公开(公告)号：WO2006086292A3

公开(公告)日：2007-10-04

申请号：PCT/US2006004071

申请日：2006-02-07

Applicant: ADVION BIOSCIENCES INC

Inventor： CORSO THOMAS N ,  VAN PELT COLLEEN K ,  LI JIE

IPC: G01N1/00

CPC classification number: G01N30/80 ,  B01L3/0275 ,  B01L3/0293 ,  B01L2300/0838 ,  G01N35/10 ,  G01N35/1016 ,  G01N2035/103 ,  G01N2035/1039 ,  G01N2035/1053 ,  G01N2035/1055 ,  Y10T436/2575

Abstract: An ultra-low volume fraction collection and concentration method provides practical application in collecting fractions, e.g. as low as 25 nL, from nanoLC columns into pipette tips at user-defined timed-intervals. The fractions are dried to create a concentrated band at the very end of the interior of the pipette tip and subsequently reconstituted directly in the pipette tips in solvent prior to analysis. As the chromatography and reconstitution solvent choice are independent, the reconstitution solvent can be selected to maximize ionization efficiency without compromising chromatography separation, hi the infusion analysis of the nanoLC fractions, a low flow electrospray chip enables each nanoLC fraction to be analyzed for over ten minutes. This increase in analysis time allows for advantages over prior methods. Optionally, the nanoLC fractions can be archived in the pipette tips for analysis at a later date.

Abstract translation: 超低体积分数收集和浓缩方法提供了实际应用于收集级分，例如。 低至25 nL，由用户定义的定时间隔从nanoLC色谱柱移至吸头。 将级分干燥以在移液管尖端内部的最末端产生浓缩带，随后在分析之前将其直接重新配置在溶剂中的吸头中。 由于色谱和重构溶剂选择是独立的，所以可以选择重构溶剂以使离子化效率最大化而不影响色谱分离。在纳米级分的输注分析中，低流电喷雾芯片使得每个纳米LC部分能够分析十分钟 。 分析时间的这种增加允许优于现有方法的优点。 任选地，nanoLC部分可以存档在移液管尖端中以供日后分析。

公开(公告)号：WO2007047542A3

公开(公告)日：2009-06-04

申请号：PCT/US2006040285

申请日：2006-10-13

Applicant: ADVION BIOSCIENCES INC

Inventor： LI JIE ,  CORSO THOMAS N

IPC: C25B9/00 ,  B01D59/44 ,  C23C14/35 ,  C23C16/00

CPC classification number: H01J49/167

Abstract: A method of preventing analyte electrolysis in use with electrospray ionization, electrophoresis, electro osmosis, electrodialysis and any apparatuses involving contact of liquids and electrodes is disclosed. The method for preventing analyte alteration by electrolysis reactions at electrode surfaces of an electrochemical system and in an electrochemical process includes coating the electrode surface using electrically insulating material including but not limited to polymers, plastics, and organic compounds by coating methods including but not limited to liquid spraying, spinning, molding, Sol Gel, dipping, physical vapor deposition and chemical vapor deposition at various ambient and substrate temperatures.

Abstract translation: 公开了一种使用电喷雾离子化，电泳，电渗透，电渗析以及涉及液体和电极接触的任何装置来防止分析物电解的方法。 用于防止通过电化学反应在电化学系统的电极表面和电化学过程中的分解物改变的方法包括使用包括但不限于聚合物，塑料和有机化合物的电绝缘材料涂覆电极表面，所述涂覆方法包括但不限于 液体喷涂，纺丝，成型，溶胶凝胶，浸渍，物理气相沉积和化学气相沉积在各种环境和基板温度。

公开(公告)号：EP1442476A4

公开(公告)日：2008-03-12

申请号：EP02766293

申请日：2002-09-17

Applicant: ADVION BIOSCIENCES INC

Inventor： LI JIE ,  CORSO THOMAS N ,  SCHULTZ GARY A

IPC: G01N27/447 ,  H01L21/306 ,  B32B7/00 ,  B81B1/00 ,  G01N30/72 ,  G01N37/00 ,  G02B1/11 ,  H01B3/10 ,  H01B3/12 ,  H01B7/282 ,  H01B17/60 ,  H01J49/04 ,  H01L29/00 ,  H01L29/74 ,  H01L29/76 ,  H01L29/78

CPC classification number: H01B7/2825 ,  G01N27/44704 ,  G01N30/7266 ,  H01B3/10 ,  H01B3/12 ,  H01L21/3143 ,  H01L21/3145 ,  H01L21/3146

Abstract: A dielectric film is provided which includes a base layer and a capping layer, preferably silicon oxynitride, wherein the film is an effective moisture and ion barrier when disposed between a conductive substrate and a liquid having an electrical potential different than the electrical potential of the substrate.