公开(公告)号：WO2010005735A3

公开(公告)日：2010-03-18

申请号：PCT/US2009047537

申请日：2009-06-16

Applicant: ACADEMIA SINICA ,  YU ALICE L ,  YU JOHN ,  WONG CHI-HUEY

Inventor： YU ALICE L ,  YU JOHN ,  WONG CHI-HUEY

IPC: A61K31/716 ,  A61K31/164 ,  A61K31/7008 ,  A61P35/00

CPC classification number: A61K39/0011 ,  A61K2039/55511 ,  A61K2039/6037 ,  A61K2039/6081 ,  A61K2039/627 ,  C12N15/1137 ,  C12N2310/14

Abstract: An immune composition containing Globo H or its fragment (e.g., SSEA3) and an adjuvant, e.g., a -GalCer, for eliciting immune responses against Globo H or its fragment and uses thereof in cancer treatment. Also disclosed is a method of treating cancer by inhibiting the activity of one of FUT1 and FUT2, both of which involve in Globo H biosynthesis.

Abstract translation: 包含Globo H或其片段（例如SSEA3）和佐剂（例如，-GalCer）的免疫组合物，用于引发针对Globo H或其片段的免疫应答及其在癌症治疗中的用途。 还公开了通过抑制FUT1和FUT2之一的活性来治疗癌症的方法，两者都涉及Globo H生物合成。

公开(公告)号：WO2010014975A3

公开(公告)日：2010-05-06

申请号：PCT/US2009052550

申请日：2009-08-03

Applicant: ACADEMIA SINICA ,  YU ALICE L ,  LIN YOU-CHIN ,  LIN RUEY-JEN

Inventor： YU ALICE L ,  LIN YOU-CHIN ,  LIN RUEY-JEN

IPC: C12Q1/68 ,  A61P35/00 ,  C12N15/10

CPC classification number: C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/178

Abstract: Methods for assessing the risk level or survival/death probability of a neuroblastoma patient based on a number of microRNA signatures, optionally in combination with Dicer, Drosha, and age at diagnosis. Also disclosed herein is use of Dicer, Drosha, or both in suppressing neuroblastoma cell growth

Abstract translation: 基于许多微小RNA标记来评估神经母细胞瘤患者的风险水平或存活/死亡概率的方法，任选地与Dicer，Drosha和诊断年龄组合。 本文还公开了使用Dicer，Drosha或两者来抑制神经母细胞瘤细胞生长

公开(公告)号：AU2014317889B2

公开(公告)日：2020-03-05

申请号：AU2014317889

申请日：2014-09-08

Applicant: ACADEMIA SINICA

Inventor： WONG CHI-HUEY ,  YU ALICE L ,  LIN KUN-HSIEN ,  WU TAI-NA

IPC: A61K35/14 ,  A61K31/7012 ,  A61K31/739

Abstract: Glycosphingolipids (GSLs) bearing α-glucose (α-Glc) that preferentially stimulate human invariant NKT (iNKT) cells are provided. GSLs with α-glucose (α-Glc) that exhibit stronger induction in humans (but weaker in mice) of cytokines and chemokines and expansion and/or activation of immune cells than those with α-galactose (α-Gal) are disclosed. GSLs bearing α-glucose (α-Glc) and derivatives of α-Glc with F at the 4 and/or 6 positions are provided. Methods for iNKT-independent induction of chemokines by the GSL with α-Glc and derivatives thereof are disclosed. Methods for immune stimulation in humans using GSLs with α-Glc and derivatives thereof are provided.

公开(公告)号：AU2015315294A1

公开(公告)日：2017-04-06

申请号：AU2015315294

申请日：2015-09-08

Applicant: ACADEMIA SINICA

Inventor： YU ALICE L ,  LIN KUN-HSIEN ,  WU TAI-NA ,  WONG CHI-HUEY

IPC: C07H15/18 ,  A61K39/39

Abstract: Glycosphingolipids (GSLs) compositions and methods for iNKT-independent induction of chemokines are disclosed.

公开(公告)号：CA2960712A1

公开(公告)日：2016-03-17

申请号：CA2960712

申请日：2015-09-08

Applicant: ACADEMIA SINICA

Inventor： WONG CHI-HUEY ,  YU ALICE L ,  LIN KUN-HSIEN ,  WU TAI-NA

IPC: C07H15/18 ,  A61K39/39

Abstract: Glycosphingolipids (GSLs) compositions and methods for iNKT-independent induction of chemokines are disclosed.

公开(公告)号：CA2923579A1

公开(公告)日：2015-03-12

申请号：CA2923579

申请日：2014-09-08

Applicant: ACADEMIA SINICA

Inventor： WONG CHI-HUEY ,  YU ALICE L ,  LIN KUN-HSIEN ,  WU TAI-NA

IPC: A61K39/39 ,  A61P35/00 ,  A61P37/04

Abstract: Glycosphingolipids (GSLs) bearing a-glucose (a-Glc) that preferentially stimulate human invariant NKT (iNKT) cells are provided. GSLs with a-glucose (a-Glc) that exhibit stronger induction in humans (but weaker in mice) of cytokines and chemokines and expansion and/or activation of immune cells than those with a-galactose (a-Gal) are disclosed. GSLs bearing a-glucose (a-Glc) and derivatives of a-Glc with F at the 4 and/or 6 positions are provided. Methods for iNKT-independent induction of chemokines by the GSL with a-Glc and derivatives thereof are disclosed. Methods for immune stimulation in humans using GSLs with a-Glc and derivatives thereof are provided.

公开(公告)号：HK1153273A1

公开(公告)日：2012-03-23

申请号：HK11107458

申请日：2011-07-18

Applicant: ACADEMIA SINICA

Inventor： WONG CHI-HUEY ,  WU CHUNG-YI ,  WANG CHENG-CHI ,  YU ALICE L

IPC: G01N20060101

Abstract: A cancer diagnostic method using a glycan array that contains Gb5 and Globo H, Bb2, Bb3, and/or Bb4.

公开(公告)号：AU2014388315A1

公开(公告)日：2016-11-17

申请号：AU2014388315

申请日：2014-10-28

Applicant: ACADEMIA SINICA ,  CHANG GUNG MEMORIAL HOSPITAL ,  DCB USA LLC ,  DEV CT BIOTECHNOLOGY

Inventor： YU ALICE L ,  YU JOHN ,  WANG YA-HUI ,  HSU CHUAN-LUNG ,  CHEN YI-CHANG ,  LOK YING-YUNG

IPC: G01N33/574

Abstract: An antibody against transmembrane coiled-coil domains protein 3 (TMCC3), or a binding fragment thereof, includes the CDR sequences set forth in the specification. A method for treating cancer includes administering to a subject in need thereof an antibody against a transmembrane coiled-coil domains protein 3 (TMCC3). The antibody binds to an epitope in an intercoil domain of TMCC3. A method of diagnosing or assessing a cancer condition includes assessing a level of expression or activity of a transmembrane coiled- coil domains protein 3 (TMCC3) in a sample, wherein an increase in the level of expression of activity of TMCC3 as compared to a standard indicates the presence of cancer stem cells in the sample.

公开(公告)号：ES2477549T3

公开(公告)日：2014-07-17

申请号：ES09798419

申请日：2009-06-16

Applicant: ACADEMIA SINICA

Inventor： WONG CHI-HUEY ,  WU CHUNG-YI ,  WANG CHENG-CHI ,  YU ALICE L

IPC: G01N33/574 ,  G01N33/53

Abstract: Procedimiento diagnóstico de cáncer para los cánceres que son positivos para Globo H y positivos para Gb5, que comprende el suministro de una muestra que contiene anticuerpos de un sujeto del cual se sospecha que tiene cáncer, en donde dicha muestra es suero, saliva o líquido de ganglio linfático, la incubación de la muestra con Gb5 y uno o varios de Globo H, Bb2 y Bb3 para permitir que los anticuerpos de la muestra se fijen a Gb5 y a uno o varios de Globo H, Bb2 y Bb3, la medición de la cantidad de anticuerpos fijados a Gb5 y la cantidad de anticuerpos fijados a Globo H, a Bb2 o a Bb3, y la determinación de si el sujeto tiene el cáncer basándose en la cantidad de los anticuerpos fijados, en donde una proporción significativamente más alta de la cantidad de anticuerpos fijados a Globo H, Bb2 o Bb3 por la cantidad de anticuerpos fijados a Gb5, en comparación con la del sujeto sin cáncer, indica que el sujeto tiene un cáncer que es positivo para Globo H y positivo para Gb5.

公开(公告)号：AU2009271411B2

公开(公告)日：2013-02-07

申请号：AU2009271411

申请日：2009-06-16

Applicant: ACADEMIA SINICA

Inventor： WANG CHENG-CHI ,  WU CHUNG-YI ,  WONG CHI-HUEY ,  YU ALICE L

IPC: G01N33/574 ,  G01N33/53

Abstract: A cancer diagnostic method using a glycan array that contains Gb5 and Globo H, Bb2, Bb3, and/or Bb4.