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1.发明申请COMPOUNDS HAVING BOTH POTENT CALCIUM ANTAGONIST AND ANTIOXIDANT ACTIVITY AND USE THEREOF AS CYTOPROTECTIVE AGENTS 审中-公开具有两种钙钙拮抗剂的化合物和抗氧化剂活性及其作为抗肿瘤剂的用途
公开(公告)号：WO1995015958A1
公开(公告)日：1995-06-15
申请号：PCT/US1994014069
申请日：1994-12-07
Applicant: ALCON LABORATORIES, INC.
Inventor： ALCON LABORATORIES, INC. , HELLBERG, Mark , BARNES, George , COLLIER, Robert, J., Jr.
IPC: C07D311/72
CPC classification number: C07D311/72
Abstract: Compounds having both calcium antagonist and antioxidant activity are disclosed. The compounds are useful in preventing or alleviating damage to tissues at the cellular level. Methods of treatment which employ these properties of the compounds and corresponding pharmaceutical compositions are also disclosed.
Abstract translation: 公开了具有钙拮抗剂和抗氧化活性的化合物。 该化合物可用于预防或减轻对细胞水平的组织的损伤。 还公开了使用化合物和相应药物组合物的这些性质的治疗方法。
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2.发明申请
公开(公告)号：WO1997023225A1
公开(公告)日：1997-07-03
申请号：PCT/US1996018235
申请日：1996-11-15
Applicant: ALCON LABORATORIES, INC.
Inventor： ALCON LABORATORIES, INC. , DEAN, Thomas, R. , HELLBERG, Mark , SALLEE, Verney, L.
IPC: A61K31/557
CPC classification number: A61K31/5585 , A61K31/557 , A61K31/5575 , A61K31/559 , A61K45/06 , Y10S514/913 , A61K2300/00
Abstract: Compositions containing DP-agonist and FP-agonists prostaglandin agonists and methods of their use in treating glaucoma or ocular hypertension are disclosed.
Abstract translation: 公开了含DP激动剂和FP-激动剂前列腺素激动剂的组合物及其用于治疗青光眼或高眼压症的方法。
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Patent Agency Ranking3.发明申请USE OF 3-OXA-D-PROSTAGLANDINS FOR THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OF GLAUCOMA 审中-公开使用3-OXA-D-PROSTAGLANDINS制造治疗GLAUCOMA的药物
公开(公告)号：WO1997023224A1
公开(公告)日：1997-07-03
申请号：PCT/US1996018068
申请日：1996-11-14
Applicant: ALCON LABORATORIES, INC.
Inventor： ALCON LABORATORIES, INC. , DEAN, Thomas, R. , HELLBERG, Mark , SALLEE, Verney, L.
IPC: A61K31/557
CPC classification number: A61K31/559 , A61K31/5575 , A61K31/5585 , Y10S514/913
Abstract: Compositions containing 3-Oxa-D-prostaglandins and methods of their use in treating glaucoma or ocular hypertension are disclosed.
Abstract translation: 公开了含有3-氧杂-D-前列腺素的组合物及其用于治疗青光眼或高眼压症的方法。
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4.发明授权
公开(公告)号：EP0799219B1
公开(公告)日：2003-05-07
申请号：EP95944517.2
申请日：1995-12-21
Applicant: ALCON LABORATORIES, INC.
Inventor： HELLBERG, Mark , GRAFF, Gustav , GAMACHE, Daniel, A. , NIXON, Jon, C. , GARNER, William, H.
IPC: C07D311/72 , A61K31/355 , C07D307/80 , A61K31/34 , C07C235/34 , A61K31/16 , C07D317/60 , A61K31/36
CPC classification number: A61K31/343 , A61K31/353 , A61K31/355 , A61K47/545 , C07C235/34 , C07D307/80 , C07D311/72
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5.发明授权COMPOUNDS HAVING BOTH POTENT CALCIUM ANTAGONIST AND ANTIOXIDANT ACTIVITY AND USE THEREOF AS CYTOPROTECTIVE AGENTS 失效连接，既坚固钙和拮抗ANTIOXYDATIEVE运动，其应用作为代理人ZELLSCHUETZENDE。
公开(公告)号：EP0682664B1
公开(公告)日：2001-03-14
申请号：EP95904837.2
申请日：1994-12-07
Applicant: ALCON LABORATORIES, INC.
Inventor： HELLBERG, Mark , BARNES, George , COLLIER, Robert, J., Jr.
IPC: C07D311/72 , C07D295/08 , A61K31/495 , A61K31/355
CPC classification number: C07D311/72
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6.发明公开
公开(公告)号：EP0799219A2
公开(公告)日：1997-10-08
申请号：EP95944517.0
申请日：1995-12-21
Applicant: ALCON LABORATORIES, INC.
Inventor： HELLBERG, Mark , GRAFF, Gustav , GAMACHE, Daniel, A. , NIXON, Jon, C. , GARNER, William, H.
CPC classification number: A61K31/343 , A61K31/353 , A61K31/355 , A61K47/545 , C07C235/34 , C07D307/80 , C07D311/72
Abstract: The compounds of the present invention are of the formula (I): A-X-(CH2)n-Y-(CH3)m-Z wherein: A is an non-steroidal anti-inflammatory agent (NSAIA); A-X is an ester or amide linkage derived from the carboxylic acid moiety of the NSAIA, wherein X is O or NR; R is H, C1-C6 alkyl or C3-C6 cycloalkyl; Y, if present, is O, NR, C(R)2, CH(OH) or S(O)n'; n is 2 to 4 and m is 1 to 4 when Y is O, NR, or S(O)n'; n is 0 to 4 and m is 0 to 4 when Y is C(R)2 or is not present; n is 1 to 4 and m is 0 to 4 when Y is CH(OH); n' is 0 to 2; and Z is (a), (b), (c), (d) or (e) wherein: R' and R3 are H, C(O)R, C(O)N(R)¿2, PO3?-, or SO¿3?-; R' is H or C¿1?-C6 alkyl; and R' and R?3¿ together may form a ring having structure: (1) or (2); and provided that when Z is (e), X is not O. The compounds of the present invention also include pharmaceutically acceptable salts of the compounds of formula (I). Methods for treating inflammatory pathologies are disclosed. Particularly, the methods utilize pharmaceutical compositions containing certain compounds having an anti-inflammatory and anti-oxidant moiety covalently linked by an amide or ester bond. The compounds are useful in preventing and treating inflammatory disorders through several mechanisms.
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7.发明公开COMPOUNDS HAVING BOTH POTENT CALCIUM ANTAGONIST AND ANTIOXIDANT ACTIVITY AND USE THEREOF AS CYTOPROTECTIVE AGENTS 失效连接，既坚固钙和拮抗ANTIOXYDATIEVE运动，其应用作为代理人ZELLSCHUETZENDE。
公开(公告)号：EP0682664A1
公开(公告)日：1995-11-22
申请号：EP95904837.0
申请日：1994-12-07
Applicant: ALCON LABORATORIES, INC.
Inventor： HELLBERG, Mark , BARNES, George , COLLIER, Robert, J., Jr.
IPC: C07D295 , A61K31 , A61P3 , A61P39 , A61P43 , C07D209 , C07D307 , C07D311 , C07D327 , C07D401 , C07D405 , C07D411 , C07D471
CPC classification number: C07D311/72
Abstract: Compounds having both calcium antagonist and antioxidant activity are disclosed. The compounds are useful in preventing or alleviating damage to tissues at the cellular level. Methods of treatment which employ these properties of the compounds and corresponding pharmaceutical compositions are also disclosed.
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