公开(公告)号：IL318755A

公开(公告)日：2025-04-01

申请号：IL31875525

申请日：2025-02-02

Applicant: ACADEMIA SINICA ,  CHI HUEY WONG ,  CHE MA ,  HAN YI HUANG

Inventor： CHI-HUEY WONG ,  CHE MA ,  HAN-YI HUANG

IPC: A61K39/00 ,  A61K39/12 ,  A61K39/215 ,  A61P31/04 ,  A61P31/14

Abstract: The present disclosure provides a glycoengineered SARS-CoV-2 spike protein which is capable of eliciting an enhanced immune response relative to a native spike protein of SARS-CoV-2 and its variants. The glycoengineered spike protein exposes the glycosylation sites and at the same time preserves the tertiary structure of the spike protein. The present disclosure therefore provides improved immunogens, vaccines, and methods for better prevention and treatment of the emerging coronavirus infections.

公开(公告)号：IL314125B1

公开(公告)日：2025-04-01

申请号：IL31412524

申请日：2024-07-04

Applicant: ACADEMIA SINICA ,  CHI HUEY WONG ,  CHE MA ,  HAN YI HUANG

Inventor： CHI-HUEY WONG ,  CHE MA ,  HAN-YI HUANG

IPC: A61K39/00 ,  A61K39/12 ,  A61K39/215 ,  A61P31/04 ,  A61P31/14

Abstract: The present disclosure provides a glycoengineered SARS-CoV-2 spike protein which is capable of eliciting an enhanced immune response relative to a native spike protein of SARS-CoV-2 and its variants. The glycoengineered spike protein exposes the glycosylation sites and at the same time preserves the tertiary structure of the spike protein. The present disclosure therefore provides improved immunogens, vaccines, and methods for better prevention and treatment of the emerging coronavirus infections.

公开(公告)号：IL299875B2

公开(公告)日：2024-12-01

申请号：IL29987523

申请日：2023-01-12

Applicant: ACADEMIA SINICA ,  CHI HUEY WONG ,  CHE MA ,  HAN YI HUANG

Inventor： CHI-HUEY WONG ,  CHE MA ,  HAN-YI HUANG

IPC: A61K39/00 ,  A61K39/12 ,  A61K39/15 ,  A61P31/14

Abstract: The present disclosure provides a glycoengineered SARS-CoV-2 spike protein which is capable of eliciting an enhanced immune response relative to a native spike protein of SARS-CoV-2 and its variants. The glycoengineered spike protein exposes the glycosylation sites and at the same time preserves the tertiary structure of the spike protein. The present disclosure therefore provides improved immunogens, vaccines, and methods for better prevention and treatment of the emerging coronavirus infections.

公开(公告)号：IL215430A

公开(公告)日：2016-11-30

申请号：IL21543011

申请日：2011-09-27

Applicant: ACADEMIA SINICA ,  CHI-HUEY WONG ,  JUINE-RUEY CHEN ,  CHE MA ,  CHENG-CHI WANG

Inventor： CHI-HUEY WONG ,  JUINE-RUEY CHEN ,  CHE MA ,  CHENG-CHI WANG

IPC: A61K20060101

Abstract: Immunogenic compositions comprising partially glycosylated viral glycoproteins for use as vaccines against viruses are provided. Vaccines formulated using mono-, di-, or tri-glycosylated viral surface glycoproteins and polypeptides provide potent and broad protection against viruses, even across strains. Pharmaceutical compositions comprising monoglycosylated hemagglutinin polypeptides and vaccines generated therefrom and methods of their use for prophylaxis or treatment of viral infections are disclosed. Methods and compositions are disclosed for influenza virus HA, NA and M2, RSV proteins F, G and SH, Dengue virus glycoproteins M or E, hepatitis C virus glycoprotein E1 or E2 and HIV glycoproteins gp120 and gp41.

公开(公告)号：IL226143A

公开(公告)日：2020-04-30

申请号：IL22614313

申请日：2013-05-02

Applicant: ACADEMIA SINICA ,  CHI HUEY WONG ,  CHE MA ,  YUNG CHIEH TSENG

Inventor： CHI-HUEY WONG ,  CHE MA ,  YUNG-CHIEH TSENG

IPC: A61K39/12 ,  A61K39/145 ,  C07K14/11 ,  C12N7/01 ,  C12N15/09 ,  C12P21/06

Abstract: Methods for producing virus particles and viral antigens with simplified glycosylation profiles, such as mono-glycosylated forms of HIV, HCV, Dengue virus, West Nile virus and influenza virus. When used as targets for vaccine production, the conserved nature of such sites generate vaccines that are less sensitive to viral mutations. Such methods may include the use of glycosylation inhibitors for production of viruses or viral antigens with simplified glycosylation profiles.

公开(公告)号：MX2013004996A

公开(公告)日：2014-02-27

申请号：MX2013004996

申请日：2011-11-04

Applicant: ACADEMIA SINICA

Inventor： CHI-HUEY WONG ,  CHE MA ,  YUNG-CHIEH TSENG

IPC: C12P21/06 ,  C12N15/09

Abstract: Se proporcionan métodos para producción de partículas de virus con glucosilación simplificada en proteínas estructurales o de superficie. Cuando se utilizan como objetivos para producción de vacunas, la naturaleza conservada de dichos sitios genera vacunas que son más sensibles a mutaciones víricas. Se describe el uso de inhibidores de glucosilación para producción de virus con perfiles de glucosilación simplificados. Se proporciona una descripción de ejemplo de los virus de la influenza y métodos para producción de partículas de virus de influenza monoglucosilada. Se proporcionan métodos para producción de formas monoglucosiladas de virus de influenza A, NIBRG-14 (H5N1).

公开(公告)号：BR112022022558A2

公开(公告)日：2022-12-13

申请号：BR112022022558

申请日：2021-05-07

Applicant: ACADEMIA SINICA

Inventor： CHI-HUEY WONG ,  HSIN-YU LIAO ,  SHIH-CHI WANG ,  YI-AN KO ,  KUO-I LIN ,  CHE MA ,  TING-JEN CHENG

IPC: A61K38/16 ,  A61K39/155 ,  C12N7/04

Abstract: POLIPEPTÍDEO DE HEMAGLUTININA (HA) DO VÍRUS INFLUENZA QUIMÉRICO, COMPOSIÇÃO IMUNOGÊNICA, MÉTODO DE IMUNIZAÇÃO DE UM INDIVÍDUO CONTRA O VÍRUS INFLUENZA OU PREVENÇÃO DE UMA DOENÇA DO VÍRUS INFLUENZA, POLINUCLEOTÍDEO RECOMBINANTE, VETOR E CÉLULA HOSPEDEIRA. A presente descrição refere-se a um polipeptídeo de hemaglutinina (HA) do vírus influenza quimérico, compreendendo uma ou mais sequências de domínio tronco, cada uma tendo pelo menos 60% de homologia com uma sequência consenso de domínio tronco do subtipo H1 HA (H1 HA) e/ou subtipo H5 HA (H5 HA), fundido com uma ou mais sequências de domínio de cabeça globular, cada uma tendo pelo menos 60% de homologia com uma sequência de consenso de domínio de cabeça globular do subtipo H1 HA (H1 HA) ou subtipo H5 HA (H5 HA).

公开(公告)号：IL248607D0

公开(公告)日：2016-12-29

申请号：IL24860716

申请日：2016-10-30

Applicant: ACADEMIA SINICA ,  CHI-HUEY WONG ,  JUINE-RUEY CHEN ,  CHE MA ,  CHENG-CHI WANG

Inventor： CHI-HUEY WONG ,  JUINE-RUEY CHEN ,  CHE MA ,  CHENG-CHI WANG

IPC: A61K20060101

Abstract: Immunogenic compositions comprising partially glycosylated viral glycoproteins for use as vaccines against viruses are provided. Vaccines formulated using mono-, di-, or tri-glycosylated viral surface glycoproteins and polypeptides provide potent and broad protection against viruses, even across strains. Pharmaceutical compositions comprising monoglycosylated hemagglutinin polypeptides and vaccines generated therefrom and methods of their use for prophylaxis or treatment of viral infections are disclosed. Methods and compositions are disclosed for influenza virus HA, NA and M2, RSV proteins F, G and SH, Dengue virus glycoproteins M or E, hepatitis C virus glycoprotein E1 or E2 and HIV glycoproteins gp120 and gp41.

公开(公告)号：AU2010229675A1

公开(公告)日：2011-10-27

申请号：AU2010229675

申请日：2010-03-26

Applicant: ACADEMIA SINICA

Inventor： CHI-HUEY WONG ,  CHE MA ,  CHENG-CHI WANG ,  JUINE-RUEY CHEN

IPC: C07K14/11 ,  A61K39/12 ,  A61K39/145 ,  A61K39/155 ,  A61K39/21 ,  A61K39/29 ,  A61P31/12 ,  A61P31/14 ,  A61P31/16 ,  A61P31/18 ,  C07K14/135 ,  C07K14/155 ,  C07K14/18 ,  C12P21/02

Abstract: Immunogenic compositions comprising partially glycosylated viral glycoproteins for use as vaccines against viruses are provided. Vaccines formulated using mono-, di-, or tri-glycosylated viral surface glycoproteins and polypeptides provide potent and broad protection against viruses, even across strains. Pharmaceutical compositions comprising monoglycosylated hemagglutinin polypeptides and vaccines generated therefrom and methods of their use for prophylaxis or treatment of viral infections are disclosed. Methods and compositions are disclosed for influenza virus HA, NA and M2, RSV proteins F, G and SH, Dengue virus glycoproteins M or E, hepatitis C virus glycoprotein E1 or E2 and HIV glycoproteins gp120 and gp41.