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1.发明申请
公开(公告)号：WO2022109242A1
公开(公告)日：2022-05-27
申请号：PCT/US2021/060048
申请日：2021-11-19
Applicant: AMGEN INC.
Inventor： ACHMATOWICZ, Michal , COYLER, John T. , CORBETT, Michael T. , GRIFFIN, Daniel J. , PARSONS, Andrew T. , ROBINSON, Joanna , QUASDORF, Kyle
IPC: C07D471/04
Abstract: Provided herein is a process for preparing compound A comprising (a) admixing 2-isopropyl-4-methylpyridin-3-amine (Compound B), or a salt thereof, a first base, and a reactive compound comprising phosgene or a phosgene equivalent in an organic solvent to form 3‑isocyanato-2-isopropyl-4-methylpyridine (Compound C); (b) admixing Compound C and 2,6-dichloro-5-fluoronicotinamide (Compound D) to form 2,6-dichloro-5-fluoro-N-((2-isopropy1-4-methylpyridin-3-yl)carbamoyl)nicotinamide (Compound E); and (c) admixing Compound E and a second base to form a product mixture comprising Compound A and the second base. Also provided herein is a process for synthesizing AMG 510 comprising using Compound A prepared according to the disclosed processes [Insert Structure] (Compound A).
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公开(公告)号：WO2022192414A2
公开(公告)日：2022-09-15
申请号：PCT/US2022/019573
申请日：2022-03-09
Applicant: AMGEN INC.
Inventor： CAILLE, Sebastien , MURRAY, James , QUASDORF, Kyle , NGUYEN, Hannah , SILVA ELIPE, Maria Victoria , ERICSON, Ari Elizabeth
IPC: C07C201/10 , C07C205/12 , C07C201/08
Abstract: Provided herein are synthetic methods for the preparation of intermediates that are utilized in the synthesis of omecamtiv mecarbil dihydrochloride.
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公开(公告)号：WO2020037164A1
公开(公告)日：2020-02-20
申请号：PCT/US2019/046726
申请日：2019-08-16
Applicant: AMGEN INC. , CYTOKINETICS, INC.
Inventor： MORRISON, Henry , CUI, Sheng , QUASDORF, Kyle , YANEZ, Evelyn , QUAN, Bin, Peter , KELLY, Ron, C. , CAILLE, Sebastien , XIAO, Lingyun , PEARSON, David , RAEBURN, Jaclyn , GOLIGHTLY, Ailsa , MORGAN, Bradley , PETERSON, Matthew , EBERLIN, Alex , OBLEZOV, Alexander
IPC: A61P9/00 , C07D213/75 , A61K31/496 , C07C55/06 , C07C55/08 , C07C55/10 , C07C57/145 , C07C57/15 , C07C59/255 , C07C309/04 , C07C309/08 , C07C309/35
Abstract: Provided herein are free base crystalline forms, crystalline salts, and an amorphous salts of omecamtiv mecarbil.
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公开(公告)号：WO2019006231A1
公开(公告)日：2019-01-03
申请号：PCT/US2018/040176
申请日：2018-06-29
Applicant: AMGEN INC.
Inventor： CAILLE, Sebastien , QUASDORF, Kyle , ROOSEN, Philipp , SHI, Xianqing , COSBIE, Andrew , WANG, Fang , WU, Zufan , NEERGUNDA, Archana , QUAN, Bin, Peter , GUAN, Lianxiu
IPC: C07D295/205 , C07D213/75
Abstract: Provided herein is a synthesis for omecamtiv mecarbil dihydrochloride hydrate and various intermediates. (I)
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公开(公告)号：EP3925950A1
公开(公告)日：2021-12-22
申请号：EP21174262.2
申请日：2018-06-29
Applicant: Amgen Inc.
Inventor： CAILLE, Sebastien , QUASDORF, Kyle , ROOSEN, Philipp , SHI, Xianqing , COSBIE, Andrew , WANG, Fang , WU, Zufan , NEERGUNDA, Archana , QUAN, Peter Bin , GUAN, Lianxiu
IPC: C07D213/75
Abstract: The invention relates to a process for preparing omecamtiv mecarbil free base and omecamtiv mecarbil dihydrochloride hydrate.
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Patent Agency Ranking
公开(公告)号：EP4265597A2
公开(公告)日：2023-10-25
申请号：EP23189293.6
申请日：2018-06-29
Applicant: Amgen Inc.
Inventor： CAILLE, Sebastien , QUASDORF, Kyle , ROOSEN, Philipp , SHI, Xianqing , COSBIE, Andrew , WANG, Fang , WU, Zufan , NEERGUNDA, Archana , QUAN, Peter Bin , GUAN, Lianxiu
IPC: C07D213/75
Abstract: Provided herein is a synthesis for omecamtiv mecarbil dihydrochloride hydrate and various intermediates.
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7.发明公开
公开(公告)号：EP4247813A1
公开(公告)日：2023-09-27
申请号：EP21827309.2
申请日：2021-11-19
Applicant: Amgen, Inc
Inventor： ACHMATOWICZ, Michal , COYLER, John T. , CORBETT, Michael T. , GRIFFIN, Daniel J. , PARSONS, Andrew T. , ROBINSON, Joanna , QUASDORF, Kyle
IPC: C07D471/04
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公开(公告)号：EP3837009A1
公开(公告)日：2021-06-23
申请号：EP19762026.3
申请日：2019-08-16
Applicant: Amgen, Inc , Cytokinetics, Inc.
Inventor： MORRISON, Henry , CUI, Sheng , QUASDORF, Kyle , YANEZ, Evelyn , QUAN, Bin, Peter , KELLY, Ron, C. , CAILLE, Sebastien , XIAO, Lingyun , PEARSON, David , RAEBURN, Jaclyn , GOLIGHTLY, Ailsa , MORGAN, Bradley , PETERSON, Matthew , EBERLIN, Alex , OBLEZOV, Alexander
IPC: A61P9/00 , C07D213/75 , A61K31/496 , C07C55/06 , C07C55/08 , C07C55/10 , C07C57/145 , C07C57/15 , C07C59/255 , C07C309/04 , C07C309/08 , C07C309/35
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公开(公告)号：EP3645518A1
公开(公告)日：2020-05-06
申请号：EP18743314.9
申请日：2018-06-29
Applicant: Amgen Inc.
Inventor： CAILLE, Sebastien , QUASDORF, Kyle , ROOSEN, Philipp , SHI, Xianqing , COSBIE, Andrew , WANG, Fang , WU, Zufan , NEERGUNDA, Archana , QUAN, Bin, Peter , GUAN, Lianxiu
IPC: C07D295/205 , C07D213/75
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公开(公告)号：EP4305018A2
公开(公告)日：2024-01-17
申请号：EP22712763.6
申请日：2022-03-09
Applicant: Amgen Inc.
Inventor： CAILLE, Sebastien , MURRAY, James , QUASDORF, Kyle , NGUYEN, Hannah , SILVA ELIPE, Maria Victoria , ERICSON, Ari Elizabeth
IPC: C07C201/10 , C07C205/12
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