公开(公告)号：JP2006234838A

公开(公告)日：2006-09-07

申请号：JP2006127976

申请日：2006-05-01

Applicant: Advion Biosciences Inc ,  Kionix Inc ,  アドヴィオン バイオサイエンシィズ インコーポレイテッド ,  キオニックス インコーポレイテッド

Inventor： MOON JAMES E ,  SCHULTZ GARY A ,  CORSO THOMAS N ,  DAVIS TIMOTHY J ,  GALVIN GREGORY J ,  LOWES STEPHEN

IPC: G01N27/62 ,  B01D15/08 ,  G01N30/60 ,  G01N30/72 ,  G01N37/00 ,  H01J49/04

CPC classification number: G01N30/6095 ,  G01N30/7266 ,  G01N2030/6013 ,  H01J49/0018 ,  H01J49/167 ,  Y10T436/24 ,  Y10T436/2575

Abstract: PROBLEM TO BE SOLVED: To provide a chemical analytical system of large capacity easy to be reproduced and allowing mass production. SOLUTION: The chemical analytical system includes the first substrate having a main face, the second substrate joined or attached thereto, a liquid chromatography system integrated thereto, and constituted to receive and treat an analytical liquid to be discharged, and a monolithic electrospray device having an inlet orifice located in a injection side, a nozzle located on a discharge face opposite to the injection side, a channel extended penetrated continuously through a monolithic device, and communicated with the inlet orifice and the nozzle, and an area recessed from the discharge face to surround the nozzle. The monolithic device is integrated on the first substrate, the injection side is constituted to receive the treated liquid from the liquid chromatography system, and the main face is constituted to distribute the liquid by electrospraying the liquid. COPYRIGHT: (C)2006,JPO&NCIPI

Abstract translation: 要解决的问题：提供容易复制的大容量化学分析系统，并允许批量生产。 解决方案：化学分析系统包括具有主面，第二基板接合或附着的第一基板，与其一体化的液相色谱系统，构成为接收和处理要排出的分析液，以及单片电喷雾 装置，其具有位于注射侧的入口孔，位于与注射侧相对的排出面上的喷嘴，延伸穿过单片装置连续穿过并与入口孔和喷嘴连通的区域， 排出面以围绕喷嘴。 该单片装置集成在第一基板上，注射侧构成为从液相色谱系统接收经处理的液体，并且主面构成为通过电喷雾液体来分配液体。 版权所有（C）2006，JPO＆NCIPI

公开(公告)号：JP2006234837A

公开(公告)日：2006-09-07

申请号：JP2006127975

申请日：2006-05-01

Applicant: Advion Biosciences Inc ,  Kionix Inc ,  アドヴィオン バイオサイエンシィズ インコーポレイテッド ,  キオニックス インコーポレイテッド

Inventor： MOON JAMES E ,  SCHULTZ GARY A ,  CORSO THOMAS N ,  DAVIS TIMOTHY J ,  GALVIN GREGORY J ,  LOWES STEPHEN

IPC: G01N27/62 ,  G01N30/60 ,  B01D15/08 ,  G01N30/72 ,  G01N37/00 ,  H01J49/04

CPC classification number: G01N30/6095 ,  G01N30/7266 ,  G01N2030/6013 ,  H01J49/0018 ,  H01J49/167 ,  Y10T436/24 ,  Y10T436/2575

Abstract: PROBLEM TO BE SOLVED: To provide a separator and a system for chemical separation of large capacity easy to be reproduced and allowing mass production. SOLUTION: The chemical separator includes a substrate for forming a channel, a plurality of columnar bodies worked of the substrate and extended from the channel, an electric insulation layer provided on a surface of the substrate, and an immobilization phase joined to the columnar bodies reacting with an analyzed sample introduced into the channel for the separation, and the analyzed sample is electrically insulated from the substrate. COPYRIGHT: (C)2006,JPO&NCIPI

Abstract translation: 要解决的问题：提供容易再现并允许批量生产的大容量化学分离分离器和系统。 解决方案：化学分离器包括用于形成通道的基板，从基板加工并从通道延伸的多个柱状体，设置在基板的表面上的电绝缘层，以及与基板接合的固定相 柱状体与引入通道的分析样品反应以进行分离，并且分析的样品与基底电绝缘。 版权所有（C）2006，JPO＆NCIPI

公开(公告)号：CA2363414A1

公开(公告)日：2000-09-08

申请号：CA2363414

申请日：2000-02-29

Applicant: ADVION BIOSCIENCES INC

Inventor： SCHULTZ GARY A ,  CORSO THOMAS N

IPC: G01N30/60 ,  G01N30/72 ,  H01J49/04 ,  G01N27/26 ,  H01J49/10

Abstract: A droplet/electrospray device and a liquid chromatography-electrospray syste m are disclosed. The droplet/electrospray device (100) comprises a substrate (102) defining a channel (104) between an entrance orifice (106) on an injection surface (108) and an exit orifice on an ejection surface (112), a nozzle (110) defined by a portion recessed from the ejection surface (112) surrounding the exit orifice, and an electrode (122) for application of an electric potential to the substrate (102) to optimize and generate droplets or an electrospray (62). A plurality of these electrospray devices (100) can be used in the form of an array of miniaturized nozzles. The liquid chromatography-electrospray device (160) comprises a separation substrate (162) defining an introduction channel (164) between an entrance orifice and a reservoir (166) and a separation channel (168) between the reservoir (166) a nd an exit orifice (170), the separation channel (168) being populated with separation posts (174) perpendicular to the fluid flow.

公开(公告)号：AU2450801A

公开(公告)日：2001-07-16

申请号：AU2450801

申请日：2000-12-22

Applicant: ADVION BIOSCIENCES INC

Inventor： SCHULTZ GARY A ,  CORSO THOMAS N ,  PROSSER SIMON J

IPC: G01N27/62 ,  B05B5/08 ,  G01N21/33 ,  G01N21/53 ,  G01N21/64 ,  G01N27/00 ,  G01N27/447 ,  G01N30/88 ,  G01N37/00 ,  H01J49/04 ,  H01J49/10 ,  H01J49/26

Abstract: A microchip-based electrospray device, system, and method of fabrication thereof are disclosed. The electrospray device includes a substrate defining a channel between an entrance orifice on an injection surface and an exit orifice on an ejection surface, a nozzle defined by a portion recessed from the ejection surface surrounding the exit orifice, and an electric field generating source for application of an electric potential to the substrate to optimize and generate an electrospray. A method and system are disclosed to generate multiple electrospray plumes from a single fluid stream that provides an ion intensity as measured by a mass spectrometer that is approximately proportional to the number of electrospray plumes formed for analytes contained within the fluid. A plurality of electrospray nozzle devices can be used in the form of an array of miniaturized nozzles for the purpose of generating multiple electrospray plumes from multiple nozzles for the same fluid stream. This invention dramatically increases the sensitivity of microchip electrospray devices compared to prior disclosed systems and methods.

公开(公告)号：CA2434569A1

公开(公告)日：2002-08-01

申请号：CA2434569

申请日：2002-01-28

Applicant: ADVION BIOSCIENCES INC

Inventor： PROSSER SIMON J ,  RULE GEOFFREY S ,  SCHULTZ GARY A ,  CORSO THOMAS N

IPC: G01N27/62 ,  G01N1/00 ,  G01N35/00 ,  G01N35/04 ,  G01N35/10 ,  H01J49/04 ,  B01D59/44 ,  H01J49/00

Abstract: A robotic autosampler (1) provides for automated manipulation of microfluidi c chips having multiple electrospray devices and/or sample inlets (113) for interface to a mass spectrometer (111) or other detection device. The autosampler also provides for connection of control voltages to the electrospray device to facilitate enablement, control and steering of charge d droplets and ions. The autosampler further provides a method of fluid delive ry that may be disposable or reusable. The delivery device may contain material s for component separation or sample purification. The delivery device may contain preloaded sample or the sample may be loaded by the autosampler. A method for automated manipulation of multiple electrosprays (115) in communication with a detector, includes: providing a robot autosampler havin g an electrospray chip (80); electrospraying at least one analyte from at leas t one electrospray device on the electrospray chip; and manipulating the electrospray chip in communication with a detector in a manner to detect analyte from the electrospray.

公开(公告)号：CA2395694A1

公开(公告)日：2001-07-12

申请号：CA2395694

申请日：2000-12-22

Applicant: ADVION BIOSCIENCES INC

Inventor： CORSO THOMAS N ,  PROSSER SIMON J ,  SCHULTZ GARY A

IPC: G01N27/62 ,  B05B5/08 ,  G01N21/33 ,  G01N21/53 ,  G01N21/64 ,  G01N27/00 ,  G01N27/447 ,  G01N30/88 ,  G01N37/00 ,  H01J49/04 ,  H01J49/10 ,  H01J49/26

Abstract: A microchip-based electrospray device, system, and method of fabrication thereof are disclosed. The electrospray device (250) includes a substrate (200) defining a channel (224) between an entrance orifice on an injection surface and an exit orifice on an ejection surface, a nozzle (232) defined b y a portion recessed from the ejection surface surrounding the exit orifice, a nd an electric field generating source for application of an electric potential to the substrate to optimize and generate an electrospray (262). A method an d system are disclosed to generate multiple electrospray plumes from a single fluid stream that provides an ion intensity as measured by a mass spectromet er that is approximately proportional to the number of electrospray plumes form ed for analytes contained within the fluid. A plurality of electrospray nozzle devices (232) can be used in the form of an array of miniaturized nozzles fo r the purpose of generating multiple electrospray plumes (262) from multiple nozzles (232) for the same fluid stream. This invention dramatically increas es the sensitivity of microchip electrospray devices (250) compared to prior disclosed systems and methods.

公开(公告)号：CA2395694C

公开(公告)日：2006-11-21

申请号：CA2395694

申请日：2000-12-22

Applicant: ADVION BIOSCIENCES INC

Inventor： CORSO THOMAS N ,  PROSSER SIMON J ,  SCHULTZ GARY A

IPC: G01N27/62 ,  H01J49/04 ,  B05B5/08 ,  G01N21/33 ,  G01N21/53 ,  G01N21/64 ,  G01N27/00 ,  G01N27/447 ,  G01N30/88 ,  G01N37/00 ,  H01J49/10 ,  H01J49/26

Abstract: A microchip-based electrospray device, system, and method of fabrication thereof are disclosed. The electrospray device (250) includes a substrate (200) defining a channel (224) between an entrance orifice on an injection surface and an exit orifice on an ejection surface, a nozzle (232) defined by a portion recessed from the ejection surface surrounding the exit orifice, and an electric field generating source for application of an electric potential to the substrate to optimize and generate an electrospray (262). A method and system are disclosed to generate multiple electrospray plumes from a single fluid stream that provides an ion intensity as measured by a mass spectrometer that is approximately proportional to the number of electrospray plumes formed for analytes contained within the fluid. A plurality of electrospray nozzle devices (232) can be used in the form of an array of miniaturized nozzles for the purpose of generating multiple electrospray plumes (262) from multiple nozzles (232) for the same fluid stream. This invention dramatically increases the sensitivity of microchip electrospray devices (250) compared to prior disclosed systems and methods.

公开(公告)号：AU2002240143A1

公开(公告)日：2002-08-06

申请号：AU2002240143

申请日：2002-01-28

Applicant: ADVION BIOSCIENCES INC

Inventor： SCHULTZ GARY A ,  CORSO THOMAS N ,  PROSSER SIMON J ,  RULE GEOFFREY S

IPC: G01N27/62 ,  G01N1/00 ,  G01N35/00 ,  G01N35/04 ,  G01N35/10 ,  H01J49/04 ,  B01D59/44 ,  H01J49/00

Abstract: A robotic autosampler provides for automated manipulation of microfluidic chips having multiple electrospray devices and/or sample inlets for interface to a mass spectrometer or other detection device. The autosampler also provides for connection of control voltages to the electrospray device to facilitate enablement, control and steering of charged droplets and ions. The autosampler further provides a method of fluid delivery that may be disposable or reusable. The delivery device may contain materials for component separation or sample purification. The delivery device may contain preloaded sample or the sample may be loaded by the autosampler. A method for automated manipulation of multiple electrosprays in communication with a detector, includes: providing a robot autosampler having an electrospray chip; electrospraying at least one analyte from at least one electrospray device on the electrospray chip; and manipulating the electrospray chip in communication with a detector in a manner to detect analyte from the electrospray.

公开(公告)号：WO2007047542A3

公开(公告)日：2009-06-04

申请号：PCT/US2006040285

申请日：2006-10-13

Applicant: ADVION BIOSCIENCES INC

Inventor： LI JIE ,  CORSO THOMAS N

IPC: C25B9/00 ,  B01D59/44 ,  C23C14/35 ,  C23C16/00

CPC classification number: H01J49/167

Abstract: A method of preventing analyte electrolysis in use with electrospray ionization, electrophoresis, electro osmosis, electrodialysis and any apparatuses involving contact of liquids and electrodes is disclosed. The method for preventing analyte alteration by electrolysis reactions at electrode surfaces of an electrochemical system and in an electrochemical process includes coating the electrode surface using electrically insulating material including but not limited to polymers, plastics, and organic compounds by coating methods including but not limited to liquid spraying, spinning, molding, Sol Gel, dipping, physical vapor deposition and chemical vapor deposition at various ambient and substrate temperatures.

Abstract translation: 公开了一种使用电喷雾离子化，电泳，电渗透，电渗析以及涉及液体和电极接触的任何装置来防止分析物电解的方法。 用于防止通过电化学反应在电化学系统的电极表面和电化学过程中的分解物改变的方法包括使用包括但不限于聚合物，塑料和有机化合物的电绝缘材料涂覆电极表面，所述涂覆方法包括但不限于 液体喷涂，纺丝，成型，溶胶凝胶，浸渍，物理气相沉积和化学气相沉积在各种环境和基板温度。

公开(公告)号：WO02059563A3

公开(公告)日：2002-09-26

申请号：PCT/US0202467

申请日：2002-01-28

Applicant: ADVION BIOSCIENCES INC

Inventor： PROSSER SIMON J ,  RULE GEOFFREY S ,  SCHULTZ GARY A ,  CORSO THOMAS N

IPC: G01N27/62 ,  G01N1/00 ,  G01N35/00 ,  G01N35/04 ,  G01N35/10 ,  H01J49/04 ,  B01D59/44 ,  H01J49/00

CPC classification number: G01N35/10 ,  G01N35/0099 ,  G01N35/04 ,  G01N2035/00158 ,  G01N2035/0491 ,  G01N2035/1034 ,  H01J49/0413 ,  H01J49/165

Abstract: A robotic autosampler (1) provides for automated manipulation of microfluidic chips having multiple electrospray devices and/or sample inlets (113) for interface to a mass spectrometer (111) or other detection device. The autosampler also provides for connection of control voltages to the electrospray device to facilitate enablement, control and steering of charged droplets and ions. The autosampler further provides a method of fluid delivery that may be disposable or reusable. The delivery device may contain materials for component separation or sample purification. The delivery device may contain preloaded sample or the sample may be loaded by the autosampler. A method for automated manipulation of multiple electrosprays (115) in communication with a detector, includes: providing a robot autosampler having an electrospray chip (80); electrospraying at least one analyte from at least one electrospray device on the electrospray chip; and manipulating the electrospray chip in communication with a detector in a manner to detect analyte from the electrospray.

Abstract translation: 机器人自动进样器（1）提供具有多个电喷雾装置和/或样品入口（113）的微流体芯片的自动操作，用于与质谱仪（111）或其它检测装置的接口。 自动进样器还提供了将控制电压连接到电喷雾装置，以便于带电液滴和离子的启用，控制和转向。 自动进样器还提供可以是一次性的或可重复使用的流体输送方法。 输送装置可以含有用于组分分离或样品纯化的材料。 输送装置可以包含预加载的样品，或者样品可以由自动进样器装载。 一种用于与检测器通信的多个电喷雾（115）的自动操作的方法，包括：提供具有电喷雾芯片（80）的机器人自动进样器; 从电喷雾芯片上的至少一个电喷雾装置电喷雾至少一种分析物; 以及以检测来自电喷雾的分析物的方式操纵与检测器通信的电喷雾芯片。