公开(公告)号：WO2008030836A3

公开(公告)日：2008-03-13

申请号：PCT/US2007/077579

申请日：2007-09-05

Applicant: ABBOTT LABORATORIES ,  ELMORE, Steven W. ,  ROSENBERG, Saul ,  GORDON, Gary

Inventor： ELMORE, Steven W. ,  ROSENBERG, Saul ,  GORDON, Gary

IPC: A61P7/02 ,  A61K31/00 ,  A61K31/5377 ,  A61K31/495 ,  A61K31/496

Abstract: Methods of reducing the number of platelets in mammals and preventing or treating pro-thrombotic conditions and diseases that are characterized by an excess of, or undesired activation of, platelets using inhibitors of anti apoptotic Bcl-2 family protein members is disclosed.

公开(公告)号：EP1181269A1

公开(公告)日：2002-02-27

申请号：EP00936388.8

申请日：2000-05-26

Applicant: ABBOTT LABORATORIES

Inventor： QUN, Li ,  SHAM, Hing ,  STEINER, Beth, A. ,  GWALTNEY, Stephen, L., II ,  BARR, Kenneth, J. ,  IMADE, Hovis, M. ,  ROSENBERG, Saul ,  WOODS, Keith, W.

IPC: C07C309/73 ,  C07C309/75 ,  C07C309/76 ,  C07C311/21 ,  C07C311/29

CPC classification number: C07C323/29 ,  C07C309/73 ,  C07C309/75 ,  C07C309/76 ,  C07C311/21 ,  C07C311/29 ,  C07C311/44 ,  C07C311/46 ,  C07C317/18 ,  C07C317/22 ,  C07C317/46 ,  C07C323/20 ,  C07D209/08 ,  C07D209/30 ,  C07D213/69 ,  C07D213/70 ,  C07D215/38 ,  C07D231/56 ,  C07D235/06 ,  C07D319/18 ,  C07D403/12

Abstract: Compounds having formula (I), inhibit cellular proliferation. Processes for the preparation of the compounds, pharmaceutical compositions containing the compounds, and methods of treatment using the compounds are disclosed.

公开(公告)号：EP1181269B1

公开(公告)日：2004-02-25

申请号：EP00936388.8

申请日：2000-05-26

Applicant: ABBOTT LABORATORIES

Inventor： QUN, Li ,  SHAM, Hing ,  STEINER, Beth, A. ,  GWALTNEY, Stephen, L., II ,  BARR, Kenneth, J. ,  IMADE, Hovis, M. ,  ROSENBERG, Saul ,  WOODS, Keith, W.

IPC: C07C309/73 ,  C07C309/75 ,  C07C309/76 ,  C07C311/21 ,  C07C311/29

CPC classification number: C07C323/29 ,  C07C309/73 ,  C07C309/75 ,  C07C309/76 ,  C07C311/21 ,  C07C311/29 ,  C07C311/44 ,  C07C311/46 ,  C07C317/18 ,  C07C317/22 ,  C07C317/46 ,  C07C323/20 ,  C07D209/08 ,  C07D209/30 ,  C07D213/69 ,  C07D213/70 ,  C07D215/38 ,  C07D231/56 ,  C07D235/06 ,  C07D319/18 ,  C07D403/12

Abstract: Compounds having formula (I), inhibit cellular proliferation. Processes for the preparation of the compounds, pharmaceutical compositions containing the compounds, and methods of treatment using the compounds are disclosed.

公开(公告)号：EP2061560A2

公开(公告)日：2009-05-27

申请号：EP07841845.6

申请日：2007-09-05

Applicant: ABBOTT LABORATORIES

Inventor： ELMORE, Steven W. ,  ROSENBERG, Saul ,  GORDON, Gary

IPC: A61P7/02 ,  A61K31/00 ,  A61K31/5377 ,  A61K31/495 ,  A61K31/496

CPC classification number: A61K31/00 ,  A61K31/495 ,  A61K31/496 ,  A61K31/5377

Abstract: Methods of reducing the number of platelets in mammals and preventing or treating pro-thrombotic conditions and diseases that are characterized by an excess of, or undesired activation of, platelets using inhibitors of anti apoptotic Bcl-2 family protein members is disclosed.