公开(公告)号：AU753307B2

公开(公告)日：2002-10-17

申请号：AU9472198

申请日：1998-09-15

Applicant: ACLARA BIOSCIENCES INC

Inventor： BJORNSON TORLEIF OVE ,  MCCORMICK RANDY M ,  SOANE DAVID S

IPC: G01N31/20 ,  B01J19/00 ,  C40B60/14 ,  G01N27/447 ,  G01N35/00 ,  G01N27/26

公开(公告)号：AU744879B2

公开(公告)日：2002-03-07

申请号：AU9375498

申请日：1998-09-15

Applicant: ACLARA BIOSCIENCES INC

Inventor： BJORNSON TORLEIF OVE ,  SMITH TIMOTHY F

IPC: G01N31/20 ,  B01D57/02 ,  B01J4/00 ,  B01J19/00 ,  B01L3/02 ,  C12N15/09 ,  C40B60/14 ,  G01N1/00 ,  G01N35/10 ,  G01N37/00 ,  G01N1/10

Abstract: The present invention concerns devices, apparatus and methods for transferring liquids. One aspect of the present invention is a device comprising a plate having a plurality of transfer elements. Each of the transfer elements comprises an aperture in the plate where the aperture is capable of being electrically activated. The plate has one of more attaching elements for attaching the plate to a multiwell plate to form a sealed system except for the apertures of the transfer elements. Usually, the device is adapted for sealing attachment to a multiwell plate. In a method in accordance with the present invention a quantity of liquid is disposed to a second side of a plate having a plurality of apertures in the plate. The apertures are capable of being electrically activated. The liquid is present in a closed well except for the apertures in the plate. To simultaneously expel liquid from the apertures, the apertures are electrically activated. Also disclosed are kits comprising a device in accordance with the present invention.

公开(公告)号：AU9375498A

公开(公告)日：1999-04-12

申请号：AU9375498

申请日：1998-09-15

Applicant: ACLARA BIOSCIENCES INC

Inventor： BJORNSON TORLEIF OVE ,  SMITH TIMOTHY F

IPC: G01N31/20 ,  B01D57/02 ,  B01J4/00 ,  B01J19/00 ,  B01L3/02 ,  C12N15/09 ,  C40B60/14 ,  G01N1/00 ,  G01N35/10 ,  G01N37/00 ,  G01N1/10

Abstract: The present invention concerns devices, apparatus and methods for transferring liquids. One aspect of the present invention is a device comprising a plate having a plurality of transfer elements. Each of the transfer elements comprises an aperture in the plate where the aperture is capable of being electrically activated. The plate has one of more attaching elements for attaching the plate to a multiwell plate to form a sealed system except for the apertures of the transfer elements. Usually, the device is adapted for sealing attachment to a multiwell plate. In a method in accordance with the present invention a quantity of liquid is disposed to a second side of a plate having a plurality of apertures in the plate. The apertures are capable of being electrically activated. The liquid is present in a closed well except for the apertures in the plate. To simultaneously expel liquid from the apertures, the apertures are electrically activated. Also disclosed are kits comprising a device in accordance with the present invention.

公开(公告)号：AU6176701A

公开(公告)日：2001-12-03

申请号：AU6176701

申请日：2001-05-17

Applicant: ACLARA BIOSCIENCES INC

Inventor： MAHER KEVIN ,  BJORNSON TORLEIF OVE

IPC: G01B11/00 ,  G01B11/03 ,  G01N21/47 ,  G01N21/64 ,  G01N27/447 ,  G01N21/00

Abstract: The present invention provides for methods and apparatus for locating a capillary channel that is disposed within a lab chip. The method provides for scanning the channel with a light source, monitoring the resulting light at the edges of the lab chip, and interpreting this information whereby the light detected at the edges of the lab chip can be used as a means for characterizing the location of the side walls of the channel within the lab chip. The apparatus provides for a carriage system to which a light source and the lab chip are attached. It also provides for one or more scatter detectors directed towards the edges of the chip and connected to a computer processor for purposes of analysis.

公开(公告)号：CA2306126A1

公开(公告)日：1999-04-22

申请号：CA2306126

申请日：1998-10-15

Applicant: ACLARA BIOSCIENCES INC

Inventor： BJORNSON TORLEIF OVE ,  SHEA LAURENCE R

IPC: B01L3/00 ,  G01N27/447 ,  G01N37/00 ,  B81B1/00 ,  G01N35/00

Abstract: A continuous form microstructure array device (20) is constructed as a flexible elongate film laminate containing microstructure arrays (26) arranged serially along the laminate. The laminate can be continuously drawn from a roll, passed through a processing and analysis device and rerolled or stacked for storage.

公开(公告)号：CA2301557A1

公开(公告)日：1999-04-01

申请号：CA2301557

申请日：1998-09-15

Applicant: ACLARA BIOSCIENCES INC

Inventor： SMITH TIMOTHY F ,  BJORNSON TORLEIF OVE

IPC: G01N31/20 ,  B01D57/02 ,  B01J4/00 ,  B01J19/00 ,  B01L3/02 ,  C12N15/09 ,  C40B60/14 ,  G01N1/00 ,  G01N35/10 ,  G01N37/00 ,  G01N1/10

Abstract: The present invention concerns devices, apparatus and methods for transferring liquids. One aspect of the present invention is a device comprising a plate having a plurality of transfer elements. Each of the transfer elements comprises an aperture in the plate where the aperture is capable of being electrically activated. The plate has one or more attaching elements for attaching the plate to a multiwell plate to form a sealed system except for the apertures of the transfer elements. Usually, the device is adapted for sealing attachment to a multiwell plate. In a method in accordance with the present invention, a quantity of liquid is disposed to a second side of a plate having a plurality of apertures in the plate. The apertures are capable of being electrically activated. The liquid is present in a closed well except for the apertures in the plate. To simultaneously expel liquid from the apertures, the apertures are electrically activated. Also disclosed are kits comprising a device in accordance with the present invention.

公开(公告)号：AU1517999A

公开(公告)日：1999-05-03

申请号：AU1517999

申请日：1998-10-15

Applicant: ACLARA BIOSCIENCES INC

Inventor： BJORNSON TORLEIF OVE ,  SHEA LAURENCE R

IPC: B01L3/00 ,  G01N27/447 ,  G01N37/00 ,  G01N25/22

Abstract: A continuous form microstructure array device is constructed as a flexible elongate film laminate containing a plurality of microstructures or arrays of microstructures arranged serially lengthwise along the laminate. The laminate can be continuously drawn from a supply roll or stack, advanced within an analytic device and, when analysis is complete, taken up in a storage roll or stack. The device provides for high throughput microfluidic processing.

公开(公告)号：AU9472198A

公开(公告)日：1999-04-12

申请号：AU9472198

申请日：1998-09-15

Applicant: ACLARA BIOSCIENCES INC

Inventor： BJORNSON TORLEIF OVE ,  MCCORMICK RANDY M ,  SOANE DAVID S

IPC: G01N31/20 ,  B01J19/00 ,  C40B60/14 ,  G01N27/447 ,  G01N35/00 ,  G01N27/26

公开(公告)号：DE60134849D1

公开(公告)日：2008-08-28

申请号：DE60134849

申请日：2001-05-17

Applicant: ACLARA BIOSCIENCES INC

Inventor： MAHER KEVIN ,  BJORNSON TORLEIF OVE

IPC: G01B11/00 ,  G01N21/47 ,  G01B11/03 ,  G01N21/64 ,  G01N27/447

Abstract: The present invention provides for methods and apparatus for locating a capillary channel that is disposed within a lab chip. The method provides for scanning the channel with a light source, monitoring the resulting light at the edges of the lab chip, and interpreting this information whereby the light detected at the edges of the lab chip can be used as a means for characterizing the location of the side walls of the channel within the lab chip. The apparatus provides for a carriage system to which a light source and the lab chip are attached. It also provides for one or more scatter detectors directed towards the edges of the chip and connected to a computer processor for purposes of analysis.

公开(公告)号：CA2301592A1

公开(公告)日：1999-04-01

申请号：CA2301592

申请日：1998-09-15

Applicant: ACLARA BIOSCIENCES INC

Inventor： MCCORMICK RANDY M ,  BJORNSON TORLEIF OVE ,  SOANE DAVID S

IPC: G01N31/20 ,  B01J19/00 ,  C40B60/14 ,  G01N27/447 ,  G01N35/00 ,  G01N35/10

Abstract: The present invention concerns an apparatus for conducting a microfluidic process. The apparatus comprises integral first and second plates (100, 110). The first plate (100) comprises an array of sample receiving elements (102) for receiving a plurality of samples from an array of sample containers and dispensing the samples. The second plate (110) comprises a planar array of microfluidic networks of cavity structures and channels for conducting a microfluidic process. Also disclosed is a method for processing an array of samples. At least a portion of each sample in an array of sample wells is simultaneously transferred to a corresponding array of microfluidic networks of cavity structures and channels by means of a corresponding array of sample receiving elements that is in integral fluid communication with the array of microfluidic networks. The samples are then processed. Also disclosed is a device for conducting a microfluidic process wherein the device comprising a planar substrate having a planar array of microfluidic networks of cavity structures and channels for conducting a microfluidic process. A plurality of such devices may be present on a continuous sheet. The invention further includes kits for carrying out microfluidic processes comprising an apparatus as described above.