公开(公告)号：AU2025201644A1

公开(公告)日：2025-03-27

申请号：AU2025201644

申请日：2025-03-06

Applicant: ACADEMIA SINICA

Inventor： LIAO HSIN-YU ,  WANG SHIH-CHI ,  KO YI-AN ,  LIN KUO-I ,  MA CHE ,  CHENG TING-JEN ,  WONG CHI-HUEY

IPC: A61K39/145 ,  A61P31/16 ,  C12N7/04

Abstract: Abstract The present disclosure relates to a chimeric influenza virus hemagglutinin (HA) polypeptide, comprising one or more stem domain sequence, each having at least 60% homology with a stem domain consensus sequence of HI subtype HA (HI HA) and/or H5 subtype HA (H5 HA), fused with one or more globular head domain sequences, each having at least 60% homology with a globular head domain consensus sequence of HI subtype HA (HI HA) or H5 subtype HA (H5 HA).

公开(公告)号：AU2021268212A1

公开(公告)日：2022-12-08

申请号：AU2021268212

申请日：2021-05-07

Applicant: ACADEMIA SINICA

Inventor： LIAO HSIN-YU ,  WANG SHIH-CHI ,  KO YI-AN ,  LIN KUO-I ,  MA CHE ,  CHENG TING-JEN

IPC: A61K38/16 ,  A61K39/155 ,  C12N7/04

Abstract: The present disclosure relates to a chimeric influenza virus hemagglutinin (HA) polypeptide, comprising one or more stem domain sequence, each having at least 60% homology with a stem domain consensus sequence of HI subtype HA (HI HA) and/or H5 subtype HA (H5 HA), fused with one or more globular head domain sequence, each having at least 60% homology with a globular head domain consensus sequence of HI subtype HA (HI HA) or H5 subtype HA (H5 HA).