公开(公告)号：JPH1067740A

公开(公告)日：1998-03-10

申请号：JP22526796

申请日：1996-08-27

Applicant: AGENCY IND SCIENCE TECHN ,  TOHKEM PROD KK

Inventor： HAYAKAWA YOSHIO ,  HAYASHI EIJI ,  FUKAYA HARUHIKO ,  TERASAWA NAOHIRO ,  ABE TAKASHI ,  OMORI KOTA

IPC: G02F1/13 ,  C07D207/10 ,  C08F20/36 ,  C09K19/34 ,  C09K19/38

Abstract: PROBLEM TO BE SOLVED: To obtain a novel compound which is useful for a liquid crystal polymer bearing a perfluoro pyrrolidine structure which can be expected to show a good orientation. SOLUTION: This novel compund is represented by formula I(R is H, methyl; Y is an alkylene; n is 1 or 2), typically 4'-[4-(6-acryloyloxyhexyloxy)benzoyloxy] 4-biphenilyl perfluoro-2-pyrrolidinopropionate. The compound of formula I is prepared by reaction of a hydroquinone or biphenyldiol of formula II with a perfluoro(2-pyrrolidinopropionyl fluoride) to form an ester of formula IV, followed by reaction of the product with 4-alkyloxybenzoyl chloride of formula V.

公开(公告)号：JPH0824363A

公开(公告)日：1996-01-30

申请号：JP31262493

申请日：1993-11-18

Applicant: AGENCY IND SCIENCE TECHN

Inventor： ABE TAKASHI ,  FUKAYA HARUHIKO ,  HAYASHI EIJI ,  HAYAKAWA YOSHIO

IPC: A62D1/06 ,  A62D1/00 ,  A62D1/02

Abstract: PURPOSE:To provide a gaseous fire extinguishing chemical formed by using polyfluoroamines having high-performance fire extinguishability without destroying the ozone layer as a substitutive material for Halon. CONSTITUTION:Fire is extinguishable without destroying the ozone layer if the polyfluoro-tertiary amine expressed by a general formula (CF3)2NRf(where Rf is respectively 1 to 2 polyfluoroalkyl group or alkenyl group) is used as the essential component of the gaseous fire extinguishing chemical.

公开(公告)号：JPH07118183A

公开(公告)日：1995-05-09

申请号：JP31247093

申请日：1993-10-25

Applicant: AGENCY IND SCIENCE TECHN ,  DAIKIN IND LTD

Inventor： ABE TAKASHI ,  HAYASHI EIJI ,  FUKAYA HARUHIKO ,  HAYAKAWA YOSHIO ,  TATEMOTO MASANAGA ,  NOSE NOBUYUKI

IPC: C07C21/18 ,  C07C17/363

Abstract: PURPOSE:To easily obtain in high yield from a readily available raw material herafluoroisobutene useful as a comonomer for produc ing fluororesins. CONSTITUTION:The objective hexafluoroisobutene can be obtained by reaction under heating of 2,2-bis(trifluoromethyl)propionyl fluoride as raw material together with an alkali metal or alkaline earth metal halide.

公开(公告)号：JPH051066A

公开(公告)日：1993-01-08

申请号：JP14891291

申请日：1991-06-20

Applicant: AGENCY IND SCIENCE TECHN ,  NIPPON OILS & FATS CO LTD

Inventor： NISHIDA MASAKAZU ,  FUJII SHOZO ,  KIMOTO HIROSHI ,  HAYAKAWA YOSHIO ,  SAWADA HIDEO ,  MITANI MOTOHIRO ,  MATSUMOTO TAKEO ,  NAKAYAMA MASAHARU

IPC: A61K31/52 ,  A61K31/522 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7052 ,  A61K31/7076 ,  A61K31/708 ,  A61P31/12 ,  A61P35/00 ,  C07D473/04 ,  C07D473/16 ,  C07D473/18 ,  C07D473/28 ,  C07D473/30 ,  C07D473/32 ,  C07D473/34 ,  C07H19/16 ,  C07H19/167

Abstract: PURPOSE:To provide the subject new compound useful as pharmaceuticals, agricultural chemicals, etc., such as carcinostatic agent and antiviral agent. CONSTITUTION:The compound of formula I [Y1 is amino, acetylamino, OH or H; Y2 is amino, acetylamino, OH, H or (CF2)nX (X is F, Cl or H; (n) is 1-10); Y3 is (CF2)nX or H; at least one of Y2 and Y3 is (CF2)nX], e.g. 8-(perfluoropropyl)adenine. The compound of formula I can be produced by reacting a purine or adenosine of formula II (Y1' and Y2' are amino, acetylamino, OH or H) with N,O-bis(trimethylsilyl)trifluoroacetamide and then with a di(haloacyl) peroxide of formula III.

公开(公告)号：JPH04149192A

公开(公告)日：1992-05-22

申请号：JP27602090

申请日：1990-10-15

Applicant: AGENCY IND SCIENCE TECHN ,  NIPPON OILS & FATS CO LTD

Inventor： NISHIDA MASAKAZU ,  FUJII SHOZO ,  KIMOTO HIROSHI ,  HAYAKAWA YOSHIO ,  SAWADA HIDEO ,  MITANI MOTOHIRO ,  NAKAYAMA MASAHARU

IPC: C07H19/067 ,  C07H19/073

Abstract: NEW MATERIAL:A compound shown by formula I (R1 and R2 are H or OH; R3 is methyl or hydroxymethyl; X is F, Cl or H; (n) is 1-10 with the proviso that, when R1 and R2 are OH, R3 is hydroxymethyl and X is F, (n) is 1-3, 5, 7 or 9 and when R1 is H, R2 is OH, R3 is hydroxymethyl and X is F, (n) is 3-10). EXAMPLE:5-(2''-Hydroxytetrafluoroethyl)uridine. USE:Useful as a synthetic intermediate for medicines, agricultural chemicals, etc., especially carcinostatic gent and antiviral agent. PREPARATION:A di(haloacyl)peroxide shown by formula II is made to react with a uridine derivative shown by formula III (R4 and R5 are H, 1-4C alkyl- containing trialkylsiloxyl; R6 is methyl or 1-4C alkyl-containing trialkylsiloxymethyl; R7 is 1-4C alkyl-containing trialkylsiloxyl).

公开(公告)号：JPH09227475A

公开(公告)日：1997-09-02

申请号：JP3813496

申请日：1996-02-26

Applicant: AGENCY IND SCIENCE TECHN ,  TOHKEM PROD KK

Inventor： HAYASHI EIJI ,  ABE TAKASHI ,  HAYAKAWA YOSHIO ,  FUKAYA HARUHIKO ,  NISHIDA MASAKAZU ,  ONO TAIZO ,  OMORI KOTA ,  YATSUYANAGI HIROYUKI

IPC: G02F1/13 ,  C07C227/02 ,  C07C229/20 ,  C07D207/10 ,  C07D211/38 ,  C07D223/04 ,  C07D265/30 ,  C09K19/12 ,  C09K19/34

Abstract: PROBLEM TO BE SOLVED: To obtain a new fluorine-containing biphenyl liquid crystal compound having a stable liquid crystal phase, useful as a material for displays, etc., and capable of being produced from easily raw materials in a high yield in simple operations. SOLUTION: A compound of formula I [Rf , Rf are each a 1-5C perfluoroalkyl, Rf and Rf may be combined with each other directly or through O or N to form a heterocyclic ring together with N; (n) is 1, 2]. For example,4- methoxy-4'-[perfluoro(dimethylaminoethano)oxy]biphenyl. The compound of formula I is obtained by reacting a compound of formula II (X is a halogen) with 4-hydroxy-4'-methoxybiphenyl.

公开(公告)号：JPH07118348A

公开(公告)日：1995-05-09

申请号：JP31246993

申请日：1993-10-25

Applicant: AGENCY IND SCIENCE TECHN ,  DAIKIN IND LTD

Inventor： ABE TAKASHI ,  HAYASHI EIJI ,  FUKAYA HARUHIKO ,  HAYAKAWA YOSHIO ,  SHIMIZU TETSUO ,  TATEMOTO MASANAGA ,  NOSE NOBUYUKI

IPC: B01J41/14 ,  C08F8/00 ,  C08F14/18 ,  C08F16/14 ,  C08F214/18 ,  C08F216/14 ,  C08L29/10

Abstract: PURPOSE:To obtain the copolymer being excellent in heat resistance and chemical resistance, having a low degree of crystallinity and giving derivatives useful for various uses by using a specified nitrogenous fluorocarbon and a specified ethylenically unsaturated compound as the constituent monomers. CONSTITUTION:A nitrogenous fluorocarbon of the formula (wherein m is 0 or 1; n is 0-10; and R and R are each 1-5C linear perfluoroalkyl, or perfluoro groups which, together with the N atom, form a ring structure) and at least one ethylenically unsaturated compound selected from among tetrafluoroethylene, vinylidene fluoride, vinyl fluoride, chlorotrifluoroethylene and ethylene are used as the constituent monomers. It is desirable that the melt viscosity of this copolymer is about 100000 to about 5000000 P, and that its molecular weight is about 5000 to 150000.

公开(公告)号：JPH05140092A

公开(公告)日：1993-06-08

申请号：JP35548791

申请日：1991-11-15

Applicant: AGENCY IND SCIENCE TECHN

Inventor： FUKAYA HARUHIKO ,  ABE TAKASHI ,  HAYASHI EIJI ,  HAYAKAWA YOSHIO

IPC: C07D207/10 ,  C07C407/00 ,  C07C409/40 ,  C07D211/36 ,  C07D211/38 ,  C07D241/04 ,  C07D263/04 ,  C07D265/30 ,  C07D295/00 ,  C08K5/34 ,  C08K5/35

Abstract: PURPOSE:To efficiently obtain the title compound as a polymerization initiator for fluorine-contg. monomers, a reagent for incorporation of nitrogen-contg. perfluoro groups, etc.. by oxidation of a specific perfluoro(dialkylamino group- substituted carboxylic acid fluoride). CONSTITUTION:The objective compound of formula II as a polymerization initiator for fluorine-contg. monomers, a reagent for incorporation of nitrogen- contg. perfluoroalkyl groups, a raw material for heating media or solvents can be obtained by oxidation of a perfluoro(dialkylamino group-substituted carboxylic acid fluoride) of formula I (Rf and Rf are each 1-5C perfluoroalkyl, or may be combined either directly or via oxygen or nitrogen atom into 5 to 7-membered ring together with nitrogen atom(s) bound thereto; Rf is 1-3C perfluoralkylene) (e.g. perfluoro-3-morpholinopropionic fluoride) in an organic solvent using hydrogen peroxide.

公开(公告)号：JPH05132451A

公开(公告)日：1993-05-28

申请号：JP29951191

申请日：1991-10-21

Applicant: AGENCY IND SCIENCE TECHN ,  TOHKEM PROD KK

Inventor： ABE TAKASHI ,  HAYASHI EIJI ,  FUKAYA HARUHIKO ,  HAYAKAWA YOSHIO ,  OMORI KOTA

IPC: C07D207/10 ,  C07C211/15 ,  C07D211/38 ,  C07D223/04 ,  C07D241/04 ,  C07D265/30

Abstract: PURPOSE:To easily obtain in high yield from readily available raw materials the title compound useful as a heating medium or fluorine-based solvent, etc., by heating treatment of a specific perfluoro-nitrogen-containing carboxylic acid in a protonic solvent. CONSTITUTION:The objective compound of formula II can be obtained by heating treatment of a perfluoro(dialkylamino-substituted carboxylic acid) of formula I (Rf and Rf are each 1-5C perfluoroalkyl; Rf is 1-3C perfluoroalkylene) in a protonic solvent. It is preferable that water, DMF, or ethylene glycol be used as the protonic solvent in the case a free nitrogen-contg. perfluorocarboxylic acid is used, an acid fluoride used, or an alkali (alkaline earth) metal salt used, as the compound of the formula I, respectively. The reaction is preferably carried out normally at 50-200 deg.C for 1-24hr.

公开(公告)号：JPH04261161A

公开(公告)日：1992-09-17

申请号：JP2090191

申请日：1991-02-14

Applicant: AGENCY IND SCIENCE TECHN ,  NIPPON OILS & FATS CO LTD

Inventor： NISHIDA MASAKAZU ,  FUJII SHOZO ,  KIMOTO HIROSHI ,  HAYAKAWA YOSHIO ,  SAWADA HIDEO ,  MITANI MOTOHIRO ,  NAKAYAMA MASAHARU

IPC: C07D239/54 ,  C07D239/553 ,  C07D239/56 ,  C07D253/06 ,  C07D253/075

Abstract: PURPOSE:To provide the subject compound useful as a drug, agricultural chemical, etc., especially as a synthetic intermediate for carcinostatic agents or antiviral agents. CONSTITUTION:A compound of formula I (R is O, S; Y is C, Ni; Z is H, 1-4C alkyl, trifluoromethyl; X is H, F, Cl; n is 1-10; m is 0,1; m is 1 when Y is C, and m is 0 when Y is N), e.g. 5-(trifluoromethyl)-6-methyluracil. The compound is produced by reacting a di(haloacyl)peroxide of formula II with a pyrimidine compound of formula III preferably in a solvent (e.g. 1,1,2- trichlorotrifluoroethane) at 0-150 deg.C. The peroxide compound and the piperidine compound are used in a molar ratio of 1:0.2-10. The compound of formula I can be readily obtained in a short time and in a high yield without a reaction catalyst and without a specific reaction device.