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1.发明专利
公开(公告)号：SG11201607046VA
公开(公告)日：2016-10-28
申请号：SG11201607046V
申请日：2015-06-16
Applicant: ACADEMIA SINICA
Inventor： CHEN JIUN-BO , SHIUNG YU-YU , CHANG TSE-WEN
Abstract: A novel humanized anti-IgE antibody is disclosed. The antibody is capable of binding to free IgE, membrane-bound IgE on B lymphocytes, IgE bound by CD23, but not to IgE bound by high-affinity IgE.Fc receptor on mast cells. The present invention relates to the treatment of IgE-mediated diseases, including allergic asthma, allergic rhinitis, atopic dermatitis, food allergy, chronic spontaneous (idiopathic) urticaria, chronic rhinosinusitis, systemic mastocytosis, cutaneous mastocytosis, allergic bronchopulmonary aspergillosis, recurrent idiopathic angioedema, and eosinophil-associated gastrointestinal disorder by administering the anti-IgE antibody of the present invention.
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2.发明专利
公开(公告)号：NZ723520A
公开(公告)日：2018-06-29
申请号：NZ72352015
申请日：2015-06-16
Applicant: ACADEMIA SINICA
Inventor： CHEN JIUN-BO , SHIUNG YU-YU , CHANG TSE-WEN
Abstract: A humanized anti-IgE antibody is disclosed. The antibody is capable of binding to free IgE, membrane-bound IgE on B lymphocytes, and IgE bound by CD23, but not to IgE bound by FcɛRI. The CDR-H1, CDR-H2 and CDR-H3 of the antibody respectively comprise the amino acid sequences of SEQ ID NOs: 5-7, and the CDR-L1, CDR-L2 and CDR-L3 of the antibody respectively comprise the amino acid sequences of SEQ ID NOs: 8-10.
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3.发明专利
公开(公告)号：AU2015277379A1
公开(公告)日：2016-09-08
申请号：AU2015277379
申请日：2015-06-16
Applicant: ACADEMIA SINICA , LIANG CHI MING
Inventor： CHEN JIUN-BO , SHIUNG YU-YU , CHANG TSE-WEN
Abstract: A novel humanized anti-IgE antibody is disclosed. The antibody is capable of binding to free IgE, membrane-bound IgE on B lymphocytes, IgE bound by CD23, but not to IgE bound by high-affinity IgE.Fc receptor on mast cells. The present invention relates to the treatment of IgE-mediated diseases, including allergic asthma, allergic rhinitis, atopic dermatitis, food allergy, chronic spontaneous (idiopathic) urticaria, chronic rhinosinusitis, systemic mastocytosis, cutaneous mastocytosis, allergic bronchopulmonary aspergillosis, recurrent idiopathic angioedema, and eosinophil-associated gastrointestinal disorder by administering the anti-IgE antibody of the present invention.
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Patent Agency Ranking
公开(公告)号：ES2811303T3
公开(公告)日：2021-03-11
申请号：ES15810347
申请日：2015-06-16
Applicant: ACADEMIA SINICA
Inventor： CHEN JIUN-BO , SHIUNG YU-YU , CHANG TSE-WEN
Abstract: Un anticuerpo humanizado que tiene una actividad de unión a IgE humana libre, IgE unidas a la membrana en linfocitos B e IgE unida a CD23, pero que es incapaz de unirse a IgE unida a FcεRI, en donde dicho anticuerpo humanizado comprende una región variable de cadena pesada (VH) y una región variable de cadena ligera (VL), en donde la región variable de cadena pesada (VH) comprende una secuencia de aminoácidos que es idéntica a SEQ ID NO: 2; y en donde la región variable de cadena ligera (VL) comprende una secuencia de aminoácidos que es idéntica a SEQ ID NO: 4.
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5.发明专利
公开(公告)号：CA2943588A1
公开(公告)日：2015-12-23
申请号：CA2943588
申请日：2015-06-16
Applicant: ACADEMIA SINICA
Inventor： CHEN JIUN-BO , SHIUNG YU-YU , CHANG TSE-WEN
Abstract: A novel humanized anti-IgE antibody is disclosed. The antibody is capable of binding to free IgE, membrane-bound IgE on B lymphocytes, IgE bound by CD23, but not to IgE bound by high-affinity IgE.Fc receptor on mast cells. The present invention relates to the treatment of IgE-mediated diseases, including allergic asthma, allergic rhinitis, atopic dermatitis, food allergy, chronic spontaneous (idiopathic) urticaria, chronic rhinosinusitis, systemic mastocytosis, cutaneous mastocytosis, allergic bronchopulmonary aspergillosis, recurrent idiopathic angioedema, and eosinophil-associated gastrointestinal disorder by administering the anti-IgE antibody of the present invention.
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公开(公告)号：DK3157951T3
公开(公告)日：2020-08-17
申请号：DK15810347
申请日：2015-06-16
Applicant: ACADEMIA SINICA
Inventor： CHEN JIUN-BO , SHIUNG YU-YU , CHANG TSE-WEN
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7.发明专利
公开(公告)号：CA2943588C
公开(公告)日：2019-04-30
申请号：CA2943588
申请日：2015-06-16
Applicant: ACADEMIA SINICA
Inventor： CHEN JIUN-BO , SHIUNG YU-YU , CHANG TSE-WEN
IPC: C07K16/00 , A61K39/395 , C07K16/42 , C07K16/46
Abstract: A novel humanized anti-IgE antibody is disclosed. The antibody is capable of binding to free IgE, membrane-bound IgE on B lymphocytes, IgE bound by CD23, but not to IgE bound by high-affinity IgE.Fc receptor on mast cells. The present invention relates to the treatment of IgE-mediated diseases, including allergic asthma, allergic rhinitis, atopic dermatitis, food allergy, chronic spontaneous (idiopathic) urticaria, chronic rhinosinusitis, systemic mastocytosis, cutaneous mastocytosis, allergic bronchopulmonary aspergillosis, recurrent idiopathic angioedema, and eosinophil-associated gastrointestinal disorder by administering the anti-IgE antibody of the present invention.
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8.发明专利
公开(公告)号：AU2015277379B2
公开(公告)日：2017-06-29
申请号：AU2015277379
申请日：2015-06-16
Applicant: ACADEMIA SINICA
Inventor： CHEN JIUN-BO , SHIUNG YU-YU , CHANG TSE-WEN
Abstract: A novel humanized anti-IgE antibody is disclosed. The antibody is capable of binding to free IgE, membrane-bound IgE on B lymphocytes, IgE bound by CD23, but not to IgE bound by high-affinity IgE.Fc receptor on mast cells. The present invention relates to the treatment of IgE-mediated diseases, including allergic asthma, allergic rhinitis, atopic dermatitis, food allergy, chronic spontaneous (idiopathic) urticaria, chronic rhinosinusitis, systemic mastocytosis, cutaneous mastocytosis, allergic bronchopulmonary aspergillosis, recurrent idiopathic angioedema, and eosinophil-associated gastrointestinal disorder by administering the anti-IgE antibody of the present invention.
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