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公开(公告)号:EP1186603A3
公开(公告)日:2003-07-09
申请号:EP01125462.0
申请日:1995-08-04
Applicant: Abbott Laboratories
Inventor: Winn, Martin , Boyd Steven A. , Hutchins, Charles W. , Jae, Hwan-Soo , Tasker, Andrew S. , Vongeldern, Thomas W. , Kester, Jeffrey A. , Sorensen, Bryan K.
IPC: C07D405/04 , C07D207/16 , C07D405/14 , C07D403/04 , C07D401/04 , A61K31/4025
CPC classification number: C07D401/04 , C07D207/16 , C07D403/04 , C07D405/04 , C07D405/14 , C07F9/5722 , C07F9/592
Abstract: Processes for preparing endothelin antagonists of formula (I) and pharmaceutically acceptable salts thereof and processes for preparing intermediates thereof.
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2.Benzo-1,3-dioxolyl- and benzofuranyl substituted pyrrolidine derivatives as endothelin antagonists 失效
Title translation: 苯并-1,3-二氧杂环戊烯和苯并呋喃基取代的吡咯烷衍生物作为内皮素拮抗剂公开(公告)号:EP1609790A3
公开(公告)日:2006-01-04
申请号:EP05106190.1
申请日:1997-02-12
Applicant: ABBOTT LABORATORIES
Inventor: Winn, Martin , Henry, Kenneth J. Jr. , Liu, Gang , Wittenberger, Steven J. , King, Steven A. , Boyd, Steven A. , Hutchins, Charles W. , Jae, Hwan-Soo , Tasker, Andrew S. , Von Geldern, Thomas W. , Kester, Jeffrey A. , Sorensen, Bryan K. , Szczepankiewicz, Bruce G.
IPC: C07D405/04 , C07D405/12 , A61K31/40 , A61K31/41 , A61K31/435
CPC classification number: C07D401/04 , C07D207/16 , C07D405/04 , C07D405/12 , C07D405/14 , Y02P20/55
Abstract: A compound of formula (I), or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.
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3.Benzo-1,3-dioxolyl- and benzofuranyl substituted pyrrolidine derivatives as endothelin antagonists 失效
Title translation: 苯并-1,3-二恶唑基 - 和苯并呋喃基取代的吡咯烷衍生物内皮素拮抗剂公开(公告)号:EP1609790A2
公开(公告)日:2005-12-28
申请号:EP05106190.1
申请日:1997-02-12
Applicant: ABBOTT LABORATORIES
Inventor: Winn, Martin , Henry, Kenneth J. Jr. , Liu, Gang , Wittenberger, Steven J. , King, Steven A. , Boyd, Steven A. , Hutchins, Charles W. , Jae, Hwan-Soo , Tasker, Andrew S. , Von Geldern, Thomas W. , Kester, Jeffrey A. , Sorensen, Bryan K. , Szczepankiewicz, Bruce G.
IPC: C07D405/04 , C07D405/12 , A61K31/40 , A61K31/41 , A61K31/435
CPC classification number: C07D401/04 , C07D207/16 , C07D405/04 , C07D405/12 , C07D405/14 , Y02P20/55
Abstract: A compound of formula (I), or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.
Abstract translation: 公开了式(I)化合物或其药学上可接受的盐,以及其制备方法和中间体,以及拮抗内皮素的方法。
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4.Processes for preparing endothelin antagonists 失效
Title translation: Verfahren zur Herstellung von Endothelin-Antagonisten公开(公告)号:EP1186603A2
公开(公告)日:2002-03-13
申请号:EP01125462.0
申请日:1995-08-04
Applicant: Abbott Laboratories
Inventor: Winn, Martin , Boyd Steven A. , Hutchins, Charles W. , Jae, Hwan-Soo , Tasker, Andrew S. , Vongeldern, Thomas W. , Kester, Jeffrey A. , Sorensen, Bryan K.
IPC: C07D405/04 , C07D207/16 , C07D405/14 , C07D403/04 , C07D401/04 , A61K31/4025
CPC classification number: C07D401/04 , C07D207/16 , C07D403/04 , C07D405/04 , C07D405/14 , C07F9/5722 , C07F9/592
Abstract: Processes for preparing endothelin antagonists of formula (I) and pharmaceutically acceptable salts thereof and processes for preparing intermediates thereof.
Abstract translation: 用于制备式(I)的内皮素拮抗剂及其药学上可接受的盐的方法及其制备中间体的方法。
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