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公开(公告)号：WO1997034923A1
公开(公告)日：1997-09-25
申请号：PCT/US1997001912
申请日：1997-02-06
Applicant: ABBOTT LABORATORIES
Inventor： ABBOTT LABORATORIES , FUNK, Kenneth, W. , LUNDELL, Edwin, O. , MILLER, Robert, B. , CHANG, Jane, L. , KISHORE, Vimal , NAPIER, James, J. , STAEGER, Michael, A.
IPC: C07K07/23
CPC classification number: C07K5/06165 , A61K38/00 , C07D307/14 , C07K5/06086 , C07K5/081 , C07K5/0812 , C07K5/0815 , C07K5/1008 , C07K5/1013 , C07K5/1019 , C07K7/23
Abstract: A method is provided for preparing decapeptide and undecapeptide derivatives of LHRH by solution phase peptide chemistry as well as intermediate peptides useful in the same method.
Abstract translation: 提供了通过溶液相肽化学制备LHRH的十肽和十一肽衍生物以及用于相同方法的中间肽的方法。
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公开(公告)号：WO1997034924A1
公开(公告)日：1997-09-25
申请号：PCT/US1997001954
申请日：1997-02-06
Applicant: ABBOTT LABORATORIES
Inventor： ABBOTT LABORATORIES , FUNK, Kenneth, W. , LUNDELL, Edwin, O. , MILLER, Robert, B. , CHANG, Jane, L. , KISHORE, Vimal , NAPIER, James, J. , STAEGER, Michael, A.
IPC: C07K07/23
CPC classification number: C07K7/23 , A61K38/00 , C07D307/14
Abstract: A method is provided for preparing decapeptide and undecapeptide derivatives of LHRH by solution phase peptide chemistry as well as intermediate peptides useful in the same method.
Abstract translation: 提供了通过溶液相肽化学制备LHRH的十肽和十一肽衍生物以及以相同方法有用的中间体肽的方法。
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公开(公告)号：EP1090009A2
公开(公告)日：2001-04-11
申请号：EP99926157.1
申请日：1999-06-03
Applicant: ABBOTT LABORATORIES
Inventor： STEWART, Andrew, O. , BOYD, Steven, A. , ARENDSEN, David, L. , BHATIA, Pramila , CONDROSKI, Kevin, R. , FREEMAN, Jennifer, C. , GUNAWARDANA, Indrani, W. , ZHU, Gui-Dong , LARTEY, Kraig , MCCARTY, Catherine, M. , MORT, Nicholas, A. , PATEL, Meena V. , STAEGER, Michael, A. , STOUT, David, M.
IPC: C07D495/04 , C07D498/04 , C07D513/04 , C07D471/04 , C07D491/04 , A61K31/44 , A61K31/50 , A61K31/505
CPC classification number: C07D471/04 , C07D491/04 , C07D495/04 , C07D513/04
Abstract: Compounds having Formula (I) are useful for treating inflammation. Also disclosed are pharmaceutical compositions comprising compouns of Formula (I), and methods of inhibiting/treating inflammatory diseases in a mammal.
Abstract translation: 具有式（I）的化合物可用于治疗炎症。 还公开了包含式（I）化合物的药物组合物，以及在哺乳动物中抑制/治疗炎性疾病的方法。
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4.发明公开
公开(公告)号：EP1165505A1
公开(公告)日：2002-01-02
申请号：EP00921654.0
申请日：2000-04-03
Applicant: ABBOTT LABORATORIES
Inventor： LINK, James , LIU, Gang , PEI, Zhonghua , VON GELDERN, Thomas, W. , WINN, Martin , XIN, Zhili , WANG, Sheldon , BOYD, Steven, A. , ZHU, Gui-Dong , FREEMAN, Jennifer, C. , GUNAWARDANA, Indrani, W. , STAEGER, Michael, A. , JAE, Hwan-Soo , LYNCH, John, K.
IPC: C07C323/62 , C07D233/61 , C07D207/26 , C07D295/18 , C07D213/74 , C07D211/22 , C07D207/14 , C07D211/46 , C07D211/62 , C07D211/60 , C07D401/04 , C07D217/02 , C07D307/68 , C07D295/26 , C07D317/66 , C07D209/08 , C07D295/205 , C07D401/12 , A61K31/165 , A61K31/33 , A61P29/00
CPC classification number: C07D207/27 , C07C323/62 , C07C2601/02 , C07D205/04 , C07D207/09 , C07D207/14 , C07D207/16 , C07D209/08 , C07D211/20 , C07D211/22 , C07D211/46 , C07D211/60 , C07D211/62 , C07D213/40 , C07D213/74 , C07D213/81 , C07D217/02 , C07D217/06 , C07D231/12 , C07D233/56 , C07D241/04 , C07D249/08 , C07D295/185 , C07D295/26 , C07D307/68 , C07D317/66 , C07D401/04 , C07D401/12
Abstract: The present invention relates to cinnamide compounds of formula (I), in which at least one of R1 to R5 is a "cis-cinnamide" (a) or a "trans-cinnamide" (b) and the other variables are as defined in the claims, that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions containing these compounds and to methods of inhibiting inflammation or suppressing immune response in a mammal.
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公开(公告)号：EP0889901A1
公开(公告)日：1999-01-13
申请号：EP97904253.0
申请日：1997-02-06
Applicant: Abbott Laboratories
Inventor： FUNK, Kenneth, W. , LUNDELL, Edwin, O. , MILLER, Robert, B. , CHANG, Jane, L. , KISHORE, Vimal , NAPIER, James, J. , STAEGER, Michael, A.
CPC classification number: C07K5/06165 , A61K38/00 , C07D307/14 , C07K5/06086 , C07K5/081 , C07K5/0812 , C07K5/0815 , C07K5/1008 , C07K5/1013 , C07K5/1019 , C07K7/23
Abstract: A method is provided for preparing decapeptide and undecapeptide derivatives of LHRH by solution phase peptide chemistry as well as intermediate peptides useful in the same method.
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Patent Agency Ranking
公开(公告)号：EP0889901B1
公开(公告)日：2001-09-19
申请号：EP97904253.8
申请日：1997-02-06
Applicant: Abbott Laboratories
Inventor： FUNK, Kenneth, W. , LUNDELL, Edwin, O. , MILLER, Robert, B. , CHANG, Jane, L. , KISHORE, Vimal , NAPIER, James, J. , STAEGER, Michael, A.
CPC classification number: C07K5/06165 , A61K38/00 , C07D307/14 , C07K5/06086 , C07K5/081 , C07K5/0812 , C07K5/0815 , C07K5/1008 , C07K5/1013 , C07K5/1019 , C07K7/23
Abstract: A method is provided for preparing decapeptide and undecapeptide derivatives of LHRH by solution phase peptide chemistry as well as intermediate peptides useful in the same method.
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公开(公告)号：EP0914334B1
公开(公告)日：2001-05-30
申请号：EP97905825.2
申请日：1997-02-06
Applicant: Abbott Laboratories
Inventor： FUNK, Kenneth, W. , LUNDELL, Edwin, O. , MILLER, Robert, B. , CHANG, Jane, L. , KISHORE, Vimal , NAPIER, James, J. , STAEGER, Michael, A.
CPC classification number: C07K7/23 , A61K38/00 , C07D307/14
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公开(公告)号：EP0914334A1
公开(公告)日：1999-05-12
申请号：EP97905825.0
申请日：1997-02-06
Applicant: Abbott Laboratories
Inventor： FUNK, Kenneth, W. , LUNDELL, Edwin, O. , MILLER, Robert, B. , CHANG, Jane, L. , KISHORE, Vimal , NAPIER, James, J. , STAEGER, Michael, A.
CPC classification number: C07K7/23 , A61K38/00 , C07D307/14
Abstract: A method is provided for preparing decapeptide and undecapeptide derivatives of LHRH by solution phase peptide chemistry as well as intermediate peptides useful in the same method.
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9.发明授权CELL ADHESION-INHIBITING ANTIINFLAMMATORY AND IMMUNE-SUPPRESSIVE COMPOUNDS 有权ZELLADHÄSION-和抗炎免疫CONNECTIONS
公开(公告)号：EP1140814B1
公开(公告)日：2005-05-25
申请号：EP99966709.0
申请日：1999-12-29
Applicant: ABBOTT LABORATORIES
Inventor： LINK, James , LIU, Gang , PEI, Zhonghua , VON GELDERN, Tom , WINN, Martin , XIN, Zhili , BOYD, Steven, A. , JAE, Hwan-Soo , LYNCH, John, K. , ZHU, Gui-Dong , FREEMAN, Jennifer, C. , GUNAWARDANA, Indrani, W. , STAEGER, Michael, A.
IPC: C07C323/00
CPC classification number: C07D207/27 , C07C323/62 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07D207/09 , C07D207/14 , C07D207/20 , C07D207/22 , C07D207/26 , C07D209/08 , C07D209/18 , C07D211/22 , C07D211/26 , C07D211/42 , C07D211/46 , C07D211/54 , C07D211/60 , C07D211/62 , C07D211/74 , C07D213/74 , C07D213/75 , C07D213/81 , C07D215/36 , C07D217/06 , C07D235/26 , C07D239/42 , C07D241/04 , C07D241/24 , C07D243/08 , C07D265/30 , C07D295/13 , C07D295/185 , C07D295/205 , C07D295/215 , C07D295/26 , C07D295/32 , C07D307/52 , C07D307/68 , C07D317/58 , C07D317/62 , C07D319/18 , C07D319/20 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/04 , C07D413/14 , C07D471/10 , C07D487/08 , C07D491/10
Abstract: The present invention relates to novel cinnamide compounds that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions containing these compounds, and to methods of inhibiting inflammation or suppressing immune response in a mammal.
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10.发明授权CELL ADHESION-INHIBITING ANTIINFLAMMATORY AND IMMUNE-SUPPRESSIVE COMPOUNDS 有权ZELLADHÄSIONINHIBIERENDEENTZÜNDUNGSHEMMENDEUND IMMUNSUPPRIVEIVE VERBINDUNGEN
公开(公告)号：EP1165505B1
公开(公告)日：2004-09-08
申请号：EP00921654.0
申请日：2000-04-03
Applicant: ABBOTT LABORATORIES
Inventor： LINK, James , LIU, Gang , PEI, Zhonghua , VON GELDERN, Thomas, W. , WINN, Martin , XIN, Zhili , WANG, Sheldon , BOYD, Steven, A. , ZHU, Gui-Dong , FREEMAN, Jennifer, C. , GUNAWARDANA, Indrani, W. , STAEGER, Michael, A. , JAE, Hwan-Soo , LYNCH, John, K.
IPC: C07C323/62 , C07D233/61 , C07D207/26 , C07D295/18 , C07D213/74 , C07D211/22 , C07D207/14 , C07D211/46 , C07D211/62 , C07D211/60 , C07D401/04 , C07D217/02 , C07D307/68 , C07D295/26 , C07D317/66 , C07D209/08 , C07D295/205 , C07D401/12 , A61K31/165 , A61K31/33 , A61P29/00
CPC classification number: C07D207/27 , C07C323/62 , C07C2601/02 , C07D205/04 , C07D207/09 , C07D207/14 , C07D207/16 , C07D209/08 , C07D211/20 , C07D211/22 , C07D211/46 , C07D211/60 , C07D211/62 , C07D213/40 , C07D213/74 , C07D213/81 , C07D217/02 , C07D217/06 , C07D231/12 , C07D233/56 , C07D241/04 , C07D249/08 , C07D295/185 , C07D295/26 , C07D307/68 , C07D317/66 , C07D401/04 , C07D401/12
Abstract: The present invention relates to cinnamide compounds of formula (I), in which at least one of R1 to R5 is a "cis-cinnamide" (a) or a "trans-cinnamide" (b) and the other variables are as defined in the claims, that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions containing these compounds and to methods of inhibiting inflammation or suppressing immune response in a mammal.
Abstract translation: 本发明涉及式（I）的肉桂酰胺化合物，其中R 1至R 5中的至少一个为“顺式 - 酰胺”（a）或“反式肉桂酰胺”（b），其它变量如 可用于治疗炎症和免疫疾病的权利要求，含有这些化合物的药物组合物和抑制哺乳动物炎症或抑制免疫应答的方法。
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