公开(公告)号：WO0160319A3

公开(公告)日：2002-03-21

申请号：PCT/US0104915

申请日：2001-02-15

Applicant: ARCH DEV CORP ,  LIAO SHUTSUNG ,  HIIPAKKA RICHARD A ,  KAO YUNG HSI

Inventor： LIAO SHUTSUNG ,  HIIPAKKA RICHARD A ,  KAO YUNG-HSI

IPC: A61K31/045 ,  A61K31/05 ,  A61K31/175 ,  A61K31/351 ,  A61K31/353 ,  A61K31/397 ,  A61K31/50 ,  A61K31/549 ,  A61P3/10 ,  A61P29/00 ,  A61P35/00 ,  A61K31/35

CPC classification number: A61K31/549 ,  A61K31/045 ,  A61K31/05 ,  A61K31/175 ,  A61K31/351 ,  A61K31/353 ,  A61K31/397 ,  A61K31/50

Abstract: A method for reducing food intake in a subject and a method for reducing the levels of an endocrine in a subject. The methods include administering to the subject in need thereof an effective amount of a compound of the formula (I). Also disclosed is a liposomal preparation which includes a liposome and a compound entrapped therein. The entrapped compound is of the formula shown above.

Abstract translation: 用于减少受试者的食物摄入的方法和降低受试者内分泌水平的方法。 所述方法包括向有需要的受试者施用有效量的式（I）化合物。 还公开了一种脂质体制剂，其包括脂质体和包埋在其中的化合物。 包埋的化合物具有如上所示的式子。

公开(公告)号：EP1214070A4

公开(公告)日：2008-07-16

申请号：EP01910769

申请日：2001-02-15

Applicant: ARCH DEV CORP

Inventor： LIAO SHUTSUNG ,  HIIPAKKA RICHARD A ,  KAO YUNG-HSI

IPC: A61K31/045 ,  A61K31/05 ,  A61K31/175 ,  A61K31/351 ,  A61K31/353 ,  A61K31/397 ,  A61K31/50 ,  A61K31/549 ,  A61P3/10 ,  A61P29/00 ,  A61P35/00 ,  A61K31/35

CPC classification number: A61K31/549 ,  A61K31/045 ,  A61K31/05 ,  A61K31/175 ,  A61K31/351 ,  A61K31/353 ,  A61K31/397 ,  A61K31/50

公开(公告)号：EP1027045A4

公开(公告)日：2004-12-08

申请号：EP98956358

申请日：1998-10-30

Applicant: ARCH DEV CORP

Inventor： LIAO SHUTSUNG ,  HIIPAKKA RICHARD A

IPC: A61K31/00 ,  A61K31/047 ,  A61K31/075 ,  A61K31/12 ,  A61K31/135 ,  A61K31/165 ,  A61K31/235 ,  A61K31/24 ,  A61K31/35 ,  A61K31/352 ,  A61K31/353 ,  A61K31/44 ,  A61P3/04 ,  A61P13/08 ,  A61P17/00 ,  A61P17/14 ,  A61P35/00 ,  A61P43/00 ,  C07C49/105 ,  C07C49/248 ,  C07C49/255 ,  C07D311/30 ,  C07D311/36 ,  C07D311/62 ,  C07D311/82 ,  C07D311/92 ,  C07C49/76 ,  C07D311/04

CPC classification number: A61K31/44 ,  A61K31/00 ,  A61K31/075 ,  A61K31/12 ,  A61K31/35 ,  C07C49/248 ,  C07C49/255 ,  C07D311/62

Abstract: Compounds that inhibit 5alpha-reductase are provided. The compounds are used to treat prostate cancer, breast cancer, obesity, skin disorders and baldness.

Abstract translation: 提供抑制5α-还原酶的化合物。 该化合物用于治疗前列腺癌，乳腺癌，肥胖，皮肤病和秃发。

公开(公告)号：AU783361B2

公开(公告)日：2005-10-20

申请号：AU3834101

申请日：2001-02-15

Applicant: ARCH DEV CORP

Inventor： LIAO SHUTSUNG ,  HIIPAKKA RICHARD A ,  KAO YUNG-HSI

IPC: A61K31/045 ,  A61K31/05 ,  A61K31/175 ,  A61K31/351 ,  A61K31/353 ,  A61K31/397 ,  A61K31/50 ,  A61K31/549 ,  A61P3/10 ,  A61P29/00 ,  A61P35/00 ,  A61K31/00

Abstract: A method for reducing food intake in a subject and a method for reducing the levels of an endocrine in a subject. The methods include administering to the subject in need thereof an effective amount of a compound of the formula: Also disclosed is a liposomal preparation which includes a liposome and a compound entrapped therein. The entrapped compound is of the formula shown above.

公开(公告)号：AU3834101A

公开(公告)日：2001-08-27

申请号：AU3834101

申请日：2001-02-15

Applicant: ARCH DEV CORP

Inventor： LIAO SHUTSUNG ,  HIIPAKKA RICHARD A ,  KAO YUNG-HSI

IPC: A61K31/045 ,  A61K31/05 ,  A61K31/175 ,  A61K31/351 ,  A61K31/353 ,  A61K31/397 ,  A61K31/50 ,  A61K31/549 ,  A61P3/10 ,  A61P29/00 ,  A61P35/00 ,  A61K31/00

Abstract: A method for reducing food intake in a subject and a method for reducing the levels of an endocrine in a subject. The methods include administering to the subject in need thereof an effective amount of a compound of the formula: Also disclosed is a liposomal preparation which includes a liposome and a compound entrapped therein. The entrapped compound is of the formula shown above.

公开(公告)号：NZ515442A

公开(公告)日：2004-03-26

申请号：NZ51544201

申请日：2001-02-15

Applicant: ARCH DEV CORP

Inventor： LIAO SHUTSUNG ,  HIIPAKKA RICHARD A ,  KAO YUNG-HSI

IPC: A61K31/045 ,  A61K31/05 ,  A61K31/175 ,  A61K31/351 ,  A61K31/353 ,  A61K31/397 ,  A61K31/50 ,  A61K31/549 ,  A61P3/10 ,  A61P29/00 ,  A61P35/00 ,  A61K31/35

Abstract: A compound of formula (I) or a salt thereof is used to reduce food intake or to reduce the level of an endocrine in a patient. The endocrine is testosterone, estradiol, leptin, insulin or insulin like growth factor or luteinizing hormone. A liposomal preparation comprises a compound of formula (I) entrapped in a lipsome. In formula (I) A is alkenyl and each of Ra to Rd is -CH2- phenyl where the phenyl is substituted in the 3, 4 and 5th position by hydroxyl.

公开(公告)号：CA2371419A1

公开(公告)日：2001-08-23

申请号：CA2371419

申请日：2001-02-15

Applicant: ARCH DEV CORP

Inventor： LIAO SHUTSUNG ,  KAO YUNG-HSI ,  HIIPAKKA RICHARD A

IPC: A61K31/045 ,  A61K31/05 ,  A61K31/175 ,  A61K31/351 ,  A61K31/353 ,  A61K31/397 ,  A61K31/50 ,  A61K31/549 ,  A61P3/10 ,  A61P29/00 ,  A61P35/00 ,  A61K31/015

Abstract: A method for reducing food intake in a subject and a method for reducing the levels of an endocrine in a subject. The methods include administering to th e subject in need thereof an effective amount of a compound of the formula (I) . Also disclosed is a liposomal preparation which includes a liposome and a compound entrapped therein. The entrapped compound is of the formula shown above.

公开(公告)号：AU1289899A

公开(公告)日：1999-05-24

申请号：AU1289899

申请日：1998-10-30

Applicant: ARCH DEV CORP

Inventor： LIAO SHUTSUNG ,  HIIPAKKA RICHARD A

IPC: A61K31/00 ,  A61K31/047 ,  A61K31/075 ,  A61K31/12 ,  A61K31/135 ,  A61K31/165 ,  A61K31/235 ,  A61K31/24 ,  A61K31/35 ,  A61K31/352 ,  A61K31/353 ,  A61K31/44 ,  A61P3/04 ,  A61P13/08 ,  A61P17/00 ,  A61P17/14 ,  A61P35/00 ,  A61P43/00 ,  C07C49/105 ,  C07C49/248 ,  C07C49/255 ,  C07D311/30 ,  C07D311/36 ,  C07D311/62 ,  C07D311/82 ,  C07D311/92 ,  C07D311/04 ,  C07C49/76

Abstract: Compounds that inhibit 5alpha-reductase are provided. The compounds are used to treat prostate cancer, breast cancer, obesity, skin disorders and baldness.