公开(公告)号：WO2004076424A1

公开(公告)日：2004-09-10

申请号：PCT/US2004/005728

申请日：2004-02-26

Applicant: ABBOTT LABORATORIES

Inventor： HASVOLD, Lisa, A. ,  HEXAMER, Laura ,  LI, Gaoquan ,  LIN, Nan-Horng ,  SHAM, Hing ,  SOWIN, Tom ,  SULLIVAN, Gerard, M. ,  WANG, Le ,  XIA, Ping Xia

IPC: C07D243/38

CPC classification number: C07D243/38 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D413/06 ,  C07D413/10 ,  C07D413/12 ,  C07D417/04 ,  C07D417/12 ,  C07D491/10

Abstract: Compounds having the formula (I) are useful for inhibiting protein kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

Abstract translation: 具有式（I）的化合物可用于抑制蛋白激酶。 还公开了制备化合物，含有化合物的组合物和使用该化合物的处理方法的方法。

公开(公告)号：WO2008079610A2

公开(公告)日：2008-07-03

申请号：PCT/US2007/086440

申请日：2007-12-05

Applicant: ABBOTT LABORATORIES ,  GU, Yu Gui ,  CLARK, Richard, F ,  LI, Qun ,  WEITZBERG, Moshe ,  SHAM, Hing

Inventor： GU, Yu Gui ,  CLARK, Richard, F ,  LI, Qun ,  WEITZBERG, Moshe ,  SHAM, Hing

IPC: C07D277/34 ,  C07C43/275 ,  A61K31/426 ,  A61K31/09 ,  A61P3/10

CPC classification number: C07D277/34 ,  C07C233/18 ,  C07C233/22

Abstract: The present invention relates to compounds of formula (I); Pharmaceutical compositions and methods that are useful in the treatment or prevention of metabolic diseases or conditions are also provided.

Abstract translation: 本发明涉及式（I）化合物; 还提供了可用于治疗或预防代谢疾病或病症的药物组合物和方法。

公开(公告)号：WO2007095603A2

公开(公告)日：2007-08-23

申请号：PCT/US2007/062181

申请日：2007-02-15

Applicant: ABBOTT LABORATORIES ,  GU, Yu Gui ,  XU, Xiangdong ,  WEITZBERG, Moshe ,  SHAM, Hing

Inventor： GU, Yu Gui ,  XU, Xiangdong ,  WEITZBERG, Moshe ,  SHAM, Hing

CPC classification number: C07D277/34 ,  C07D417/04

Abstract: The present invention relates to compounds of Formula (I), which inhibit acetyl-CoA carboxylase (ACC) and are useful for the prevention or treatment of metabolic syndrome, type II diabetes, obesity, atherosclerosis and cardiovascular diseases in humans.

Abstract translation: 本发明涉及抑制乙酰辅酶A羧化酶（ACC）并可用于预防或治疗人类代谢综合征，II型糖尿病，肥胖症，动脉粥样硬化和心血管疾病的式（I）化合物。

公开(公告)号：WO2007095602A2

公开(公告)日：2007-08-23

申请号：PCT/US2007/062180

申请日：2007-02-15

Applicant: ABBOTT LABORATORIES ,  GU, Yu Gui ,  WEITZBERG, Moshe ,  XU, Xiangdong ,  CLARK, Richard, F. ,  ZHANG, Tianyuan ,  LI, Qun ,  HANSEN, Todd, M. ,  SHAM, Hing ,  BEUTEL, Bruce, A. ,  CAMP, Heidi, S. ,  WANG, Xiaojun

Inventor： GU, Yu Gui ,  WEITZBERG, Moshe ,  XU, Xiangdong ,  CLARK, Richard, F. ,  ZHANG, Tianyuan ,  LI, Qun ,  HANSEN, Todd, M. ,  SHAM, Hing ,  BEUTEL, Bruce, A. ,  CAMP, Heidi, S. ,  WANG, Xiaojun

CPC classification number: C07D277/34 ,  C07D261/08 ,  C07D277/56 ,  C07D413/04 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14

Abstract: The present invention relates to compounds of Formula (I), which inhibit acetyl-CoA carboxylase (ACC) and are useful for the prevention or treatment of metabolic syndrome, type II diabetes, obesity, atherosclerosis and cardiovascular diseases in humans.

Abstract translation: 本发明涉及抑制乙酰辅酶A羧化酶（ACC）并可用于预防或治疗代谢综合征，II型糖尿病，肥胖症，动脉粥样硬化和心血管疾病的式（I）化合物 人类疾病。

公开(公告)号：WO2004080973A1

公开(公告)日：2004-09-23

申请号：PCT/US2004/006921

申请日：2004-03-04

Applicant: ABBOTT LABORATORIES

Inventor： TONG, Yunsung ,  CLAIBORNE, Akiyo, K. ,  LI, Gaoquan ,  LIN, Nan-Horng ,  SHAM, Hing ,  TAO, Zhi-Fu ,  SOWIN, Tom

IPC: C07D231/54

CPC classification number: C07D249/08 ,  C07D231/12 ,  C07D231/54 ,  C07D233/56 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/10 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D417/14

Abstract: Compounds having the formula (I) (I), are useful for inhibiting protein kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

Abstract translation: 具有式（I）（I）的化合物可用于抑制蛋白激酶。 还公开了制备化合物，含有化合物的组合物和使用该化合物的处理方法的方法。

公开(公告)号：EP1181269B1

公开(公告)日：2004-02-25

申请号：EP00936388.8

申请日：2000-05-26

Applicant: ABBOTT LABORATORIES

Inventor： QUN, Li ,  SHAM, Hing ,  STEINER, Beth, A. ,  GWALTNEY, Stephen, L., II ,  BARR, Kenneth, J. ,  IMADE, Hovis, M. ,  ROSENBERG, Saul ,  WOODS, Keith, W.

IPC: C07C309/73 ,  C07C309/75 ,  C07C309/76 ,  C07C311/21 ,  C07C311/29

CPC classification number: C07C323/29 ,  C07C309/73 ,  C07C309/75 ,  C07C309/76 ,  C07C311/21 ,  C07C311/29 ,  C07C311/44 ,  C07C311/46 ,  C07C317/18 ,  C07C317/22 ,  C07C317/46 ,  C07C323/20 ,  C07D209/08 ,  C07D209/30 ,  C07D213/69 ,  C07D213/70 ,  C07D215/38 ,  C07D231/56 ,  C07D235/06 ,  C07D319/18 ,  C07D403/12

Abstract: Compounds having formula (I), inhibit cellular proliferation. Processes for the preparation of the compounds, pharmaceutical compositions containing the compounds, and methods of treatment using the compounds are disclosed.

公开(公告)号：EP1606268A1

公开(公告)日：2005-12-21

申请号：EP04715097.4

申请日：2004-02-26

Applicant: ABBOTT LABORATORIES

Inventor： HASVOLD, Lisa, A. ,  HEXAMER, Laura ,  LI, Gaoquan ,  LIN, Nan-Horng ,  SHAM, Hing ,  SOWIN, Tom ,  SULLIVAN, Gerard, M. ,  WANG, Le ,  XIA, Ping Xia

IPC: C07D243/38 ,  A61K31/551 ,  A61P35/00

CPC classification number: C07D243/38 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D413/06 ,  C07D413/10 ,  C07D413/12 ,  C07D417/04 ,  C07D417/12 ,  C07D491/10

Abstract: Compounds having the formula (I) are useful for inhibiting protein kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

公开(公告)号：EP1603885A1

公开(公告)日：2005-12-14

申请号：EP04717503.9

申请日：2004-03-04

Applicant: ABBOTT LABORATORIES

Inventor： TONG, Yunsong ,  CLAIBORNE, Akiyo, K. ,  LI, Gaoquan ,  LIN, Nan-Horng ,  SHAM, Hing ,  TAO, Zhi-Fu ,  SOWIN, Tom

IPC: C07D231/54 ,  C07D401/06 ,  C07D401/04 ,  C07D403/10 ,  C07D401/12 ,  C07D403/12 ,  C07D403/14 ,  C07D401/14 ,  C07D405/14 ,  C07D417/14 ,  C07D405/12 ,  C07D417/12 ,  C07D403/04 ,  A61K31/416 ,  A61P35/00

CPC classification number: C07D249/08 ,  C07D231/12 ,  C07D231/54 ,  C07D233/56 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/10 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D417/14

Abstract: Compounds having the formula (I) (I), are useful for inhibiting protein kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

公开(公告)号：EP1999119A2

公开(公告)日：2008-12-10

申请号：EP07757026.5

申请日：2007-02-15

Applicant: ABBOTT LABORATORIES

Inventor： GU, Yu Gui ,  WEITZBERG, Moshe ,  XU, Xiangdong ,  CLARK, Richard, F. ,  ZHANG, Tianyuan ,  LI, Qun ,  HANSEN, Todd, M. ,  SHAM, Hing ,  BEUTEL, Bruce, A. ,  CAMP, Heidi, S. ,  WANG, Xiaojun

IPC: C07D277/34 ,  A61K31/427 ,  C07D261/08 ,  C07D277/56 ,  C07D413/04 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14

CPC classification number: C07D277/34 ,  C07D261/08 ,  C07D277/56 ,  C07D413/04 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14

Abstract: The present invention relates to compounds of formula (I), wherein R1 is selected from the group consisting of hydrogen, cycloalkyl, alkyl and haloalkyl; Y is selected from the group consisting of -(CR4aR-4b)m-, -C(O)-, -O-, -N(H)-, -N(alkyl)- and -S-; wherein m is 1, 2 or 3; Ar3 is phenyl or monocyclic heteroaryl; wherein Ar3 is substituted with 1, 2 or 3 or 4 substituents. Ar1 is selected from the group consisting of phenyl and a monocyclic, five or six- membered heteroaryl; Ar2 is a monocyclic five membered heteroaryl, wherein each Ar2 is independently unsubstituted or substituted with 1 or 2 substituents selected from the group consisting of alkyl, alkenyl, halogen, -CN, -NO2, hydroxy, alkoxy, -NH2, -N(H)(alkyl), -N(alkyl)2. -C(O)OH, -C(O)Oalkyl, -C(O)H, -C(O)alkyl, and haloalkyl; Z is selected from the group consisting of -OR9a, -alkylenyl-OR9a, -NR6R99b; and -alkylenyl-NR6R9b; which inhibit acetyl-CoA carboxylase (ACC) and are useful for the prevention or treatment of metabolic syndrome, type U diabetes, obesity, atherosclerosis and cardiovascular diseases in humans.

公开(公告)号：EP1991536A2

公开(公告)日：2008-11-19

申请号：EP07757027.3

申请日：2007-02-15

Applicant: ABBOTT LABORATORIES

Inventor： GU, Yu Gui ,  XU, Xiangdong ,  WEITZBERG, Moshe ,  SHAM, Hing

IPC: C07D277/34 ,  C07D417/04 ,  A61K31/426 ,  A61K31/427

CPC classification number: C07D277/34 ,  C07D417/04

Abstract: The present invention is directed to compounds of formula (I), or a pharmaceutically acceptable salt, prodrug, salt of a prodrug, or combination thereof, wherein Y is selected from the group consisting of-CRxRy-, -C(O)-, -O-, -N(H)-, -N(alkyl)- and -S-; wherein each of Rx and Ry is independently selected from the group consisting of hydrogen. alkyl, hydroxyalkyl, and haloalkyl; or Rx and Ry together with the carbon to which they are attached form a monocyclic cycloalkyl or heterocycle ring, Ar1 is selected from the group consisting of phenyl and a monocyclic, five or six- membered heteroaryl, Ar3 is phenyl or monocyclic heteroaryl, wherein Ar3 is substituted with 1, 2, 3 or 4 substituents Ar2 is a group of formula (a), (b), (c), (d), or (e); wherein R is hydrogen, cycloalkyj, alkyl or haloalkyl, Z1, Z2, Z3 and Z4 are C(R101), or one or two of Z1, Z2, Z3 and Z4 is N and the others are C(R101); Z5, Z6 and Z7 are C(102). or one or two of Z5, Z6 and Z7 are N, and the others are C(R102), Z is selected from the group consisting of -OR5, -alkylenyl-OR5, -N(R6)(R7) and -alkylenyI-N(R6)(R7), which inhibit acetyl-CoA carboxylase (ACC) and are useful for the prevention or treatment of metabolic syndrome, type II diabetes, obesity, atherosclerosis and cardiovascular diseases in humans.