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1.发明申请SUBSTITUTED 1H-BENZIMIDAZOLE-4-CARBOXAMIDES ARE POTENT PARP INHIBITORS 审中-公开取代的1H-苯并咪唑-4-羧酰胺是残留的PARP抑制剂
公开(公告)号：WO2007131016A2
公开(公告)日：2007-11-15
申请号：PCT/US2007/067991
申请日：2007-05-02
Applicant: ABBOTT LABORATORIES , GIRANDA, Vincent L. , PENNING, Thomas D. , GANDHI, Virajkumar B. , THOMAS, Sheela A. , ZHU, Gui-dong , GONG, Jianchun
Inventor： GIRANDA, Vincent L. , PENNING, Thomas D. , GANDHI, Virajkumar B. , THOMAS, Sheela A. , ZHU, Gui-dong , GONG, Jianchun
IPC: A61K31/4184 , C07D403/02
CPC classification number: C07D403/10 , C07D235/18 , C07D409/04
Abstract: The present invention relates to 1H-benzimidazole-4-carboxamides of formula (I), their preparation, and their use as inhibitors of the enzyme poly(ADP-ribose)polymerase for the preparation of drugs.
Abstract translation: 本发明涉及式（I）的1H-苯并咪唑-4-甲酰胺，其制备及其作为制备药物的聚（ADP-核糖）聚合酶的抑制剂的用途。
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公开(公告)号：WO2008083027A1
公开(公告)日：2008-07-10
申请号：PCT/US2007/088319
申请日：2007-12-20
Applicant: ABBOTT LABORATORIES , GANDHI, Viraj B. , GIRANDA, Vincent L. , GONG, Jianchun , PENNING, Thomas D. , ZHU, Gui-dong
Inventor： GANDHI, Viraj B. , GIRANDA, Vincent L. , GONG, Jianchun , PENNING, Thomas D. , ZHU, Gui-dong
IPC: A01N43/58 , A61K31/50 , A61K31/495
CPC classification number: C07D403/10 , C07D237/32 , C07D403/12 , C07D403/14 , Y02P20/582
Abstract: Inhibitors of poly(ADP-ribose)polymerase, ways to make them and methods of treating patients using them are disclosed.
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3.发明申请
公开(公告)号：WO2006110683A1
公开(公告)日：2006-10-19
申请号：PCT/US2006/013366
申请日：2006-04-11
Applicant: ABBOTT LABORATORIES , ZHU, Guidong , GANDHI, Virajkumar B. , GONG, Jianchun , PENNING, Thomas D. , GIRANDA, Vincent L. , THOMAS, Sheela
Inventor： ZHU, Guidong , GANDHI, Virajkumar B. , GONG, Jianchun , PENNING, Thomas D. , GIRANDA, Vincent L. , THOMAS, Sheela
IPC: C07D235/14 , C07D401/04 , C07D401/12 , C07D403/06 , A61K31/4184 , A61K31/4439 , A61K31/454 , A61P29/00 , A61P31/00
CPC classification number: C07D235/14 , C07D401/04 , C07D401/12 , C07D403/06
Abstract: Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compounds of Formula (I).
Abstract translation: 式（I）的化合物抑制PARP酶，并且可用于治疗与PARP相关的疾病或病症。 还公开了包含式（I）化合物，包含式（I）化合物的治疗方法的药物组合物，以及抑制包含式（I）化合物的PARP酶的方法。
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4.发明授权SUBSTITUTED 1H-BENZIMIDAZOLE-4-CARBOXAMIDES ARE POTENT PARP INHIBITORS 有权取代的1H-苯并咪唑-4-甲酰胺是有效的PARP抑制剂
公开(公告)号：EP1966157B1
公开(公告)日：2010-03-24
申请号：EP06837694.6
申请日：2006-11-15
Applicant: ABBOTT LABORATORIES
Inventor： PENNING, Thomas D. , THOMAS, Sheela A. , ZHU, Gui-Dong , GONG, Jianchun , GIRANDA, Vincent L. , GANDHI, Viraj B.
IPC: C07D235/18
CPC classification number: C07D235/18 , C07D409/04 , C07D413/04 , C07D417/04
Abstract: Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compounds of Formula (I).
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公开(公告)号：EP1976515A2
公开(公告)日：2008-10-08
申请号：EP07716699.9
申请日：2007-01-17
Applicant: ABBOTT LABORATORIES
Inventor： WERNET, Wolfgang , PENNING, Thomas D. , GIRANDA, Vincent L.
IPC: A61K31/41 , A61K31/4164 , C07D401/02 , C07D471/00 , A61K49/00
CPC classification number: C07D403/04 , A61K31/41 , A61K31/4164 , A61K41/0038 , A61K45/06 , A61N2005/1098 , A61K2300/00
Abstract: The present invention describes benzimidazole derivatives of Formula (I) which constitute potent PARP inhibitors in combination with radiotherapy or in combination with other chemotherapeutic agents.
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Patent Agency Ranking
公开(公告)号：EP2114948A2
公开(公告)日：2009-11-11
申请号：EP07855102.5
申请日：2007-12-12
Applicant: ABBOTT LABORATORIES
Inventor： GIRANDA, Vincent L. , MIYASHIRO, Julie M. , PENNING, Thomas D. , WOODS, Keith W.
IPC: C07D487/04 , C07D243/14 , C07D241/06 , C07D241/36 , A61K31/4188 , A61K31/4965 , A61K31/502 , A61K31/5513 , A61K31/5517
CPC classification number: C07D241/08 , C07D241/44 , C07D243/08 , C07D243/14 , C07D471/04 , C07D487/04
Abstract: Inhibitors of poly(ADP-ribose)polymerase, ways to make them and methods of treating patients using them are disclosed.
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7.发明公开SUBSTITUTED 1H-BENZIMIDAZOLE-4-CARBOXAMIDES ARE POTENT PARP INHIBITORS 有权取代的1H-苯并咪唑-4-甲酰胺是有效的PARP抑制剂
公开(公告)号：EP1966157A2
公开(公告)日：2008-09-10
申请号：EP06837694.6
申请日：2006-11-15
Applicant: ABBOTT LABORATORIES
Inventor： PENNING, Thomas D. , THOMAS, Sheela A. , ZHU, Gui-Dong , GONG, Jianchun , GIRANDA, Vincent L. , GANDHI, Viraj B.
IPC: C07D235/18
CPC classification number: C07D235/18 , C07D409/04 , C07D413/04 , C07D417/04
Abstract: Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compounds of Formula (I).
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8.发明公开PYRROLIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF NEURAMINIDASES 审中-公开吡咯烷衍生物，其制备方法及其用途作为抑制剂neuramidases
公开(公告)号：EP1358154A2
公开(公告)日：2003-11-05
申请号：EP00972042.6
申请日：2000-10-10
Applicant: Abbott Laboratories
Inventor： MARING, Clarence J. , GIRANDA, Vincent L. , KEMPF, Dale J. , STOLL, Vincent S. , SUN, Minghua , ZHAO, Chen , GU, Yu Gui , HANESSIAN, Stephen , WANG, Gary T. , KRUEGER, Allan C. , CHEN, Hui-Ju , CHEN, Yuanwei , DEGOEY, David A. , FLOSI, William J. , GRAMPOVNIK, David J. , KATI, Warren M. , KENNEDY, April L. , KLEIN, Larry L. , LIN, Zhen , MADIGAN, Darold L. , MCDANIEL, Keith F. , MUCHMORE, Steven W. , SHAM, Hing L. , STEWART, Kent D. , TU, Noah P. , WAGENAAR, Frank L. , WANG, Sheldon , WIEDEMAN, Paul E. , XU, Yibo , YEUNG, Ming C. , BAYRAKDARIAN, Malken , LUO, Xuehong
IPC: C07D207/16 , C07D403/04 , C07D417/04
CPC classification number: C07D207/16 , C07D207/26 , C07D207/327 , C07D207/38 , C07D207/46 , C07D231/12 , C07D233/56 , C07D249/08 , C07D303/16 , C07D403/04 , C07D405/04 , C07D405/06 , C07D409/06 , C07D413/04 , C07D417/04 , C07D417/06
Abstract: Enantiomerically enriched compounds having the absolute stereochemistry of the formula (I) or a pharmaceutically acceptable salt, ester or prodrug thereof, which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminidase. Also disclosed are compositions and methods for preventing and treating diseases caused by microorganisms having a neuraminidase, processes for preparing the compounds and synthetic intermediates used in these processes.
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9.发明授权SUBSTITUTED 1H-BENZIMIDAZOLE-4-CARBOXAMIDES ARE POTENT PARP INHIBITORS 有权取代的1H-苯并咪唑-4-甲酰胺作为有效的PARP抑制剂
公开(公告)号：EP2012780B1
公开(公告)日：2012-04-11
申请号：EP07761722.3
申请日：2007-05-02
Applicant: ABBOTT LABORATORIES
Inventor： GIRANDA, Vincent L. , PENNING, Thomas D. , GANDHI, Virajkumar B. , THOMAS, Sheela A. , ZHU, Gui-dong , GONG, Jianchun
IPC: C07D403/10 , C07D235/18 , C07D409/04 , A61P29/00 , A61P37/00 , A61K31/4184
CPC classification number: C07D403/10 , C07D235/18 , C07D409/04
Abstract: The present invention relates to 1H-benzimidazole-4-carboxamides of formula (I), their preparation, and their use as inhibitors of the enzyme poly(ADP-ribose)polymerase for the preparation of drugs.
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公开(公告)号：EP2120579A1
公开(公告)日：2009-11-25
申请号：EP07869628.3
申请日：2007-12-20
Applicant: ABBOTT LABORATORIES
Inventor： GANDHI, Viraj B. , GIRANDA, Vincent L. , GONG, Jianchun , PENNING, Thomas D. , ZHU, Gui-dong
IPC: A01N43/58 , A61K31/50 , A61K31/495
CPC classification number: C07D403/10 , C07D237/32 , C07D403/12 , C07D403/14 , Y02P20/582
Abstract: Inhibitors of poly(ADP-ribose)polymerase, ways to make them and methods of treating patients using them are disclosed.
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