公开(公告)号：HK1222137A1

公开(公告)日：2017-06-23

申请号：HK16110377

申请日：2016-09-01

Applicant: THE CHEMO-SERO-THERAPEUTIC RES INST ,  NAT UNIV CORP TOKYO MEDICAL AND ,  UNIV SAPPORO MEDICAL ,  ADEKA CORP

Inventor： MATSUDA JUNICHI ,  MIYABASHIRA SUMIKA ,  HARANO SATOMI ,  KISHIDA AKIO ,  KIMURA TSUYOSHI ,  NEGISHI JUN ,  HIGAMI TETSUYA ,  FUNAMOTO SEIICHI ,  HIWATARI KEN-ICHIRO ,  TASAKI AKIKO

IPC: A61L20060101 ,  A61K20060101 ,  A61P20060101

公开(公告)号：CA2911592C

公开(公告)日：2021-10-26

申请号：CA2911592

申请日：2014-05-02

Applicant: THE CHEMO SERO THERAPEUTIC RES INSTITUTE ,  UNIV NAT CORP TOKYO MEDICAL & DENTAL ,  UNIV SAPPORO MEDICAL ,  ADEKA CORP

Inventor： MATSUDA JUNICHI ,  MIYABASHIRA SUMIKA ,  HARANO SATOMI ,  KISHIDA AKIO ,  KIMURA TSUYOSHI ,  NEGISHI JUN ,  HIGAMI TETSUYA ,  FUNAMOTO SEIICHI ,  HIWATARI KEN-ICHIRO ,  TASAKI AKIKO

IPC: A61L27/00 ,  A61K9/06 ,  A61K35/12 ,  A61K35/28 ,  A61K35/30 ,  A61K35/34 ,  A61K35/407 ,  A61K35/42 ,  A61K38/43 ,  A61K38/48 ,  A61P9/10

Abstract: A hybrid gel comprising a particulate decellularized tissue obtained by pulverizing animal-derived biological tissues that are decellularized (decellularized biological tissues), fibrinogen and thrombin; a cell culture material comprising the hybrid gel; a method for preparing the hybrid gel; and a kit comprising a particulate decellularized tissue and a biological tissue adhesive are provided. The hybrid gel may exert the effect to promote differentiation and gain of function of stem cells and the therapeutic effect to a variety of diseases.

公开(公告)号：CA2911592A1

公开(公告)日：2014-11-13

申请号：CA2911592

申请日：2014-05-02

Applicant: CHEMO SERO THERAPEUT RES INST ,  NAT UNIV CORP TOKYO MED & DENT ,  UNIV SAPPORO MEDICAL ,  ADEKA CORP

Inventor： MATSUDA JUNICHI ,  MIYABASHIRA SUMIKA ,  HARANO SATOMI ,  KISHIDA AKIO ,  KIMURA TSUYOSHI ,  NEGISHI JUN ,  HIGAMI TETSUYA ,  FUNAMOTO SEIICHI ,  HIWATARI KEN-ICHIRO ,  TASAKI AKIKO

IPC: A61L27/00 ,  A61K9/06 ,  A61K35/12 ,  A61K35/28 ,  A61K35/30 ,  A61K35/34 ,  A61K35/407 ,  A61K35/42 ,  A61K38/43 ,  A61K38/48 ,  A61P9/10

Abstract: Provided are: a hybrid gel that contains a particulate decellularized tissue (a product prepared by grinding a decellularized biological tissue that is obtained by decellularizing a biological tissue derived from an animal), fibrinogen and thrombin; a cell culture base material containing the hybrid gel; a method for preparing the hybrid gel; and a kit containing a particulate decellularized tissue and an adhesive for biological tissues. The hybrid gel according to the present invention has an effect of promoting the differentiation and function acquisition of stem cells and therapeutic effects on various diseases.

公开(公告)号：CA2978401C

公开(公告)日：2022-04-12

申请号：CA2978401

申请日：2016-03-07

Applicant: THE CHEMO SERO THERAPEUTIC RES INSTITUTE ,  ADEKA CORP ,  UNIV NAT CORP TOKYO MEDICAL & DENTAL ,  UNIV SAPPORO MEDICAL

Inventor： UCHIDA TAKANORI ,  SAGA HIDEKI ,  TOKOROZAKI SHOKO ,  HIWATARI KEN-ICHIRO ,  OBARA HARUKI ,  KISHIDA AKIO ,  KIMURA TSUYOSHI ,  NEGISHI JUN ,  HIGAMI TETSUYA ,  FUNAMOTO SEIICHI

IPC: A61L31/00

Abstract: An anti-adhesion material comprising a decellularized tissue and a biocompatible polymer or fibrin glue; a method for producing an anti-adhesion material, comprising applying a biocompatible polymer or fibrin glue to a decellularized tissue; an anti-adhesion material kit comprising a decellularized tissue and a biocompatible polymer or fibrin glue; an artificial biological membrane comprising a decellularized tissue and a biocompatible polymer or fibrin glue; a method for producing an artificial biological membrane, comprising applying a biocompatible polymer or fibrin glue to a decellularized tissue; and an artificial biological membrane kit comprising a decellularized tissue and a biocompatible polymer or fibrin glue.

公开(公告)号：CA3065498A1

公开(公告)日：2018-12-06

申请号：CA3065498

申请日：2018-05-25

Applicant: ADEKA CORP

Inventor： HIGAMI TETSUYA ,  HIWATARI KENICHIRO ,  YAMAGUCHI YU ,  OBARA HARUKI ,  KIMURA TAKUYA ,  HOMMA MITSUMASA ,  OCHIAI KYOHEI ,  KINOSHITA KEITA ,  MORIMOTO NAOKI

IPC: A61L27/36 ,  A61F2/06

Abstract: The purpose of the present invention is to provide a method for producing a decellularized material for transplantation that can be used in a graft composition and minimizes the portion sutured by thread. To achieve the above purpose, the present invention provides a method for producing a decellularized material for transplantation that includes (a) a step for collecting a branched blood vessel from a vertebrate animal (donor), (b) a step for decellularizing the blood vessel, and (c) a step for adhering the portion from which the branch has been excised by protein denaturation treatment and closing the vessel. The present invention also provides a graft composition comprising a biocompatible material that includes the decellularized material for transplantation.

公开(公告)号：CA2978401A1

公开(公告)日：2016-09-15

申请号：CA2978401

申请日：2016-03-07

Applicant: THE CHEMO-SERO-THERAPEUTIC RES INST ,  ADEKA CORP ,  NAT UNIV CORP TOKYO MEDICAL & DENTAL UNIV ,  UNIV SAPPORO MEDICAL

Inventor： SAGA HIDEKI ,  UCHIDA TAKANORI ,  TOKOROZAKI SHOKO ,  HIWATARI KEN-ICHIRO ,  OBARA HARUKI ,  KISHIDA AKIO ,  KIMURA TSUYOSHI ,  NEGISHI JUN ,  HIGAMI TETSUYA ,  FUNAMOTO SEIICHI

IPC: A61L31/00

Abstract: An anti-adhesion material comprising a decellularized tissue and a biocompatible polymer or fibrin glue; a method for producing an anti-adhesion material, comprising applying a biocompatible polymer or fibrin glue to a decellularized tissue; an anti-adhesion material kit comprising a decellularized tissue and a biocompatible polymer or fibrin glue; an artificial biological membrane comprising a decellularized tissue and a biocompatible polymer or fibrin glue; a method for producing an artificial biological membrane, comprising applying a biocompatible polymer or fibrin glue to a decellularized tissue; and an artificial biological membrane kit comprising a decellularized tissue and a biocompatible polymer or fibrin glue.

公开(公告)号：EP2995326A4

公开(公告)日：2017-01-11

申请号：EP14795291

申请日：2014-05-02

Applicant: THE CHEMO-SERO-THERAPEUTIC RES INST ,  NAT UNIV CORP TOKYO MEDICAL & DENTAL UNIV ,  UNIV SAPPORO MEDICAL ,  ADEKA CORP

Inventor： MATSUDA JUNICHI ,  MIYABASHIRA SUMIKA ,  HARANO SATOMI ,  KISHIDA AKIO ,  KIMURA TSUYOSHI ,  NEGISHI JUN ,  HIGAMI TETSUYA ,  FUNAMOTO SEIICHI ,  HIWATARI KEN-ICHIRO ,  TASAKI AKIKO

IPC: A61L27/00 ,  A61K9/06 ,  A61K35/12 ,  A61K35/28 ,  A61K35/30 ,  A61K35/34 ,  A61K35/407 ,  A61K35/42 ,  A61K38/43 ,  A61K38/48 ,  A61P9/10

CPC classification number: A61L27/52 ,  A61K35/22 ,  A61K35/30 ,  A61K35/34 ,  A61K35/407 ,  A61K35/42 ,  A61K38/363 ,  A61K38/4833 ,  A61L27/225 ,  A61L27/26 ,  A61L27/3633 ,  A61L27/3683 ,  A61L27/3691 ,  A61L27/3695 ,  A61L27/54 ,  A61L2430/00 ,  A61L2430/20 ,  A61L2430/32 ,  C12N5/0068 ,  C12N2533/50 ,  C12N2533/56 ,  C12N2533/90

Abstract: A hybrid gel comprising a particulate decellularized tissue (obtained by pulverizing animal-derived biological tissues that are decellularized (decellularized biological tissues)), fibrinogen and thrombin; a cell culture material comprising the hybrid gel; a method for preparing the hybrid gel; and a kit comprising a particulate decellularized tissue and a biological tissue adhesive are provided. The hybrid gel of the present invention exerts the effect to promote differentiation and gain of function of stem cells and the therapeutic effect to a variety of diseases.

Abstract translation: 一种混合凝胶，其包含颗粒脱细胞组织（通过粉碎去细胞化的（来自细胞的生物组织）的动物衍生的生物组织），纤维蛋白原和凝血酶获得; 包含该混合凝胶的细胞培养物质; 制备混合凝胶的方法; 并提供了包含颗粒脱细胞组织和生物组织粘合剂的试剂盒。 本发明的混合凝胶发挥促进干细胞分化和功能增强的效果以及对各种疾病的治疗效果。