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公开(公告)号：ES2811303T3
公开(公告)日：2021-03-11
申请号：ES15810347
申请日：2015-06-16
Applicant: ACADEMIA SINICA
Inventor： CHEN JIUN-BO , SHIUNG YU-YU , CHANG TSE-WEN
Abstract: Un anticuerpo humanizado que tiene una actividad de unión a IgE humana libre, IgE unidas a la membrana en linfocitos B e IgE unida a CD23, pero que es incapaz de unirse a IgE unida a FcεRI, en donde dicho anticuerpo humanizado comprende una región variable de cadena pesada (VH) y una región variable de cadena ligera (VL), en donde la región variable de cadena pesada (VH) comprende una secuencia de aminoácidos que es idéntica a SEQ ID NO: 2; y en donde la región variable de cadena ligera (VL) comprende una secuencia de aminoácidos que es idéntica a SEQ ID NO: 4.
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公开(公告)号：SG11201705323WA
公开(公告)日：2017-07-28
申请号：SG11201705323W
申请日：2016-01-18
Applicant: ACADEMIA SINICA
Inventor： CHANG TSE-WEN , CHU HSING-MAO , CHEN JOU-HAN , LIN CHUN-YU , LIN CHIEN-JEN
IPC: A61K39/395 , C07K16/46 , C12P21/08
Abstract: The present disclosure provides various core constructs. According to embodiments of the present disclosure, the core construct can be used to configure pharmaceutical molecules. In particular, the core construct may be conjugated with a functional element via the click chemistry.
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3.发明专利
公开(公告)号：CA2943588A1
公开(公告)日：2015-12-23
申请号：CA2943588
申请日：2015-06-16
Applicant: ACADEMIA SINICA
Inventor： CHEN JIUN-BO , SHIUNG YU-YU , CHANG TSE-WEN
Abstract: A novel humanized anti-IgE antibody is disclosed. The antibody is capable of binding to free IgE, membrane-bound IgE on B lymphocytes, IgE bound by CD23, but not to IgE bound by high-affinity IgE.Fc receptor on mast cells. The present invention relates to the treatment of IgE-mediated diseases, including allergic asthma, allergic rhinitis, atopic dermatitis, food allergy, chronic spontaneous (idiopathic) urticaria, chronic rhinosinusitis, systemic mastocytosis, cutaneous mastocytosis, allergic bronchopulmonary aspergillosis, recurrent idiopathic angioedema, and eosinophil-associated gastrointestinal disorder by administering the anti-IgE antibody of the present invention.
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公开(公告)号：AU2018217311B2
公开(公告)日：2019-09-12
申请号：AU2018217311
申请日：2018-08-17
Applicant: ACADEMIA SINICA
Inventor： CHANG TSE-WEN , CHU HSING-MAO , CHEN JOU-HAN , LIN CHUN-YU , LIN CHIEN-JEN
IPC: C07K16/46 , A61K39/395 , C12P21/08
Abstract: The present disclosure provides various core constructs. According to embodiments of the present disclosure, the core construct can be used to configure pharmaceutical molecules. In particular, the core construct may be conjugated with a functional element 5 via the click chemistry.
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5.发明专利
公开(公告)号：NZ723520A
公开(公告)日：2018-06-29
申请号：NZ72352015
申请日：2015-06-16
Applicant: ACADEMIA SINICA
Inventor： CHEN JIUN-BO , SHIUNG YU-YU , CHANG TSE-WEN
Abstract: A humanized anti-IgE antibody is disclosed. The antibody is capable of binding to free IgE, membrane-bound IgE on B lymphocytes, and IgE bound by CD23, but not to IgE bound by FcɛRI. The CDR-H1, CDR-H2 and CDR-H3 of the antibody respectively comprise the amino acid sequences of SEQ ID NOs: 5-7, and the CDR-L1, CDR-L2 and CDR-L3 of the antibody respectively comprise the amino acid sequences of SEQ ID NOs: 8-10.
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Patent Agency Ranking6.发明专利
公开(公告)号：AU2015277379A1
公开(公告)日：2016-09-08
申请号：AU2015277379
申请日：2015-06-16
Applicant: ACADEMIA SINICA , LIANG CHI MING
Inventor： CHEN JIUN-BO , SHIUNG YU-YU , CHANG TSE-WEN
Abstract: A novel humanized anti-IgE antibody is disclosed. The antibody is capable of binding to free IgE, membrane-bound IgE on B lymphocytes, IgE bound by CD23, but not to IgE bound by high-affinity IgE.Fc receptor on mast cells. The present invention relates to the treatment of IgE-mediated diseases, including allergic asthma, allergic rhinitis, atopic dermatitis, food allergy, chronic spontaneous (idiopathic) urticaria, chronic rhinosinusitis, systemic mastocytosis, cutaneous mastocytosis, allergic bronchopulmonary aspergillosis, recurrent idiopathic angioedema, and eosinophil-associated gastrointestinal disorder by administering the anti-IgE antibody of the present invention.
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公开(公告)号：RU2696378C2
公开(公告)日：2019-08-01
申请号：RU2017128109
申请日：2016-01-18
Applicant: ACADEMIA SINICA
Inventor： CHANG TSE-WEN , CHU HSING-MAO , CHEN JOU-HAN , LIN CHUN-YU , LIN CHIEN-JEN
IPC: C07K16/46 , C07K14/485 , C07K14/655 , C07K14/705 , C12P21/08
Abstract: Изобретениеотноситсяк областибиотехнологии, конкретнок линкерномузвену, иможетбытьиспользованов качествесшивающегосредствадляобъединенияразличныхантителилииныхбиологическиактивныхагентовв конъюгатыи построениямолекулярныхконструкцийс конкретнойкомбинациейнацеливающихи эффекторныхэлементовс применениемхимическогосинтеза, либорекомбинантнойтехнологии. 2 з.п. ф-лы, 4 ил., 72 пр.
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公开(公告)号：AU2018217311A1
公开(公告)日：2018-09-06
申请号：AU2018217311
申请日：2018-08-17
Applicant: ACADEMIA SINICA
Inventor： CHANG TSE-WEN , CHU HSING-MAO , CHEN JOU-HAN , LIN CHUN-YU , LIN CHIEN-JEN
IPC: C07K16/46 , A61K39/395 , C12P21/08
Abstract: The present disclosure provides various core constructs. According to embodiments of the present disclosure, the core construct can be used to configure pharmaceutical molecules. In particular, the core construct may be conjugated with a functional element 5 via the click chemistry.
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公开(公告)号：AU2016207112A1
公开(公告)日：2017-06-15
申请号：AU2016207112
申请日：2016-01-18
Applicant: ACADEMIA SINICA
Inventor： CHANG TSE-WEN , CHU HSING-MAO , CHEN JOU-HAN , LIN CHUN-YU , LIN CHIEN-JEN
IPC: C07K16/46 , A61K39/395 , C12P21/08
Abstract: The present disclosure provides various molecular constructs having a targeting element and an effector element. Methods for treating various diseases using such molecular constructs are also disclosed.
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10.发明专利
公开(公告)号：SG11201607046VA
公开(公告)日：2016-10-28
申请号：SG11201607046V
申请日：2015-06-16
Applicant: ACADEMIA SINICA
Inventor： CHEN JIUN-BO , SHIUNG YU-YU , CHANG TSE-WEN
Abstract: A novel humanized anti-IgE antibody is disclosed. The antibody is capable of binding to free IgE, membrane-bound IgE on B lymphocytes, IgE bound by CD23, but not to IgE bound by high-affinity IgE.Fc receptor on mast cells. The present invention relates to the treatment of IgE-mediated diseases, including allergic asthma, allergic rhinitis, atopic dermatitis, food allergy, chronic spontaneous (idiopathic) urticaria, chronic rhinosinusitis, systemic mastocytosis, cutaneous mastocytosis, allergic bronchopulmonary aspergillosis, recurrent idiopathic angioedema, and eosinophil-associated gastrointestinal disorder by administering the anti-IgE antibody of the present invention.
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