CAPILLARY ELECTROFLOW APPARATUS AND METHOD

    公开(公告)号:CA2301592A1

    公开(公告)日:1999-04-01

    申请号:CA2301592

    申请日:1998-09-15

    Abstract: The present invention concerns an apparatus for conducting a microfluidic process. The apparatus comprises integral first and second plates (100, 110). The first plate (100) comprises an array of sample receiving elements (102) for receiving a plurality of samples from an array of sample containers and dispensing the samples. The second plate (110) comprises a planar array of microfluidic networks of cavity structures and channels for conducting a microfluidic process. Also disclosed is a method for processing an array of samples. At least a portion of each sample in an array of sample wells is simultaneously transferred to a corresponding array of microfluidic networks of cavity structures and channels by means of a corresponding array of sample receiving elements that is in integral fluid communication with the array of microfluidic networks. The samples are then processed. Also disclosed is a device for conducting a microfluidic process wherein the device comprising a planar substrate having a planar array of microfluidic networks of cavity structures and channels for conducting a microfluidic process. A plurality of such devices may be present on a continuous sheet. The invention further includes kits for carrying out microfluidic processes comprising an apparatus as described above.

    CAPILLARY ELECTROFLOW APPARATUS AND METHOD
    5.
    发明公开
    CAPILLARY ELECTROFLOW APPARATUS AND METHOD 审中-公开
    VORRICHTUNG UND VERFAHREN ZURKAPILLARSTRÖMUNGMIT EINEM ELEKTRISCHEN FELD

    公开(公告)号:EP1019712A4

    公开(公告)日:2002-08-07

    申请号:EP98948072

    申请日:1998-09-15

    Abstract: The present invention concerns an apparatus for conducting a microfluidic process. The apparatus comprises integral first and second plates (100, 110). The first plate (100) comprises an array of sample receiving elements (102) for receiving a plurality of samples from an array of sample containers and dispensing the samples. The second plate (110) comprises a planar array of microfluidic networks of cavity structures and channels for conducting a microfluidic process. Also disclosed is a method for processing an array of samples. At least a portion of each sample in an array of sample wells is simultaneously transferred to a corresponding array of microfluidic networks of cavity structures and channels by means of a corresponding array of sample receiving elements that is in integral fluid communication with the array of microfluidic networks. The samples are then processed. Also disclosed is a device for conducting a microfluidic process wherein the device comprising a planar substrate having a planar array of microfluidic networks of cavity structures and channels for conducting a microfluidic process. A plurality of such devices may be present on a continuous sheet. The invention further includes kits for carrying out microfluidic processes comprising an apparatus as described above.

    Abstract translation: 本发明涉及用于进行微流体过程的设备。 该设备包括整体的第一和第二板(100,110)。 第一板(100)包括样品接收元件(102)的阵列,用于接收来自样品容器阵列的多个样品并分配样品。 第二板(110)包括用于进行微流体过程的空腔结构和通道的微流体网络的平面阵列。 还公开了用于处理样本阵列的方法。 样品孔阵列中的每个样品的至少一部分借助与微流体网络阵列整体流体连通的样品接收元件的对应阵列被同时转移到腔结构和通道的微流体网络的对应阵列 。 然后处理样本。 还公开了一种用于进行微流体过程的装置,其中该装置包括平面基底,该平面基底具有用于进行微流体过程的腔体结构和通道的微流体网络的平面阵列。 多个这样的装置可以存在于连续片材上。 本发明进一步包括用于执行包括如上所述的装置的微流体过程的试剂盒。

    METHOD FOR SAMPLE INJECTION IN MICROCHANNEL DEVICE
    6.
    发明公开
    METHOD FOR SAMPLE INJECTION IN MICROCHANNEL DEVICE 失效
    方法PROBENEINPRITZUNG在微通道设备

    公开(公告)号:EP1021707A4

    公开(公告)日:2002-09-18

    申请号:EP98931345

    申请日:1998-06-17

    Abstract: A method and device are provided for transporting a liquid sample into a third microchannel (13) from an intersection (5) of at least a first microchannel (11), a second microchannel (12), and a fourth microchannel (14), by stages. In a first stage, liquid sample is moved in and from the fourth microchannel through the intersection and into the second microchannel and concurrently carrier liquid is moved in and from the first and third microchannels through the intersection and into the second microchannel. Thereafter in a second stage, at least part of the contents of the intersection is moved into the third channel and concurrently a part of the contents of the second and fourth microchannels is moved through the intersection and into the third microchannel. Thereafter in a third stage, carrier liquid is moved from the first microchannel simultaneously through the intersection and into the second, third, and fourth microchannels. In some embodiments the liquid sample and the carrier liquid are moved electrokinetically, that is, by application of an electric field to segments of the microchannels.

    SURFACE MODIFIED ELECTROPHORETIC CHAMBERS
    7.
    发明公开
    SURFACE MODIFIED ELECTROPHORETIC CHAMBERS 失效
    电泳钱伯斯改性表面。

    公开(公告)号:EP0927352A4

    公开(公告)日:2002-06-12

    申请号:EP97942670

    申请日:1997-09-18

    CPC classification number: G01N27/44704 G01N27/44752

    Abstract: Electrophoretic chambers having at least a region of surface modification, and methods for their fabrication, are provided. In some embodiments the subject chambers include in the region of surface modification an anchoring polymeric layer interpenetrating the surface of the chamber and an electrophoretic polymeric layer copolymerized with the anchoring polymeric layer. The subject chambers are prepared by sequentially contacting the chamber surface with a first monomer capable of interpenetrating the surface and a second monomer capable of copolymerization with the first monomer, followed by copolymerization of the first and second monomers. In other embodiments an electrophoretic polymeric layer is noncovalently bound on the surface of a rigid polymeric base material without the aid of a separate anchoring polymeric layer. The subject devices find use in any of a variety of electrophoretic applications in which entities are moved through a medium under the influence of an applied electric field.

Patent Agency Ranking