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    PHARMACEUTICAL COMPOSITION CONTAINING FIBROBLAST GROWTH FACTOR CHIMERA PROTEIN
    2.
    发明专利
    PHARMACEUTICAL COMPOSITION CONTAINING FIBROBLAST GROWTH FACTOR CHIMERA PROTEIN 失效

    公开(公告)号：JPH08310966A

    公开(公告)日：1996-11-26

    申请号：JP11941995

    申请日：1995-05-18

    Applicant: AGENCY IND SCIENCE TECHN

    Inventor： IMAMURA TORU ,  OKA SHUICHI

    IPC: A61K38/22 ,  A61P1/16 ,  A61P25/28 ,  A61P43/00 ,  C07K14/50 ,  C07K19/00

    Abstract: PURPOSE: To obtain the subject heparin-independent composition having excellent action to proliferate hepatocyte and action to promote the differentiation and survival of neurocyte by using a chimera protein containing partial peptides of both acidic and basic fibroblast growth factor proteins as an active component. CONSTITUTION: A chimera protein containing a partial peptide of an acidic fibroblast growth factor (FGF-1) and a partial peptide of a basic fibroblast growth factor (FGF-2) is used as an active component of the subject pharmaceutical composition. Preferably, the chimera protein is e.g. a protein having the amino acid sequence of formula obtained by recombining the amino acid sequence of FGF-1 with the amino acid sequence of FGF-2. The chimera protein is produced preferably by preparing a cDNA coding for FGF-1 and FGF-2 by cassette format, producing a chimera on the cDNA and expressing the chimera by using an expression system such as E.coli. The amount of the chimera protein in the composition is preferably 0.000001-1wt.%.

    MAST CELL DEGRANULATION INHIBITOR
    4.
    发明专利
    MAST CELL DEGRANULATION INHIBITOR 失效

    公开(公告)号：JP2000143528A

    公开(公告)日：2000-05-23

    申请号：JP33266699

    申请日：1999-11-24

    Applicant: AGENCY IND SCIENCE TECHN

    Inventor： OKA SHUICHI ,  INOUE MASAMI ,  NAKAGOME KAZUYA ,  TAKAGI SHINOBU ,  MARUYAMA SUSUMU ,  TOMIZUKA NOBORU ,  ITO SHOTA ,  HATADA KIYOTAKA

    IPC: A23L1/30 ,  A61K8/00 ,  A61K8/96 ,  A61K8/97 ,  A61K36/02 ,  A61P37/08 ,  A61P43/00 ,  A61K35/80 ,  A61K7/00

    Abstract: PROBLEM TO BE SOLVED: To obtain the subject inhibitor having high safety, readily producible, having an inhibiting action on degranulation of mast cell by making the inhibitor include an extract of an alga with water as an active ingredient. SOLUTION: This inhibitor comprises an extract of an alga such as green algae, brown algae, red algae, etc., with water as an active ingredient. The extract, for example, is obtained by removing dirt and organisms attached to the surface of the alga, air-drying and lyophilizing the alga, rewashing the surface of the alga with water, cutting the alga into about 2-5 cm, adding 10-100 mg of the cut alga together with 5-8 ml distilled water into an extracting container, shaking the container for 30 minutes and filtering. The concentration of the active ingredient is 1-100 ppm in the case of a cosmetic and the concentration of the active ingredient is about 0.5 μm to 50 mg/kg weight daily in the administration to a human body. The active ingredient is administered once to several times dividedly.

    ANTI-HIV ACTIVE SUBSTANCE AND ITS PRODUCTION
    5.
    发明专利
    ANTI-HIV ACTIVE SUBSTANCE AND ITS PRODUCTION 失效

    公开(公告)号：JPH115745A

    公开(公告)日：1999-01-12

    申请号：JP15715397

    申请日：1997-06-13

    Applicant: AGENCY IND SCIENCE TECHN ,  OKA SHUICHI ,  HOKUREN

    Inventor： OKA SHUICHI ,  YAMAZAKI YUKINAE ,  TOMIZUKA NOBORU ,  INOUE MASAMI ,  YAMAMOTO YUKIORI ,  FUJITA YASUKO ,  OTAKE TORU ,  KAWABATA TAKUYA ,  FUKUMORI YASUNORI

    IPC: A61K36/00 ,  A61K36/53 ,  A61P31/12 ,  A61P31/18 ,  A61P37/04 ,  A61K35/78

    Abstract: PROBLEM TO BE SOLVED: To obtain the subject substance very low in cytotoxicity, safe, highly active and useful for an anti-HIV agent, anti-HIV food, etc., by subjecting plant of perilla order to extraction treatment by using water, purifying the extract through a DEAE anion ion-exchange chromatography and collecting the eluted fractions. SOLUTION: This anti-HIV active substance is obtained by cutting, slitting and powdering the leaves, stems, seeds, etc., of the plants belonging to plant of perilla order, preferably, Prostrate Bugle subfamily, Lavender subfamily, Perilla subfamily and Isodon subfamily of plant of perilla family (e.g. blue chirimen perilla, red chirimen perilla, Prunella Spike, Kassou) subjecting the powdered material to extraction treatment by using water at room temperatures to the boiling temperature, adding a precipitant (e.g. cetyl pyridinium chloride) to the extract to form the precipitate, eluting water-soluble components from the precipitate, purifying the eluted material by a DEAE anion ion-exchange chromatography and collecting the fractions eluted by using e.g. a solution of sodium chloride as an eluting liquid.

    ANTIMICROBIAL AGENT FOR FISH DISEASE
    6.
    发明专利
    ANTIMICROBIAL AGENT FOR FISH DISEASE 失效

    公开(公告)号：JPH10182454A

    公开(公告)日：1998-07-07

    申请号：JP1221398

    申请日：1998-01-26

    Applicant: AGENCY IND SCIENCE TECHN

    Inventor： KONO YASUHIRO ,  HIGASHIHARA TAKANORI ,  NAKANISHI HIROSHI ,  NAKAWA YOSHINOBU ,  OKA SHUICHI ,  ASADA SHINKO ,  INOUE MASAMI ,  NAKAGOME KAZUYA

    IPC: C12P17/14 ,  A01N43/26 ,  A61K31/39 ,  A61P31/04 ,  A61P33/00 ,  A61P37/08 ,  C07D327/04 ,  C12N1/20 ,  C12R1/01

    Abstract: PROBLEM TO BE SOLVED: To obtain an antimicrobial agent for fish diseases having antimicrobial activities against the fish disease and antimicroalgal and antiallergic activities by making the agent include thiogropocin as an active ingredient. SOLUTION: This antimicrobial agent for fish diseases comprises thiotropocin, separated and collected from cultured product prepared by culturing, e.g. a microorganism belonging to the genus Caulobacter (FERM BP-5080) under conditions of a pH within the range of 7.4-7.6, 10-35 deg.C temperature, 5-7 days, aeration spinner culture, etc., as an active ingredient. The method for administering the objective antimicrobial agent for the fish diseases is carried out by including 5-10% thiotorpicin in, e.g. lactose, which is a preparation substrate, providing a powdery or a granular form, mixing the preparation in a daily dose of 0.1-0.5g/kg body weight of the fishes with a blended feed and administering the resultant blended feed to the fishes for 5-7 days.

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