公开(公告)号：WO2007131016A2

公开(公告)日：2007-11-15

申请号：PCT/US2007/067991

申请日：2007-05-02

Applicant: ABBOTT LABORATORIES ,  GIRANDA, Vincent L. ,  PENNING, Thomas D. ,  GANDHI, Virajkumar B. ,  THOMAS, Sheela A. ,  ZHU, Gui-dong ,  GONG, Jianchun

Inventor： GIRANDA, Vincent L. ,  PENNING, Thomas D. ,  GANDHI, Virajkumar B. ,  THOMAS, Sheela A. ,  ZHU, Gui-dong ,  GONG, Jianchun

IPC: A61K31/4184 ,  C07D403/02

CPC classification number: C07D403/10 ,  C07D235/18 ,  C07D409/04

Abstract: The present invention relates to 1H-benzimidazole-4-carboxamides of formula (I), their preparation, and their use as inhibitors of the enzyme poly(ADP-ribose)polymerase for the preparation of drugs.

Abstract translation: 本发明涉及式（I）的1H-苯并咪唑-4-甲酰胺，其制备及其作为制备药物的聚（ADP-核糖）聚合酶的抑制剂的用途。

公开(公告)号：WO2007140233A1

公开(公告)日：2007-12-06

申请号：PCT/US2007/069630

申请日：2007-05-24

Applicant: ABBOTT LABORATORIES ,  DIEBOLD, Robert B. ,  DJURIC, Stevan W. ,  GIRANDA, Vincent L ,  HEXAMER, Laura ,  LIN, Nan-horng ,  MIYASHIRO, Julie M. ,  PENNING, Thomas D. ,  PRZYTULINSKA, Magdalena ,  SOWIN, Thomas ,  SULLIVAN, Gerard ,  TAO, Zhi-fu ,  TONG, Yunsong ,  VASUDEVAN, Anil ,  WANG, Le ,  WOODS, Keith W. ,  XIA, Zhiren ,  ZHANG, Henry Q.

Inventor： DIEBOLD, Robert B. ,  DJURIC, Stevan W. ,  GIRANDA, Vincent L ,  HEXAMER, Laura ,  LIN, Nan-horng ,  MIYASHIRO, Julie M. ,  PENNING, Thomas D. ,  PRZYTULINSKA, Magdalena ,  SOWIN, Thomas ,  SULLIVAN, Gerard ,  TAO, Zhi-fu ,  TONG, Yunsong ,  VASUDEVAN, Anil ,  WANG, Le ,  WOODS, Keith W. ,  XIA, Zhiren ,  ZHANG, Henry Q.

IPC: C07C225/20 ,  C07D249/14 ,  C07D277/64 ,  C07D285/06 ,  C07D333/20 ,  A61P35/00 ,  A61K31/132 ,  A61K31/505

CPC classification number: C07D249/14 ,  C07C225/20 ,  C07C2601/02 ,  C07C2601/04 ,  C07D277/64 ,  C07D285/06 ,  C07D333/20

Abstract: Compounds that inhibit Plk1, compositions containing the compounds and methods of treating diseases using the compounds are disclosed.

Abstract translation: 公开了抑制Plk1的化合物，含有该化合物的组合物和使用该化合物治疗疾病的方法。

公开(公告)号：WO2013012681A1

公开(公告)日：2013-01-24

申请号：PCT/US2012/046482

申请日：2012-07-12

Applicant: ABBOTT LABORATORIES ,  WOODS, Keith W. ,  LAI, Chunqiu ,  PENNING, Thomas D. ,  MIYASHIRO, Julie

Inventor： WOODS, Keith W. ,  LAI, Chunqiu ,  PENNING, Thomas D. ,  MIYASHIRO, Julie

IPC: C07D513/04 ,  C07D513/14 ,  A61K31/542 ,  A61K31/546 ,  A61P35/00

CPC classification number: C07D513/04 ,  C07D513/14

Abstract: The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein R 1 , R 2 , R 3 , A, B, and n are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as wee-1 and methods of treating diseases such as cancer.

Abstract translation: 本发明涉及式（I）化合物或其药学上可接受的盐，其中R1，R2，R3，A，B和n在说明书中定义。 本发明还涉及含有所述化合物的组合物，其可用于抑制诸如wee-1的激酶和治疗诸如癌症的疾病的方法。

公开(公告)号：WO2012100135A1

公开(公告)日：2012-07-26

申请号：PCT/US2012/021985

申请日：2012-01-20

Applicant: ABBOTT LABORATORIES ,  VASUDEVAN, Anil ,  PENNING, Thomas D. ,  PLIUSCHEV, Marina

Inventor： VASUDEVAN, Anil ,  PENNING, Thomas D. ,  PLIUSCHEV, Marina

IPC: C07D213/81 ,  C07D401/12 ,  C07D409/12 ,  C07D413/12 ,  A61K31/444 ,  A61P35/00

CPC classification number: C07D401/12 ,  C07D213/81 ,  C07D409/12 ,  C07D413/12

Abstract: The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein R 1 , R 2 , R 3 , A, B, Z, n, and m are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as ALK and methods of treating diseases such as cancer.

Abstract translation: 本发明涉及式（I）化合物或其药学上可接受的盐，其中R 1，R 2，R 3，A，B，Z，n和m在说明书中定义。 本发明还涉及含有可用于抑制ALK等激酶的化合物的组合物和治疗诸如癌症的疾病的方法。

公开(公告)号：WO2011130481A1

公开(公告)日：2011-10-20

申请号：PCT/US2011/032439

申请日：2011-04-14

Applicant: ABBOTT LABORATORIES ,  ZHU, Guidong ,  GANDHI, Virajkumar B. ,  SHOEMAKER, Alex R. ,  PENNING, Thomas D. ,  GONG, Jianchun

Inventor： ZHU, Guidong ,  GANDHI, Virajkumar B. ,  SHOEMAKER, Alex R. ,  PENNING, Thomas D. ,  GONG, Jianchun

IPC: C07D487/04 ,  C07D519/00 ,  A61K31/4985 ,  A61P35/00

CPC classification number: C07D487/04 ,  C07D519/00

Abstract: The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, (Formula (I)) wherein R 1a , R 1b , R 1c , X, Y, Z, n, and m are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as Cdc7 and methods of treating diseases such as cancer.

Abstract translation: 本发明涉及式（I）化合物或其药学上可接受的盐（式（I）），其中R 1a，R 1b，R 1c，X，Y，Z，n和m在说明书中定义。 本发明还涉及含有所述化合物的组合物，其可用于抑制诸如Cdc7的激酶和治疗诸如癌症的疾病的方法。

公开(公告)号：WO2008083027A1

公开(公告)日：2008-07-10

申请号：PCT/US2007/088319

申请日：2007-12-20

Applicant: ABBOTT LABORATORIES ,  GANDHI, Viraj B. ,  GIRANDA, Vincent L. ,  GONG, Jianchun ,  PENNING, Thomas D. ,  ZHU, Gui-dong

Inventor： GANDHI, Viraj B. ,  GIRANDA, Vincent L. ,  GONG, Jianchun ,  PENNING, Thomas D. ,  ZHU, Gui-dong

IPC: A01N43/58 ,  A61K31/50 ,  A61K31/495

CPC classification number: C07D403/10 ,  C07D237/32 ,  C07D403/12 ,  C07D403/14 ,  Y02P20/582

Abstract: Inhibitors of poly(ADP-ribose)polymerase, ways to make them and methods of treating patients using them are disclosed.

公开(公告)号：WO2011133388A1

公开(公告)日：2011-10-27

申请号：PCT/US2011/032464

申请日：2011-04-14

Applicant: ABBOTT LABORATORIES ,  PENNING, Thomas D. ,  WOODS, Keith W. ,  LAI, Chunqiu ,  FLORJANCIC, Alan S. ,  TONG, Yungsong

Inventor： PENNING, Thomas D. ,  WOODS, Keith W. ,  LAI, Chunqiu ,  FLORJANCIC, Alan S. ,  TONG, Yungsong

IPC: C07D471/04 ,  A61K31/513 ,  A61K31/444 ,  A61P35/00

CPC classification number: C07D471/04

Abstract: The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, Formula (I) wherein R 1a , R 1b , R 1c , X, and Y are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as Cdc7 and methods of treating diseases such as cancer.

Abstract translation: 本发明涉及式（I）化合物或其药学上可接受的盐，式（I）其中R 1a，R 1b，R 1c，X和Y在说明书中定义。 本发明还涉及含有所述化合物的组合物，其可用于抑制诸如Cdc7的激酶和治疗诸如癌症的疾病的方法。

公开(公告)号：WO2011130478A1

公开(公告)日：2011-10-20

申请号：PCT/US2011/032433

申请日：2011-04-14

Applicant: ABBOTT LABORATORIES ,  ZHU, Guidong ,  GANDHI, Virajkumar B. ,  SHOEMAKER, Alex R. ,  PENNING, Thomas D. ,  GONG, Jianchun

Inventor： ZHU, Guidong ,  GANDHI, Virajkumar B. ,  SHOEMAKER, Alex R. ,  PENNING, Thomas D. ,  GONG, Jianchun

IPC: C07D401/04 ,  C07D471/04 ,  A61K31/502 ,  A61P35/00

CPC classification number: C07D471/04 ,  C07D401/04

Abstract: The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, (I) wherein R 1a , R 1b , R 1c , X, Y, Z, n, and m are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as Cdc7 and methods of treating diseases such as cancer.

Abstract translation: 本发明涉及式（I）化合物或其药学上可接受的盐，（I）其中R1a，R1b，R1c，X，Y，Z，n和m在说明书中定义。 本发明还涉及含有所述化合物的组合物，其可用于抑制诸如Cdc7的激酶和治疗诸如癌症的疾病的方法。

公开(公告)号：WO2006110683A1

公开(公告)日：2006-10-19

申请号：PCT/US2006/013366

申请日：2006-04-11

Applicant: ABBOTT LABORATORIES ,  ZHU, Guidong ,  GANDHI, Virajkumar B. ,  GONG, Jianchun ,  PENNING, Thomas D. ,  GIRANDA, Vincent L. ,  THOMAS, Sheela

Inventor： ZHU, Guidong ,  GANDHI, Virajkumar B. ,  GONG, Jianchun ,  PENNING, Thomas D. ,  GIRANDA, Vincent L. ,  THOMAS, Sheela

IPC: C07D235/14 ,  C07D401/04 ,  C07D401/12 ,  C07D403/06 ,  A61K31/4184 ,  A61K31/4439 ,  A61K31/454 ,  A61P29/00 ,  A61P31/00

CPC classification number: C07D235/14 ,  C07D401/04 ,  C07D401/12 ,  C07D403/06

Abstract: Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compounds of Formula (I).

Abstract translation: 式（I）的化合物抑制PARP酶，并且可用于治疗与PARP相关的疾病或病症。 还公开了包含式（I）化合物，包含式（I）化合物的治疗方法的药物组合物，以及抑制包含式（I）化合物的PARP酶的方法。

公开(公告)号：EP1966157A2

公开(公告)日：2008-09-10

申请号：EP06837694.6

申请日：2006-11-15

Applicant: ABBOTT LABORATORIES

Inventor： PENNING, Thomas D. ,  THOMAS, Sheela A. ,  ZHU, Gui-Dong ,  GONG, Jianchun ,  GIRANDA, Vincent L. ,  GANDHI, Viraj B.

IPC: C07D235/18

CPC classification number: C07D235/18 ,  C07D409/04 ,  C07D413/04 ,  C07D417/04

Abstract: Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compounds of Formula (I).