公开(公告)号：WO1993017681A1

公开(公告)日：1993-09-16

申请号：PCT/US1993001594

申请日：1993-02-24

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  WINN, Martin ,  DE, Biswanath ,  ZYDOWSKY, Thomas, M. ,  KERKMAN, Daniel, J. ,  DeBERNARDIS, John, F. ,  ROSENBERG, Saul, H. ,  SHIOSAKI, Kazumi ,  BASHA, Fatima, Z. ,  SPINA, Kenneth, P. ,  VON GELDERN, Thomas, W. ,  BOYD, Steven ,  YAMAMOTO, Diane, M. ,  FUNG, Anthony, K., L.

IPC: A61K31/41

CPC classification number: C07D403/12 ,  C07D413/10 ,  C07D417/12

Abstract: Compounds are disclosed having formula (I) wherein D, E, G, L, M, A, R'1, L', and M' are defined herein. The compounds of the invention are angiotensin II receptor antagonists.

Abstract translation: 公开了具有式（I）的化合物，其中D，E，G，L，M，A，R'1，L'和M'在本文中定义。 本发明的化合物是血管紧张素II受体拮抗剂。

公开(公告)号：WO1996022992A1

公开(公告)日：1996-08-01

申请号：PCT/US1996000072

申请日：1996-01-11

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  MEYER, Michael, D. ,  ALTENBACH, Robert, J. ,  BASHA, Fatima, Z. ,  CARROLL, William, A. ,  DRIZIN, Irene ,  KERWIN, James, F., Jr. ,  LEBOLD, Suzanne, A. ,  LEE, Edmund, L. ,  ELMORE, Steven, W. ,  SIPPY, Kevin, B. ,  TIETJE, Karin, R. ,  WENDT, Michael, D. ,  YAMAMOTO, Diane, M.

IPC: C07D495/04

CPC classification number: C07D403/06 ,  C07D471/04 ,  C07D471/14 ,  C07D487/04 ,  C07D487/14 ,  C07D491/04 ,  C07D491/14 ,  C07D495/04 ,  C07D495/14

Abstract: The present invention relates to a compound of formula (I) and the pharmaceutically acceptable salts thereof wherein W is a tricyclic heterocyclic ring system; which is an alpha -1 adrenergic antagonist and is useful in the treatment of BPH; also disclosed are alpha -1 antagonist compositions and a method for antagonizing alpha -1 receptors and treating BPH.

Abstract translation: 本发明涉及式（I）化合物及其药学上可接受的盐，其中W是三环杂环体系; 其是α-1肾上腺素能拮抗剂，可用于治疗BPH; 还公开了α-1拮抗剂组合物和拮抗α-1受体并治疗BPH的方法。

公开(公告)号：WO1996022991A1

公开(公告)日：1996-08-01

申请号：PCT/US1996000178

申请日：1996-01-11

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  MEYER, Michael, D. ,  ALTENBACH, Robert, J. ,  BASHA, Fatima, Z. ,  CARROLL, William, A. ,  DRIZIN, Irene ,  KERWIN, James, F., Jr. ,  LEBOLD, Suzanne, A. ,  LEE, Edmund, L. ,  PRATT, John, K. ,  SIPPY, Kevin, B. ,  TIETJE, Karin, R. ,  YAMAMOTO, Diane, M.

IPC: C07D487/02

CPC classification number: C07D401/06 ,  C07D403/06 ,  C07D471/04 ,  C07D473/04 ,  C07D475/02 ,  C07D487/04 ,  C07D491/04 ,  C07D495/04

Abstract: The present invention relates to a compound of formula (I) and the pharmaceutically acceptable salts thereof wherein W is a bicyclic heterocyclic ring system. The compounds are alpha -1 adrenergic antagonists and are useful in the treatment of BPH; also disclosed are alpha -1 antagonist compositions and a method for antagonizing alpha -1 receptors and treating BPH.

Abstract translation: 本发明涉及式（I）化合物及其药学上可接受的盐，其中W是双环杂环体系。 这些化合物是α-1肾上腺素能拮抗剂，可用于治疗BPH; 还公开了α-1拮抗剂组合物和拮抗α-1受体并治疗BPH的方法。

公开(公告)号：WO1993017682A1

公开(公告)日：1993-09-16

申请号：PCT/US1993001177

申请日：1993-02-09

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  ZYDOWSKY, Thomas, M. ,  DE, Biswanath ,  SHIOSAKI, Kazumi ,  BASHA, Fatima, Z. ,  WINN, Martin ,  DeBERNARDIS, John, F. ,  VON GELDERN, Thomas, W. ,  YAMAMOTO, Diane, M. ,  KERKMAN, Daniel, J. ,  BOYD, Steven, A. ,  FUNG, Anthony, K., L.

IPC: A61K31/415

CPC classification number: C07D257/04 ,  A61K31/44 ,  A61K31/47 ,  A61K31/505 ,  C07D401/12 ,  C07D403/12 ,  C07D471/04 ,  C07D475/06

Abstract: Compounds are disclosed having formula (I). The compounds of the invention are angiotensin II receptor antagonists.

Abstract translation: 式（I）化合物是血管紧张素II受体拮抗剂。

公开(公告)号：WO2002062761A1

公开(公告)日：2002-08-15

申请号：PCT/US2002/002949

申请日：2002-01-31

Applicant: ABBOTT LABORATORIES

Inventor： KORT, Michael, E. ,  CARROLL, William, A. ,  PEREZ MEDRANO, Arturo ,  DINGES, Jurgen ,  GREGG, Robert, J. ,  BASHA, Fatima, Z.

IPC: C07D213/74

CPC classification number: C07D213/74 ,  C07C233/78 ,  C07C2601/04 ,  C07D213/75 ,  C07D213/76 ,  C07D213/81 ,  C07D213/82 ,  C07D241/20 ,  C07D405/12 ,  C07D409/12

Abstract: Compounds of formula (I), may be useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.

Abstract translation: 式（I）化合物可用于治疗由钾通道开放剂预防或改善的疾病。 还公开了钾通道开放组合物和在哺乳动物中开放钾通道的方法。

公开(公告)号：WO1996038435A1

公开(公告)日：1996-12-05

申请号：PCT/US1996007361

申请日：1996-05-22

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  SCHOENLEBER, Robert, W. ,  DENINNO, Michael, P. ,  BASHA, Fatima, Z. ,  EHRLICH, Paul, P. ,  PERNER, Richard, J. ,  MEYER, Michael, D. ,  CAMPBELL, James, R. ,  MARTIN, Yvonne, C. ,  STOUT, David, M. ,  DEBERNARDIS, John, F. ,  MORTON, Howard, E. ,  MICHAELIDES, Michael, R.

IPC: C07D311/76

CPC classification number: C07D221/20 ,  A61K38/00 ,  C07C215/44 ,  C07C215/64 ,  C07C217/74 ,  C07C233/18 ,  C07C237/08 ,  C07C271/16 ,  C07C271/44 ,  C07C309/65 ,  C07C323/60 ,  C07C2601/14 ,  C07C2602/10 ,  C07C2603/28 ,  C07C2603/74 ,  C07C2603/93 ,  C07D209/62 ,  C07D221/10 ,  C07D311/76 ,  C07D311/78 ,  C07D311/96 ,  C07D493/10 ,  C07K5/06026

Abstract: Novel compounds having formula (I) and the pharmaceutically acceptable salts, esters and amides thereof, wherein A is -O-; R , R , R , R , R , R , R , R , X and Y are specifically defined such that X and Y are not both hydrogen; and up to one combination of (a) R and R , (b) R and R , (c) R and R , (d) R and R , and (e) R and Y, taken together with the atoms to which they are attached, may form a ring, the compounds being useful for treating dopamine-related neurological, psychological and cardiovascular disorders as well as in the treatment of cognitive impairment, attention deficit disorder, and substance abuse and other addictive behavior disorders. Also disclosed are intermediates and processes useful in the preparation of the above compounds.

Abstract translation: 具有式（I）的新型化合物及其药学上可接受的盐，酯和酰胺，其中A是-O-; R 1，R 3，R 4，R 5，R 6，R 7，R 9，R 10，X和Y具体定义为使得X和 Y不是氢; 和（a）R 2和R 5的一个组合，（b）R 5和R 6，（c）R 5和R 7，（d） 6＆gt;和R 7，和（e）R 7和Y与它们所连接的原子一起可以形成环，该化合物可用于治疗多巴胺相关的神经系统，心理和心血管疾病 以及治疗认知障碍，注意力缺陷障碍，药物滥用和其他成瘾行为障碍。 还公开了可用于制备上述化合物的中间体和方法。

公开(公告)号：WO1993018035A1

公开(公告)日：1993-09-16

申请号：PCT/US1993001105

申请日：1993-02-04

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  ZYDOWSKY, Thomas, M. ,  DE, Biswanath ,  SHIOSAKI, Kazumi ,  BASHA, Fatima, Z. ,  WINN, Martin ,  DeBERNARDIS, John, F. ,  VON GELDERN, Thomas, W. ,  YAMAMOTO, Diane, M. ,  ROSENBERG, Saul, H. ,  KERKMAN, Daniel, J. ,  BOYD, Steven, A. ,  FUNG, Anthony, K., L.

IPC: C07D471/04

CPC classification number: C07D473/00 ,  C07D401/12 ,  C07D471/04 ,  C07D473/34 ,  C07D473/40 ,  C07D487/04 ,  C07D491/04 ,  C07D495/04 ,  C07D513/04

Abstract: Compounds are disclosed having formula (I). The compounds of the invention are angiotensin II receptor antagonists.

Abstract translation: 公开了具有式（I）的化合物。 本发明的化合物是血管紧张素II受体拮抗剂。

公开(公告)号：EP0808318A1

公开(公告)日：1997-11-26

申请号：EP96903340.0

申请日：1996-01-11

Applicant: Abbott Laboratories

Inventor： MEYER, Michael, D. ,  ALTENBACH, Robert, J. ,  BASHA, Fatima, Z. ,  CARROLL, William, A. ,  DRIZIN, Irene ,  KERWIN, James, F., Jr. ,  LEBOLD, Suzanne, A. ,  LEE, Edmund, L. ,  ELMORE, Steven, W. ,  SIPPY, Kevin, B. ,  TIETJE, Karin, R. ,  WENDT, Michael, D. ,  YAMAMOTO, Diane, M.

IPC: A61K31 ,  A61P13 ,  A61P43 ,  C07D403 ,  C07D471 ,  C07D487 ,  C07D491 ,  C07D495

CPC classification number: C07D403/06 ,  C07D471/04 ,  C07D471/14 ,  C07D487/04 ,  C07D487/14 ,  C07D491/04 ,  C07D491/14 ,  C07D495/04 ,  C07D495/14

Abstract: The present invention relates to a compound of formula (I) and the pharmaceutically acceptable salts thereof wherein W is a tricyclic heterocyclic ring system; which is an α-1 adrenergic antagonist and is useful in the treatment of BPH; also disclosed are α-1 antagonist compositions and a method for antagonizing α-1 receptors and treating BPH.

公开(公告)号：EP1131322A2

公开(公告)日：2001-09-12

申请号：EP99970991.8

申请日：1999-10-28

Applicant: ABBOTT LABORATORIES

Inventor： CARROLL, William, A. ,  AGRIOS, Konstantinos, A. ,  BASHA, Fatima, Z. ,  CHEN, Yiyuan ,  KORT, Michael, E. ,  KYM, Philip, R. ,  TANG, Rui ,  TURNER, Sean, C. ,  YI, Lin

IPC: C07D471/00 ,  C07D491/04 ,  A61K31/435

CPC classification number: C07D471/04 ,  C07D471/14 ,  C07D491/04 ,  C07D491/14 ,  C07D495/14

Abstract: Compounds having formula (I) are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.

公开(公告)号：EP1358160A1

公开(公告)日：2003-11-05

申请号：EP02704321.5

申请日：2002-01-31

Applicant: Abbott Laboratories

Inventor： KORT, Michael, E. ,  CARROLL, William, A. ,  PEREZ MEDRANO, Arturo ,  DINGES, Jurgen ,  GREGG, Robert, J. ,  BASHA, Fatima, Z.

IPC: C07D213/74 ,  C07D405/12 ,  C07C233/78 ,  C07D213/76 ,  C07D213/75 ,  C07D409/12 ,  C07D241/20 ,  C07D213/82 ,  C07D213/81 ,  A61K31/44 ,  A61K31/4965 ,  A61P9/00 ,  A61P27/00 ,  A61P25/00

CPC classification number: C07D213/74 ,  C07C233/78 ,  C07C2601/04 ,  C07D213/75 ,  C07D213/76 ,  C07D213/81 ,  C07D213/82 ,  C07D241/20 ,  C07D405/12 ,  C07D409/12

Abstract: Compounds of formula (I), may be useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.

Abstract translation: 式（I）化合物可用于治疗由钾通道开放剂预防或改善的疾病。 还公开了钾通道开放组合物和在哺乳动物中开放钾通道的方法。