公开(公告)号：WO2008111942A2

公开(公告)日：2008-09-18

申请号：PCT/US2007/006953

申请日：2007-03-20

Applicant: ABBOTT LABORATORIES ,  THOMPSON, Melody ,  WEIDA, Sandra ,  BARRETT-REIS, Bridgette ,  MAZER, Terry

Inventor： THOMPSON, Melody ,  WEIDA, Sandra ,  BARRETT-REIS, Bridgette ,  MAZER, Terry

IPC: A23L1/29

CPC classification number: A23L33/16 ,  A23L33/10 ,  A23L33/15 ,  A23L33/30 ,  A23L33/40 ,  A23V2002/00 ,  A23V2250/1578 ,  A23V2250/1642 ,  A23V2250/1588 ,  A23V2250/1614 ,  A23V2250/702 ,  A23V2250/71 ,  A23V2250/7056 ,  A23V2250/7046 ,  A23V2250/705 ,  A23V2250/706 ,  A23V2250/708

Abstract: Disclosed is a method of tailoring infant formulas to individual nutrition needs prior to use. The method comprises (A) determining the desired volume and optimal caloric density of a formula to be fed to a preterm or low birth weight infant; (B) obtaining a plurality of base infant formulas, all in liquid form, comprising fat, protein, carbohydrate, vitamins, and minerals, each of which has an osmolality of from about 200 to about 360 mOsm/kg water and a different caloric density within a range of from about 609 to about 1082 kcal/L; (C) selecting two of the base liquid formulas having a caloric density value above and below the optimal caloric density, (D) calculating the volume of each selected base formula needed to produce the desired volume of an infant formula blend having the optimal caloric density; (E) combining the calculated volumes to produce a an isotonic blend having the desired feeding volume and optimal caloric density. The formula is then fed to the preterm or low birth weight infant. Also disclosed is a hypercaloric infant formula suitable for use in the disclosed method, and infant formula kits comprising the plurality of base formulas and a device (e.g. calculator, computer program, chart with precalculated blend volumes) for calculating blend volumes.

Abstract translation: 公开了一种在使用前将婴儿配方调配到个体营养需求的方法。 该方法包括（A）确定要喂给早产或低出生体重婴儿的配方的期望体积和最佳热量密度; （B）获得多种液体形式的基础婴儿配方食品，包括脂肪，蛋白质，碳水化合物，维生素和矿物质，其各自具有约200至约360mOsm / kg水的重量摩尔渗透压浓度和不同的热量密度 在约609至约1082kcal / L的范围内; （C）选择具有高于和低于最佳热量密度的热量密度值的两种基础液体配方，（D）计算产生具有最佳热量密度的婴儿配方配方所需体积所需的每种所选碱基配方的体积 ; （E）组合计算的体积以产生具有所需进料体积和最佳热量密度的等渗混合物。 然后将该配方喂给早产或低出生体重的婴儿。 还公开了适用于所公开的方法的超热量婴儿配方食品，以及包含多种基础配方的婴儿配方药盒和用于计算混合体积的装置（例如计算器，计算机程序，具有预先计算的混合物体积的图表）。

公开(公告)号：WO2006102451A3

公开(公告)日：2006-09-28

申请号：PCT/US2006/010468

申请日：2006-03-21

Applicant: ABBOTT LABORATORIES ,  MAZER, Terry ,  EDENS, Neile ,  BERGANA, Marti ,  SHEARER, Kati ,  WOLF, David ,  WALTON, Joseph

Inventor： MAZER, Terry ,  EDENS, Neile ,  BERGANA, Marti ,  SHEARER, Kati ,  WOLF, David ,  WALTON, Joseph

IPC: A61K31/223

Abstract: Disclosed are compositions, including low-calorie beverages or liquids, comprising isoleucine, leucine, valine, cysteine, and methionine, in specified amounts, weight ratios, or both. The compositions are especially useful in treating individuals afflicted with impaired glucose tolerance or diabetes.

公开(公告)号：WO2009086054A1

公开(公告)日：2009-07-09

申请号：PCT/US2008/087597

申请日：2008-12-19

Applicant: ABBOTT LABORATORIES ,  LAI, Chron-si ,  WALTON, Joseph ,  SHEARER, Kati ,  MAZER, Terry ,  WEN-LIU, James ,  STEPP, Emily, A.

Inventor： LAI, Chron-si ,  WALTON, Joseph ,  SHEARER, Kati ,  MAZER, Terry ,  WEN-LIU, James ,  STEPP, Emily, A.

IPC: A23L1/29 ,  A23L1/035 ,  A23L1/302 ,  A23L1/304 ,  A23L1/305 ,  A23L2/38 ,  A23L2/52

CPC classification number: A23L2/52 ,  A23L2/38 ,  A23L29/10 ,  A23L29/35 ,  A23L33/15 ,  A23L33/16 ,  A23L33/17 ,  A23L33/40

Abstract: Disclosed are nutritional emulsions comprising fat, protein and carbohydrate. The emulsions include a V-complex or aqueous phase comprising a food grade surfactant complexed with a polydextrose having an average degree of polymerization of at least about 10; wherein the nutritional emulsion has a first viscosity at 20° C of less than about 300 cps and a second viscosity at a temperature of from 0° C to 8° C that is at least about 50 cps higher than said first viscosity. Also disclosed is a process for the making the nutritional emulsion. The nutritional emulsions develop a surprisingly thick, creamy texture when chilled prior to use.

Abstract translation: 公开了包含脂肪，蛋白质和碳水化合物的营养乳液。 所述乳液包括V-络合物或水相，其包含与平均聚合度至少约10的聚右旋糖络合的食品级表面活性剂; 其中所述营养乳液在20℃下的第一粘度小于约300cps，在0℃至8℃的温度下具有比所述第一粘度高至少约50cps的第二粘度。 还公开了制备营养乳液的方法。 营养乳液在使用前冷冻时会产生令人惊讶的厚实的乳状质地。

公开(公告)号：WO2008030998A2

公开(公告)日：2008-03-13

申请号：PCT/US2007/077824

申请日：2007-09-07

Applicant: ABBOTT LABORATORIES ,  ATKINSON, Judith, R. ,  EDENS, Neile ,  DEWILLE, Normanella, T. ,  MAZER, Terry ,  YOSICK, Kelley, J. ,  OGILVIE, Allison ,  WEARLY, Douglas

Inventor： ATKINSON, Judith, R. ,  EDENS, Neile ,  DEWILLE, Normanella, T. ,  MAZER, Terry ,  YOSICK, Kelley, J. ,  OGILVIE, Allison ,  WEARLY, Douglas

IPC: A23L1/29 ,  A23L1/00 ,  A23L1/164

CPC classification number: A23L7/126 ,  A23L7/122 ,  A23P20/12 ,  A23P20/18 ,  A23P20/20 ,  A23V2002/00 ,  A23V2200/22 ,  A23V2200/328 ,  A23V2250/606

Abstract: The present invention provides a food product comprising: a formed reduced glycemic response cereal component; and a non-sticky reduced glyccmic response sweetener coating over the formed cereal component, the sweetener coating comprising: a first sticky layer comprising at least about 30% fructose (of the total sweetener coating); a second less sticky layer having a DE value of about 60 or less and comprising up to about 17% fructose and at least about 1% non-fructose carbohydrates (of the total sweetener coating); and third layer comprising crystalline fructose. The present invention also provides a process for forming the sweetener coating over the formed cereal component comprising the following steps: (a) providing a formed cereal component having thereon a first sticky layer comprising fructose; (b) forming over the first sticky layer a less sticky second layer comprising non- fructose carbohydrates and optionally fructose; and (c) applying crystalline fructose over the second layer.

Abstract translation: 本发明提供一种食品，其包含：形成的降低的血糖反应谷物成分; 并且所述甜味剂涂层包含：包含至少约30％的果糖（总甜味剂涂层的）的第一粘性层;以及在所形成的谷物组分上的非粘性减少的糖应答甜味剂涂层。 DE值为约60或更小的第二较低粘性层，包含高达约17％的果糖和至少约1％的非果糖碳水化合物（总甜味剂涂层）; 和包含结晶果糖的第三层。 本发明还提供了一种用于在所形成的谷物成分上形成甜味剂涂层的方法，包括以下步骤：（a）提供形成有谷物成分的谷物成分，其上含有果糖的第一粘性层; （b）在第一粘性层上形成较少粘性的第二层，其包含非果糖碳水化合物和任选的果糖; 和（c）在第二层上施加结晶果糖。

公开(公告)号：WO2006099013A2

公开(公告)日：2006-09-21

申请号：PCT/US2006/008354

申请日：2006-03-08

Applicant: ABBOTT LABORATORIES ,  BARRETT-REIS, Bridget ,  MAZER, Terry ,  BLACK, Cynthia

Inventor： BARRETT-REIS, Bridget ,  MAZER, Terry ,  BLACK, Cynthia

IPC: A23L1/29

CPC classification number: A23C9/206 ,  A23L33/18 ,  A23L33/185 ,  A23L33/19 ,  A23L33/40 ,  A23V2002/00 ,  A23V2250/1578 ,  A23V2250/1642 ,  A23V2250/1592 ,  A23V2250/1588 ,  A23V2250/1612 ,  A23V2250/1626 ,  A23V2250/1598 ,  A23V2250/702 ,  A23V2250/704 ,  A23V2250/71 ,  A23V2250/712 ,  A23V2250/714 ,  A23V2250/628 ,  A23V2250/54252 ,  A23V2250/5424 ,  A23V2250/1944 ,  A23V2250/1868 ,  A23V2250/1842 ,  A23V2250/1862 ,  A23V2250/70 ,  A23V2250/0644 ,  A23V2250/641 ,  A23V2250/54246

Abstract: Disclosed are concentrated, liquid, human milk fortifier compositions comprising from about 15% to about 45% by weight of protein, on a dry weight basis, and having a caloric density of from about 1.25 kcal/ml to about 6.0 kcal/ml, wherein the liquid human milk fortifier composition is added to human milk in a volume-volume ratio of from about 1:3 to about 1:9. These composition include embodiments comprising carbohydrate and fat, that are formulated with improved stability by selecting any one of the following variations: 1) certain whey-casein protein blends, 2) water insoluble calcium-containing materials, 3) protein hydrolysates, and 4) aseptically packaged concentrates. The liquid concentrates are especially useful for providing nutrition to preterm infants in neonatal intensive care units or similar other institutional setting, and to minimize the risk of introducing microbial contaminants such as Enterobacter sakazakii to infant feedings during preparation in such institutional settings.

Abstract translation: 公开了浓缩的液体人乳强化剂组合物，其包含以干重计约15重量％至约45重量％的蛋白质，并具有约1.25kcal / ml的热量密度 至约6.0kcal / ml，其中所述液体母乳强化剂组合物以约1：3至约1：9的体积 - 体积比加入人乳中。 这些组合物包括包含碳水化合物和脂肪的实施方案，其通过选择以下变体中的任一个而以改善的稳定性配制：1）某些乳清 - 酪蛋白混合物，2）水不溶性含钙材料，3）蛋白质水解产物，以及4） 无菌包装的浓缩物。 液体浓缩物尤其适用于为新生儿重症监护病房或类似的其他机构环境中的早产儿提供营养，并且最大限度地降低在这种机构环境中制备期间将微生物污染物（如阪崎肠杆菌）引入婴儿喂食的风险。

公开(公告)号：EP2244592A1

公开(公告)日：2010-11-03

申请号：EP08867813.1

申请日：2008-12-19

Applicant: Abbott Laboratories

Inventor： LAI, Chron-si ,  WALTON, Joseph ,  SHEARER, Kati ,  MAZER, Terry ,  WEN-LIU, James ,  STEPP, Emily, A.

IPC: A23L1/29 ,  A23L1/035 ,  A23L1/302 ,  A23L1/304 ,  A23L1/305 ,  A23L2/38 ,  A23L2/52

CPC classification number: A23L2/52 ,  A23L2/38 ,  A23L29/10 ,  A23L29/35 ,  A23L33/15 ,  A23L33/16 ,  A23L33/17 ,  A23L33/40

Abstract: Disclosed are nutritional emulsions comprising fat, protein and carbohydrate. The emulsions include a V-complex or aqueous phase comprising a food grade surfactant complexed with a polydextrose having an average degree of polymerization of at least about 10; wherein the nutritional emulsion has a first viscosity at 20° C of less than about 300 cps and a second viscosity at a temperature of from 0° C to 8° C that is at least about 50 cps higher than said first viscosity. Also disclosed is a process for the making the nutritional emulsion. The nutritional emulsions develop a surprisingly thick, creamy texture when chilled prior to use.

公开(公告)号：EP1871182A2

公开(公告)日：2008-01-02

申请号：EP06737520.4

申请日：2006-03-08

Applicant: ABBOTT LABORATORIES

Inventor： BARRETT-REIS, Bridget ,  MAZER, Terry ,  BLACK, Cynthia

IPC: A23L1/29

CPC classification number: A23C9/206 ,  A23L33/18 ,  A23L33/185 ,  A23L33/19 ,  A23L33/40 ,  A23V2002/00 ,  A23V2250/1578 ,  A23V2250/1642 ,  A23V2250/1592 ,  A23V2250/1588 ,  A23V2250/1612 ,  A23V2250/1626 ,  A23V2250/1598 ,  A23V2250/702 ,  A23V2250/704 ,  A23V2250/71 ,  A23V2250/712 ,  A23V2250/714 ,  A23V2250/628 ,  A23V2250/54252 ,  A23V2250/5424 ,  A23V2250/1944 ,  A23V2250/1868 ,  A23V2250/1842 ,  A23V2250/1862 ,  A23V2250/70 ,  A23V2250/0644 ,  A23V2250/641 ,  A23V2250/54246

Abstract: Disclosed are concentrated, liquid, human milk fortifier compositions comprising from about 15% to about 45% by weight of protein, on a dry weight basis, and having a caloric density of from about 1.25 kcal/ml to about 6.0 kcal/ml, wherein the liquid human milk fortifier composition is added to human milk in a volume-volume ratio of from about 1:3 to about 1:9. These composition include embodiments comprising carbohydrate and fat, that are formulated with improved stability by selecting any one of the following variations: 1) certain whey-casein protein blends, 2) water insoluble calcium-containing materials, 3) protein hydrolysates, and 4) aseptically packaged concentrates. The liquid concentrates are especially useful for providing nutrition to preterm infants in neonatal intensive care units or similar other institutional setting, and to minimize the risk of introducing microbial contaminants such as Enterobacter sakazakii to infant feedings during preparation in such institutional settings.

公开(公告)号：EP1863472B1

公开(公告)日：2013-02-20

申请号：EP06739315.7

申请日：2006-03-21

Applicant: ABBOTT LABORATORIES

Inventor： MAZER, Terry ,  EDENS, Neile ,  BERGANA, Marti ,  SHEARER, Kati ,  WOLF, David ,  WALTON, Joseph

IPC: A61K31/223 ,  A61K31/198 ,  A61K31/401 ,  A61K31/405 ,  A61K31/4172

CPC classification number: A61K31/223 ,  A61K31/198 ,  A61K31/401 ,  A61K31/405 ,  A61K31/4172 ,  A61K2300/00 ,  Y10S514/866

Abstract: Disclosed are compositions, including low-calorie beverages or liquids, comprising isoleucine, leucine, valine, cysteine, and methionine, in specified amounts, weight ratios, or both. The compositions are especially useful in treating individuals afflicted with impaired glucose tolerance or diabetes.

公开(公告)号：EP2061348A2

公开(公告)日：2009-05-27

申请号：EP07842026.2

申请日：2007-09-07

Applicant: ABBOTT LABORATORIES

Inventor： ATKINSON, Judith, R. ,  EDENS, Neile ,  DEWILLE, Normanella, T. ,  MAZER, Terry ,  YOSICK, Kelley, J. ,  OGILVIE, Allison ,  WEARLY, Douglas

IPC: A23L1/29 ,  A23L1/00 ,  A23L1/164

CPC classification number: A23L7/126 ,  A23L7/122 ,  A23P20/12 ,  A23P20/18 ,  A23P20/20 ,  A23V2002/00 ,  A23V2200/22 ,  A23V2200/328 ,  A23V2250/606

Abstract: The present invention provides a food product comprising: a formed reduced glycemic response cereal component; and a non-sticky reduced glyccmic response sweetener coating over the formed cereal component, the sweetener coating comprising: a first sticky layer comprising at least about 30% fructose (of the total sweetener coating); a second less sticky layer having a DE value of about 60 or less and comprising up to about 17% fructose and at least about 1% non-fructose carbohydrates (of the total sweetener coating); and third layer comprising crystalline fructose. The present invention also provides a process for forming the sweetener coating over the formed cereal component comprising the following steps: (a) providing a formed cereal component having thereon a first sticky layer comprising fructose; (b) forming over the first sticky layer a less sticky second layer comprising non- fructose carbohydrates and optionally fructose; and (c) applying crystalline fructose over the second layer.

公开(公告)号：EP1871182B1

公开(公告)日：2011-04-20

申请号：EP06737520.4

申请日：2006-03-08

Applicant: ABBOTT LABORATORIES

Inventor： BARRETT-REIS, Bridget ,  MAZER, Terry ,  BLACK, Cynthia

IPC: A23L1/29

CPC classification number: A23C9/206 ,  A23L33/18 ,  A23L33/185 ,  A23L33/19 ,  A23L33/40 ,  A23V2002/00 ,  A23V2250/1578 ,  A23V2250/1642 ,  A23V2250/1592 ,  A23V2250/1588 ,  A23V2250/1612 ,  A23V2250/1626 ,  A23V2250/1598 ,  A23V2250/702 ,  A23V2250/704 ,  A23V2250/71 ,  A23V2250/712 ,  A23V2250/714 ,  A23V2250/628 ,  A23V2250/54252 ,  A23V2250/5424 ,  A23V2250/1944 ,  A23V2250/1868 ,  A23V2250/1842 ,  A23V2250/1862 ,  A23V2250/70 ,  A23V2250/0644 ,  A23V2250/641 ,  A23V2250/54246

Abstract: Disclosed are concentrated, liquid, human milk fortifier compositions comprising from about 15% to about 45% by weight of protein, on a dry weight basis, and having a caloric density of from about 1.25 kcal/ml to about 6.0 kcal/ml, wherein the liquid human milk fortifier composition is added to human milk in a volume-volume ratio of from about 1:3 to about 1:9. These composition include embodiments comprising carbohydrate and fat, that are formulated with improved stability by selecting any one of the following variations: 1) certain whey-casein protein blends, 2) water insoluble calcium-containing materials, 3) protein hydrolysates, and 4) aseptically packaged concentrates. The liquid concentrates are especially useful for providing nutrition to preterm infants in neonatal intensive care units or similar other institutional setting, and to minimize the risk of introducing microbial contaminants such as Enterobacter sakazakii to infant feedings during preparation in such institutional settings.