiaofeng , MCLAUGHLIN, Maureen A. , NOONAN, William T. , PEI, Zhonghua , WU-WONG, Jinshyun Ruth
IPC: C07C401/00
CPC classification number: C07C401/00 , C07C2601/14 , C07C2602/24
Abstract: The invention relates to compounds that are vitamin D receptor activators, compositions comprising such compounds, methods of using such compounds and compositions, processes for preparing such compounds, and intermediates obtained during such processes.
Abstract translation: 本发明涉及作为维生素D受体激活剂的化合物，包含这些化合物的组合物，使用这些化合物和组合物的方法，制备此类化合物的方法以及在此过程中获得的中间体。
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2.发明申请PHARMACEUTICAL COMPOSITIONS AS INHIBITORS OF DIPEPTIDYL PEPTIDASE-IV (DPP-IV) 审中-公开作为DIPPTIDYL PEPTIDASE-IV（DPP-IV）的抑制剂的药物组合物
公开(公告)号：WO2004026822A2
公开(公告)日：2004-04-01
申请号：PCT/US2003/029018
申请日：2003-09-15
Applicant: ABBOTT LABORATORIES
Inventor： MADAR, David , PEI, Zhonghua , PIREH, Daisy , DJURIC, Stevan, W. , WIEDEMAN, Paul, E. , YONG, Hong , FEENSTRA, Melissa, J. , KOPECKA, Hana , LI, Xiaofeng , LONGENECKER, Kenton , SHAM, Hing, L. , STEWART, Kent, D. , SZCZEPANKIEWICZ, Bruce, G.
IPC: C07D207/00
CPC classification number: C07D207/27 , C07D207/16 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D417/12
Abstract: The present invention relates to compounds which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases.
Abstract translation: 本发明涉及抑制二肽基肽酶IV（DPP-IV）的化合物，其可用于预防或治疗糖尿病，特别是II型糖尿病，以及高血糖症，X综合征，高胰岛素血症，肥胖症，动脉粥样硬化和各种免疫调节疾病 。
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3.发明申请PYRROLIDINE-2-CARBONITRILE DERIVATIVES AND THEIR USE AS INHIBITORS OF DIPEPTIDYL PEPTIDASE-IV (DPP-IV) 审中-公开吡咯烷-2-碳酮衍生物及其作为DIPEPTIDYL PEPTIDASE-IV（DPP-IV）的抑制剂的用途
公开(公告)号：WO2005023762A1
公开(公告)日：2005-03-17
申请号：PCT/US2004/028886
申请日：2004-09-07
Applicant: ABBOTT LABORATORIES , PEI, Zhonghua , LI, Xiaofeng , LONGENECKER, Kenton, L. , SHAM, Hing, L. , WIEDEMAN, Paul, E.
Inventor： PEI, Zhonghua , LI, Xiaofeng , LONGENECKER, Kenton, L. , SHAM, Hing, L. , WIEDEMAN, Paul, E.
IPC: C07D207/16
CPC classification number: C07D401/14 , C07D207/16
Abstract: The present invention relates to compounds of formula (I), (I), which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, syndrome X, hyperinsulinemia, b-cell failure, obesity, satiety disorders, atherosclerosis, and various immunomodulatory diseases.
Abstract translation: 本发明涉及抑制二肽基肽酶IV（DPP-IV）的式（I），（I）的化合物，其可用于预防或治疗糖尿病，特别是II型糖尿病，以及高血糖症，综合征X， 高胰岛素血症，b细胞衰竭，肥胖症，饱腹感障碍，动脉粥样硬化和各种免疫调节疾病。
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公开(公告)号：WO2007027651A3
公开(公告)日：2007-03-08
申请号：PCT/US2006/033620
申请日：2006-08-25
Applicant: ABBOTT LABORATORIES , PEI, Zhonghua , VON GELDERN, Thomas , MADAR, David, J. , LI, Xiaofeng , BASHA, Fatima , YONG, Hong , LONGENECKER, Kenton, L. , BACKES, Bradley, J. , JUDD, Andrew, S. , MULHERN, Mathew, M. , STEWART, Kent, D.
Inventor： PEI, Zhonghua , VON GELDERN, Thomas , MADAR, David, J. , LI, Xiaofeng , BASHA, Fatima , YONG, Hong , LONGENECKER, Kenton, L. , BACKES, Bradley, J. , JUDD, Andrew, S. , MULHERN, Mathew, M. , STEWART, Kent, D.
IPC: C07C211/40 , C07C211/54 , C07C211/62 , C07D213/38 , C07D213/68 , C07D317/64 , C07D487/04 , A61K31/137
Abstract: The present invention relates to compounds, which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, metabolic syndrome , hyperinsulinemia, obesity, atherosclerosis, various immunomodulatory diseases, and other diseases.
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公开(公告)号：WO2003072537A3
公开(公告)日：2003-09-04
申请号：PCT/US2003/003663
申请日：2003-02-06
Applicant: ABBOTT LABORATORIES
Inventor： SZCZEPANKIEWICZ, Bruce, G. , LIU, Gang , JANOWICK, David, A. , PEI, Zhonghua , XIN, Zhili , LI, Xiaofeng , OOST, Thorsten, K.
IPC: C07C237/22
Abstract: Compounds of formula (I), or therapeutically acceptable salts thereof, are selective protein tyrosine kinase-B (PTP1B) inhibitors. Preparation of the compounds, compositions containing the compounds, and treatment of disorders using the compounds are disclosed.
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Patent Agency Ranking
公开(公告)号：WO2003072537A2
公开(公告)日：2003-09-04
申请号：PCT/US2003/003663
申请日：2003-02-06
Applicant: ABBOTT LABORATORIES
Inventor： SZCZEPANKIEWICZ, Bruce, G. , LIU, Gang , JANOWICK, David, A. , PEI, Zhonghua , XIN, Zhili , LI, Xiaofeng , OOST, Thorsten, K.
IPC: C07C237/22
CPC classification number: C07C209/68 , C07C233/42 , C07C233/56 , C07C235/74 , C07C237/22 , C07C237/24 , C07C237/42 , C07C271/20 , C07C271/22 , C07C275/24 , C07C311/06 , C07C311/47 , C07C317/40 , C07C323/59 , C07C2601/04 , C07C2601/14 , C07C2601/18 , C07C2602/10 , C07D209/08 , C07D209/44 , C07D211/20 , C07D241/18 , C07D265/06 , C07D295/135 , C07D295/155 , C07D295/185 , C07D319/18
Abstract: Compounds of formula (I), or therapeutically acceptable salts thereof, are selective protein tyrosine kinase-B (PTP1B) inhibitors. Preparation of the compounds, compositions containing the compounds, and treatment of disorders using the compounds are disclosed.
Abstract translation: 式（I）化合物或其治疗可接受的盐是选择性蛋白酪氨酸激酶-B（PTP1B）抑制剂。 该化合物的制备，含有该化合物的组合物以及使用该化合物治疗疾病被公开。
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7.发明授权PHARMACEUTICAL COMPOSITIONS AS INHIBITORS OF DIPEPTIDYL PEPTIDASE-IV (DPP-IV) 有权药物组合物及其用途作为二肽基肽酶IV抑制剂（DPP-IV）
公开(公告)号：EP1560811B1
公开(公告)日：2007-08-01
申请号：EP03774478.6
申请日：2003-09-15
Applicant: ABBOTT LABORATORIES
Inventor： MADAR, David , PEI, Zhonghua , PIREH, Daisy , DJURIC, Stevan, W. , WIEDEMAN, Paul, E. , YONG, Hong , MICHMERHUIZEN, Melissa, J. , KOPECKA, Hana , LI, Xiaofeng , LONGENECKER, Kenton , SHAM, Hing, L. , STEWART, Kent, D. , SZCZEPANKIEWICZ, Bruce, G.
IPC: C07D207/00
CPC classification number: C07D207/27 , C07D207/16 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D417/12
Abstract: The present invention relates to compounds of formula I which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases. Or pharmaceutically acceptable salts or prodrugs thereof, wherein X,R,R1,R2 and R3 have the definitions given in the description.
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8.发明公开PHARMACEUTICAL COMPOSITIONS AS INHIBITORS OF DIPEPTIDYL PEPTIDASE-IV (DPP-IV) 有权药物组合物及其用途作为二肽基肽酶IV抑制剂（DPP-IV）
公开(公告)号：EP1560811A2
公开(公告)日：2005-08-10
申请号：EP03774478.6
申请日：2003-09-15
Applicant: Abbott Laboratories
Inventor： MADAR, David , PEI, Zhonghua , PIREH, Daisy , DJURIC, Stevan, W. , WIEDEMAN, Paul, E. , YONG, Hong , FEENSTRA, Melissa, J. , KOPECKA, Hana , LI, Xiaofeng , LONGENECKER, Kenton , SHAM, Hing, L. , STEWART, Kent, D. , SZCZEPANKIEWICZ, Bruce, G.
IPC: C07D207/00
CPC classification number: C07D207/27 , C07D207/16 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D417/12
Abstract: The present invention relates to compounds of formula I which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases. Or pharmaceutically acceptable salts or prodrugs thereof, wherein X,R,R1,R2 and R3 have the definitions given in the description.
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9.发明公开PHARMACEUTICAL COMPOSITIONS AS INHIBITORS OF DIPEPTIDYL PEPTIDASE-IV (DPP-IV) 有权药用植物精华素抑制剂抑制剂脯氨酸酯酶IV（DPP-IV）
公开(公告)号：EP1919854A2
公开(公告)日：2008-05-14
申请号：EP06790057.1
申请日：2006-08-25
Applicant: ABBOTT LABORATORIES
Inventor： PEI, Zhonghua , VON GELDERN, Thomas , MADAR, David, J. , LI, Xiaofeng , BASHA, Fatima , YONG, Hong , LONGENECKER, Kenton, L. , BACKES, Bradley, J. , JUDD, Andrew, S. , MULHERN, Mathew, M. , STEWART, Kent, D.
IPC: C07C211/40 , C07C211/54 , C07C211/62 , C07D213/38 , C07D213/68 , C07D317/64 , C07D487/04 , A61K31/137
CPC classification number: C07C211/48 , C07C211/40 , C07C217/52 , C07C217/54 , C07C217/74 , C07C217/84 , C07C217/86 , C07C225/22 , C07C229/42 , C07C229/48 , C07C229/60 , C07C233/43 , C07C233/78 , C07C235/46 , C07C237/24 , C07C237/30 , C07C237/42 , C07C255/54 , C07C255/58 , C07C311/22 , C07C311/36 , C07C317/22 , C07C317/36 , C07C2601/14 , C07C2601/16 , C07D207/16 , C07D209/08 , C07D209/48 , C07D211/46 , C07D211/60 , C07D211/62 , C07D213/30 , C07D213/38 , C07D213/64 , C07D213/68 , C07D213/74 , C07D213/82 , C07D217/04 , C07D263/56 , C07D263/60 , C07D277/04 , C07D277/64 , C07D295/135 , C07D295/185 , C07D295/205 , C07D317/66 , C07D319/18 , C07D333/34 , C07D333/38 , C07D409/04 , C07D487/04 , C07D491/048 , C07D495/04 , C07D498/04 , C07D513/04
Abstract: The present invention relates to compounds, which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, metabolic syndrome , hyperinsulinemia, obesity, atherosclerosis, various immunomodulatory diseases, and other diseases.
Abstract translation: 本发明涉及抑制二肽基肽酶IV（DPP-IV）的化合物，其可用于预防或治疗糖尿病，特别是II型糖尿病，以及高血糖症，代谢综合征，高胰岛素血症，肥胖症，动脉粥样硬化，各种免疫调节疾病， 和其他疾病。
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10.发明公开NEW VITAMIN D RECEPTOR ACTIVATORS AND METHODS OF MAKING 审中-公开维生素D-REZEPTORAKTIVATOREN联合HERSTELLUNGSVERFAHREN
公开(公告)号：EP2222635A2
公开(公告)日：2010-09-01
申请号：EP08851351.0
申请日：2008-11-20
Applicant: Abbott Laboratories
Inventor： VON GELDERN, Thomas W. , BARKALOW, Jufang, H. , BARNES, David M. , HAIGHT, Anthony R. , HENGEVELD, John E. , LI, Xiaofeng , MCLAUGHLIN, Maureen A. , NOONAN, William T. , PEI, Zhonghua , WU-WONG, Jinshyun Ruth
IPC: C07C401/00
CPC classification number: C07C401/00 , C07C2601/14 , C07C2602/24
Abstract: The invention relates to compounds that are vitamin D receptor activators, compositions comprising such compounds, methods of using such compounds and compositions, processes for preparing such compounds, and intermediates obtained during such processes.
Abstract translation: 本发明涉及作为维生素D受体激活剂的化合物，包含这些化合物的组合物，使用这些化合物和组合物的方法，制备此类化合物的方法以及在此过程中获得的中间体。
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