公开(公告)号：WO2007095602A2

公开(公告)日：2007-08-23

申请号：PCT/US2007/062180

申请日：2007-02-15

Applicant: ABBOTT LABORATORIES ,  GU, Yu Gui ,  WEITZBERG, Moshe ,  XU, Xiangdong ,  CLARK, Richard, F. ,  ZHANG, Tianyuan ,  LI, Qun ,  HANSEN, Todd, M. ,  SHAM, Hing ,  BEUTEL, Bruce, A. ,  CAMP, Heidi, S. ,  WANG, Xiaojun

Inventor： GU, Yu Gui ,  WEITZBERG, Moshe ,  XU, Xiangdong ,  CLARK, Richard, F. ,  ZHANG, Tianyuan ,  LI, Qun ,  HANSEN, Todd, M. ,  SHAM, Hing ,  BEUTEL, Bruce, A. ,  CAMP, Heidi, S. ,  WANG, Xiaojun

CPC classification number: C07D277/34 ,  C07D261/08 ,  C07D277/56 ,  C07D413/04 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14

Abstract: The present invention relates to compounds of Formula (I), which inhibit acetyl-CoA carboxylase (ACC) and are useful for the prevention or treatment of metabolic syndrome, type II diabetes, obesity, atherosclerosis and cardiovascular diseases in humans.

Abstract translation: 本发明涉及抑制乙酰辅酶A羧化酶（ACC）并可用于预防或治疗代谢综合征，II型糖尿病，肥胖症，动脉粥样硬化和心血管疾病的式（I）化合物 人类疾病。

公开(公告)号：EP1999119A2

公开(公告)日：2008-12-10

申请号：EP07757026.5

申请日：2007-02-15

Applicant: ABBOTT LABORATORIES

Inventor： GU, Yu Gui ,  WEITZBERG, Moshe ,  XU, Xiangdong ,  CLARK, Richard, F. ,  ZHANG, Tianyuan ,  LI, Qun ,  HANSEN, Todd, M. ,  SHAM, Hing ,  BEUTEL, Bruce, A. ,  CAMP, Heidi, S. ,  WANG, Xiaojun

IPC: C07D277/34 ,  A61K31/427 ,  C07D261/08 ,  C07D277/56 ,  C07D413/04 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14

CPC classification number: C07D277/34 ,  C07D261/08 ,  C07D277/56 ,  C07D413/04 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14

Abstract: The present invention relates to compounds of formula (I), wherein R1 is selected from the group consisting of hydrogen, cycloalkyl, alkyl and haloalkyl; Y is selected from the group consisting of -(CR4aR-4b)m-, -C(O)-, -O-, -N(H)-, -N(alkyl)- and -S-; wherein m is 1, 2 or 3; Ar3 is phenyl or monocyclic heteroaryl; wherein Ar3 is substituted with 1, 2 or 3 or 4 substituents. Ar1 is selected from the group consisting of phenyl and a monocyclic, five or six- membered heteroaryl; Ar2 is a monocyclic five membered heteroaryl, wherein each Ar2 is independently unsubstituted or substituted with 1 or 2 substituents selected from the group consisting of alkyl, alkenyl, halogen, -CN, -NO2, hydroxy, alkoxy, -NH2, -N(H)(alkyl), -N(alkyl)2. -C(O)OH, -C(O)Oalkyl, -C(O)H, -C(O)alkyl, and haloalkyl; Z is selected from the group consisting of -OR9a, -alkylenyl-OR9a, -NR6R99b; and -alkylenyl-NR6R9b; which inhibit acetyl-CoA carboxylase (ACC) and are useful for the prevention or treatment of metabolic syndrome, type U diabetes, obesity, atherosclerosis and cardiovascular diseases in humans.