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    Integrated monolithic microfabricated electrospray, and system and method for liquid chromatography
    1.
    发明专利
    Integrated monolithic microfabricated electrospray, and system and method for liquid chromatography 审中-公开
    一体化单晶微电极，以及用于液相色谱的系统和方法

    公开(公告)号：JP2006234838A

    公开(公告)日：2006-09-07

    申请号：JP2006127976

    申请日：2006-05-01

    Applicant: Advion Biosciences Inc ,  Kionix Inc ,  アドヴィオン バイオサイエンシィズ インコーポレイテッド ,  キオニックス インコーポレイテッド

    Inventor： MOON JAMES E ,  SCHULTZ GARY A ,  CORSO THOMAS N ,  DAVIS TIMOTHY J ,  GALVIN GREGORY J ,  LOWES STEPHEN

    IPC: G01N27/62 ,  B01D15/08 ,  G01N30/60 ,  G01N30/72 ,  G01N37/00 ,  H01J49/04

    CPC classification number: G01N30/6095 ,  G01N30/7266 ,  G01N2030/6013 ,  H01J49/0018 ,  H01J49/167 ,  Y10T436/24 ,  Y10T436/2575

    Abstract: PROBLEM TO BE SOLVED: To provide a chemical analytical system of large capacity easy to be reproduced and allowing mass production. SOLUTION: The chemical analytical system includes the first substrate having a main face, the second substrate joined or attached thereto, a liquid chromatography system integrated thereto, and constituted to receive and treat an analytical liquid to be discharged, and a monolithic electrospray device having an inlet orifice located in a injection side, a nozzle located on a discharge face opposite to the injection side, a channel extended penetrated continuously through a monolithic device, and communicated with the inlet orifice and the nozzle, and an area recessed from the discharge face to surround the nozzle. The monolithic device is integrated on the first substrate, the injection side is constituted to receive the treated liquid from the liquid chromatography system, and the main face is constituted to distribute the liquid by electrospraying the liquid. COPYRIGHT: (C)2006,JPO&NCIPI

    Abstract translation: 要解决的问题：提供容易复制的大容量化学分析系统，并允许批量生产。 解决方案：化学分析系统包括具有主面，第二基板接合或附着的第一基板，与其一体化的液相色谱系统，构成为接收和处理要排出的分析液，以及单片电喷雾 装置，其具有位于注射侧的入口孔，位于与注射侧相对的排出面上的喷嘴，延伸穿过单片装置连续穿过并与入口孔和喷嘴连通的区域， 排出面以围绕喷嘴。 该单片装置集成在第一基板上，注射侧构成为从液相色谱系统接收经处理的液体，并且主面构成为通过电喷雾液体来分配液体。 版权所有（C）2006，JPO＆NCIPI

    Detection of single nucleotide polymorphisms
    3.
    发明专利
    Detection of single nucleotide polymorphisms 未知

    公开(公告)号：AU3803001A

    公开(公告)日：2001-08-14

    申请号：AU3803001

    申请日：2001-02-02

    Applicant: ADVION BIOSCIENCES INC

    Inventor： SCHULTZ GARY A ,  ZHANG SHENG ,  PELT COLLEEN K VAN

    IPC: C12Q1/68

    Abstract: The present invention relates to a method of detecting single nucleotide polymorphisms by providing a target nucleic acid molecule, an oligonucleotide primer complementary to a portion of the target nucleic acid molecule, a nucleic acid polymerizing enzyme, and a plurality of types of nucleotide analogs. The target nucleic molecule, the oligonucleotide primer, the nucleic acid polymerizing enzyme, and the nucleotide analogs, each type being present in a first amount, are blended to form an extension solution where the oligonucleotide primer is hybridized to the target nucleic acid molecule to form a primed target nucleic acid molecule and the nucleic acid polymerizing enzyme is positioned to add nucleotide analogs to the primed target nucleic acid molecule at an active site. The oligonucleotide primer in the extension solution is extended by using the nucleic acid polymerizing enzyme to add a nucleotide analog to the oligonucleotide primer at the active site. This forms an extended oligonucleotide primer, wherein the nucleotide analog being added is complementary to the nucleotide of the target nucleic acid molecule at the active site. The amounts of each type of the nucleotide analogs in the extension solution after the extending step are then determined where each type is present in a second amount. The first and second amounts of each type of the nucleotide analog are compared. The type of nucleotide analog where the first and second amounts differ as the nucleotide added to the oligonucleotide primer at the active site is then identified. The steps of extending, determining the amounts of each type of the nucleotide analog, comparing the first and second amounts of the nucleotide analog, and said identifying the type of nucleotide analog added may be repeated, either after repeating the blending with the extended oligonucleotide primer or after determining the amounts of each type of dideoxynucleotide or dideoxynucleotide analog remaining in the extension solution as the new first amount. As a result, the nucleotide at the active site of the target nucleic acid molecule is determined. Also disclosed is an apparatus and composition for carrying out this method.

    INTEGRATED MONOLITHIC MICROFABRICATED DISPENSING NOZZLE AND LIQUID CHROMATOGRAPHY-ELECTROSPRAY SYSTEM AND METHOD
    4.
    发明专利
    INTEGRATED MONOLITHIC MICROFABRICATED DISPENSING NOZZLE AND LIQUID CHROMATOGRAPHY-ELECTROSPRAY SYSTEM AND METHOD 未知

    公开(公告)号：CA2363414A1

    公开(公告)日：2000-09-08

    申请号：CA2363414

    申请日：2000-02-29

    Applicant: ADVION BIOSCIENCES INC

    Inventor： SCHULTZ GARY A ,  CORSO THOMAS N

    IPC: G01N30/60 ,  G01N30/72 ,  H01J49/04 ,  G01N27/26 ,  H01J49/10

    Abstract: A droplet/electrospray device and a liquid chromatography-electrospray syste m are disclosed. The droplet/electrospray device (100) comprises a substrate (102) defining a channel (104) between an entrance orifice (106) on an injection surface (108) and an exit orifice on an ejection surface (112), a nozzle (110) defined by a portion recessed from the ejection surface (112) surrounding the exit orifice, and an electrode (122) for application of an electric potential to the substrate (102) to optimize and generate droplets or an electrospray (62). A plurality of these electrospray devices (100) can be used in the form of an array of miniaturized nozzles. The liquid chromatography-electrospray device (160) comprises a separation substrate (162) defining an introduction channel (164) between an entrance orifice and a reservoir (166) and a separation channel (168) between the reservoir (166) a nd an exit orifice (170), the separation channel (168) being populated with separation posts (174) perpendicular to the fluid flow.

    Multiple electrospray device, systems and methods
    6.
    发明专利
    Multiple electrospray device, systems and methods 未知

    公开(公告)号：AU2450801A

    公开(公告)日：2001-07-16

    申请号：AU2450801

    申请日：2000-12-22

    Applicant: ADVION BIOSCIENCES INC

    Inventor： SCHULTZ GARY A ,  CORSO THOMAS N ,  PROSSER SIMON J

    IPC: G01N27/62 ,  B05B5/08 ,  G01N21/33 ,  G01N21/53 ,  G01N21/64 ,  G01N27/00 ,  G01N27/447 ,  G01N30/88 ,  G01N37/00 ,  H01J49/04 ,  H01J49/10 ,  H01J49/26

    Abstract: A microchip-based electrospray device, system, and method of fabrication thereof are disclosed. The electrospray device includes a substrate defining a channel between an entrance orifice on an injection surface and an exit orifice on an ejection surface, a nozzle defined by a portion recessed from the ejection surface surrounding the exit orifice, and an electric field generating source for application of an electric potential to the substrate to optimize and generate an electrospray. A method and system are disclosed to generate multiple electrospray plumes from a single fluid stream that provides an ion intensity as measured by a mass spectrometer that is approximately proportional to the number of electrospray plumes formed for analytes contained within the fluid. A plurality of electrospray nozzle devices can be used in the form of an array of miniaturized nozzles for the purpose of generating multiple electrospray plumes from multiple nozzles for the same fluid stream. This invention dramatically increases the sensitivity of microchip electrospray devices compared to prior disclosed systems and methods.

    ROBOTIC AUTOSAMPLER FOR AUTOMATED ELECTROSPRAY FROM A MICROFLUIDIC CHIP
    7.
    发明专利
    ROBOTIC AUTOSAMPLER FOR AUTOMATED ELECTROSPRAY FROM A MICROFLUIDIC CHIP 未知

    公开(公告)号：CA2434569A1

    公开(公告)日：2002-08-01

    申请号：CA2434569

    申请日：2002-01-28

    Applicant: ADVION BIOSCIENCES INC

    Inventor： PROSSER SIMON J ,  RULE GEOFFREY S ,  SCHULTZ GARY A ,  CORSO THOMAS N

    IPC: G01N27/62 ,  G01N1/00 ,  G01N35/00 ,  G01N35/04 ,  G01N35/10 ,  H01J49/04 ,  B01D59/44 ,  H01J49/00

    Abstract: A robotic autosampler (1) provides for automated manipulation of microfluidi c chips having multiple electrospray devices and/or sample inlets (113) for interface to a mass spectrometer (111) or other detection device. The autosampler also provides for connection of control voltages to the electrospray device to facilitate enablement, control and steering of charge d droplets and ions. The autosampler further provides a method of fluid delive ry that may be disposable or reusable. The delivery device may contain material s for component separation or sample purification. The delivery device may contain preloaded sample or the sample may be loaded by the autosampler. A method for automated manipulation of multiple electrosprays (115) in communication with a detector, includes: providing a robot autosampler havin g an electrospray chip (80); electrospraying at least one analyte from at leas t one electrospray device on the electrospray chip; and manipulating the electrospray chip in communication with a detector in a manner to detect analyte from the electrospray.

    MULTIPLE ELECTROSPRAY DEVICE, SYSTEMS AND METHODS
    9.
    发明专利
    MULTIPLE ELECTROSPRAY DEVICE, SYSTEMS AND METHODS 未知

    公开(公告)号：CA2395694A1

    公开(公告)日：2001-07-12

    申请号：CA2395694

    申请日：2000-12-22

    Applicant: ADVION BIOSCIENCES INC

    Inventor： CORSO THOMAS N ,  PROSSER SIMON J ,  SCHULTZ GARY A

    IPC: G01N27/62 ,  B05B5/08 ,  G01N21/33 ,  G01N21/53 ,  G01N21/64 ,  G01N27/00 ,  G01N27/447 ,  G01N30/88 ,  G01N37/00 ,  H01J49/04 ,  H01J49/10 ,  H01J49/26

    Abstract: A microchip-based electrospray device, system, and method of fabrication thereof are disclosed. The electrospray device (250) includes a substrate (200) defining a channel (224) between an entrance orifice on an injection surface and an exit orifice on an ejection surface, a nozzle (232) defined b y a portion recessed from the ejection surface surrounding the exit orifice, a nd an electric field generating source for application of an electric potential to the substrate to optimize and generate an electrospray (262). A method an d system are disclosed to generate multiple electrospray plumes from a single fluid stream that provides an ion intensity as measured by a mass spectromet er that is approximately proportional to the number of electrospray plumes form ed for analytes contained within the fluid. A plurality of electrospray nozzle devices (232) can be used in the form of an array of miniaturized nozzles fo r the purpose of generating multiple electrospray plumes (262) from multiple nozzles (232) for the same fluid stream. This invention dramatically increas es the sensitivity of microchip electrospray devices (250) compared to prior disclosed systems and methods.

    FABRICATION OF A MICROCHIP-BASED ELECTROSPRAY DEVICE
    10.
    发明申请
    FABRICATION OF A MICROCHIP-BASED ELECTROSPRAY DEVICE 审中-公开
    基于微电脑的电子装置的制造

    公开(公告)号：WO2003025991A1

    公开(公告)日：2003-03-27

    申请号：PCT/US2002/029504

    申请日：2002-09-17

    Applicant: ADVION BIOSCIENCES, INC.

    Inventor： CORSO, Thomas, N.

    IPC: H01L21/302

    CPC classification number: B81C1/00087 ,  B81B2201/058 ,  B81C2201/0142

    Abstract: A method for fabricating a nozzle of microchip-based electrospray device is disclosed. The method includes using a primary mask to accurately define the nozzle feature including the annulus and the through hole of the electrospray device. A secondary masking step is conducted to pattern the through channel (typical the photoresist would serve as the secondary mask), followed by the defining and etching of the primary mask containing the full nozzle feature. The secondary mask serves to selectively mask given areas of the primary mask for subsequent etching. The through hole feature of the secondary mask aligns over the already patterned primary mask through channel, except that the secondary mask contains a slightly larger through channel diameter. This serves to mask off the annulus, but allowing the silicon through channel to be exposed for etching.

    Abstract translation: 公开了一种用于制造基于微芯片的电喷雾装置的喷嘴的方法。 该方法包括使用主掩模来精确地限定包括电喷雾装置的环形区域和通孔的喷嘴特征。 进行二次掩模步骤以对穿通通道进行图案化（典型地，光致抗蚀剂将用作辅助掩模），然后限定和蚀刻含有全喷嘴特征的主掩模。 辅助掩模用于选择性地掩蔽初级掩模的给定区域用于随后的蚀刻。 辅助掩模的通孔特征通过通道对准已经图案化的初级掩模，不同之处在于次要掩模包含稍大的通道直径。 这用于掩盖环形，但允许硅通过沟道暴露以进行蚀刻。

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