公开(公告)号：WO2022109242A1

公开(公告)日：2022-05-27

申请号：PCT/US2021/060048

申请日：2021-11-19

Applicant: AMGEN INC.

Inventor： ACHMATOWICZ, Michal ,  COYLER, John T. ,  CORBETT, Michael T. ,  GRIFFIN, Daniel J. ,  PARSONS, Andrew T. ,  ROBINSON, Joanna ,  QUASDORF, Kyle

IPC: C07D471/04

Abstract: Provided herein is a process for preparing compound A comprising (a) admixing 2-isopropyl-4-methylpyridin-3-amine (Compound B), or a salt thereof, a first base, and a reactive compound comprising phosgene or a phosgene equivalent in an organic solvent to form 3‑isocyanato-2-isopropyl-4-methylpyridine (Compound C); (b) admixing Compound C and 2,6-dichloro-5-fluoronicotinamide (Compound D) to form 2,6-dichloro-5-fluoro-N-((2-isopropy1-4-methylpyridin-3-yl)carbamoyl)nicotinamide (Compound E); and (c) admixing Compound E and a second base to form a product mixture comprising Compound A and the second base. Also provided herein is a process for synthesizing AMG 510 comprising using Compound A prepared according to the disclosed processes [Insert Structure] (Compound A).

公开(公告)号：EP4247813A1

公开(公告)日：2023-09-27

申请号：EP21827309.2

申请日：2021-11-19

Applicant: Amgen, Inc

Inventor： ACHMATOWICZ, Michal ,  COYLER, John T. ,  CORBETT, Michael T. ,  GRIFFIN, Daniel J. ,  PARSONS, Andrew T. ,  ROBINSON, Joanna ,  QUASDORF, Kyle

IPC: C07D471/04