公开(公告)号：DE69331526T2

公开(公告)日：2002-10-24

申请号：DE69331526

申请日：1993-11-16

Applicant: ARCH DEV CORP

Inventor： LEIDEN M ,  BARR ELIAV

IPC: C12N15/09 ,  A61K31/7088 ,  A61K35/76 ,  A61K38/00 ,  A61K38/22 ,  A61K45/00 ,  A61K48/00 ,  A61P9/10 ,  C07K14/47 ,  C12N5/10 ,  C12N15/12 ,  C12N15/861 ,  C12P21/00 ,  C12R1/91 ,  C12N15/63 ,  C12N15/86 ,  C07K2/00

Abstract: The present invention relates to the use of adenovirus-mediated gene transfer to regulate function in cardiac and vascular smooth muscle cells. A recombinant adenovirus comprising a DNA sequence that codes for a gene product is delivered to a cardiac or vascular smooth muscle cell and the cell is maintained until that gene product is expressed. Delivery is direct injection into a muscle cell or infusing a pharmaceutical composition containing an adenovirus vector construct intravascularly.

公开(公告)号：DE69331526D1

公开(公告)日：2002-03-14

申请号：DE69331526

申请日：1993-11-16

Applicant: ARCH DEV CORP

Inventor： LEIDEN M ,  BARR ELIAV

IPC: C12N15/09 ,  A61K31/7088 ,  A61K35/76 ,  A61K38/00 ,  A61K38/22 ,  A61K45/00 ,  A61K48/00 ,  A61P9/10 ,  C07K14/47 ,  C12N5/10 ,  C12N15/12 ,  C12N15/861 ,  C12P21/00 ,  C12R1/91 ,  C12N15/63 ,  C12N15/86 ,  C07K2/00

Abstract: The present invention relates to the use of adenovirus-mediated gene transfer to regulate function in cardiac and vascular smooth muscle cells. A recombinant adenovirus comprising a DNA sequence that codes for a gene product is delivered to a cardiac or vascular smooth muscle cell and the cell is maintained until that gene product is expressed. Delivery is direct injection into a muscle cell or infusing a pharmaceutical composition containing an adenovirus vector construct intravascularly.