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1.发明申请
公开(公告)号：WO9808481A3
公开(公告)日：1999-03-18
申请号：PCT/US9714994
申请日：1997-08-26
Applicant: ARCH DEV CORP , ROTMENSCH JACOB , WHITLOCK JENNY L , HINES JOHN J , HARPER PAUL V
Inventor： ROTMENSCH JACOB , WHITLOCK JENNY L , HINES JOHN J , HARPER PAUL V
CPC classification number: G21G1/001 , A61K51/1282 , G21G1/0005 , G21G2001/0084
Abstract: A process for producing substantially radio-impurity-free Bi-212 is disclosed. An acidic feed solution containing Pb-212 is contacted with an extraction medium to bind the Pb-212 thereto. The extraction medium is rinsed with a second acid solution to remove impurities therefrom, leaving a substantially impurity-free Pb-212-laden extraction medium. The Pb-212 grows on the extraction medium to form Bi-212 by radioactive decay. The Bi-212 is then eluted from the extraction medium with an acid solution to form a substantially radio-impurity-free Bi-212 acid solution. An apparatus for carrying out this process and a process for the therapeutic use thereof are also disclosed.
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公开(公告)号：EP0988634A4
公开(公告)日：2002-11-20
申请号：EP98925207
申请日：1998-06-03
Applicant: ARCH DEV CORP
Inventor： HORWITZ E PHILIP , HINES JOHN J , CHIARIZIA RENATO , DIETZ MARK L
CPC classification number: A61K51/1282 , G21F9/007 , G21F9/12 , G21G4/08
Abstract: A process for producing substantially impurity-free Bi-213 cations is disclosed. An aqueous acid feed solution containing Ac-225 cations is contacted with an ion exchange medium to bind the Ac-225 cations and form an Ac-225-laden ion exchange medium. The bound Ac-225 incubates on the ion exchange medium to form Bi-213 cations by radioactive decay. The Bi-213 cations are then recovered from the Ac-225-laden ion exchange medium to form a substantially impurity-free aqueous Bi-213 cation acid solution. An apparatus for carrying out this process is also disclosed.
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3.发明公开
公开(公告)号：EP0979513A4
公开(公告)日：2002-04-10
申请号：EP97940622
申请日：1997-08-26
Applicant: ARCH DEV CORP
Inventor： ROTMENSCH JACOB , WHITLOCK JENNY L , HINES JOHN J , HARPER PAUL V
IPC: A61K51/00 , A61K31/00 , A61K51/12 , A61P35/00 , C01G29/00 , G21G4/04 , G21G4/08 , G21G1/00 , B01D59/00
CPC classification number: G21G1/001 , A61K51/1282 , G21G1/0005 , G21G2001/0084
Abstract: PCT No. PCT/US97/14994 Sec. 371 Date Jan. 28, 1999 Sec. 102(e) Date Jan. 28, 1999 PCT Filed Aug. 26, 1997 PCT Pub. No. WO98/08481 PCT Pub. Date Mar. 5, 1998A process for producing substantially radio-impurity-free Bi-212 is disclosed. An acidic feed solution containing Pb-212 is contacted with an extraction medium to bind the Pb-212 thereto. The extraction medium is rinsed with a second acid solution to remove impurities therefrom, leaving a substantially impurity-free Pb-212-laden extraction medium The Pb-212 grows on the extraction medium to form Bi-212 by radioactive decay. The Bi-212 is then eluted from the extraction medium with an acid solution to form a substantially radio-impurity-free Bi-212 acid solution. An apparatus for carving out this process and a process for the therapeutic use thereof are also disclosed.
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公开(公告)号：AU743466B2
公开(公告)日：2002-01-24
申请号：AU7721198
申请日：1998-06-03
Applicant: ARCH DEV CORP
Inventor： HORWITZ E PHILIP , HINES JOHN J , CHIARIZIA RENATO , DIETZ MARK L
Abstract: A process for producing substantially impurity-free Bi-213 cations is disclosed. An aqueous acid feed solution containing Ac-225 cations is contacted with an ion exchange medium to bind the Ac-225 cations and form an Ac-225-laden ion exchange medium. The bound Ac-225 incubates on the ion exchange medium to form Bi-213 cations by radioactive decay. The Bi-213 cations are then recovered from the Ac-225-laden ion exchange medium to form a substantially impurity-free aqueous Bi-213 cation acid solution. An apparatus for carrying out this process is also disclosed.
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公开(公告)号：CA2292621A1
公开(公告)日：1998-12-17
申请号：CA2292621
申请日：1998-06-03
Applicant: ARCH DEV CORP
Inventor： CHIARIZIA RENATO , HINES JOHN J , DIETZ MARK L , HORWITZ E PHILIP
Abstract: A process for producing substantially impurity-free Bi-213 cations is disclosed. An aqueous acid feed solution containing Ac-225 cations is contacted with an ion exchange medium to bind the Ac-225 cations and form an Ac-225-laden ion exchange medium. The bound Ac-225 incubates on the ion exchange medium to form Bi-213 cations by radioactive decay. The Bi-213 cations are then recovered from the Ac-225-laden ion exchange medium to form a substantially impurity-free aqueous Bi-213 cation acid solution. An apparatus for carrying out this process is also disclosed.
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Patent Agency Ranking
公开(公告)号：CA2292621C
公开(公告)日：2002-12-10
申请号：CA2292621
申请日：1998-06-03
Applicant: ARCH DEV CORP
Inventor： CHIARIZIA RENATO , HINES JOHN J , HORWITZ E PHILIP , DIETZ MARK L
Abstract: A process for producing substantially impurity-free Bi-213 cations is disclosed. An aqueous acid feed solution containing Ac-225 cations is contacted with an ion exchange medium to bind the Ac-225 cations and form an Ac-225-laden ion exchange medium. The bound Ac-225 incubates on the ion exchange medium to form Bi-213 cations by radioactive decay. The Bi-213 cations are then recovered from the Ac-225-laden ion exchange medium to form a substantially impurity-free aqueous Bi-213 cation acid solution. An apparatu s for carrying out this process is also disclosed.
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公开(公告)号：CA2261772A1
公开(公告)日：1998-03-05
申请号：CA2261772
申请日：1997-08-26
Applicant: ARCH DEV CORP
Inventor： ROTMENSCH JACOB , HINES JOHN J , WHITLOCK JENNY L , HARPER PAUL V
Abstract: A process for producing substantially radio-impurity-free Bi-212 is disclosed. An acidic feed solution containing Pb-212 is contacted with an extraction medium to bind the Pb-212 thereto. The extraction medium is rinsed with a second acid solution to remove impurities therefrom, leaving a substantially impurity-free Pb-212-laden extraction medium. The Pb-212 grows on the extraction medium to form Bi-212 by radioactive decay. The Bi-212 is then eluted from the extraction medium with an acid solution to form a substantially radio-impurity-free Bi-212 acid solution. An apparatus for carrying out this process and a process for the therapeutic use thereof are also disclosed.
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公开(公告)号：AU719602B2
公开(公告)日：2000-05-11
申请号：AU4235997
申请日：1997-08-26
Applicant: ARCH DEV CORP
Inventor： ROTMENSCH JACOB , WHITLOCK JENNY L , HINES JOHN J , HARPER PAUL V
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公开(公告)号：CA2261772C
公开(公告)日：2003-12-09
申请号：CA2261772
申请日：1997-08-26
Applicant: ARCH DEV CORP
Inventor： WHITLOCK JENNY L , ROTMENSCH JACOB , HARPER PAUL V , HINES JOHN J
Abstract: A process for producing substantially radio-impurity-free Bi-212 is disclose d. An acidic feed solution containing Pb-212 is contacted with an extraction medium to bind the Pb-212 thereto. The extraction medium is rinsed with a second acid solution to remove impurities therefrom, leaving a substantially impurity-free Pb-212-laden extraction medium. The Pb-212 grows on the extraction medium to form Bi-212 by radioactive decay. The Bi-212 is then eluted from the extraction medium with an acid solution to form a substantially radio-impurity-free Bi-212 acid solution. An apparatus for carrying out this process and a process for the therapeutic use thereof are also disclosed.
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公开(公告)号：AU7721198A
公开(公告)日：1998-12-30
申请号：AU7721198
申请日：1998-06-03
Applicant: ARCH DEV CORP
Inventor： HORWITZ E PHILIP , HINES JOHN J , CHIARIZIA RENATO , DIETZ MARK L
Abstract: A process for producing substantially impurity-free Bi-213 cations is disclosed. An aqueous acid feed solution containing Ac-225 cations is contacted with an ion exchange medium to bind the Ac-225 cations and form an Ac-225-laden ion exchange medium. The bound Ac-225 incubates on the ion exchange medium to form Bi-213 cations by radioactive decay. The Bi-213 cations are then recovered from the Ac-225-laden ion exchange medium to form a substantially impurity-free aqueous Bi-213 cation acid solution. An apparatus for carrying out this process is also disclosed.
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