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公开(公告)号：WO2021097207A1
公开(公告)日：2021-05-20
申请号：PCT/US2020/060415
申请日：2020-11-13
Applicant: AMGEN INC.
Inventor： CORBETT, Michael Thomas , CAILLE, Sebastien
IPC: C07D213/73 , C07D213/85 , A61K31/44
Abstract: The present disclosure relates to an improved, efficient, scalable process to prepare intermediate compounds, such as 2-isopropyl-4-methylpyridin-3-amine, useful for the synthesis of compounds, such as Compound 9, for the treatment of KRAS G12C mutated cancers.
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公开(公告)号：WO2020047424A1
公开(公告)日：2020-03-05
申请号：PCT/US2019/049087
申请日：2019-08-30
Applicant: AMGEN, INC.
Inventor： CAILLE, Sebastien , CORBETT, Michael , SMITH, Austin
IPC: A61K31/45 , C07D211/76 , C07D471/04 , C07D498/04
Abstract: The present invention provides commercial processes for preparing 2- ((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-l-((S)-l-(isopropylsulfonyl)-3-methylbutan-2-yl)-3 -m ethyl-2-oxopiperi din-3 -yl)acetic acid as well as intermediates thereof.
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公开(公告)号：WO2020047424A9
公开(公告)日：2020-03-05
申请号：PCT/US2019/049087
申请日：2019-08-30
Applicant: AMGEN, INC.
Inventor： CAILLE, Sebastien , CORBETT, Michael , SMITH, Austin
IPC: A61K31/45 , C07D211/76 , C07D471/04 , C07D498/04
Abstract: The present invention provides commercial processes for preparing 2- ((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-l-((S)-l-(isopropylsulfonyl)-3-methylbutan-2-yl)-3 -m ethyl-2-oxopiperi din-3 -yl)acetic acid as well as intermediates thereof.
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公开(公告)号：WO2014200937A1
公开(公告)日：2014-12-18
申请号：PCT/US2014/041594
申请日：2014-06-09
Applicant: AMGEN INC.
Inventor： BIO, Matthew , CAILLE, Sebastien , COCHRAN, Brian , FANG, Yuanqing , FOX, Brian, M. , LUCAS, Brian, S. , MCGEE, Lawrence, R. , VOUNATSOS, Filisaty , WIEDEMANN, Sean , WORTMAN, Sarah
IPC: C07D211/76 , A61K31/45 , A61P35/00 , C07C309/04 , C07D498/04
CPC classification number: A61K31/451 , C07B2200/13 , C07C309/04 , C07C309/25 , C07C309/35 , C07C313/02 , C07D211/76 , C07D211/94 , C07D491/048 , C07D498/04
Abstract: The present invention provides processes for making 2-((3R,5R,6S)-5-(3- chlorophenyl)-6-(4-chlorophenyl)-l-((S)-l-(isopropylsulfonyl)-3-methylbutan-2-yl)-3- methyl-2-oxopiperidin-3-yl)acetic acid as well as intermediates and processes for making the intermediates. Also provided are crystalline forms of the compound and the intermediates.
Abstract translation: 本发明提供了制备2 - （（3R，5R，6S）-5-（3-氯苯基）-6-（4-氯苯基）-1 - （（S）-1-（异丙基磺酰基）-3-甲基丁基 -2-基）-3-甲基-2-氧代哌啶-3-基）乙酸，以及制备中间体的中间体和方法。 还提供了化合物和中间体的晶型。
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公开(公告)号：WO2022192414A2
公开(公告)日：2022-09-15
申请号：PCT/US2022/019573
申请日：2022-03-09
Applicant: AMGEN INC.
Inventor： CAILLE, Sebastien , MURRAY, James , QUASDORF, Kyle , NGUYEN, Hannah , SILVA ELIPE, Maria Victoria , ERICSON, Ari Elizabeth
IPC: C07C201/10 , C07C205/12 , C07C201/08
Abstract: Provided herein are synthetic methods for the preparation of intermediates that are utilized in the synthesis of omecamtiv mecarbil dihydrochloride.
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Patent Agency Ranking
公开(公告)号：WO2020037164A1
公开(公告)日：2020-02-20
申请号：PCT/US2019/046726
申请日：2019-08-16
Applicant: AMGEN INC. , CYTOKINETICS, INC.
Inventor： MORRISON, Henry , CUI, Sheng , QUASDORF, Kyle , YANEZ, Evelyn , QUAN, Bin, Peter , KELLY, Ron, C. , CAILLE, Sebastien , XIAO, Lingyun , PEARSON, David , RAEBURN, Jaclyn , GOLIGHTLY, Ailsa , MORGAN, Bradley , PETERSON, Matthew , EBERLIN, Alex , OBLEZOV, Alexander
IPC: A61P9/00 , C07D213/75 , A61K31/496 , C07C55/06 , C07C55/08 , C07C55/10 , C07C57/145 , C07C57/15 , C07C59/255 , C07C309/04 , C07C309/08 , C07C309/35
Abstract: Provided herein are free base crystalline forms, crystalline salts, and an amorphous salts of omecamtiv mecarbil.
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公开(公告)号：WO2019006231A1
公开(公告)日：2019-01-03
申请号：PCT/US2018/040176
申请日：2018-06-29
Applicant: AMGEN INC.
Inventor： CAILLE, Sebastien , QUASDORF, Kyle , ROOSEN, Philipp , SHI, Xianqing , COSBIE, Andrew , WANG, Fang , WU, Zufan , NEERGUNDA, Archana , QUAN, Bin, Peter , GUAN, Lianxiu
IPC: C07D295/205 , C07D213/75
Abstract: Provided herein is a synthesis for omecamtiv mecarbil dihydrochloride hydrate and various intermediates. (I)
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公开(公告)号：EP3837009A1
公开(公告)日：2021-06-23
申请号：EP19762026.3
申请日：2019-08-16
Applicant: Amgen, Inc , Cytokinetics, Inc.
Inventor： MORRISON, Henry , CUI, Sheng , QUASDORF, Kyle , YANEZ, Evelyn , QUAN, Bin, Peter , KELLY, Ron, C. , CAILLE, Sebastien , XIAO, Lingyun , PEARSON, David , RAEBURN, Jaclyn , GOLIGHTLY, Ailsa , MORGAN, Bradley , PETERSON, Matthew , EBERLIN, Alex , OBLEZOV, Alexander
IPC: A61P9/00 , C07D213/75 , A61K31/496 , C07C55/06 , C07C55/08 , C07C55/10 , C07C57/145 , C07C57/15 , C07C59/255 , C07C309/04 , C07C309/08 , C07C309/35
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公开(公告)号：EP4265597A2
公开(公告)日：2023-10-25
申请号：EP23189293.6
申请日：2018-06-29
Applicant: Amgen Inc.
Inventor： CAILLE, Sebastien , QUASDORF, Kyle , ROOSEN, Philipp , SHI, Xianqing , COSBIE, Andrew , WANG, Fang , WU, Zufan , NEERGUNDA, Archana , QUAN, Peter Bin , GUAN, Lianxiu
IPC: C07D213/75
Abstract: Provided herein is a synthesis for omecamtiv mecarbil dihydrochloride hydrate and various intermediates.
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公开(公告)号：EP3008039B1
公开(公告)日：2020-11-11
申请号：EP14735785.9
申请日：2014-06-09
Applicant: AMGEN INC.
Inventor： BIO, Matthew , CAILLE, Sebastien , COCHRAN, Brian , FANG, Yuanqing , FOX, Brian, M. , LUCAS, Brian, S. , MCGEE, Lawrence, R. , VOUNATSOS, Filisaty , WIEDEMANN, Sean , WORTMAN, Sarah
IPC: C07D211/76 , A61K31/45 , A61P35/00 , C07C309/04 , C07D498/04
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