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公开(公告)号：EP1186603A3
公开(公告)日：2003-07-09
申请号：EP01125462.0
申请日：1995-08-04
Applicant: Abbott Laboratories
Inventor： Winn, Martin , Boyd Steven A. , Hutchins, Charles W. , Jae, Hwan-Soo , Tasker, Andrew S. , Vongeldern, Thomas W. , Kester, Jeffrey A. , Sorensen, Bryan K.
IPC: C07D405/04 , C07D207/16 , C07D405/14 , C07D403/04 , C07D401/04 , A61K31/4025
CPC classification number: C07D401/04 , C07D207/16 , C07D403/04 , C07D405/04 , C07D405/14 , C07F9/5722 , C07F9/592
Abstract: Processes for preparing endothelin antagonists of formula (I) and pharmaceutically acceptable salts thereof and processes for preparing intermediates thereof.
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Patent Agency Ranking
公开(公告)号：EP0475206A3
公开(公告)日：1992-08-05
申请号：EP91114542.3
申请日：1991-08-29
Applicant: ABBOTT LABORATORIES
Inventor： Winn, Martin , De, Biswanath , Zydowsky, Thomas M. , Kerkman, Daniel J. , De Bernardis, John F. , Rosenberg, Saul H. , Shiosaki, Kazumi , Basha, Fatima Z. , Tasker, Andrew S. , Von Geldern, Thomas W. , Kester, Jeffrey A. , Holleman, William H.
IPC: C07D403/12 , A61K31/44 , C07D401/12 , C07D239/42 , C07D257/04 , C07D405/14 , A61K31/495
CPC classification number: C07D239/42 , C07D257/04 , C07D401/12 , C07D403/12 , C07D405/14
Abstract: Novel pyrimidine, pyridine, pyridazine, pyrazine and triazine compounds are provided of the formula (I).
The compounds of the invention are useful for treating hypertension, edema, renal failure, congestive heart failure, psoriasis and glaucoma, and in the prevention and treatment of atherosclerosis or to treat gastrointestinal disorders associated with enhanced contractility and/or motility of intestinal smooth muscle or to treat contractile disorders of the uterus.-
3.发明公开Benzo-1,3-dioxolyl- and benzofuranyl substituted pyrrolidine derivatives as endothelin antagonists 失效苯并-1,3-二氧杂环戊烯和苯并呋喃基取代的吡咯烷衍生物作为内皮素拮抗剂
公开(公告)号：EP1609790A3
公开(公告)日：2006-01-04
申请号：EP05106190.1
申请日：1997-02-12
Applicant: ABBOTT LABORATORIES
Inventor： Winn, Martin , Henry, Kenneth J. Jr. , Liu, Gang , Wittenberger, Steven J. , King, Steven A. , Boyd, Steven A. , Hutchins, Charles W. , Jae, Hwan-Soo , Tasker, Andrew S. , Von Geldern, Thomas W. , Kester, Jeffrey A. , Sorensen, Bryan K. , Szczepankiewicz, Bruce G.
IPC: C07D405/04 , C07D405/12 , A61K31/40 , A61K31/41 , A61K31/435
CPC classification number: C07D401/04 , C07D207/16 , C07D405/04 , C07D405/12 , C07D405/14 , Y02P20/55
Abstract: A compound of formula (I), or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.
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公开(公告)号：EP0475206A2
公开(公告)日：1992-03-18
申请号：EP91114542.3
申请日：1991-08-29
Applicant: ABBOTT LABORATORIES
Inventor： Winn, Martin , De, Biswanath , Zydowsky, Thomas M. , Kerkman, Daniel J. , De Bernardis, John F. , Rosenberg, Saul H. , Shiosaki, Kazumi , Basha, Fatima Z. , Tasker, Andrew S. , Von Geldern, Thomas W. , Kester, Jeffrey A. , Holleman, William H.
IPC: C07D403/12 , A61K31/44 , C07D401/12 , C07D239/42 , C07D257/04 , C07D405/14 , A61K31/495
CPC classification number: C07D239/42 , C07D257/04 , C07D401/12 , C07D403/12 , C07D405/14
Abstract: Novel pyrimidine, pyridine, pyridazine, pyrazine and triazine compounds are provided of the formula (I).
The compounds of the invention are useful for treating hypertension, edema, renal failure, congestive heart failure, psoriasis and glaucoma, and in the prevention and treatment of atherosclerosis or to treat gastrointestinal disorders associated with enhanced contractility and/or motility of intestinal smooth muscle or to treat contractile disorders of the uterus.Abstract translation: 由式（I）提供新的嘧啶，吡啶，哒嗪，吡嗪和三嗪化合物。 本发明的化合物可用于治疗高血压，水肿，肾衰竭，充血性心力衰竭，牛皮癣和青光眼，以及预防和治疗动脉粥样硬化或治疗与增强的肠收缩力和/或运动性相关的胃肠道疾病 平滑肌或治疗子宫收缩性疾病。
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5.发明公开Benzo-1,3-dioxolyl- and benzofuranyl substituted pyrrolidine derivatives as endothelin antagonists 失效苯并-1,3-二恶唑基 - 和苯并呋喃基取代的吡咯烷衍生物内皮素拮抗剂
公开(公告)号：EP1609790A2
公开(公告)日：2005-12-28
申请号：EP05106190.1
申请日：1997-02-12
Applicant: ABBOTT LABORATORIES
Inventor： Winn, Martin , Henry, Kenneth J. Jr. , Liu, Gang , Wittenberger, Steven J. , King, Steven A. , Boyd, Steven A. , Hutchins, Charles W. , Jae, Hwan-Soo , Tasker, Andrew S. , Von Geldern, Thomas W. , Kester, Jeffrey A. , Sorensen, Bryan K. , Szczepankiewicz, Bruce G.
IPC: C07D405/04 , C07D405/12 , A61K31/40 , A61K31/41 , A61K31/435
CPC classification number: C07D401/04 , C07D207/16 , C07D405/04 , C07D405/12 , C07D405/14 , Y02P20/55
Abstract: A compound of formula (I), or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.
Abstract translation: 公开了式（I）化合物或其药学上可接受的盐，以及其制备方法和中间体，以及拮抗内皮素的方法。
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6.发明公开Processes for preparing endothelin antagonists 失效Verfahren zur Herstellung von Endothelin-Antagonisten
公开(公告)号：EP1186603A2
公开(公告)日：2002-03-13
申请号：EP01125462.0
申请日：1995-08-04
Applicant: Abbott Laboratories
Inventor： Winn, Martin , Boyd Steven A. , Hutchins, Charles W. , Jae, Hwan-Soo , Tasker, Andrew S. , Vongeldern, Thomas W. , Kester, Jeffrey A. , Sorensen, Bryan K.
IPC: C07D405/04 , C07D207/16 , C07D405/14 , C07D403/04 , C07D401/04 , A61K31/4025
CPC classification number: C07D401/04 , C07D207/16 , C07D403/04 , C07D405/04 , C07D405/14 , C07F9/5722 , C07F9/592
Abstract: Processes for preparing endothelin antagonists of formula (I) and pharmaceutically acceptable salts thereof and processes for preparing intermediates thereof.
Abstract translation: 用于制备式（I）的内皮素拮抗剂及其药学上可接受的盐的方法及其制备中间体的方法。
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