公开(公告)号：WO1996014887A1

公开(公告)日：1996-05-23

申请号：PCT/US1995014912

申请日：1995-11-16

Applicant: ALCON LABORATORIES, INC.

Inventor： ALCON LABORATORIES, INC. ,  Llanos, Gerard ,  KARAKELLE, Mutlu ,  HARRIS, Joe, Milton

IPC: A61L27/00

CPC classification number: A61F2/16 ,  A61L2/206 ,  A61L27/34 ,  A61L29/085 ,  A61L33/068 ,  C08L71/02

Abstract: Polyethylene oxide (PEO) coatings providing improved biocompatibility for implantable medical devices are disclosed. The PEO coatings comprise functionalized, end-capped PEO which is attached at one end to the medical device. The PEO compounds are then cross-linked by 1) exposure to a high energy source for a time sufficient to cause the PEO compounds to form a cross-linked, insoluble network or 2) by reacting the free functionalized ends of a sufficient number of bound PEO compounds with a crosslinking agent whose functional groups are reactive toward the bound PEO chain's functionalized ends. These PEO coatings are able to survive ethylene oxide sterilization procedures with minimal loss of protein or cell repulsion ability.

Abstract translation: 公开了提供用于可植入医疗装置的改善的生物相容性的聚环氧乙烷（PEO）涂层。 PEO涂层包括功能化的端封PEO，其一端连接到医疗装置。 然后将PEO化合物通过1）暴露于高能量源足以使PEO化合物形成交联的不溶性网络的时间进行交联，或2）通过使足够数量的结合的游离官能化末端反应 具有交联剂的PEO化合物，其官能团对结合的PEO链的官能化末端具有反应性。 这些PEO涂层能够以最小的蛋白质损失或细胞排斥能力在环氧乙烷灭菌程序中存活。

公开(公告)号：EP0739218A1

公开(公告)日：1996-10-30

申请号：EP95939997.0

申请日：1995-11-16

Applicant: ALCON LABORATORIES, INC.

Inventor： Llanos, Gerard ,  KARAKELLE, Mutlu ,  HARRIS, Joe, Milton

IPC: A61L27 ,  A61L2 ,  A61L29 ,  A61L33

CPC classification number: A61F2/16 ,  A61L2/206 ,  A61L27/34 ,  A61L29/085 ,  A61L33/068 ,  C08L71/02

Abstract: Polyethylene oxide (PEO) coatings providing improved biocompatibility for implantable medical devices are disclosed. The PEO coatings comprise functionalized, end-capped PEO which is attached at one end to the medical device. The PEO compounds are then cross-linked by 1) exposure to a high energy source for a time sufficient to cause the PEO compounds to form a cross-linked, insoluble network or 2) by reacting the free functionalized ends of a sufficient number of bound PEO compounds with a crosslinking agent whose functional groups are reactive toward the bound PEO chain's functionalized ends. These PEO coatings are able to survive ethylene oxide sterilization procedures with minimal loss of protein or cell repulsion ability.