公开(公告)号：DE3778195D1

公开(公告)日：1992-05-21

申请号：DE3778195

申请日：1987-04-06

Applicant: AGENCY IND SCIENCE TECHN ,  SUMITOMO ELECTRIC INDUSTRIES ,  WATANABE YAKUHIN KOGYO KK

Inventor： KODAMA MAKOTO ,  SAKAI TSUKASA ,  TSUDA KEISHIRO ,  OKITA KOICHI ,  ASAKO SHIGERU ,  KOMAMIYA MASAHARU ,  OINUMA HIROSHI

IPC: A61L33/00 ,  A61L33/06

Abstract: An antithrombogenic material is described, comprising an expanded polytetrafluoroethylene base having a collagen layer provided on the surface thereof, and further provided thereon a composite layer of collagen and a mucopolysaccharide, and said collagen is crosslinked with a crosslinking agent.

公开(公告)号：CA1299937C

公开(公告)日：1992-05-05

申请号：CA533835

申请日：1987-04-03

Applicant: AGENCY IND SCIENCE TECHN ,  SUMITOMO ELECTRIC INDUSTRIES ,  WATANABE YAKUHIN KOGYO KK

Inventor： KODAMA MAKOTO ,  SAKAI TSUKASA ,  TSUDA KEISHIRO ,  OKITA KOICHI ,  ASAKO SHIGERU ,  KOMAMIYA MASAHARU ,  OINUMA HIROSHI

IPC: A61L33/10 ,  A61F2/06 ,  A61L27/00 ,  A61L33/00

Abstract: SO-2-45211HC/YU/87 An antithrombogenic material is described, comprising an expanded polytetrafluoroethylene base having a collagen layer provided on the surface thereof, and further provided thereon a composite layer of collagen and a mucopolysaccharide, and said collagen is crosslinked with a crosslinking agent.

公开(公告)号：FR2516525B1

公开(公告)日：1986-05-23

申请号：FR8219048

申请日：1982-11-15

Applicant: AGENCY IND SCIENCE TECHN

Inventor： ASAI MICHIHIKO ,  TSUDA KEISHIRO ,  IMADA KIYOSHI ,  UENO SUSUMU ,  NOMURA HIROKAZU ,  SHIMURA YUKIO

IPC: C08J7/00 ,  B05D3/06 ,  B05D7/26 ,  B29C71/04 ,  C08J7/04 ,  C08J7/12 ,  C08J7/18 ,  C08K5/54 ,  C08L25/04 ,  C08L77/00 ,  C08J7/10

公开(公告)号：FR2516525A1

公开(公告)日：1983-05-20

申请号：FR8219048

申请日：1982-11-15

Applicant: AGENCY IND SCIENCE TECHN

Inventor： ASAI MICHIHIKO ,  TSUDA KEISHIRO ,  IMADA KIYOSHI ,  UENO SUSUMU ,  NOMURA HIROKAZU ,  SHIMURA YUKIO

IPC: C08J7/00 ,  B05D3/06 ,  B05D7/26 ,  B29C71/04 ,  C08J7/04 ,  C08J7/12 ,  C08J7/18 ,  C08K5/54 ,  C08L25/04 ,  C08L77/00 ,  C08J7/10

公开(公告)号：GB2111064B

公开(公告)日：1985-06-12

申请号：GB8232527

申请日：1982-11-15

Applicant: SHINETSU CHEMICAL CO ,  AGENCY IND SCIENCE TECHN

Inventor： ASAI MICHIHIKO ,  SHIMURA YUKIO ,  TSUDA KEISHIRO ,  UENO SUSUMU ,  NOMURA HIROKAZU ,  IMADA KIYOSHI

IPC: C08J7/00 ,  B05D3/06 ,  B05D7/26 ,  B29C71/04 ,  C08J7/04 ,  C08J7/12 ,  C08J7/18 ,  C08K5/54 ,  C08L25/04 ,  C08L77/00 ,  C08J7/10

公开(公告)号：DE3242229A1

公开(公告)日：1983-09-01

申请号：DE3242229

申请日：1982-11-15

Applicant: SHINETSU CHEMICAL CO ,  AGENCY IND SCIENCE TECHN

Inventor： ASAI MICHIHIKO ,  SHIMURA YUKIO ,  TSUDA KEISHIRO ,  UENO SUSUMU ,  NOMURA HIROKAZU ,  IMADA KIYOSHI

IPC: C08J7/00 ,  B05D3/06 ,  B05D7/26 ,  B29C71/04 ,  C08J7/04 ,  C08J7/12 ,  C08J7/18 ,  C08K5/54 ,  C08L25/04 ,  C08L77/00

公开(公告)号：GB2111064A

公开(公告)日：1983-06-29

申请号：GB8232527

申请日：1982-11-15

Applicant: SHINETSU CHEMICAL CO ,  AGENCY IND SCIENCE TECHN

Inventor： ASAI MICHIHIKO ,  SHIMURA YUKIO ,  TSUDA KEISHIRO ,  UENO SUSUMU ,  NOMURA HIROKAZU ,  IMADA KIYOSHI

IPC: C08J7/00 ,  B05D3/06 ,  B05D7/26 ,  B29C71/04 ,  C08J7/04 ,  C08J7/12 ,  C08J7/18 ,  C08K5/54 ,  C08L25/04 ,  C08L77/00 ,  C08J7/10

公开(公告)号：DE2847304A1

公开(公告)日：1979-05-03

申请号：DE2847304

申请日：1978-10-31

Applicant: AGENCY IND SCIENCE TECHN

Inventor： ASAI MICHIHIKO ,  TSUDA KEISHIRO ,  OKATA AKIRA

IPC: C08J7/00 ,  B29C35/08 ,  B29C59/16 ,  B05D3/06 ,  C08J7/10

Abstract: Shaped articles of polyvinyl chloride resins containing low-molecular plasticizers are irradiated with ultraviolet light of a wavelength in the vacuum ultraviolet region to cause the shaped articles to form therein a cross linked layer capable of preventing otherwise possible exudation of plasticizers to their surface.

公开(公告)号：JPS6438099A

公开(公告)日：1989-02-08

申请号：JP8540687

申请日：1987-04-07

Applicant: AGENCY IND SCIENCE TECHN

Inventor： IWAKURA MASAHIRO ,  TSUDA KEISHIRO

IPC: C12N15/09 ,  C07K7/06 ,  C07K14/00 ,  C07K19/00 ,  C12N1/21 ,  C12N15/00 ,  C12P21/02 ,  C12R1/19

Abstract: NEW MATERIAL:A compound, produced by Escherichia coli C600 strain containing a recombinant plasmid pBLAK1 and having an amino acid sequence expressed by the formula. USE:A hypotensive agent (vasodilator) and intestinal contracting agent. PREPARATION:For example, Escherichia coli C6,000 strain containing a recombinant plasmid pBLAK1 is cultivated in a culture medium and centrifuging is carried out to collect microbial cells, which are then suspended in a buffer solution at pH 7.0. The cells are subsequently crushed by ultrasonic crushing and centrifuged to afford a supernatant. The resultant cell-free extract solution of the cultivated cells is then purified by means of ion exchange column chromatography and succeeding gel filtration column chromatography using a dihydrofolate reductase activity as a measure to provide the aimed protein expressed by the formula.

公开(公告)号：JPS63258597A

公开(公告)日：1988-10-26

申请号：JP9288187

申请日：1987-04-15

Applicant: AGENCY IND SCIENCE TECHN

Inventor： IWAKURA MASAHIRO ,  KOKUBU TOMOKUNI ,  FURUSAWA KIYOTAKA ,  OHASHI SHINICHI ,  TSUDA KEISHIRO

IPC: C12N15/09 ,  C07K1/16 ,  C07K14/00 ,  C07K14/575 ,  C07K14/655 ,  C07K19/00 ,  C12N9/06 ,  C12N13/00 ,  C12P21/02 ,  C12R1/19

Abstract: PURPOSE:To enable purification of the titled protein from a culture liquid, by passing a cell-free extract liquid of cultured microbial cells through an ion exchange column and gel-filtration column. CONSTITUTION:Microbial cells are collected from cultured product of E.coli C600 (FERM P-9301) containing recombinant plasmid pGIF1 and are disintegrated by ultrasonic radiation. The disintegrated product is subjected to centrifugal separation and the obtained supernatant liquid is purified by ion exchange chromatography and subsequent gel-filtration chromatography. The titled protein having amino acid sequence of formula, i.e. fused protein of dihydrofolic acid reductase and somatostatin is produced by the process.