公开(公告)号：JP2013079940A

公开(公告)日：2013-05-02

申请号：JP2012182467

申请日：2012-08-21

Applicant: Arkray Inc ,  アークレイ株式会社

Inventor： SHIMOMURA YUKA ,  KOSAKA HIDEKO

IPC: G01N31/00 ,  G01N31/22

CPC classification number: C22B7/006 ,  C22B3/44 ,  G01N31/22 ,  G01N33/84 ,  Y02P10/234

Abstract: PROBLEM TO BE SOLVED: To provide a method for recovering heavy metals by which the variation in heavy metal recovery rate among samples can be suppressed.SOLUTION: A mixture of a sample and a chelating agent capable of chelating with a heavy metal is prepared. A complex between a heavy metal being in the sample and the chelating agent is formed in the presence of a masking agent for a thiol group in the mixture. The heavy metal in the sample is recovered by recovering the complex. By this method, a heavy metal can be recovered with suppressing the variation in the recovery rate among samples. The chelating agent preferably is 1,5-diphenyl-3-thiocarbazone (dithizone). As the masking agent, N-ethylmaleimide, iodoacetamide, iodoacetic acid, or the like can be used.

Abstract translation: 待解决的问题：提供一种回收重金属的方法，通过该方法可以抑制样品中重金属回收率的变化。 溶液：制备能够与重金属螯合的样品和螯合剂的混合物。 在混合物中的硫醇基掩蔽剂存在下，形成样品中的重金属和螯合剂之间的络合物。 通过回收复合物来回收样品中的重金属。 通过这种方法，可以回收重金属，抑制样品中回收率的变化。 螯合剂优选为1,5-二苯基-3-硫代卡巴腙（双硫腙）。 作为掩蔽剂，可以使用N-乙基马来酰亚胺，碘乙酰胺，碘乙酸等。 版权所有（C）2013，JPO＆INPIT

公开(公告)号：JP2004138408A

公开(公告)日：2004-05-13

申请号：JP2002300959

申请日：2002-10-15

Applicant: Arkray Inc ,  アークレイ株式会社

Inventor： KOSAKA HIDEKO

IPC: G01N21/78 ,  G01N33/52 ,  G01N33/70

CPC classification number: G01N33/526 ,  G01N33/523 ,  G01N33/70 ,  G01N2800/347 ,  Y10T436/147777

Abstract: PROBLEM TO BE SOLVED: To provide a new test piece for measurement of creatinine. SOLUTION: A porous material contains a compound represented by Formula (1), and a metal and a buffering agent which form a coloration complex with the compound. The coloration complex formed by the compound and metal is optically measured, and the degree of formation blocking of the coloring complex by creatinine is measured, thus measuring the amount of creatinine. In the expression (1), R 1 indicates H, SO 3 X, and COOX; R 4 and R 6 indicate OH, SO 3 X, and COOX, where each may be the same or different; R 2 , R 3 , R 5 , and R 7 indicate H, OH, Cl, Br, I, NO 2 , NO, and CH 3 , where each may be the same or different; X in R 1 , R 4 , and R 6 indicates H, Na, K, and NH 4 , where each may be the same or different. COPYRIGHT: (C)2004,JPO

公开(公告)号：JP2004138407A

公开(公告)日：2004-05-13

申请号：JP2002300958

申请日：2002-10-15

Applicant: Arkray Inc ,  アークレイ株式会社

Inventor： FUJITA YOSHIICHI ,  KOSAKA HIDEKO

IPC: G01N33/70 ,  G01N21/78 ,  G01N33/52

Abstract: PROBLEM TO BE SOLVED: To provide a new test piece for creatinine measurement.
SOLUTION: A compound of formula (1) is included in a porous material to form the test piece for creatinine measurement. The porous material preferably contains a metal forming a color complex with the compound and a buffer agent. Within the test piece, the color complex formed by the compound and the metal is optically measured to determine the degree of inhibition of formation of the color complex by creatinine, whereby the creatinine amount is measured.
COPYRIGHT: (C)2004,JPO

公开(公告)号：AT525656T

公开(公告)日：2011-10-15

申请号：AT05703979

申请日：2005-01-21

Applicant: ARKRAY INC

Inventor： KOSAKA HIDEKO ,  SAKAMOTO HISASHI

IPC: G01N33/68 ,  C12Q1/34 ,  G01N21/77 ,  G01N21/78 ,  G01N21/82 ,  G01N33/70

Abstract: The present invention relates to a technique of measuring a protein based on a degree of coloring in a liquid sample mixed with a protein measurement indicator. In the present invention, information reflecting creatinine concentration in the liquid sample is obtained, and then an influence quantity caused by creatinine to the protein concentration measurement is eliminated based on the information.

公开(公告)号：JP2008046018A

公开(公告)日：2008-02-28

申请号：JP2006222582

申请日：2006-08-17

Applicant: Arkray Inc ,  アークレイ株式会社

Inventor： KOSAKA HIDEKO ,  SAKAMOTO HISASHI

IPC: G01N33/50 ,  C09B11/28 ,  G01N21/78 ,  G01N33/68

Abstract: PROBLEM TO BE SOLVED: To provide a liquid reagent capable of specifically and simply measuring a very small amount of albumin in a liquid sample such as urine or the like inclusively of modified albumin, which is easily measured by immunoassay, with high sensitivity equal to immunoassay.
SOLUTION: The liquid reagent for measuring a very small amount of albumin in the liquid sample contains a buffer solution, an albumin measuring indicator having a chemical structure represented by a chemical formula 1 and a water-soluble polymer such as hydroxypropyl cellulose or the like being a sensitizer.
COPYRIGHT: (C)2008,JPO&INPIT

Abstract translation: 要解决的问题：提供一种液体试剂，其能够特异性且简单地测量包含修饰白蛋白的液体样品如尿等中的非常少量的白蛋白，其通过免疫测定容易测量，具有高灵敏度 等于免疫测定。 解决方案：用于测量液体样品中非常少量白蛋白的液体试剂含有缓冲溶液，具有由化学式1表示的化学结构的白蛋白测量指示剂和水溶性聚合物如羟丙基纤维素或 像是敏化剂。 版权所有（C）2008，JPO＆INPIT

公开(公告)号：AU2003252383A1

公开(公告)日：2004-02-25

申请号：AU2003252383

申请日：2003-08-04

Applicant: ARKRAY INC

Inventor： KOSAKA HIDEKO

IPC: G01N33/52 ,  G01N33/68 ,  G01N33/84

公开(公告)号：JP2011180037A

公开(公告)日：2011-09-15

申请号：JP2010045879

申请日：2010-03-02

Applicant: Arkray Inc ,  アークレイ株式会社

Inventor： FUJIMOTO KOJI ,  FURUSATO NORIAKI ,  KOSAKA HIDEKO

IPC: G01N35/02 ,  G01N21/78

CPC classification number: G01N21/00 ,  G01N21/64 ,  G01N33/00

Abstract: PROBLEM TO BE SOLVED: To provide a technology, capable of facilitating authenticity determination of an analysis tool used for sample analysis processing, and thereby guaranteeing reliability of analysis results.
SOLUTION: An identification device for identifying an analysis tool having a reagent part, used for sample analysis processing, and having further a marker part for identification formed by using an invisible material, includes an irradiator for irradiating the marker part for identification with light, a light receiver for receiving light emitted from the invisible material forming the marker part for identification exposed to irradiation light by the irradiator, and an identification unit for identifying the analysis tool based on a light reception result by the light receiver.
COPYRIGHT: (C)2011,JPO&INPIT

Abstract translation: 要解决的问题：提供能够促进用于样品分析处理的分析工具的真实性确定的技术，从而保证分析结果的可靠性。 解决方案：用于识别具有用于样品分析处理的试剂部分并且还具有通过使用不可见材料形成的用于识别的标记部分的分析工具的识别装置包括用于将标记部分照射以进行鉴定的辐照器 光接收器，用于接收从形成标记部分的不可见材料发射的光，用于通过照射器暴露于照射光的识别;以及识别单元，用于基于光接收器的光接收结果识别分析工具。 版权所有（C）2011，JPO＆INPIT

公开(公告)号：JP2008046053A

公开(公告)日：2008-02-28

申请号：JP2006223689

申请日：2006-08-18

Applicant: Arkray Inc ,  Kyushu Univ ,  アークレイ株式会社 ,  国立大学法人九州大学

Inventor： KOSAKA HIDEKO ,  SAKAMOTO HISASHI ,  SOTOZONO EISAKU ,  SASANO YOSHICHIKA ,  OSAWA SUSUMU

IPC: G01N33/68 ,  C09B11/28 ,  G01N21/77 ,  G01N21/78 ,  G01N33/50

Abstract: PROBLEM TO BE SOLVED: To provide a liquid reagent reacting with various proteins containing albumin when the total protein in a liquid sample such as a biosample or the like is measured on the basis of the theory of a coloring matter bonding method corresponding to screening inspection to measure the total protein with extremely high sensitivity.
SOLUTION: The liquid reagent for measuring the total protein in the liquid sample contains a protein measuring indicator having a chemical structure represented by the chemical formula 1, a formic acid buffer solution the pH of which is adjusted to 1.0-3.5 and a nonionic surfactant.
COPYRIGHT: (C)2008,JPO&INPIT

Abstract translation: 待解决的问题：为了在液体样品例如生物样品等中的总蛋白质的基础上，根据与对应的色素结合方法的理论，测定与含有白蛋白的各种蛋白质反应的液体试剂 筛选检测以极高的灵敏度测量总蛋白质。 解决方案：用于测量液体样品中总蛋白质的液体试剂含有具有由化学式1表示的化学结构的蛋白质测量指示剂，其pH值调节至1.0-3.5的甲酸缓冲溶液和 非离子表面活性剂。 版权所有（C）2008，JPO＆INPIT

公开(公告)号：JP2008046052A

公开(公告)日：2008-02-28

申请号：JP2006223688

申请日：2006-08-18

Applicant: Arkray Inc ,  Kyushu Univ ,  アークレイ株式会社 ,  国立大学法人九州大学

Inventor： KOSAKA HIDEKO ,  SAKAMOTO HISASHI ,  SOTOZONO EISAKU ,  SASANO YOSHICHIKA ,  OSAWA SUSUMU

IPC: G01N33/50 ,  C09B11/28 ,  G01N21/78 ,  G01N33/68

Abstract: PROBLEM TO BE SOLVED: To provide a liquid reagent capable of specifically and simply measuring a very small amount of albumin in a liquid sample such as urine or the like inclusively of modified albumin (immunological unresponsive albumin), which is not measured by immunoassay, with high sensitivity equal to the immunoassay.
SOLUTION: The liquid reagent for measuring a very small amount of albumin in the liquid sample contains an indicator having a chemical structure represented by the chemical formula 1, at least one of a citric acid buffer solution adjusted to 1.0-3.0 in pH and an acetic acid buffer solution and a nonionic interface activator.
COPYRIGHT: (C)2008,JPO&INPIT

Abstract translation: 要解决的问题：提供一种液体试剂，其能够特异性地简单地测量包含修饰白蛋白（免疫反应性白蛋白）的液体样品如尿等中的非常少量的白蛋白，其不是由 免疫测定，具有高灵敏度等于免疫测定。 解决方案：用于测量液体样品中非常少量白蛋白的液体试剂含有具有由化学式1表示的化学结构的指示剂，柠檬酸缓冲溶液中的至少一种调节至1.0-3.0，pH值 和乙酸缓冲溶液和非离子界面活化剂。 版权所有（C）2008，JPO＆INPIT

公开(公告)号：DE60334548D1

公开(公告)日：2010-11-25

申请号：DE60334548

申请日：2003-08-04

Applicant: ARKRAY INC

Inventor： KOSAKA HIDEKO

IPC: G01N33/68 ,  G01N33/84