公开(公告)号：WO1993017681A1

公开(公告)日：1993-09-16

申请号：PCT/US1993001594

申请日：1993-02-24

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  WINN, Martin ,  DE, Biswanath ,  ZYDOWSKY, Thomas, M. ,  KERKMAN, Daniel, J. ,  DeBERNARDIS, John, F. ,  ROSENBERG, Saul, H. ,  SHIOSAKI, Kazumi ,  BASHA, Fatima, Z. ,  SPINA, Kenneth, P. ,  VON GELDERN, Thomas, W. ,  BOYD, Steven ,  YAMAMOTO, Diane, M. ,  FUNG, Anthony, K., L.

IPC: A61K31/41

CPC classification number: C07D403/12 ,  C07D413/10 ,  C07D417/12

Abstract: Compounds are disclosed having formula (I) wherein D, E, G, L, M, A, R'1, L', and M' are defined herein. The compounds of the invention are angiotensin II receptor antagonists.

Abstract translation: 公开了具有式（I）的化合物，其中D，E，G，L，M，A，R'1，L'和M'在本文中定义。 本发明的化合物是血管紧张素II受体拮抗剂。

公开(公告)号：WO2002070507A2

公开(公告)日：2002-09-12

申请号：PCT/US2002/004541

申请日：2002-01-16

Applicant: ABBOTT LABORATORIES

Inventor： KYM, Philip, R. ,  LANE, Benjamin, C. ,  PRATT, John, K. ,  VON GELDERN, Tom ,  WINN, Martin ,  PATEL, Jyoti, R. ,  ARENDSEN, David, L. ,  AKRITOPOULOU-ZANZE, Irini ,  ASHWORTH, Kimba, L. ,  HARTANDI, Kresna ,  BRENNEMAN, Jehrod

IPC: C07D311/80

CPC classification number: C07D407/04 ,  C07D311/80 ,  C07D409/04

Abstract: Compounds of formula (I) are useful for treating type (II) diabetes, obesity, hyperglycemia, inadequate glucose clearance, hyperinsulinemia, hypertriglyceridemia, and high-circulating glucocorticoid levels, preparations of the compounds, compositions containing the compounds, and methods of treatment using the compounds.

Abstract translation: 式（I）化合物可用于治疗II型糖尿病，肥胖症，高血糖症，葡萄糖清除不足，高胰岛素血症，高甘油三酯血症和高循环糖皮质激素水平，所述化合物的制剂，含有 化合物和使用这些化合物的治疗方法。

公开(公告)号：WO1997030045A1

公开(公告)日：1997-08-21

申请号：PCT/US1997001936

申请日：1997-02-12

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  WINN, Martin ,  BOYD, Steven, A. ,  HUTCHINS, Charles, W. ,  JAE, Hwan-Soo ,  TASKER, Andrew, S. ,  VON GELDERN, Thomas, W. ,  KESTER, Jeffrey, A. ,  SORENSEN, Bryan, K. ,  SZCZEPANKIEWICZ, Bruce, G. ,  HENRY, Kenneth, J., Jr. ,  LIU, Gang ,  WITTENBERGER, Steven, J. ,  KING, Steven, A.

IPC: C07D405/04

CPC classification number: C07D401/04 ,  C07D207/16 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14 ,  Y02P20/55

Abstract: A compound of formula (I), or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.

Abstract translation: 公开了式（I）化合物或其药学上可接受的盐，以及其制备方法和中间体，以及拮抗内皮素的方法。

公开(公告)号：WO1996011927A1

公开(公告)日：1996-04-25

申请号：PCT/US1995013373

申请日：1995-10-10

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  VON GELDERN, Thomas ,  KESTER, Jeffrey, A. ,  TASKER, Andrew, S. ,  SORENSEN, Brian, K. ,  ROSENBERG, Saul, H. ,  HUTCHINS, Charles, W. ,  WINN, Martin

IPC: C07D413/06

CPC classification number: C07D403/06 ,  C07D413/06 ,  C07D413/14 ,  C07D417/06

Abstract: A compound of formula (I), or a pharmaceutically acceptable salt thereof, as well as processes for and intermediates in the preparation thereof, and methods and compositions for antagonizing endothelin.

Abstract translation: 式（I）化合物或其药学上可接受的盐，以及其制备方法和中间体，以及拮抗内皮素的方法和组合物。

公开(公告)号：WO1995008550A1

公开(公告)日：1995-03-30

申请号：PCT/US1994010049

申请日：1994-09-07

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  vonGELDERN, Thomas, W. ,  KESTER, Jeffrey, A. ,  ROSENBERG, Saul, H. ,  WINN, Martin ,  HUTCHINS, Charles, W.

IPC: C07D403/14

CPC classification number: C07D401/14 ,  C07D403/06 ,  C07D413/06 ,  C07D413/14 ,  C07D417/06 ,  C07D471/04

Abstract: A compound of formula (I) or a pharmaceutically acceptable salt thereof, as well as processes for and intermediates in the preparation thereof, and methods and compositions of antagonizing endothelin.

Abstract translation: 式（I）化合物或其药学上可接受的盐，以及其制备方法和中间体，以及拮抗内皮素的方法和组合物。

公开(公告)号：WO1993018035A1

公开(公告)日：1993-09-16

申请号：PCT/US1993001105

申请日：1993-02-04

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  ZYDOWSKY, Thomas, M. ,  DE, Biswanath ,  SHIOSAKI, Kazumi ,  BASHA, Fatima, Z. ,  WINN, Martin ,  DeBERNARDIS, John, F. ,  VON GELDERN, Thomas, W. ,  YAMAMOTO, Diane, M. ,  ROSENBERG, Saul, H. ,  KERKMAN, Daniel, J. ,  BOYD, Steven, A. ,  FUNG, Anthony, K., L.

IPC: C07D471/04

CPC classification number: C07D473/00 ,  C07D401/12 ,  C07D471/04 ,  C07D473/34 ,  C07D473/40 ,  C07D487/04 ,  C07D491/04 ,  C07D495/04 ,  C07D513/04

Abstract: Compounds are disclosed having formula (I). The compounds of the invention are angiotensin II receptor antagonists.

Abstract translation: 公开了具有式（I）的化合物。 本发明的化合物是血管紧张素II受体拮抗剂。

公开(公告)号：WO2009026422A3

公开(公告)日：2009-02-26

申请号：PCT/US2008/073830

申请日：2008-08-21

Applicant: ABBOTT LABORATORIES ,  BITNER, R., Scott ,  BROWMAN, Kaitlin, E ,  BRUNE, Michael, E ,  CHEN, Yixian ,  DINGES, Jurgen ,  DRESCHER, Karla ,  JACOBSON, Peer ,  JAE, Hwan-soo ,  KURUKULASURIYA, Ravi ,  LINK, James, T. ,  MADAR, David, J. ,  PATEL, Jyoti, R. ,  PLIUSHCHEV, Marina, A. ,  ROHDE, Jeffrey, J. ,  RUETER, Lynne, E. ,  SHUAI, Qi ,  SORENSEN, Bryan, K. ,  WANG, Jiahong ,  WICKE, Karsten, M. ,  WINN, Martin ,  WODKA, Dariusz ,  YEH, Vince ,  YONG, Hong

Inventor： BITNER, R., Scott ,  BROWMAN, Kaitlin, E ,  BRUNE, Michael, E ,  CHEN, Yixian ,  DINGES, Jurgen ,  DRESCHER, Karla ,  JACOBSON, Peer ,  JAE, Hwan-soo ,  KURUKULASURIYA, Ravi ,  LINK, James, T. ,  MADAR, David, J. ,  PATEL, Jyoti, R. ,  PLIUSHCHEV, Marina, A. ,  ROHDE, Jeffrey, J. ,  RUETER, Lynne, E. ,  SHUAI, Qi ,  SORENSEN, Bryan, K. ,  WANG, Jiahong ,  WICKE, Karsten, M. ,  WINN, Martin ,  WODKA, Dariusz ,  YEH, Vince ,  YONG, Hong

IPC: A61K31/495 ,  A61K31/445 ,  C07C233/23 ,  C07D471/02

Abstract: A method for treating a patient suffering from disorders and deficits of the central nervous system associated with diabetes, associated with aging and neurodegeneration, comprising attention deficit disorder in general, attention deficit hyperactivity disorder (ADHD), Alzheimer's disease (AD), mild cognitive impairment, senile dementia, AIDS dementia, neurodegeneration, depression, and schizophrenia, comprising administering to a patient in need of such treatment an effective amount of a selective inhibitor of the 11-β-hydroxysteroid dehydrogenase Type 1 enzyme activity.

公开(公告)号：WO2006074244A2

公开(公告)日：2006-07-13

申请号：PCT/US2006/000210

申请日：2006-01-05

Applicant: ABBOTT LABORATORIES ,  PATEL, Jyoti, R. ,  SHUAI, Qi ,  LINK, James, T. ,  ROHDE, Jeffrey, J. ,  DINGES, Jurgen ,  SORENSEN, Bryan, K. ,  WINN, Martin ,  YONG, Hong ,  YEH, Vince, S.

Inventor： PATEL, Jyoti, R. ,  SHUAI, Qi ,  LINK, James, T. ,  ROHDE, Jeffrey, J. ,  DINGES, Jurgen ,  SORENSEN, Bryan, K. ,  WINN, Martin ,  YONG, Hong ,  YEH, Vince, S.

IPC: C07C235/14 ,  C07C317/16 ,  C07C323/41 ,  C07D257/04 ,  C07D233/54 ,  C07D261/08 ,  C07D213/64 ,  C07D207/48 ,  A61K31/4402 ,  A61P3/10

CPC classification number: C07C233/23 ,  C07C235/14 ,  C07C237/24 ,  C07C255/31 ,  C07C255/47 ,  C07C259/16 ,  C07C311/08 ,  C07C311/29 ,  C07C311/46 ,  C07C311/51 ,  C07C317/22 ,  C07C317/30 ,  C07C317/44 ,  C07C323/41 ,  C07C323/60 ,  C07C2601/04 ,  C07C2601/14 ,  C07C2601/18 ,  C07C2602/08 ,  C07C2602/10 ,  C07C2603/74 ,  C07D207/48 ,  C07D213/64 ,  C07D233/64 ,  C07D257/04 ,  C07D261/08

Abstract: The present invention relates to compounds which are inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme. The present invention further relates to the use of inhibitors of 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme for the treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome and other diseases and conditions that are mediated by excessive glucocorticoid action.

Abstract translation: 本发明涉及作为11-β-羟基类固醇脱氢酶1型酶抑制剂的化合物。 本发明还涉及11-β-羟基类固醇脱氢酶1型抑制剂用于治疗非胰岛素依赖性2型糖尿病，胰岛素抵抗，肥胖症，脂质障碍，代谢综合征和其他介导的疾病和病症的用途 由过度的糖皮质激素作用。

公开(公告)号：WO1997030046A1

公开(公告)日：1997-08-21

申请号：PCT/US1997002128

申请日：1997-02-10

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  TASKER, Andrew, S. ,  BOYD, Steven, A. ,  SORENSEN, Bryan, K. ,  WINN, Martin ,  JAE, Hwan-Soo ,  VON GELDERN, Thomas, W. ,  HENRY, Kenneth, J.

IPC: C07D405/04

CPC classification number: C07D405/04 ,  A61K9/2059 ,  A61K9/4866

Abstract: A compound of formula (I) or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.

Abstract translation: 公开了式（I）化合物或其药学上可接受的盐，以及其制备方法和中间体，以及拮抗内皮素的方法。

公开(公告)号：WO1996006095A1

公开(公告)日：1996-02-29

申请号：PCT/US1995009924

申请日：1995-08-04

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  WINN, Martin ,  BOYD, Steven, A. ,  HUTCHINS, Charles, W. ,  JAE, Hwan-Soo ,  TASKER, Andrew, S. ,  VONGELDERN, Thomas, W. ,  KESTER, Jeffrey, A. ,  SORENSEN, Bryan, K.

IPC: C07D405/04

CPC classification number: C07D401/04 ,  C07D207/16 ,  C07D403/04 ,  C07D405/04 ,  C07D405/14 ,  C07F9/572 ,  C07F9/59

Abstract: A compound of formula (I) or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.

Abstract translation: 公开了式（I）化合物或其药学上可接受的盐，以及其制备方法和中间体，以及拮抗内皮素的方法。