公开(公告)号：WO2007095602A2

公开(公告)日：2007-08-23

申请号：PCT/US2007/062180

申请日：2007-02-15

Applicant: ABBOTT LABORATORIES ,  GU, Yu Gui ,  WEITZBERG, Moshe ,  XU, Xiangdong ,  CLARK, Richard, F. ,  ZHANG, Tianyuan ,  LI, Qun ,  HANSEN, Todd, M. ,  SHAM, Hing ,  BEUTEL, Bruce, A. ,  CAMP, Heidi, S. ,  WANG, Xiaojun

Inventor： GU, Yu Gui ,  WEITZBERG, Moshe ,  XU, Xiangdong ,  CLARK, Richard, F. ,  ZHANG, Tianyuan ,  LI, Qun ,  HANSEN, Todd, M. ,  SHAM, Hing ,  BEUTEL, Bruce, A. ,  CAMP, Heidi, S. ,  WANG, Xiaojun

CPC classification number: C07D277/34 ,  C07D261/08 ,  C07D277/56 ,  C07D413/04 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14

Abstract: The present invention relates to compounds of Formula (I), which inhibit acetyl-CoA carboxylase (ACC) and are useful for the prevention or treatment of metabolic syndrome, type II diabetes, obesity, atherosclerosis and cardiovascular diseases in humans.

Abstract translation: 本发明涉及抑制乙酰辅酶A羧化酶（ACC）并可用于预防或治疗代谢综合征，II型糖尿病，肥胖症，动脉粥样硬化和心血管疾病的式（I）化合物 人类疾病。

公开(公告)号：WO2008079610A2

公开(公告)日：2008-07-03

申请号：PCT/US2007/086440

申请日：2007-12-05

Applicant: ABBOTT LABORATORIES ,  GU, Yu Gui ,  CLARK, Richard, F ,  LI, Qun ,  WEITZBERG, Moshe ,  SHAM, Hing

Inventor： GU, Yu Gui ,  CLARK, Richard, F ,  LI, Qun ,  WEITZBERG, Moshe ,  SHAM, Hing

IPC: C07D277/34 ,  C07C43/275 ,  A61K31/426 ,  A61K31/09 ,  A61P3/10

CPC classification number: C07D277/34 ,  C07C233/18 ,  C07C233/22

Abstract: The present invention relates to compounds of formula (I); Pharmaceutical compositions and methods that are useful in the treatment or prevention of metabolic diseases or conditions are also provided.

Abstract translation: 本发明涉及式（I）化合物; 还提供了可用于治疗或预防代谢疾病或病症的药物组合物和方法。

公开(公告)号：WO2007095603A2

公开(公告)日：2007-08-23

申请号：PCT/US2007/062181

申请日：2007-02-15

Applicant: ABBOTT LABORATORIES ,  GU, Yu Gui ,  XU, Xiangdong ,  WEITZBERG, Moshe ,  SHAM, Hing

Inventor： GU, Yu Gui ,  XU, Xiangdong ,  WEITZBERG, Moshe ,  SHAM, Hing

CPC classification number: C07D277/34 ,  C07D417/04

Abstract: The present invention relates to compounds of Formula (I), which inhibit acetyl-CoA carboxylase (ACC) and are useful for the prevention or treatment of metabolic syndrome, type II diabetes, obesity, atherosclerosis and cardiovascular diseases in humans.

Abstract translation: 本发明涉及抑制乙酰辅酶A羧化酶（ACC）并可用于预防或治疗人类代谢综合征，II型糖尿病，肥胖症，动脉粥样硬化和心血管疾病的式（I）化合物。

公开(公告)号：WO2004083207A1

公开(公告)日：2004-09-30

申请号：PCT/US2003/007689

申请日：2003-03-12

Applicant: ABBOTT LABORATORIES

Inventor： ANDERSON, David ,  BEUTEL, Bruce ,  BOSSE, Todd, D. ,  CLARK, Richard ,  COOPER, Curt ,  DANDLIKER, Peter ,  DAVID, Caroline ,  GU, Yu-Gui ,  HANSEN, Todd, Matthew ,  HINMAN, Mira ,  KALVIN, Douglas ,  LARSON, Daniel, P. ,  LYNCH, Linda ,  MA, Zhenkun ,  MOTTER, Christopher ,  PALAZZO, Fabio ,  ROSENBERG, Teresa ,  REHM, Tamara ,  SANDERS, William ,  TUFANO, Michael ,  WAGNER, Rolf ,  WEITZBERG, Moshe ,  YONG, Hong ,  ZHANG, Tianyuan

IPC: C07D471/04

CPC classification number: C07D471/04

Abstract: Antibacterials having formula (I), and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates used in the processes, compositions containing the compounds, and methods of prophylaxis and treatment of bacterial infections using the compounds are disclosed.

Abstract translation: 公开了具有式（I）的抗菌剂及其前体药物的盐，前药和盐，用于制备本方法中使用的化合物和中间体的方法，含该化合物的组合物，以及使用该化合物预防和治疗细菌感染的方法。

公开(公告)号：EP1276722A1

公开(公告)日：2003-01-22

申请号：EP01934906.7

申请日：2001-04-25

Applicant: Abbott Laboratories

Inventor： BRUNCKO, Milan ,  DALTON, Christopher, R. ,  GIRANDA, Vincent, L. ,  GONG, Jianchun ,  MCCLELLAN, William, J. ,  NIENABER, Vicki, L. ,  ROCKWAY, Todd, W. ,  SAUER, Daryl, R. ,  WEITZBERG, Moshe

IPC: C07D217/02 ,  C07D217/04 ,  C07D217/06 ,  C07D405/04 ,  C07D401/06 ,  A61K31/472 ,  A61P29/00

CPC classification number: C07D401/06 ,  C07D217/02 ,  C07D217/04 ,  C07D217/06 ,  C07D405/04

Abstract: Compounds having formula (I) are inhibitors of urokinase and are useful in the treatment of diseases in which urokinase plays a role. Also disclosed are urokinase-inhibiting compositions, methods for the preparation of urokinase-inhibitors, and a method of inhibiting urokinase in a mammal.

公开(公告)号：EP1631570A1

公开(公告)日：2006-03-08

申请号：EP03723732.8

申请日：2003-03-12

Applicant: ABBOTT LABORATORIES

Inventor： ANDERSON, David ,  BEUTEL, Bruce ,  BOSSE, Todd, D. ,  CLARK, Richard ,  COOPER, Curt ,  DANDLIKER, Peter ,  DAVID, Caroline ,  GU, Yu-Gui ,  HANSEN, Todd, Matthew ,  HINMAN, Mira ,  KALVIN, Douglas ,  LARSON, Daniel, P. ,  LYNCH, Linda ,  MA, Zhenkun ,  MOTTER, Christopher ,  PALAZZO, Fabio ,  ROSENBERG, Teresa ,  REHM, Tamara ,  SANDERS, William ,  TUFANO, Michael ,  WAGNER, Rolf ,  WEITZBERG, Moshe ,  YONG, Hong ,  ZHANG, Tianyuan

IPC: C07D471/04 ,  A61K31/435 ,  A61P31/04

CPC classification number: C07D471/04

Abstract: Antibacterials having formula (I), and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates used in the processes, compositions containing the compounds, and methods of prophylaxis and treatment of bacterial infections using the compounds are disclosed.

公开(公告)号：EP1276722B1

公开(公告)日：2006-03-08

申请号：EP01934906.7

申请日：2001-04-25

Applicant: ABBOTT LABORATORIES

Inventor： BRUNCKO, Milan ,  DALTON, Christopher, R. ,  GIRANDA, Vincent, L. ,  GONG, Jianchun ,  MCCLELLAN, William, J. ,  NIENABER, Vicki, L. ,  ROCKWAY, Todd, W. ,  SAUER, Daryl, R. ,  WEITZBERG, Moshe

IPC: C07D217/02 ,  C07D217/04 ,  C07D217/06 ,  C07D405/04 ,  C07D401/06 ,  A61K31/472 ,  A61P29/00

CPC classification number: C07D401/06 ,  C07D217/02 ,  C07D217/04 ,  C07D217/06 ,  C07D405/04

Abstract: Compounds having formula (I) are inhibitors of urokinase and are useful in the treatment of diseases in which urokinase plays a role. Also disclosed are urokinase-inhibiting compositions, methods for the preparation of urokinase-inhibitors, and a method of inhibiting urokinase in a mammal.

Abstract translation: 具有式（I）的化合物是尿激酶的抑制剂并且可用于治疗尿激酶起作用的疾病。 还公开了尿激酶抑制组合物，用于制备尿激酶抑制剂的方法以及在哺乳动物中抑制尿激酶的方法。

公开(公告)号：EP1999119A2

公开(公告)日：2008-12-10

申请号：EP07757026.5

申请日：2007-02-15

Applicant: ABBOTT LABORATORIES

Inventor： GU, Yu Gui ,  WEITZBERG, Moshe ,  XU, Xiangdong ,  CLARK, Richard, F. ,  ZHANG, Tianyuan ,  LI, Qun ,  HANSEN, Todd, M. ,  SHAM, Hing ,  BEUTEL, Bruce, A. ,  CAMP, Heidi, S. ,  WANG, Xiaojun

IPC: C07D277/34 ,  A61K31/427 ,  C07D261/08 ,  C07D277/56 ,  C07D413/04 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14

CPC classification number: C07D277/34 ,  C07D261/08 ,  C07D277/56 ,  C07D413/04 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14

Abstract: The present invention relates to compounds of formula (I), wherein R1 is selected from the group consisting of hydrogen, cycloalkyl, alkyl and haloalkyl; Y is selected from the group consisting of -(CR4aR-4b)m-, -C(O)-, -O-, -N(H)-, -N(alkyl)- and -S-; wherein m is 1, 2 or 3; Ar3 is phenyl or monocyclic heteroaryl; wherein Ar3 is substituted with 1, 2 or 3 or 4 substituents. Ar1 is selected from the group consisting of phenyl and a monocyclic, five or six- membered heteroaryl; Ar2 is a monocyclic five membered heteroaryl, wherein each Ar2 is independently unsubstituted or substituted with 1 or 2 substituents selected from the group consisting of alkyl, alkenyl, halogen, -CN, -NO2, hydroxy, alkoxy, -NH2, -N(H)(alkyl), -N(alkyl)2. -C(O)OH, -C(O)Oalkyl, -C(O)H, -C(O)alkyl, and haloalkyl; Z is selected from the group consisting of -OR9a, -alkylenyl-OR9a, -NR6R99b; and -alkylenyl-NR6R9b; which inhibit acetyl-CoA carboxylase (ACC) and are useful for the prevention or treatment of metabolic syndrome, type U diabetes, obesity, atherosclerosis and cardiovascular diseases in humans.

公开(公告)号：EP1991536A2

公开(公告)日：2008-11-19

申请号：EP07757027.3

申请日：2007-02-15

Applicant: ABBOTT LABORATORIES

Inventor： GU, Yu Gui ,  XU, Xiangdong ,  WEITZBERG, Moshe ,  SHAM, Hing

IPC: C07D277/34 ,  C07D417/04 ,  A61K31/426 ,  A61K31/427

CPC classification number: C07D277/34 ,  C07D417/04

Abstract: The present invention is directed to compounds of formula (I), or a pharmaceutically acceptable salt, prodrug, salt of a prodrug, or combination thereof, wherein Y is selected from the group consisting of-CRxRy-, -C(O)-, -O-, -N(H)-, -N(alkyl)- and -S-; wherein each of Rx and Ry is independently selected from the group consisting of hydrogen. alkyl, hydroxyalkyl, and haloalkyl; or Rx and Ry together with the carbon to which they are attached form a monocyclic cycloalkyl or heterocycle ring, Ar1 is selected from the group consisting of phenyl and a monocyclic, five or six- membered heteroaryl, Ar3 is phenyl or monocyclic heteroaryl, wherein Ar3 is substituted with 1, 2, 3 or 4 substituents Ar2 is a group of formula (a), (b), (c), (d), or (e); wherein R is hydrogen, cycloalkyj, alkyl or haloalkyl, Z1, Z2, Z3 and Z4 are C(R101), or one or two of Z1, Z2, Z3 and Z4 is N and the others are C(R101); Z5, Z6 and Z7 are C(102). or one or two of Z5, Z6 and Z7 are N, and the others are C(R102), Z is selected from the group consisting of -OR5, -alkylenyl-OR5, -N(R6)(R7) and -alkylenyI-N(R6)(R7), which inhibit acetyl-CoA carboxylase (ACC) and are useful for the prevention or treatment of metabolic syndrome, type II diabetes, obesity, atherosclerosis and cardiovascular diseases in humans.

公开(公告)号：EP1000018A2

公开(公告)日：2000-05-17

申请号：EP98937082.0

申请日：1998-07-24

Applicant: Abbott Laboratories

Inventor： GEYER, Andrew, G. ,  MCCLELLAN, William, J. ,  ROCKWAY, Todd, W. ,  STEWART, Kent, D. ,  WEITZBERG, Moshe ,  WENDT, Michael, D.

IPC: C07C249/00

CPC classification number: C07D249/08 ,  C07C257/18 ,  C07C259/18 ,  C07C271/22 ,  C07C271/30 ,  C07C271/66 ,  C07C275/40 ,  C07C311/13 ,  C07C311/16 ,  C07C323/56 ,  C07C323/62 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/10 ,  C07C2601/14 ,  C07C2602/08 ,  C07D207/08 ,  C07D209/08 ,  C07D213/58 ,  C07D213/74 ,  C07D215/38 ,  C07D217/02 ,  C07D231/12 ,  C07D231/40 ,  C07D231/56 ,  C07D233/56 ,  C07D237/20 ,  C07D239/34 ,  C07D239/42 ,  C07D239/545 ,  C07D241/18 ,  C07D241/20 ,  C07D261/14 ,  C07D263/32 ,  C07D277/34 ,  C07D277/42 ,  C07D295/088 ,  C07D303/46 ,  C07D307/16 ,  C07D307/18 ,  C07D307/54 ,  C07D307/64 ,  C07D317/68 ,  C07D333/24 ,  C07D405/12

Abstract: Compounds having formula (I) are inhibitors of urokinase and are useful in the treatment of diseases in which urokinase plays a role. Also disclosed are urokinase-inhibiting compositions and a method of inhibiting urokinase in a mammal.

Abstract translation: 具有式（I）的化合物是尿激酶的抑制剂，可用于治疗尿激酶起作用的疾病。 还公开了尿激酶抑制组合物和抑制哺乳动物尿激酶的方法。