公开(公告)号：WO2007084532A2

公开(公告)日：2007-07-26

申请号：PCT/US2007/001189

申请日：2007-01-17

Applicant: ABBOTT LABORATORIES ,  WERNET, Wolfgang ,  PENNING, Thomas, D. ,  GIRANDA, Vincent, L.

Inventor： WERNET, Wolfgang ,  PENNING, Thomas, D. ,  GIRANDA, Vincent, L.

IPC: A61K31/41 ,  A61K31/4164 ,  C07D401/02 ,  C07D471/00 ,  A61K49/00

CPC classification number: C07D403/04 ,  A61K31/41 ,  A61K31/4164 ,  A61K41/0038 ,  A61K45/06 ,  A61N2005/1098 ,  A61K2300/00

Abstract: The present invention describes benzimidazole derivatives of Formula (I) which constitute potent PARP inhibitors in combination with radiotherapy or in combination with other chemotherapeutic agents.

Abstract translation: 本发明描述了式（I）的苯并咪唑衍生物，其与放射治疗组合或与其它化学治疗剂组合地构成有效的PARP抑制剂。

公开(公告)号：EP2217583B1

公开(公告)日：2011-11-30

申请号：EP08845310.5

申请日：2008-10-31

Applicant: Abbott GmbH & Co. KG ,  Abbott Laboratories

Inventor： BRAJE, Wilfried ,  TURNER, Sean Colm ,  HAUPT, Andreas ,  LANGE, Udo ,  DRESCHER, Karla ,  WICKE, Karsten ,  UNGER, Liliane ,  MEZLER, Mario ,  WERNET, Wolfgang ,  MAYRER, Matthias ,  JONGEN-RELO, Ana Lucia ,  BESPALOV, Anton ,  ZHANG, Min

IPC: C07D295/12 ,  C07D405/12 ,  A61K31/495 ,  A61K31/496 ,  A61P3/04 ,  A61P25/00 ,  A61P25/18 ,  A61P25/28 ,  A61P25/30

CPC classification number: C07D295/12 ,  C07D405/12

Abstract: The present invention relates to novel benzenesulfonanilide compounds of the formulae I and I' and physiologically tolerated acid addition salts and the N-oxides thereof. The compounds possess valuable therapeutic properties and are particularly suitable, for treating diseases that respond to modulation of the serotonin 5-HT6 receptor. wherein R1 is hydrogen or methyl R2 is hydrogen or methyl R3 hydrogen, fluorine C1-C2 alkoxy or fluorinated C1-C2 alkoxy; R4 is hydrogen, C1-C4 alkyl or fluorinated C1-C4 alkyl; R5 is hydrogen, fluorine, C1-C2 alkyl, fluorinated C1-C2 alkyl, C1-C2 alkoxy or fluorinated C1-C2 alkoxy; and R6 is hydrogen, fluorine or chlorine.

公开(公告)号：EP2217583A1

公开(公告)日：2010-08-18

申请号：EP08845310.5

申请日：2008-10-31

Applicant: Abbott GmbH & Co. KG ,  Abbott Laboratories

Inventor： BRAJE, Wilfried ,  TURNER, Sean Colm ,  HAUPT, Andreas ,  LANGE, Udo ,  DRESCHER, Karla ,  WICKE, Karsten ,  UNGER, Liliane ,  MEZLER, Mario ,  WERNET, Wolfgang ,  MAYRER, Matthias ,  JONGEN-RELO, Ana Lucia ,  BESPALOV, Anton ,  ZHANG, Min

IPC: C07D295/12 ,  C07D405/12 ,  A61K31/495 ,  A61K31/496 ,  A61P3/04 ,  A61P25/00 ,  A61P25/18 ,  A61P25/28 ,  A61P25/30

CPC classification number: C07D295/12 ,  C07D405/12

Abstract: The present invention relates to novel benzenesulfonanilide compounds of the formulae I and I' and physiologically tolerated acid addition salts and the N-oxides thereof. The compounds possess valuable therapeutic properties and are particularly suitable, for treating diseases that respond to modulation of the serotonin 5-HT6 receptor. wherein R1 is hydrogen or methyl R2 is hydrogen or methyl R3 hydrogen, fluorine C1-C2 alkoxy or fluorinated C1-C2 alkoxy; R4 is hydrogen, C1-C4 alkyl or fluorinated C1-C4 alkyl; R5 is hydrogen, fluorine, C1-C2 alkyl, fluorinated C1-C2 alkyl, C1-C2 alkoxy or fluorinated C1-C2 alkoxy; and R6 is hydrogen, fluorine or chlorine.

公开(公告)号：EP1976515A2

公开(公告)日：2008-10-08

申请号：EP07716699.9

申请日：2007-01-17

Applicant: ABBOTT LABORATORIES

Inventor： WERNET, Wolfgang ,  PENNING, Thomas D. ,  GIRANDA, Vincent L.

IPC: A61K31/41 ,  A61K31/4164 ,  C07D401/02 ,  C07D471/00 ,  A61K49/00

CPC classification number: C07D403/04 ,  A61K31/41 ,  A61K31/4164 ,  A61K41/0038 ,  A61K45/06 ,  A61N2005/1098 ,  A61K2300/00

Abstract: The present invention describes benzimidazole derivatives of Formula (I) which constitute potent PARP inhibitors in combination with radiotherapy or in combination with other chemotherapeutic agents.