公开(公告)号：AT525656T

公开(公告)日：2011-10-15

申请号：AT05703979

申请日：2005-01-21

Applicant: ARKRAY INC

Inventor： KOSAKA HIDEKO ,  SAKAMOTO HISASHI

IPC: G01N33/68 ,  C12Q1/34 ,  G01N21/77 ,  G01N21/78 ,  G01N21/82 ,  G01N33/70

Abstract: The present invention relates to a technique of measuring a protein based on a degree of coloring in a liquid sample mixed with a protein measurement indicator. In the present invention, information reflecting creatinine concentration in the liquid sample is obtained, and then an influence quantity caused by creatinine to the protein concentration measurement is eliminated based on the information.

公开(公告)号：JP2008046018A

公开(公告)日：2008-02-28

申请号：JP2006222582

申请日：2006-08-17

Applicant: Arkray Inc ,  アークレイ株式会社

Inventor： KOSAKA HIDEKO ,  SAKAMOTO HISASHI

IPC: G01N33/50 ,  C09B11/28 ,  G01N21/78 ,  G01N33/68

Abstract: PROBLEM TO BE SOLVED: To provide a liquid reagent capable of specifically and simply measuring a very small amount of albumin in a liquid sample such as urine or the like inclusively of modified albumin, which is easily measured by immunoassay, with high sensitivity equal to immunoassay.
SOLUTION: The liquid reagent for measuring a very small amount of albumin in the liquid sample contains a buffer solution, an albumin measuring indicator having a chemical structure represented by a chemical formula 1 and a water-soluble polymer such as hydroxypropyl cellulose or the like being a sensitizer.
COPYRIGHT: (C)2008,JPO&INPIT

Abstract translation: 要解决的问题：提供一种液体试剂，其能够特异性且简单地测量包含修饰白蛋白的液体样品如尿等中的非常少量的白蛋白，其通过免疫测定容易测量，具有高灵敏度 等于免疫测定。 解决方案：用于测量液体样品中非常少量白蛋白的液体试剂含有缓冲溶液，具有由化学式1表示的化学结构的白蛋白测量指示剂和水溶性聚合物如羟丙基纤维素或 像是敏化剂。 版权所有（C）2008，JPO＆INPIT

公开(公告)号：JP2008046053A

公开(公告)日：2008-02-28

申请号：JP2006223689

申请日：2006-08-18

Applicant: Arkray Inc ,  Kyushu Univ ,  アークレイ株式会社 ,  国立大学法人九州大学

Inventor： KOSAKA HIDEKO ,  SAKAMOTO HISASHI ,  SOTOZONO EISAKU ,  SASANO YOSHICHIKA ,  OSAWA SUSUMU

IPC: G01N33/68 ,  C09B11/28 ,  G01N21/77 ,  G01N21/78 ,  G01N33/50

Abstract: PROBLEM TO BE SOLVED: To provide a liquid reagent reacting with various proteins containing albumin when the total protein in a liquid sample such as a biosample or the like is measured on the basis of the theory of a coloring matter bonding method corresponding to screening inspection to measure the total protein with extremely high sensitivity.
SOLUTION: The liquid reagent for measuring the total protein in the liquid sample contains a protein measuring indicator having a chemical structure represented by the chemical formula 1, a formic acid buffer solution the pH of which is adjusted to 1.0-3.5 and a nonionic surfactant.
COPYRIGHT: (C)2008,JPO&INPIT

Abstract translation: 待解决的问题：为了在液体样品例如生物样品等中的总蛋白质的基础上，根据与对应的色素结合方法的理论，测定与含有白蛋白的各种蛋白质反应的液体试剂 筛选检测以极高的灵敏度测量总蛋白质。 解决方案：用于测量液体样品中总蛋白质的液体试剂含有具有由化学式1表示的化学结构的蛋白质测量指示剂，其pH值调节至1.0-3.5的甲酸缓冲溶液和 非离子表面活性剂。 版权所有（C）2008，JPO＆INPIT

公开(公告)号：JP2008046052A

公开(公告)日：2008-02-28

申请号：JP2006223688

申请日：2006-08-18

Applicant: Arkray Inc ,  Kyushu Univ ,  アークレイ株式会社 ,  国立大学法人九州大学

Inventor： KOSAKA HIDEKO ,  SAKAMOTO HISASHI ,  SOTOZONO EISAKU ,  SASANO YOSHICHIKA ,  OSAWA SUSUMU

IPC: G01N33/50 ,  C09B11/28 ,  G01N21/78 ,  G01N33/68

Abstract: PROBLEM TO BE SOLVED: To provide a liquid reagent capable of specifically and simply measuring a very small amount of albumin in a liquid sample such as urine or the like inclusively of modified albumin (immunological unresponsive albumin), which is not measured by immunoassay, with high sensitivity equal to the immunoassay.
SOLUTION: The liquid reagent for measuring a very small amount of albumin in the liquid sample contains an indicator having a chemical structure represented by the chemical formula 1, at least one of a citric acid buffer solution adjusted to 1.0-3.0 in pH and an acetic acid buffer solution and a nonionic interface activator.
COPYRIGHT: (C)2008,JPO&INPIT

Abstract translation: 要解决的问题：提供一种液体试剂，其能够特异性地简单地测量包含修饰白蛋白（免疫反应性白蛋白）的液体样品如尿等中的非常少量的白蛋白，其不是由 免疫测定，具有高灵敏度等于免疫测定。 解决方案：用于测量液体样品中非常少量白蛋白的液体试剂含有具有由化学式1表示的化学结构的指示剂，柠檬酸缓冲溶液中的至少一种调节至1.0-3.0，pH值 和乙酸缓冲溶液和非离子界面活化剂。 版权所有（C）2008，JPO＆INPIT

公开(公告)号：JP2001258593A

公开(公告)日：2001-09-25

申请号：JP2000080883

申请日：2000-03-22

Applicant: ORIENTAL YEAST CO LTD ,  NAGASE & CO LTD ,  ARKRAY INC ,  BML INC ,  GENZYME CORP

Inventor： SAKAMOTO HISASHI ,  TSUBOI ISAMI ,  TORRENCE DAVID JOHN

IPC: C12Q1/26 ,  C12Q1/37 ,  G01N33/68

Abstract: PROBLEM TO BE SOLVED: To provide a method for assaying saccharogenic albumin, by which the saccharogenic albumin in a specimen can simply be assayed without using a special device. SOLUTION: This method for assaying the saccharogenic albumin, characterized by measuring the concentration of the saccharogenic albumin in a specimen with an enzyme and then determining the ratio to the otherwise measured concentration of all albumins in the specimen.

公开(公告)号：EP1770399A4

公开(公告)日：2012-03-14

申请号：EP05811276

申请日：2005-12-01

Applicant: ARKRAY INC

Inventor： SAKAMOTO HISASHI ,  FUJII SHIGEO

IPC: B01L3/00

CPC classification number: B01L3/545 ,  B01L3/5082 ,  B01L2300/021 ,  B01L2300/0825 ,  B01L2300/165 ,  G01N2035/00752

公开(公告)号：EP1715347A4

公开(公告)日：2008-09-10

申请号：EP05703979

申请日：2005-01-21

Applicant: ARKRAY INC

Inventor： KOSAKA HIDEKO ,  SAKAMOTO HISASHI

IPC: G01N33/68 ,  C12Q1/34 ,  G01N21/77 ,  G01N21/78 ,  G01N21/82 ,  G01N33/70

CPC classification number: G01N21/78 ,  G01N33/6827 ,  G01N33/70

Abstract: A technique for performing protein measurement on the basis of the level of coloring upon coexistence of a liquid sample with an indicator for protein measurement. In this technique, information reflecting the concentration of creatinine in a liquid sample is procured, and in accordance with this information, the amount of creatinine influence on the measurement of protein concentration is removed.

Abstract translation: 一种基于液体样品与蛋白质测量指示物共存时的着色水平进行蛋白质测量的技术。 在该技术中，获得了反映液体样品中肌酸酐浓度的信息，根据该信息，去除了肌酸酐对蛋白质浓度测量的影响量。

公开(公告)号：EP1586901A4

公开(公告)日：2008-05-28

申请号：EP04792597

申请日：2004-10-19

Applicant: ARKRAY INC

Inventor： SAKAMOTO HISASHI ,  MATSUDA TAKESHI ,  EGAWA KOUJI ,  SAIJI TETSUAKI

IPC: G01N33/52 ,  G01N33/543 ,  G06K19/06

CPC classification number: G01N33/523

Abstract: A tool for analyzing a specimen having a sufficient volume of information, and being capable of providing the information accurately and reading out that information without requiring any special mechanism. In the tool (1) for analyzing a specimen having a reagent layer (11) and an information recording layer (12) formed on a substrate (13), the information recording layer is divided into one or a plurality of regions and each region is colored with a single color. Information is recorded by at least one of a combination of gray levels of single color in the plurality of regions and the area of each region.

公开(公告)号：EP1707962A4

公开(公告)日：2008-04-09

申请号：EP05703967

申请日：2005-01-21

Applicant: ARKRAY INC

Inventor： SAKAMOTO HISASHI ,  MURATA YASUHITO

IPC: G01N33/52 ,  G01N33/543

CPC classification number: G01N33/54386 ,  G01N33/521

Abstract: A specimen analyzing tool automatically fed to an analyzing part without inconvenience even if the number of items to be inspected by the tool is small when the tool is set to an analyzer. One or more reagent pads are disposed on a substrate, and a balance pad to keep at least one of a weight balance and a friction balance is disposed on the substrate. The substrate is formed in a strip shape, and one end part of the substrate forms a holding part and the other part than the one end part forms a pad arrangement area. The reagent pads are disposed on the opposite side of the holding part in the pad arrangement area, and the balance pad is disposed on the holding part side in the pad arrangement area.