公开(公告)号：IL215430A

公开(公告)日：2016-11-30

申请号：IL21543011

申请日：2011-09-27

Applicant: ACADEMIA SINICA ,  CHI-HUEY WONG ,  JUINE-RUEY CHEN ,  CHE MA ,  CHENG-CHI WANG

Inventor： CHI-HUEY WONG ,  JUINE-RUEY CHEN ,  CHE MA ,  CHENG-CHI WANG

IPC: A61K20060101

Abstract: Immunogenic compositions comprising partially glycosylated viral glycoproteins for use as vaccines against viruses are provided. Vaccines formulated using mono-, di-, or tri-glycosylated viral surface glycoproteins and polypeptides provide potent and broad protection against viruses, even across strains. Pharmaceutical compositions comprising monoglycosylated hemagglutinin polypeptides and vaccines generated therefrom and methods of their use for prophylaxis or treatment of viral infections are disclosed. Methods and compositions are disclosed for influenza virus HA, NA and M2, RSV proteins F, G and SH, Dengue virus glycoproteins M or E, hepatitis C virus glycoprotein E1 or E2 and HIV glycoproteins gp120 and gp41.

公开(公告)号：IL248607D0

公开(公告)日：2016-12-29

申请号：IL24860716

申请日：2016-10-30

Applicant: ACADEMIA SINICA ,  CHI-HUEY WONG ,  JUINE-RUEY CHEN ,  CHE MA ,  CHENG-CHI WANG

Inventor： CHI-HUEY WONG ,  JUINE-RUEY CHEN ,  CHE MA ,  CHENG-CHI WANG

IPC: A61K20060101

Abstract: Immunogenic compositions comprising partially glycosylated viral glycoproteins for use as vaccines against viruses are provided. Vaccines formulated using mono-, di-, or tri-glycosylated viral surface glycoproteins and polypeptides provide potent and broad protection against viruses, even across strains. Pharmaceutical compositions comprising monoglycosylated hemagglutinin polypeptides and vaccines generated therefrom and methods of their use for prophylaxis or treatment of viral infections are disclosed. Methods and compositions are disclosed for influenza virus HA, NA and M2, RSV proteins F, G and SH, Dengue virus glycoproteins M or E, hepatitis C virus glycoprotein E1 or E2 and HIV glycoproteins gp120 and gp41.

公开(公告)号：AU2010229675A1

公开(公告)日：2011-10-27

申请号：AU2010229675

申请日：2010-03-26

Applicant: ACADEMIA SINICA

Inventor： CHI-HUEY WONG ,  CHE MA ,  CHENG-CHI WANG ,  JUINE-RUEY CHEN

IPC: C07K14/11 ,  A61K39/12 ,  A61K39/145 ,  A61K39/155 ,  A61K39/21 ,  A61K39/29 ,  A61P31/12 ,  A61P31/14 ,  A61P31/16 ,  A61P31/18 ,  C07K14/135 ,  C07K14/155 ,  C07K14/18 ,  C12P21/02

Abstract: Immunogenic compositions comprising partially glycosylated viral glycoproteins for use as vaccines against viruses are provided. Vaccines formulated using mono-, di-, or tri-glycosylated viral surface glycoproteins and polypeptides provide potent and broad protection against viruses, even across strains. Pharmaceutical compositions comprising monoglycosylated hemagglutinin polypeptides and vaccines generated therefrom and methods of their use for prophylaxis or treatment of viral infections are disclosed. Methods and compositions are disclosed for influenza virus HA, NA and M2, RSV proteins F, G and SH, Dengue virus glycoproteins M or E, hepatitis C virus glycoprotein E1 or E2 and HIV glycoproteins gp120 and gp41.