公开(公告)号：WO2008074035A1

公开(公告)日：2008-06-19

申请号：PCT/US2007/088936

申请日：2007-12-27

Applicant: ABBOTT LABORATORIES ,  GREEN, Brian E. ,  ANDERSON, David D. ,  BOSSE, Todd D. ,  COOPER, Curt S. ,  KLEIN, Larry L. ,  KRUEGER, Allan C. ,  LARSON, Daniel P. ,  LIU, Dachun ,  MCDANIEL, Keith F. ,  MOTTER, Christopher E. ,  PRATT, John K. ,  ROCKWAY, Todd W. ,  ROSENBERG, Teresa A. ,  YEUNG, Ming C. ,  CHEN, Hui-Ju ,  SHANLEY, Jason P.

Inventor： GREEN, Brian E. ,  ANDERSON, David D. ,  BOSSE, Todd D. ,  COOPER, Curt S. ,  KLEIN, Larry L. ,  KRUEGER, Allan C. ,  LARSON, Daniel P. ,  LIU, Dachun ,  MCDANIEL, Keith F. ,  MOTTER, Christopher E. ,  PRATT, John K. ,  ROCKWAY, Todd W. ,  ROSENBERG, Teresa A. ,  YEUNG, Ming C. ,  CHEN, Hui-Ju ,  SHANLEY, Jason P.

IPC: C07K7/02 ,  A61K38/08

CPC classification number: C07D403/12 ,  C07D207/16 ,  C07D241/24 ,  C07D403/14 ,  C07D409/14 ,  C07K7/02

Abstract: This invention relates to: (a) compounds of formula (I) and salts thereof that, inter alia , are useful as hepatitis C virus (HCV) inhibitors; (b) intermediates useful for the preparation of such compounds and salts; (c) pharmaceutical compositions comprising such compounds and salts; and (d) methods of use of such compounds, salts, and compositions.

Abstract translation: 本发明涉及：（a）式（I）化合物及其盐，其特别是可用作丙型肝炎病毒（HCV）抑制剂; （b）可用于制备这些化合物和盐的中间体; （c）包含这些化合物和盐的药物组合物; 和（d）使用这些化合物，盐和组合物的方法。

公开(公告)号：EP1979349A2

公开(公告)日：2008-10-15

申请号：EP06848056.5

申请日：2006-12-20

Applicant: ABBOTT LABORATORIES

Inventor： ROCKWAY, Todd W. ,  BETEBENNER, David A. ,  KRUEGER, Allan C. ,  IWASAKI, Nobuhiko ,  COOPER, Curt S. ,  ANDERSON, David D. ,  KEMPF, Dale J. ,  MADIGAN, Darold L. ,  MOTTER, Christopher E. ,  SHANLEY, Jason P. ,  TUFANO, Michael D. ,  WAGNER, Rolf ,  ZHANG, Rong ,  MOLLA, Akhteruzzaman ,  MO, Hongmei ,  PILOT-MATIAS, Tami ,  MASSE, Sherie VL. ,  CARRICK, Robert J. ,  HE, Weping ,  LU, Liangjun

IPC: C07D471/04

CPC classification number: C07D471/04

Abstract: Compounds effective in inhibiting replication of Hepatitis C virus ('HCV') or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.

公开(公告)号：EP1979349B1

公开(公告)日：2010-07-28

申请号：EP06848056.5

申请日：2006-12-20

Applicant: ABBOTT LABORATORIES

Inventor： ROCKWAY, Todd W. ,  BETEBENNER, David A. ,  KRUEGER, Allan C. ,  IWASAKI, Nobuhiko ,  COOPER, Curt S. ,  ANDERSON, David D. ,  KEMPF, Dale J. ,  MADIGAN, Darold L. ,  MOTTER, Christopher E. ,  SHANLEY, Jason P. ,  TUFANO, Michael D. ,  WAGNER, Rolf ,  ZHANG, Rong ,  MOLLA, Akhteruzzaman ,  MO, Hongmei ,  PILOT-MATIAS, Tami ,  MASSE, Sherie VL. ,  CARRICK, Robert J. ,  HE, Weping ,  LU, Liangjun

IPC: C07D471/04

CPC classification number: C07D471/04

Abstract: Compounds effective in inhibiting replication of Hepatitis C virus ('HCV') or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.