公开(公告)号：CA2977462A1

公开(公告)日：2016-09-01

申请号：CA2977462

申请日：2016-02-19

Applicant: ADEKA CORP

Inventor： NEGISHI JUN ,  HIWATARI KEN-ICHIRO ,  OCHIAI KYOHEI

IPC: A61L27/00 ,  A61K35/12 ,  A61P43/00

Abstract: The present invention addresses the problem of providing a decellularized tissue having excellent cell adhesion properties. Provided is a decellularized tissue prepared by decellularizing a biological tissue, said decellularized tissue being characterized in that the ratio of endothermic energy amount, in terms of dry mass, of the decellularized tissue to the biological tissue before the decellularization is 0.70 or greater when measured by differential scanning calorimetry. The ratio by mass of DNA amount, in terms of dry mass, of the decellularized tissue to the biological tissue before the decellularization may be 0.300 or smaller.

公开(公告)号：HK1222137A1

公开(公告)日：2017-06-23

申请号：HK16110377

申请日：2016-09-01

Applicant: THE CHEMO-SERO-THERAPEUTIC RES INST ,  NAT UNIV CORP TOKYO MEDICAL AND ,  UNIV SAPPORO MEDICAL ,  ADEKA CORP

Inventor： MATSUDA JUNICHI ,  MIYABASHIRA SUMIKA ,  HARANO SATOMI ,  KISHIDA AKIO ,  KIMURA TSUYOSHI ,  NEGISHI JUN ,  HIGAMI TETSUYA ,  FUNAMOTO SEIICHI ,  HIWATARI KEN-ICHIRO ,  TASAKI AKIKO

IPC: A61L20060101 ,  A61K20060101 ,  A61P20060101

公开(公告)号：CA2911592C

公开(公告)日：2021-10-26

申请号：CA2911592

申请日：2014-05-02

Applicant: THE CHEMO SERO THERAPEUTIC RES INSTITUTE ,  UNIV NAT CORP TOKYO MEDICAL & DENTAL ,  UNIV SAPPORO MEDICAL ,  ADEKA CORP

Inventor： MATSUDA JUNICHI ,  MIYABASHIRA SUMIKA ,  HARANO SATOMI ,  KISHIDA AKIO ,  KIMURA TSUYOSHI ,  NEGISHI JUN ,  HIGAMI TETSUYA ,  FUNAMOTO SEIICHI ,  HIWATARI KEN-ICHIRO ,  TASAKI AKIKO

IPC: A61L27/00 ,  A61K9/06 ,  A61K35/12 ,  A61K35/28 ,  A61K35/30 ,  A61K35/34 ,  A61K35/407 ,  A61K35/42 ,  A61K38/43 ,  A61K38/48 ,  A61P9/10

Abstract: A hybrid gel comprising a particulate decellularized tissue obtained by pulverizing animal-derived biological tissues that are decellularized (decellularized biological tissues), fibrinogen and thrombin; a cell culture material comprising the hybrid gel; a method for preparing the hybrid gel; and a kit comprising a particulate decellularized tissue and a biological tissue adhesive are provided. The hybrid gel may exert the effect to promote differentiation and gain of function of stem cells and the therapeutic effect to a variety of diseases.

公开(公告)号：CA2911592A1

公开(公告)日：2014-11-13

申请号：CA2911592

申请日：2014-05-02

Applicant: CHEMO SERO THERAPEUT RES INST ,  NAT UNIV CORP TOKYO MED & DENT ,  UNIV SAPPORO MEDICAL ,  ADEKA CORP

Inventor： MATSUDA JUNICHI ,  MIYABASHIRA SUMIKA ,  HARANO SATOMI ,  KISHIDA AKIO ,  KIMURA TSUYOSHI ,  NEGISHI JUN ,  HIGAMI TETSUYA ,  FUNAMOTO SEIICHI ,  HIWATARI KEN-ICHIRO ,  TASAKI AKIKO

IPC: A61L27/00 ,  A61K9/06 ,  A61K35/12 ,  A61K35/28 ,  A61K35/30 ,  A61K35/34 ,  A61K35/407 ,  A61K35/42 ,  A61K38/43 ,  A61K38/48 ,  A61P9/10

Abstract: Provided are: a hybrid gel that contains a particulate decellularized tissue (a product prepared by grinding a decellularized biological tissue that is obtained by decellularizing a biological tissue derived from an animal), fibrinogen and thrombin; a cell culture base material containing the hybrid gel; a method for preparing the hybrid gel; and a kit containing a particulate decellularized tissue and an adhesive for biological tissues. The hybrid gel according to the present invention has an effect of promoting the differentiation and function acquisition of stem cells and therapeutic effects on various diseases.

公开(公告)号：CA2978401C

公开(公告)日：2022-04-12

申请号：CA2978401

申请日：2016-03-07

Applicant: THE CHEMO SERO THERAPEUTIC RES INSTITUTE ,  ADEKA CORP ,  UNIV NAT CORP TOKYO MEDICAL & DENTAL ,  UNIV SAPPORO MEDICAL

Inventor： UCHIDA TAKANORI ,  SAGA HIDEKI ,  TOKOROZAKI SHOKO ,  HIWATARI KEN-ICHIRO ,  OBARA HARUKI ,  KISHIDA AKIO ,  KIMURA TSUYOSHI ,  NEGISHI JUN ,  HIGAMI TETSUYA ,  FUNAMOTO SEIICHI

IPC: A61L31/00

Abstract: An anti-adhesion material comprising a decellularized tissue and a biocompatible polymer or fibrin glue; a method for producing an anti-adhesion material, comprising applying a biocompatible polymer or fibrin glue to a decellularized tissue; an anti-adhesion material kit comprising a decellularized tissue and a biocompatible polymer or fibrin glue; an artificial biological membrane comprising a decellularized tissue and a biocompatible polymer or fibrin glue; a method for producing an artificial biological membrane, comprising applying a biocompatible polymer or fibrin glue to a decellularized tissue; and an artificial biological membrane kit comprising a decellularized tissue and a biocompatible polymer or fibrin glue.

公开(公告)号：CA2978401A1

公开(公告)日：2016-09-15

申请号：CA2978401

申请日：2016-03-07

Applicant: THE CHEMO-SERO-THERAPEUTIC RES INST ,  ADEKA CORP ,  NAT UNIV CORP TOKYO MEDICAL & DENTAL UNIV ,  UNIV SAPPORO MEDICAL

Inventor： SAGA HIDEKI ,  UCHIDA TAKANORI ,  TOKOROZAKI SHOKO ,  HIWATARI KEN-ICHIRO ,  OBARA HARUKI ,  KISHIDA AKIO ,  KIMURA TSUYOSHI ,  NEGISHI JUN ,  HIGAMI TETSUYA ,  FUNAMOTO SEIICHI

IPC: A61L31/00

Abstract: An anti-adhesion material comprising a decellularized tissue and a biocompatible polymer or fibrin glue; a method for producing an anti-adhesion material, comprising applying a biocompatible polymer or fibrin glue to a decellularized tissue; an anti-adhesion material kit comprising a decellularized tissue and a biocompatible polymer or fibrin glue; an artificial biological membrane comprising a decellularized tissue and a biocompatible polymer or fibrin glue; a method for producing an artificial biological membrane, comprising applying a biocompatible polymer or fibrin glue to a decellularized tissue; and an artificial biological membrane kit comprising a decellularized tissue and a biocompatible polymer or fibrin glue.

公开(公告)号：EP2995326A4

公开(公告)日：2017-01-11

申请号：EP14795291

申请日：2014-05-02

Applicant: THE CHEMO-SERO-THERAPEUTIC RES INST ,  NAT UNIV CORP TOKYO MEDICAL & DENTAL UNIV ,  UNIV SAPPORO MEDICAL ,  ADEKA CORP

Inventor： MATSUDA JUNICHI ,  MIYABASHIRA SUMIKA ,  HARANO SATOMI ,  KISHIDA AKIO ,  KIMURA TSUYOSHI ,  NEGISHI JUN ,  HIGAMI TETSUYA ,  FUNAMOTO SEIICHI ,  HIWATARI KEN-ICHIRO ,  TASAKI AKIKO

IPC: A61L27/00 ,  A61K9/06 ,  A61K35/12 ,  A61K35/28 ,  A61K35/30 ,  A61K35/34 ,  A61K35/407 ,  A61K35/42 ,  A61K38/43 ,  A61K38/48 ,  A61P9/10

CPC classification number: A61L27/52 ,  A61K35/22 ,  A61K35/30 ,  A61K35/34 ,  A61K35/407 ,  A61K35/42 ,  A61K38/363 ,  A61K38/4833 ,  A61L27/225 ,  A61L27/26 ,  A61L27/3633 ,  A61L27/3683 ,  A61L27/3691 ,  A61L27/3695 ,  A61L27/54 ,  A61L2430/00 ,  A61L2430/20 ,  A61L2430/32 ,  C12N5/0068 ,  C12N2533/50 ,  C12N2533/56 ,  C12N2533/90

Abstract: A hybrid gel comprising a particulate decellularized tissue (obtained by pulverizing animal-derived biological tissues that are decellularized (decellularized biological tissues)), fibrinogen and thrombin; a cell culture material comprising the hybrid gel; a method for preparing the hybrid gel; and a kit comprising a particulate decellularized tissue and a biological tissue adhesive are provided. The hybrid gel of the present invention exerts the effect to promote differentiation and gain of function of stem cells and the therapeutic effect to a variety of diseases.

Abstract translation: 一种混合凝胶，其包含颗粒脱细胞组织（通过粉碎去细胞化的（来自细胞的生物组织）的动物衍生的生物组织），纤维蛋白原和凝血酶获得; 包含该混合凝胶的细胞培养物质; 制备混合凝胶的方法; 并提供了包含颗粒脱细胞组织和生物组织粘合剂的试剂盒。 本发明的混合凝胶发挥促进干细胞分化和功能增强的效果以及对各种疾病的治疗效果。

公开(公告)号：EP2752192A4

公开(公告)日：2015-05-20

申请号：EP12827099

申请日：2012-09-03

Applicant: ADEKA CORP

Inventor： KISHIDA AKIO ,  FUNAMOTO SEIICHI ,  HASHIMOTO YOSHIHIDE ,  NEGISHI JUN ,  KUWA SOUICHIRO ,  EMA TAKAO ,  KOBAYASHI KUNIHARU

IPC: A61L27/00 ,  A61L27/36

CPC classification number: A61K35/36 ,  A61K35/30 ,  A61K35/34 ,  A61L27/3604 ,  A61L27/362 ,  A61L27/3625 ,  A61L27/3691 ,  A61L2430/40

Abstract: Provided are: a method for preparing a decellularized tissue product in which decellularized tissue can be filled with liquid while changes in the structure of support tissue constituting the decellularized tissue are inhibited; and a graft provided with a decellularized tissue product. The method for preparing a decellularized tissue product includes a reduced-pressure step for bringing an animal-derived decellularized tissue material and a liquid into contact under reduced-pressure conditions, and/or a pressurized step for bringing same into contact under pressurized conditions. The graft is provided with a decellularized tissue product prepared by the method of preparation.

公开(公告)号：EP2995325A4

公开(公告)日：2016-12-21

申请号：EP14794303

申请日：2014-05-02

Applicant: NAT UNIV CORP TOKYO MEDICAL & DENTAL UNIV ,  ADEKA CORP

Inventor： KISHIDA AKIO ,  KIMURA TSUYOSHI ,  NEGISHI JUN ,  HIWATARI KEN-ICHIRO ,  TASAKI AKIKO

IPC: A61L27/00

CPC classification number: A61L27/3691 ,  A61L27/3604 ,  A61L27/3633 ,  A61L27/54 ,  A61L27/58 ,  A61L2300/412 ,  A61L2430/34 ,  C12M25/14 ,  C12N5/0081 ,  C12N2521/00

Abstract: A particulate decellularized tissue is provided which shows sufficiently effective tissue regeneration and does not show cytotoxicity when used as material for cell culture. In accordance with the method for preparing a particulate decellularized tissue comprising a step of applying a high hydrostatic pressure to animal-derived tissues in a medium, a particulate decellularized tissue is obtained which does not show cytotoxicity but shows the effect of cellular attraction and the effect of induction of cellular differentiation and shows a high effect of tissue regeneration.