公开(公告)号：AU2020227040A1

公开(公告)日：2020-09-17

申请号：AU2020227040

申请日：2020-09-02

Applicant: ACADEMIA SINICA

Inventor： YU ALICE L ,  LIN KUN-HSIEN ,  WU TAI-NA ,  WONG CHI-HUEY

IPC: C07H15/18 ,  A61K39/39

Abstract: HUMAN INKT CELL ACTIVATION USING GLYCOLIPIDS Glycosphingolipids (GS Ls) compositions and methods for iNKT-independent induction of chemokines are disclosed.

公开(公告)号：AU2015315294B2

公开(公告)日：2020-09-17

申请号：AU2015315294

申请日：2015-09-08

Applicant: ACADEMIA SINICA

Inventor： YU ALICE L ,  LIN KUN-HSIEN ,  WU TAI-NA ,  WONG CHI-HUEY

IPC: C07H15/18 ,  A61K39/39

Abstract: Glycosphingolipids (GSLs) compositions and methods for iNKT-independent induction of chemokines are disclosed.

公开(公告)号：AU2014317889A1

公开(公告)日：2016-03-17

申请号：AU2014317889

申请日：2014-09-08

Applicant: ACADEMIA SINICA

Inventor： WONG CHI-HUEY ,  YU ALICE L ,  LIN KUN-HSIEN ,  WU TAI-NA

IPC: A61K35/14 ,  A61K31/7012 ,  A61K31/739

Abstract: Glycosphingolipids (GSLs) bearing α-glucose (α-Glc) that preferentially stimulate human invariant NKT (iNKT) cells are provided. GSLs with α-glucose (α-Glc) that exhibit stronger induction in humans (but weaker in mice) of cytokines and chemokines and expansion and/or activation of immune cells than those with α-galactose (α-Gal) are disclosed. GSLs bearing α-glucose (α-Glc) and derivatives of α-Glc with F at the 4 and/or 6 positions are provided. Methods for iNKT-independent induction of chemokines by the GSL with α-Glc and derivatives thereof are disclosed. Methods for immune stimulation in humans using GSLs with α-Glc and derivatives thereof are provided.

公开(公告)号：AU2014317889B2

公开(公告)日：2020-03-05

申请号：AU2014317889

申请日：2014-09-08

Applicant: ACADEMIA SINICA

Inventor： WONG CHI-HUEY ,  YU ALICE L ,  LIN KUN-HSIEN ,  WU TAI-NA

IPC: A61K35/14 ,  A61K31/7012 ,  A61K31/739

Abstract: Glycosphingolipids (GSLs) bearing α-glucose (α-Glc) that preferentially stimulate human invariant NKT (iNKT) cells are provided. GSLs with α-glucose (α-Glc) that exhibit stronger induction in humans (but weaker in mice) of cytokines and chemokines and expansion and/or activation of immune cells than those with α-galactose (α-Gal) are disclosed. GSLs bearing α-glucose (α-Glc) and derivatives of α-Glc with F at the 4 and/or 6 positions are provided. Methods for iNKT-independent induction of chemokines by the GSL with α-Glc and derivatives thereof are disclosed. Methods for immune stimulation in humans using GSLs with α-Glc and derivatives thereof are provided.

公开(公告)号：AU2015315294A1

公开(公告)日：2017-04-06

申请号：AU2015315294

申请日：2015-09-08

Applicant: ACADEMIA SINICA

Inventor： YU ALICE L ,  LIN KUN-HSIEN ,  WU TAI-NA ,  WONG CHI-HUEY

IPC: C07H15/18 ,  A61K39/39

Abstract: Glycosphingolipids (GSLs) compositions and methods for iNKT-independent induction of chemokines are disclosed.

公开(公告)号：CA2960712A1

公开(公告)日：2016-03-17

申请号：CA2960712

申请日：2015-09-08

Applicant: ACADEMIA SINICA

Inventor： WONG CHI-HUEY ,  YU ALICE L ,  LIN KUN-HSIEN ,  WU TAI-NA

IPC: C07H15/18 ,  A61K39/39

Abstract: Glycosphingolipids (GSLs) compositions and methods for iNKT-independent induction of chemokines are disclosed.

公开(公告)号：CA2923579A1

公开(公告)日：2015-03-12

申请号：CA2923579

申请日：2014-09-08

Applicant: ACADEMIA SINICA

Inventor： WONG CHI-HUEY ,  YU ALICE L ,  LIN KUN-HSIEN ,  WU TAI-NA

IPC: A61K39/39 ,  A61P35/00 ,  A61P37/04

Abstract: Glycosphingolipids (GSLs) bearing a-glucose (a-Glc) that preferentially stimulate human invariant NKT (iNKT) cells are provided. GSLs with a-glucose (a-Glc) that exhibit stronger induction in humans (but weaker in mice) of cytokines and chemokines and expansion and/or activation of immune cells than those with a-galactose (a-Gal) are disclosed. GSLs bearing a-glucose (a-Glc) and derivatives of a-Glc with F at the 4 and/or 6 positions are provided. Methods for iNKT-independent induction of chemokines by the GSL with a-Glc and derivatives thereof are disclosed. Methods for immune stimulation in humans using GSLs with a-Glc and derivatives thereof are provided.