公开(公告)号：WO2008074035A1

公开(公告)日：2008-06-19

申请号：PCT/US2007/088936

申请日：2007-12-27

Applicant: ABBOTT LABORATORIES ,  GREEN, Brian E. ,  ANDERSON, David D. ,  BOSSE, Todd D. ,  COOPER, Curt S. ,  KLEIN, Larry L. ,  KRUEGER, Allan C. ,  LARSON, Daniel P. ,  LIU, Dachun ,  MCDANIEL, Keith F. ,  MOTTER, Christopher E. ,  PRATT, John K. ,  ROCKWAY, Todd W. ,  ROSENBERG, Teresa A. ,  YEUNG, Ming C. ,  CHEN, Hui-Ju ,  SHANLEY, Jason P.

Inventor： GREEN, Brian E. ,  ANDERSON, David D. ,  BOSSE, Todd D. ,  COOPER, Curt S. ,  KLEIN, Larry L. ,  KRUEGER, Allan C. ,  LARSON, Daniel P. ,  LIU, Dachun ,  MCDANIEL, Keith F. ,  MOTTER, Christopher E. ,  PRATT, John K. ,  ROCKWAY, Todd W. ,  ROSENBERG, Teresa A. ,  YEUNG, Ming C. ,  CHEN, Hui-Ju ,  SHANLEY, Jason P.

IPC: C07K7/02 ,  A61K38/08

CPC classification number: C07D403/12 ,  C07D207/16 ,  C07D241/24 ,  C07D403/14 ,  C07D409/14 ,  C07K7/02

Abstract: This invention relates to: (a) compounds of formula (I) and salts thereof that, inter alia , are useful as hepatitis C virus (HCV) inhibitors; (b) intermediates useful for the preparation of such compounds and salts; (c) pharmaceutical compositions comprising such compounds and salts; and (d) methods of use of such compounds, salts, and compositions.

Abstract translation: 本发明涉及：（a）式（I）化合物及其盐，其特别是可用作丙型肝炎病毒（HCV）抑制剂; （b）可用于制备这些化合物和盐的中间体; （c）包含这些化合物和盐的药物组合物; 和（d）使用这些化合物，盐和组合物的方法。

公开(公告)号：WO2008133753A2

公开(公告)日：2008-11-06

申请号：PCT/US2007/088027

申请日：2007-12-19

Applicant: ABBOTT LABORATORIES ,  BETEBENNER, David A. ,  MARING, Clarence J. ,  ROCKWAY, Todd W. ,  COOPER, Curt S. ,  ANDERSON, David D. ,  WAGNER, Rolf ,  ZHANG, Rong ,  MOLLA, Akhteruzzaman ,  MO, Hongmei ,  PILOT-MATIAS, Tami J. ,  MASSE, Sherie Vl. ,  CARRICK, Robert J. ,  HE, Wenping ,  LU, Liangjun

Inventor： BETEBENNER, David A. ,  MARING, Clarence J. ,  ROCKWAY, Todd W. ,  COOPER, Curt S. ,  ANDERSON, David D. ,  WAGNER, Rolf ,  ZHANG, Rong ,  MOLLA, Akhteruzzaman ,  MO, Hongmei ,  PILOT-MATIAS, Tami J. ,  MASSE, Sherie Vl. ,  CARRICK, Robert J. ,  HE, Wenping ,  LU, Liangjun

IPC: A61K31/675

CPC classification number: C07D471/04 ,  C07D239/94 ,  C07D487/04 ,  C07D487/14 ,  C07D519/00

Abstract: Compounds effective in inhibiting replication of Hepatitis C virus ( HCV ) or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, coformulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.

Abstract translation: 公开了有效抑制丙型肝炎病毒（HCV）或其他病毒复制的化合物。 本发明还涉及包含这些化合物的组合物，这些化合物与其它抗病毒剂或治疗剂的共配制或共同给药，用于合成这些化合物的方法和中间体，以及使用这些化合物治疗HCV或 其他病毒感染。

公开(公告)号：EP0723545B1

公开(公告)日：2002-05-08

申请号：EP94929998.6

申请日：1994-09-30

Applicant: ABBOTT LABORATORIES

Inventor： CHU, Daniel T. ,  LI, Qun ,  COOPER, Curt S. ,  FUNG, Anthony K. L. ,  LEE, Cheuk M. ,  PLATTNER, Jacob J.

IPC: C07D455/02 ,  C07D213/68 ,  C07D213/61 ,  C07D471/04 ,  C07D491/16 ,  A61K31/535 ,  A61K31/495 ,  A61K31/435

CPC classification number: C07D471/04 ,  A61K38/00 ,  C07D213/61 ,  C07D213/68 ,  C07D455/02 ,  C07K5/06026

Abstract: Antibacterical coumpounds having formula (I) and the pharmaceutically acceptable salts, esters and amides thereof, preferred examples of which include those coumpounds wherein R1 is cycloalkyl of from three to eight carbon atoms or substituted phenyl; R2is selected from the group consisting of (a) halogen, (b) loweralkyl, (c) loweralkenyl, (d) cycloalkyl of from three to eight carbons, (e) cycloalkenyl of from four to eight carbons, (f) loweralkoxy, (g) aryloxy, (h) aryl(loweralkyl)oxy, (i) aryl(loweralkyl), (j) cycloalkyl(loweralkyl), (k) amino, (l) (loweralkyl)amino, (m) aryl(loweralkyl)amino, (n) hydroxy substituted (loweralkyl)amino, (o) phenyl, (p) substituted phenyl, (q) bicyclic nitrogen-containing heterocycle, (r) nitrogen-containingaromatic heterocycle, and (s) nitrogen-containing heterocycle having formula (Ia) where x is between zero and three; R3 is halogen; R4 is hydrogen, loweralkyl, a pharmaceutically acceptable cation, or a prodrug ester group; R5 is hydrogen, loweralkyl, halo(loweralkyl), or -NR?13R14; and R6¿ is loweralkyl, as wellas pharmaceutical compositions containing such compounds and the use of the same in the treatment of bacterial infections.

Abstract translation: 具有式（I）的抗菌化合物及其药学上可接受的盐，酯和酰胺，其优选实例包括其中R 1为3至8个碳原子的环烷基或取代的苯基的化合物; （b）低级烷基，（c）低级链烯基，（d）三至八个碳的环烷基，（e）四至八个碳的环烯基，（f）低级烷氧基，（ （低级烷基）氧基，（i）芳基（低级烷基），（j）环烷基（低级烷基），（k）氨基，（l）（低级烷基）氨基，（m） ，（n）羟基取代的（低级烷基）氨基，（o）苯基，（p）取代的苯基，（q）双环含氮杂环，（r）含氮芳香族杂环和（s）含氮杂环， Ia）其中x在0和3之间; R3是卤素; R4是氢，低级烷基，药学上可接受的阳离子或前药酯基团; R5是氢，低级烷基，卤代（低级烷基）或-NR8R14; 和R6是低级烷基，以及含有这些化合物的药物组合物及其在治疗细菌感染中的用途。

公开(公告)号：EP1979349A2

公开(公告)日：2008-10-15

申请号：EP06848056.5

申请日：2006-12-20

Applicant: ABBOTT LABORATORIES

Inventor： ROCKWAY, Todd W. ,  BETEBENNER, David A. ,  KRUEGER, Allan C. ,  IWASAKI, Nobuhiko ,  COOPER, Curt S. ,  ANDERSON, David D. ,  KEMPF, Dale J. ,  MADIGAN, Darold L. ,  MOTTER, Christopher E. ,  SHANLEY, Jason P. ,  TUFANO, Michael D. ,  WAGNER, Rolf ,  ZHANG, Rong ,  MOLLA, Akhteruzzaman ,  MO, Hongmei ,  PILOT-MATIAS, Tami ,  MASSE, Sherie VL. ,  CARRICK, Robert J. ,  HE, Weping ,  LU, Liangjun

IPC: C07D471/04

CPC classification number: C07D471/04

Abstract: Compounds effective in inhibiting replication of Hepatitis C virus ('HCV') or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.

公开(公告)号：EP1979349B1

公开(公告)日：2010-07-28

申请号：EP06848056.5

申请日：2006-12-20

Applicant: ABBOTT LABORATORIES

Inventor： ROCKWAY, Todd W. ,  BETEBENNER, David A. ,  KRUEGER, Allan C. ,  IWASAKI, Nobuhiko ,  COOPER, Curt S. ,  ANDERSON, David D. ,  KEMPF, Dale J. ,  MADIGAN, Darold L. ,  MOTTER, Christopher E. ,  SHANLEY, Jason P. ,  TUFANO, Michael D. ,  WAGNER, Rolf ,  ZHANG, Rong ,  MOLLA, Akhteruzzaman ,  MO, Hongmei ,  PILOT-MATIAS, Tami ,  MASSE, Sherie VL. ,  CARRICK, Robert J. ,  HE, Weping ,  LU, Liangjun

IPC: C07D471/04

CPC classification number: C07D471/04

Abstract: Compounds effective in inhibiting replication of Hepatitis C virus ('HCV') or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.

公开(公告)号：EP2094276A2

公开(公告)日：2009-09-02

申请号：EP07874373.9

申请日：2007-12-19

Applicant: Abbott Laboratories

Inventor： BETEBENNER, David A. ,  MARING, Clarence J. ,  ROCKWAY, Todd W. ,  COOPER, Curt S. ,  ANDERSON, David D. ,  WAGNER, Rolf ,  ZHANG, Rong ,  MOLLA, Akhteruzzaman ,  MO, Hongmei ,  PILOT-MATIAS, Tami J. ,  MASSE, Sherie Vl. ,  CARRICK, Robert J. ,  HE, Wenping ,  LU, Liangjun

IPC: A61K31/675

CPC classification number: C07D471/04 ,  C07D239/94 ,  C07D487/04 ,  C07D487/14 ,  C07D519/00

Abstract: Compounds effective in inhibiting replication of Hepatitis C virus ( HCV ) or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, coformulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.

Abstract translation: 公开了有效抑制丙型肝炎病毒（HCV）或其他病毒复制的化合物。 本发明还涉及包含此类化合物的组合物，这类化合物与其它抗病毒剂或治疗剂的共配制或共同施用，用于合成这些化合物的方法和中间体，以及使用此类化合物治疗HCV或 其他病毒感染。