公开(公告)号：WO2010062087A2

公开(公告)日：2010-06-03

申请号：PCT/KR2009006883

申请日：2009-11-23

Applicant: AMOREPACIFIC CORP ,  KIM EUN JOO ,  RHO HO SIK ,  KIM SU JONG ,  MOON EUN JEONG ,  CHO GA YOUNG ,  PARK HYE YOON ,  HA JUNG CHUL ,  KIM DUCK HEE ,  KIM HAN KON

Inventor： KIM EUN JOO ,  RHO HO SIK ,  KIM SU JONG ,  MOON EUN JEONG ,  CHO GA YOUNG ,  PARK HYE YOON ,  HA JUNG CHUL ,  KIM DUCK HEE ,  KIM HAN KON

IPC: A61K8/97 ,  A61Q19/02

CPC classification number: A61Q19/02 ,  A61K8/97 ,  A61K2800/782

Abstract: Disclosed is a whitening composition for external skin application. Containing one or more of Oldenlandia diffusa Willd extract, Rheum undulatum extract and Broussonetia kazinoki extract as an effective ingredient, the whitening composition for external skin application exhibits superior melanogenesis inhibition and skin whitening effect. Accordingly, it may be used in various skin whitening cosmetics.

Abstract translation: 公开了一种用于外用皮肤的美白组合物。 含有一种或多种奥兰德里亚苦参提取物，大黄未提取物和布鲁氏菌提取物作为有效成分，外用皮肤应用的美白组合物表现出优异的黑素生成抑制和皮肤美白效果。 因此，它可以用于各种皮肤美白化妆品。

公开(公告)号：WO2009108021A3

公开(公告)日：2010-02-18

申请号：PCT/KR2009000979

申请日：2009-02-27

Applicant: AMOREPACIFIC CORP ,  IND ACADEMIC COOP ,  CHANG HUIKYOUNG ,  KIM SU JONG ,  AHN SOO MI ,  HWANG JAE SUNG ,  YOON TAE-JIN ,  LEE JEUNG HOON ,  KIM JIN HWA

Inventor： CHANG HUIKYOUNG ,  KIM SU JONG ,  AHN SOO MI ,  HWANG JAE SUNG ,  YOON TAE-JIN ,  LEE JEUNG HOON ,  KIM JIN HWA

IPC: C12N15/12

CPC classification number: C07K14/47

Abstract: The present invention relates to a biomarker for diagnosing hyperpigmentation of skin, which comprises a gene selected from the group consisting of genes listed in Table 1, or a protein selected from the group consisting of proteins listed in Table 1.

Abstract translation: 本发明涉及用于诊断皮肤色素沉着过度的生物标志物，其包含选自表1所列基因的基因或选自表1所列蛋白质的蛋白质。

公开(公告)号：WO2009048282A3

公开(公告)日：2009-09-17

申请号：PCT/KR2008005945

申请日：2008-10-09

Applicant: AMOREPACIFIC CORP ,  KIM SU JONG ,  HWANG JUNG SUN ,  HWANG JAE SUNG ,  LEE YONG SUNG

Inventor： KIM SU JONG ,  HWANG JUNG SUN ,  HWANG JAE SUNG ,  LEE YONG SUNG

IPC: C12Q1/68

CPC classification number: C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/6893 ,  G01N2500/04 ,  G01N2800/20

Abstract: Disclosed are a kit for diagnosing skin aging using one or more polynucleotides or their complementary polynucleotides that hybridize with a gene sequence, a pair of primers for the gene sequence; or one or more monoclonal antibodies binding to the polypeptide encoded by the gene, which are used to identify the genes of which the expression pattern is changed in a skin keratin-forming cell by female hormone and used to diagnose degree of skin aging caused by female hormonal deficiency by using the information, and a method using the same.

Abstract translation: 公开了一种用于诊断皮肤老化的试剂盒，其使用与基因序列，基因序列的一对引物杂交的一种或多种多核苷酸或它们的互补多核苷酸; 或与由该基因编码的多肽结合的一种或多种单克隆抗体，其用于鉴定表达模式在皮肤角质形成细胞中由雌激素改变的基因，并用于诊断由雌性引起的皮肤老化程度 使用该信息的激素缺乏症以及使用该信息的方法。

公开(公告)号：KR20120103537A

公开(公告)日：2012-09-19

申请号：KR20120098405

申请日：2012-09-05

Applicant: AMOREPACIFIC CORP

Inventor： KIM SU JONG ,  HWANG JAE SUNG ,  LEE JEUNG HOON ,  KIM CHANG DEOK

IPC: C12N15/63 ,  C12N15/12 ,  G01N33/15

Abstract: PURPOSE: A method for screening an agent for preventing aberrant keratinocyte differentiation is provided to use a gene as a gene target for developing a therapeutic agent for treating dermatitis and to evaluate the agent. CONSTITUTION: A method for screening an agent for preventing aberrant keratinocyte differentiation comprises: a step of transfection of plasmids to cells; a step of treating the cell to a test compound; and a step of identifying whether the test compound stimulates the reporter gene. The plasmids includes: a plasmid containing Nrf-2 gene and universal promoter; a plasmid contains DNA which binds with a transcription factor and a reporter gene; and a plasmid containing Nkx-2.5, AP-1, MEIS1A/HOXA9, MEIS1B/HOXA9, CREB, ISRE-BP, Hand1/E47, Pax-6, c-Myb, v-Maf, Elk-1, E47, CRE-BP1, IRF-1, IRF-2, c-Rel, c-Ets-1(p54), USF, VBP, Hox-1.3, Brn-2, COMP1-factor, CDP_CR1, CP2 or NF-kB(p50) gene and a universal promoter. The agent is a therapeutic agent for treating psoriasis. [Reference numerals] (AA) Gene pattern in which expression is reduced during differentiation; (BB) Relative expression level(times); (CC) Time(days)

Abstract translation: 目的：提供一种筛选用于预防异常角化细胞分化的药剂的方法，以使用基因作为开发用于治疗皮炎的治疗剂的基因靶标并评价该药物。 构成：筛选用于预防异常角化细胞分化的药剂的方法包括：将质粒转染至细胞的步骤; 将细胞处理成测试化合物的步骤; 以及鉴定测试化合物是否刺激报道基因的步骤。 质粒包括：含有Nrf-2基因和通用启动子的质粒; 质粒含有与转录因子和报告基因结合的DNA; 和含有Nkx-2.5，AP-1，MEIS1A / HOXA9，MEIS1B / HOXA9，CREB，ISRE-BP，Hand1 / E47，Pax-6，c-Myb，v-Maf，Elk-1，E47，CRE- BP1，IRF-1，IRF-2，c-Rel，c-Ets-1（p54），USF，VBP，Hox-1.3，Brn-2，COMP1因子，CDP_CR1，CP2或NF-kB（p50） 和通用启动子。 该药剂是治疗牛皮癣的治疗剂。 （AA）分化期间表达降低的基因模式; （BB）相对表达水平（次）; （CC）时间（天）

公开(公告)号：EP1660437A4

公开(公告)日：2006-09-20

申请号：EP04774404

申请日：2004-08-26

Applicant: AMOREPACIFIC CORP

Inventor： RHO HO SIK ,  BAEK HEUNG SOO ,  KIM SU JONG ,  KIM SU NAM ,  CHAE BYUNG GEUN ,  LEE BYOUNG SEOK ,  KIM BAE HWAN ,  CHOI GYU HO ,  SON EUI DONG ,  LEE HAE KWANG ,  LEE HYE WON ,  CHO JUN-CHEOL ,  KIM DUCK HEE ,  CHANG IH SEOP ,  LEE OK SUB

IPC: C07C259/06 ,  C07C259/10

CPC classification number: A61K8/40 ,  A61Q19/08 ,  C07C259/06 ,  C07C259/10 ,  C07C2603/74

Abstract: The present invention provides hydroxamic acid derivatives represented by the following formula (I), having anti-aging efficacy and a method for preparation thereof: wherein, R1 is or, herein, R5 and R6 each independently represents a hydrogen atom, a C1-C10 alkyl group or a C3-C6 cyclic alkyl group; R2 is CONH, NHCO, CONR7 or NR7CO, herein, R7 represents a C1-C10 alkyl group; R3 is (CH)n-, herein, n=0 or 1; and R4 is a hydrogen atom or a C1-C10 alkyl group. Further, the present invention provides skin-care external compositions for preventing skin aging, containing said hydroxamic acid derivatives represented by the formula (I) as an active ingredient.