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1.发明申请HYDRATE, CRYSTALLINE HYDRATE AND CRYSTALLINE ANHYDRATE FORMS OF N-((1S)-1-(7-FLUORO-2-(2-PYRIDINYL)-3-QUINOLINYL)ETHYL)-9H-PURIN-6-AMINE, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND METHODS FOR TREATING CANCER. 审中-公开N，（（1S）-1-（7-氟-2-（2-吡啶基）-3-喹啉基）乙基）-9H-嘌呤-6-胺，含有它们的药物组合物的水合物，晶体水合物和晶体结构形式 和治疗癌症的方法。
公开(公告)号：WO2015171725A1
公开(公告)日：2015-11-12
申请号：PCT/US2015/029413
申请日：2015-05-06
Applicant: AMGEN INC.
Inventor： KELLY, Ron, C. , WORTMAN, Sarah
IPC: C07D473/34 , A61K31/52 , A61P35/00
CPC classification number: C07D473/34
Abstract: Provided herein are novel hydrate and anhydrate forms of N-((1S)-1-(7-fluoro-2-(2-pyridinyl)-3-quinolinyl)ethyl)-9H-purin-6-amine. Also provided herein are pharmaceutical compositions containing the forms, and methods for using such compositions for treating cancer.
Abstract translation: 本文提供了N - （（1S）-1-（7-氟-2-（2-吡啶基）-3-喹啉基）乙基）-9H-嘌呤-6-胺的新型水合物和无水物形式。 本文还提供含有形式的药物组合物，以及使用这些组合物治疗癌症的方法。
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公开(公告)号：WO2014200937A1
公开(公告)日：2014-12-18
申请号：PCT/US2014/041594
申请日：2014-06-09
Applicant: AMGEN INC.
Inventor： BIO, Matthew , CAILLE, Sebastien , COCHRAN, Brian , FANG, Yuanqing , FOX, Brian, M. , LUCAS, Brian, S. , MCGEE, Lawrence, R. , VOUNATSOS, Filisaty , WIEDEMANN, Sean , WORTMAN, Sarah
IPC: C07D211/76 , A61K31/45 , A61P35/00 , C07C309/04 , C07D498/04
CPC classification number: A61K31/451 , C07B2200/13 , C07C309/04 , C07C309/25 , C07C309/35 , C07C313/02 , C07D211/76 , C07D211/94 , C07D491/048 , C07D498/04
Abstract: The present invention provides processes for making 2-((3R,5R,6S)-5-(3- chlorophenyl)-6-(4-chlorophenyl)-l-((S)-l-(isopropylsulfonyl)-3-methylbutan-2-yl)-3- methyl-2-oxopiperidin-3-yl)acetic acid as well as intermediates and processes for making the intermediates. Also provided are crystalline forms of the compound and the intermediates.
Abstract translation: 本发明提供了制备2 - （（3R，5R，6S）-5-（3-氯苯基）-6-（4-氯苯基）-1 - （（S）-1-（异丙基磺酰基）-3-甲基丁基 -2-基）-3-甲基-2-氧代哌啶-3-基）乙酸，以及制备中间体的中间体和方法。 还提供了化合物和中间体的晶型。
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公开(公告)号：EP3008039A1
公开(公告)日：2016-04-20
申请号：EP14735785.9
申请日：2014-06-09
Applicant: AMGEN, INC.
Inventor： BIO, Matthew , CAILLE, Sebastien , COCHRAN, Brian , FANG, Yuanqing , FOX, Brian, M. , LUCAS, Brian, S. , MCGEE, Lawrence, R. , VOUNATSOS, Filisaty , WIEDEMANN, Sean , WORTMAN, Sarah
IPC: C07D211/76 , A61K31/45 , A61P35/00 , C07C309/04 , C07D498/04
Abstract: The present invention provides processes for making 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid as well as intermediates and processes for making the intermediates. Also provided are crystalline forms of the compound and the intermediates.
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公开(公告)号：EP3008039B1
公开(公告)日：2020-11-11
申请号：EP14735785.9
申请日：2014-06-09
Applicant: AMGEN INC.
Inventor： BIO, Matthew , CAILLE, Sebastien , COCHRAN, Brian , FANG, Yuanqing , FOX, Brian, M. , LUCAS, Brian, S. , MCGEE, Lawrence, R. , VOUNATSOS, Filisaty , WIEDEMANN, Sean , WORTMAN, Sarah
IPC: C07D211/76 , A61K31/45 , A61P35/00 , C07C309/04 , C07D498/04
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