公开(公告)号：WO2008030836A3

公开(公告)日：2008-03-13

申请号：PCT/US2007/077579

申请日：2007-09-05

Applicant: ABBOTT LABORATORIES ,  ELMORE, Steven W. ,  ROSENBERG, Saul ,  GORDON, Gary

Inventor： ELMORE, Steven W. ,  ROSENBERG, Saul ,  GORDON, Gary

IPC: A61P7/02 ,  A61K31/00 ,  A61K31/5377 ,  A61K31/495 ,  A61K31/496

Abstract: Methods of reducing the number of platelets in mammals and preventing or treating pro-thrombotic conditions and diseases that are characterized by an excess of, or undesired activation of, platelets using inhibitors of anti apoptotic Bcl-2 family protein members is disclosed.

公开(公告)号：WO2011068560A1

公开(公告)日：2011-06-09

申请号：PCT/US2010/036844

申请日：2010-06-01

Applicant: ABBOTT LABORATORIES ,  BRUNCKO, Milan ,  DAI, Yujia ,  DING, Hong ,  DOHERTY, George A. ,  ELMORE, Steven W. ,  HASVOLD, Lisa ,  HEXAMER, Laura ,  KUNZER, Aaron ,  MANTEI, Robert A. ,  McCLELLAN, William J. ,  PARK, Chang H. ,  PARK, Cheol-Min ,  PETROS, Andrew M. ,  SONG, Xiaohong ,  SOUERS, Andrew J. ,  SULLIVAN, Gerard M. ,  TAO, Zhi-Fu ,  WANG, Gary T. ,  WANG, Le ,  WANG, Xilu ,  WENDT, Michael D. ,  HANSEN, Todd M.

Inventor： BRUNCKO, Milan ,  DAI, Yujia ,  DING, Hong ,  DOHERTY, George A. ,  ELMORE, Steven W. ,  HASVOLD, Lisa ,  HEXAMER, Laura ,  KUNZER, Aaron ,  MANTEI, Robert A. ,  McCLELLAN, William J. ,  PARK, Chang H. ,  PARK, Cheol-Min ,  PETROS, Andrew M. ,  SONG, Xiaohong ,  SOUERS, Andrew J. ,  SULLIVAN, Gerard M. ,  TAO, Zhi-Fu ,  WANG, Gary T. ,  WANG, Le ,  WANG, Xilu ,  WENDT, Michael D. ,  HANSEN, Todd M.

IPC: C07D209/08 ,  C07D211/58 ,  C07D213/74 ,  C07D213/84 ,  C07D231/56 ,  C07D235/06 ,  C07D277/24 ,  C07D309/04 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04

CPC classification number: C07D209/08 ,  A61K31/635 ,  C07D211/58 ,  C07D213/74 ,  C07D213/84 ,  C07D231/56 ,  C07D235/06 ,  C07D277/24 ,  C07D295/30 ,  C07D309/04 ,  C07D309/08 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.

公开(公告)号：EP1299392A2

公开(公告)日：2003-04-09

申请号：EP01948754.5

申请日：2001-06-27

Applicant: Abbott Laboratories ,  LIGAND PHARMACEUTICALS INCORPORATED

Inventor： COGHLAN, Michael J. ,  EDWARDS, James P. ,  ELMORE, Steven W. ,  JONES, Todd K. ,  KORT, Michael E. ,  KYM, Philip R. ,  MOORE, Jimmie L. ,  PRATT, John K. ,  WANG, Alan X.

IPC: C07D491/04 ,  A61K31/435

CPC classification number: C07D491/04

Abstract: Compounds having formula I are useful for partially or fully antagonizing, repressing, agonizing, or modulating the glucocorticoid receptor and treating immune, autoimmune and inflammatory diseases in a mammal. Also disclosed are pharmaceutical compositions comprising compounds of formula I and methods of inhibiting immune or autoimmune diseases in a mammal.

公开(公告)号：EP2507211A1

公开(公告)日：2012-10-10

申请号：EP10722500.5

申请日：2010-06-01

Applicant: Abbott Laboratories

Inventor： BRUNCKO, Milan ,  DAI, Yujia ,  DING, Hong ,  DOHERTY, George A. ,  ELMORE, Steven W. ,  HASVOLD, Lisa ,  HEXAMER, Laura ,  KUNZER, Aaron ,  MANTEI, Robert A. ,  McCLELLAN, William J. ,  PARK, Chang H. ,  PARK, Cheol-Min ,  PETROS, Andrew M. ,  SONG, Xiaohong ,  SOUERS, Andrew J. ,  SULLIVAN, Gerard M. ,  TAO, Zhi-Fu ,  WANG, Gary T. ,  WANG, Le ,  WANG, Xilu ,  WENDT, Michael D. ,  HANSEN, Todd M.

IPC: C07D209/08 ,  C07D211/58 ,  C07D213/74 ,  C07D213/84 ,  C07D231/56 ,  C07D235/06 ,  C07D277/24 ,  C07D309/04 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04

CPC classification number: C07D209/08 ,  A61K31/635 ,  C07D211/58 ,  C07D213/74 ,  C07D213/84 ,  C07D231/56 ,  C07D235/06 ,  C07D277/24 ,  C07D295/30 ,  C07D309/04 ,  C07D309/08 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.

Abstract translation: 公开了抑制抗凋亡Bcl-2蛋白活性的化合物，含有该化合物的组合物和治疗表达抗凋亡Bcl-2蛋白的疾病的方法。

公开(公告)号：EP2061560A2

公开(公告)日：2009-05-27

申请号：EP07841845.6

申请日：2007-09-05

Applicant: ABBOTT LABORATORIES

Inventor： ELMORE, Steven W. ,  ROSENBERG, Saul ,  GORDON, Gary

IPC: A61P7/02 ,  A61K31/00 ,  A61K31/5377 ,  A61K31/495 ,  A61K31/496

CPC classification number: A61K31/00 ,  A61K31/495 ,  A61K31/496 ,  A61K31/5377

Abstract: Methods of reducing the number of platelets in mammals and preventing or treating pro-thrombotic conditions and diseases that are characterized by an excess of, or undesired activation of, platelets using inhibitors of anti apoptotic Bcl-2 family protein members is disclosed.